JAX
Mouse Strain Datasheet - 006911
B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm2(tetO-Pou5f1)Jae/J
Also Known As: Oct-4/rtTA (R26-M2rtTA;Col1a1-tetO-Oct4)
These "Oct-4/rtTA" mutant mice (R26-M2rtTA;Col1a1-tetO-Oct4) may be useful for studies of tumorigenesis and pluripotent stem cells.
Donating Investigator
Dr. Rudolf Jaenisch, Whitehead Institute (MIT)
Genetic overview
| Genetic Background | Generation |
|---|---|
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Col1a1tm2(tetO-Pou5f1)Jae
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Inducible, Inserted expressed sequence, RMCE-ready) | Col1a1 | collagen, type I, alpha 1 |
Gt(ROSA)26Sortm1(rtTA*M2)Jae
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Transactivator) | Gt(ROSA)26Sor | gene trap ROSA 26, Philippe Soriano |
Research Applications
- Cancer Research
- Cell Biology Research
- Research Tools
Detailed Description
Mice heterozygous for both targeted mutations (R26-rtTA and Cola1a::tetO-Oct4) are viable and fertile. These "Oct-4/rtTA" mice express rtTA-M2, an optimized form of reverse tetracycline-controlled transactivator (rtTA) protein, in multiple tissues. In the absence of the tetracycline analog doxycycline (dox), Oct4 (Pou5f1) expression from the Col1a1 locus is not detected. Following dox administration, high Oct4 expression is induced in liver, bone marrow, stomach, intestine, and skin, with lower levels in the heart, lungs, kidney, spleen, and thymus; no expression was detected in the brain and testes. Dox-inducd activation of Oct4 results in dysplasia in epithelial tissues. These mutant mice may be useful for studies of tumorigenesis and pluripotent cells.
Development
The R26-M2rtTA targeted mutation has an optimized form of reverse tetracycline controlled transactivator (rtTA-M2) followed by a β-globin intron, polyA signal and PGK-puromycin cassette, all inserted downstream of the Gt(ROSA)26Sor promoter. The targeting vector was electroporated into (C57BL/6 x 129S4Sv/Jae)F1-derived V6.5 embryonic stem (ES) cells. In addition, these ES cells were retargeted to insert an frt-flanked PGK-Neo was into the 3' UTR of the Col1a1 locus. Correctly targeted ES cells were selected and the frt-flanked PGK-Neo in the 3' UTR of the Col1a1 locus was replaced by injecting both a "flip-in plasmid" containing a splice acceptor-double polyA sequence and the tetracycline responsive element (TRE or tetO) upstream of the mouse Oct4 (Pou5f1) cDNA sequence, as well as a Flpe-expressing plasmid to facilitate tetO-Oct4 recombination into the 3' UTR of the Col1a1 locus. The resulting ES cells (now targeted with rtTA-M2 in the Gt(ROSA)26Sor locus and tetO-Oct4 in the Col1a1 locus) were injected into B6D2F1 tetraploid blastocysts. Chimeric mice were bred together for many generations prior to arrival at The Jackson Laboratory Repository.
Expression Data
| Expressed Gene | Pou5f1, POU domain, class 5, transcription factor 1, mouse, laboratory |
|---|---|
| Site of Expression | With doxycycline treatment, Pou5f1 expression from the Col1a1 locus is widespread with high levels in skin, intestine and stomach, while lower levels are seen in the heart, spleen, thymus and several other organs. |
| Expressed Gene | rtTA, reverse tetracycline-controlled transactivator, E. coli |
| Site of Expression | Expresses an optimized rtTA protein (rtTA-M2). Inducible target gene expression is detected in liver, bone marrow, stomach, intestine, and skin, with lower levels in the heart, lungs, kidney, spleen, and thymus; no expression is detected in the brain and testes. |
Control Suggestions
Approximate Controls
Additional Information
Selected References
- Hochedlinger K; Yamada Y; Beard C; Jaenisch R. 2005. Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Cell 121(3):465-77. PubMed: 15882627MGI: J:98920
Col1a1tm2(tetO-Pou5f1)Jae
Allele Symbol: Col1a1tm2(tetO-Pou5f1)Jae
| Allele Name | targeted mutation 2, Rudolf Jaenisch |
|---|---|
| Allele Type | Targeted (Inducible, Inserted expressed sequence, RMCE-ready) |
| Allele Synonym(s) | Col1a1::TetOP-Oct4; TetON-Oct4 |
| Gene Symbol and Name | Col1a1, collagen, type I, alpha 1 |
