Eva Eicher, The Jackson Laboratory
Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Targeted (Conditional ready (e.g. floxed), No functional change) | Nr0b1 | nuclear receptor subfamily 0, group B, member 1 |
The Nr0b1tm1Lja floxed targeted mutation was generated in the mixed 129-derived ES cell line R1 and the resulting mice were bred with 129S1/SvImJ. This floxed allele arrived at The Jackson Laboratory on a primarily 129 background and was backcrossed once to C57BL/6J and then backcrossed repeatedly to C57BL/6JEi in the laboratory of Dr. Eva Eicher.
Allele Name | targeted mutation 1, J Larry Jameson |
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Allele Type | Targeted (Conditional ready (e.g. floxed), No functional change) |
Allele Synonym(s) | Ahchflox2; B6-DAX1; Dax1flox |
Gene Symbol and Name | Nr0b1, nuclear receptor subfamily 0, group B, member 1 |
Gene Synonym(s) | |
Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl+ |
Chromosome | X |
Molecular Note | A floxed PGK-neomycin resistance cassette was inserted downstream of exon 2 and a third loxP site was inserted upstream of the splice acceptor signal in exon 2. |
When using the B6Ei-Dax1flox mouse strain in a publication, please cite the originating article(s) and include JAX stock #007006 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
X linked - Heterozygous females and Wild-type Males for Nr0b1<tm1Lja> |
Frozen Mouse Embryo | B6Ei.129-Nr0b1<tm1Lja>/EiJ Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | B6Ei.129-Nr0b1<tm1Lja>/EiJ Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | B6Ei.129-Nr0b1<tm1Lja>/EiJ Frozen Embryo | $3373.50 |
Frozen Mouse Embryo | B6Ei.129-Nr0b1<tm1Lja>/EiJ Frozen Embryo | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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