| Gene Synonym(s) | COLIA1; Col1a-1; Col1a-1; Cola-1; Cola-1; Cola1; Cola1; EDSC; Moloney leukemia virus 13; Mov-13; Mov-13; OI1; OI2; OI3; OI4 |
| Promoter | tetO, tet operator, |
| Expressed Gene | Pou5f1, POU domain, class 5, transcription factor 1, mouse, laboratory |
| Site of Expression | With doxycycline treatment, Pou5f1 expression from the Col1a1 locus is widespread with high levels in skin, intestine and stomach, while lower levels are seen in the heart, spleen, thymus and several other organs. |
| Strain of Origin | (C57BL/6 x 129S4/SvJae)F1 |
| Chromosome | 11 |
| Molecular Note | ES cells containing the Gt(ROSA)26Sortm1(rtTA2S-M2)Jae mutation were retargeted. Cells were injected with a "flip-in plasmid" containing a tetracycline responsive element (TRE or tetO) and mouse Oct4 (Pou5f1) cDNA sequence (and a Flpe-recombinase plasmid to facilitate tetO-Oct4 integration into the 3' UTR region of Col1a1). With doxycycline treatment, Pou5f1 expression from the Col1a1 locus is widespread with high levels in skin, intestine and stomach, while lower levels are seen in the heart, spleen, thymus and several other organs. No expression is seen in the brain or testes. |
Gt(ROSA)26Sortm1(rtTA*M2)Jae
Allele Symbol: Gt(ROSA)26Sortm1(rtTA*M2)Jae
| Allele Name | targeted mutation 1, Rudolf Jaenisch |
|---|---|
| Allele Type | Targeted (Transactivator) |
| Allele Synonym(s) | Gt(ROSA)26Sortm1(M2rtTA)Jae; M2; M2-rtTA; R26-M2rtTA; R26-rtTA; Rosa26-M2rtTA |
| Gene Symbol and Name | Gt(ROSA)26Sor, gene trap ROSA 26, Philippe Soriano |
| Gene Synonym(s) | AV258896; Gtrgeo26; Gtrgeo26; Gtrosa26; Gtrosa26; R26; ROSA26; SETD5-AS1; Thumpd3as1; beta geo; expressed sequence AV258896; gene trap ROSA 26; gene trap ROSA b-geo 26 |
| Expressed Gene | rtTA, reverse tetracycline-controlled transactivator, E. coli |
| Site of Expression | Expresses an optimized rtTA protein (rtTA-M2). Inducible target gene expression is detected in liver, bone marrow, stomach, intestine, and skin, with lower levels in the heart, lungs, kidney, spleen, and thymus; no expression is detected in the brain and testes. |
| Strain of Origin | (C57BL/6 x 129S4/SvJae)F1 |
| Chromosome | 6 |
| General Note | This mutation was created during the generation of mutant ES cell line KH2, which also contains a frt docking site downstream of the endogenous Col1a1 locus on Chr 11 (Col1a1 |
| Molecular Note | An optimized form of reverse tetracycline controlled transactivator (rtTA-M2) was inserted downstream of the Gt(ROSA)26Sor promoter and was followed by a PGK-puro selection cassette. This mutant form of rtTA termed M2 has five amino acid substitutions in the tetR moiety of tTA: S12G, E19G, A56P, D148E and H179R. This mutated form of transactivator protein has increased doxycycline sensitivity. Mice have widespread expression of the rtTA-M2 protein. |
| Mutations Made By | Dr. Rudolf Jaenisch, Whitehead Institute (MIT) |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Cancer Research
- Other
- Cell Biology Research
- Transcriptional Regulation
- Research Tools
- Cancer Research
- Tetop Tet System
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Tetop Tet System
- Mutagenesis and Transgenesis: transcriptional activation
- Tet Expression Systems
- tTA/rtTA Expressing Strains
- tTA/rtTA Responsive Strains
- Cancer Research
Mammalian Phenotype Terms by Genotype
Genotype: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+ Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
involves: 129S4/SvJae * C57BL/6
mortality/aging
- premature death
endocrine/exocrine gland phenotype
- abnormal intermediate gastric gland morphology
- hyperplastic fundic glands are seen in doxycycline treated mice (MGI Ref ID J:98920)
- thymus atrophy
- atrophy and absence of CD4, CD8 double positive cells in doxycycline treated mice (MGI Ref ID J:98920)
digestive/alimentary phenotype
- abnormal forestomach morphology
- in doxycycline treated mice, cells in the forestomach show a marked atypia and increased mitotic activity (MGI Ref ID J:98920)
- abnormal intermediate gastric gland morphology
- hyperplastic fundic glands are seen in doxycycline treated mice (MGI Ref ID J:98920)
- abnormal intestinal epithelium morphology
- after doxycline treatment, dysplastic cells are found in the entire epithelium; cells have structural and cytological dysplasia which mimics adenocarcinoma (MGI Ref ID J:98920)
- abnormal small intestine morphology
- after 5 days of doxycycline treatment, proliferative zone expands; postmitotic, differentiated cells lining the villus are replaced (MGI Ref ID J:98920)
- the proximal part of the small intestine is most severely affected by doxycycline treatment with abnormal cells often almost obstructing the lumen (MGI Ref ID J:98920)
- upon cessation of treatment, cells migrate to final destinations and differentiate (MGI Ref ID J:98920)
- upon cessation of treatment, cells migrate to final destinations and differentiate resulting in restoration of normal morphology (MGI Ref ID J:98920)
- abnormal stomach epithelium morphology
- in doxycycline treated mice, forestomach epithelium is thickened and stomach shows lack of differentiation into granular and cornified cell layers compared to control mice (MGI Ref ID J:98920)
- the thickened epithelium consists of atypical cells with enlarged nuclei and prominent nucleoli (MGI Ref ID J:98920)
- abnormal stomach glandular epithelium morphology
- after doxycycline treatment, mice display severe dysplasia and increased proliferation (MGI Ref ID J:98920)
- abnormal stomach mucosa morphology
- pyloric mucosa contains lesions resembling high grade-dysplasia in doxycycline treated mice (MGI Ref ID J:98920)
- stomach epithelial hyperplasia
- cells show atypia and increased mitotic activity throughout the squamous epithelial layer in doxycycline treated mice (MGI Ref ID J:98920)
homeostasis/metabolism phenotype
- dehydration
- after 3-5 days of doxycycline treatment, animals display severe dehydration (MGI Ref ID J:98920)
cellular phenotype
- abnormal cell proliferation
behavior/neurological phenotype
- lethargy
- animals become lethargic with doxycycline treatment within 3-5 days (MGI Ref ID J:98920)
hematopoietic system phenotype
- spleen atrophy
- in doxycycline treated mice (MGI Ref ID J:98920)
- thymus atrophy
- atrophy and absence of CD4, CD8 double positive cells in doxycycline treated mice (MGI Ref ID J:98920)
immune system phenotype
- spleen atrophy
- in doxycycline treated mice (MGI Ref ID J:98920)
- thymus atrophy
- atrophy and absence of CD4, CD8 double positive cells in doxycycline treated mice (MGI Ref ID J:98920)
neoplasm
- increased skin tumor incidence
- in doxycycline treated mice, tumors originating from the outer-root-sheath progenitors and invading the subcutaneous layer are seen (MGI Ref ID J:98920)
integument phenotype
- abnormal epidermal layer morphology
- after 5-10 days of doxycycline treatment, mice show mild to moderate epidermal dysplasia with a decrease in differentiation in dysplastic cells (MGI Ref ID J:98920)
- abnormal hair follicle morphology
- increased numbers of immature cells in the hair follicles of the skin are seen after 5-10 days of doxycycline (MGI Ref ID J:98920)
- increased skin tumor incidence
- in doxycycline treated mice, tumors originating from the outer-root-sheath progenitors and invading the subcutaneous layer are seen (MGI Ref ID J:98920)
References
- Hochedlinger K; Yamada Y; Beard C; Jaenisch R. 2005. Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Cell 121(3):465-77. PubMed: 15882627MGI: J:98920
Additional - Col1a1tm2(tetO-Pou5f1)Jae related
- Jaako P; Flygare J; Olsson K; Quere R; Ehinger M; Henson A; Ellis S; Schambach A; Baum C; Richter J; Larsson J; Bryder D; Karlsson S. 2011. Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia. Blood 118(23):6087-96. PubMed: 21989989MGI: J:179085
- Kuzmichev AN; Kim SK; D'Alessio AC; Chenoweth JG; Wittko IM; Campanati L; McKay RD. 2012. Sox2 acts through Sox21 to regulate transcription in pluripotent and differentiated cells. Curr Biol 22(18):1705-10. PubMed: 22902753MGI: J:199754
- Maherali N; Sridharan R; Xie W; Utikal J; Eminli S; Arnold K; Stadtfeld M; Yachechko R; Tchieu J; Jaenisch R; Plath K; Hochedlinger K. 2007. Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell 1(1):55-70. PubMed: 18371336MGI: J:158493
- Paliwal P; Conboy IM. 2011. Inhibitors of tyrosine phosphatases and apoptosis reprogram lineage-marked differentiated muscle to myogenic progenitor cells. Chem Biol 18(9):1153-66. PubMed: 21944754MGI: J:190199
- Watanabe S; Hirai H; Asakura Y; Tastad C; Verma M; Keller C; Dutton JR; Asakura A. 2011. MyoD gene suppression by Oct4 is required for reprogramming in myoblasts to produce induced pluripotent stem cells. Stem Cells 29(3):505-16. PubMed: 21425413MGI: J:175957
- Zhao W; Li Q; Ayers S; Gu Y; Shi Z; Zhu Q; Chen Y; Wang HY; Wang RF. 2013. Jmjd3 inhibits reprogramming by upregulating expression of INK4a/Arf and targeting PHF20 for ubiquitination. Cell 152(5):1037-50. PubMed: 23452852MGI: J:228713
Additional - Gt(ROSA)26Sortm1(rtTA*M2)Jae related
- Abad M; Mosteiro L; Pantoja C; Canamero M; Rayon T; Ors I; Grana O; Megias D; Dominguez O; Martinez D; Manzanares M; Ortega S; Serrano M. 2013. Reprogramming in vivo produces teratomas and iPS cells with totipotency features. Nature :. PubMed: 24025773MGI: J:201192
- Aoki H; Hara A; Era T; Kunisada T; Yamada Y. 2012. Genetic ablation of Rest leads to in vitro-specific derepression of neuronal genes during neurogenesis. Development 139(4):667-77. PubMed: 22241837MGI: J:181188
- Aoki H; Tomita H; Hara A; Kunisada T. 2015. Conditional Deletion of Kit in Melanocytes: White Spotting Phenotype Is Cell Autonomous. J Invest Dermatol 135(7):1829-38. PubMed: 25734811MGI: J:222747
- Araujo L; Khim P; Mkhikian H; Mortales CL; Demetriou M. 2017. Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation. Elife 6:. PubMed: 28059703MGI: J:240169
- Bain CC; Hawley CA; Garner H; Scott CL; Schridde A; Steers NJ; Mack M; Joshi A; Guilliams M; Mowat AM; Geissmann F; Jenkins SJ. 2016. Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities. Nat Commun 7:ncomms11852. PubMed: 27292029MGI: J:239892
- Beard C; Hochedlinger K; Plath K; Wutz A; Jaenisch R. 2006. Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells. Genesis 44(1):23-8. PubMed: 16400644MGI: J:159351
- Blas-Rus N; Bustos-Moran E; Perez de Castro I; de Carcer G; Borroto A; Camafeita E; Jorge I; Vazquez J; Alarcon B; Malumbres M; Martin-Cofreces NB; Sanchez-Madrid F. 2016. Aurora A drives early signalling and vesicle dynamics during T-cell activation. Nat Commun 7:11389. PubMed: 27091106MGI: J:236886
- Bolden JE; Tasdemir N; Dow LE; van Es JH; Wilkinson JE; Zhao Z; Clevers H; Lowe SW. 2014. Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition. Cell Rep 8(6):1919-29. PubMed: 25242322MGI: J:218548
- Boquoi A; Arora S; Chen T; Litwin S; Koh J; Enders GH. 2015. Reversible cell cycle inhibition and premature aging features imposed by conditional expression of p16Ink4a. Aging Cell 14(1):139-47. PubMed: 25481981MGI: J:220759
- Bowles J; Secker G; Nguyen C; Kazenwadel J; Truong V; Frampton E; Curtis C; Skoczylas R; Davidson TL; Miura N; Hong YK; Koopman P; Harvey NL; Francois M. 2014. Control of retinoid levels by CYP26B1 is important for lymphatic vascular development in the mouse embryo. Dev Biol 386(1):25-33. PubMed: 24361262MGI: J:206581
- Bozec A; Bakiri L; Jimenez M; Rosen ED; Catala-Lehnen P; Schinke T; Schett G; Amling M; Wagner EF. 2013. Osteoblast-specific expression of Fra-2/AP-1 controls adiponectin and osteocalcin expression and affects metabolism. J Cell Sci 126(Pt 23):5432-40. PubMed: 24046454MGI: J:211215
- Brambrink T; Foreman R; Welstead GG; Lengner CJ; Wernig M; Suh H; Jaenisch R. 2008. Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell 2(2):151-9. PubMed: 18371436MGI: J:149805
- Brennand K; Huangfu D; Melton D. 2007. All beta Cells Contribute Equally to Islet Growth and Maintenance. PLoS Biol 5(7):e163. PubMed: 17535113MGI: J:124045
- Camargo FD; Gokhale S; Johnnidis JB; Fu D; Bell GW; Jaenisch R; Brummelkamp TR. 2007. YAP1 increases organ size and expands undifferentiated progenitor cells. Curr Biol 17(23):2054-60. PubMed: 17980593MGI: J:141457
- Carey BW; Markoulaki S; Beard C; Hanna J; Jaenisch R. 2010. Single-gene transgenic mouse strains for reprogramming adult somatic cells. Nat Methods 7(1):56-9. PubMed: 20010831MGI: J:157298
- Chakkalakal SA; Uchibe K; Convente MR; Zhang D; Economides AN; Kaplan FS; Pacifici M; Iwamoto M; Shore EM. 2016. Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation. J Bone Miner Res 31(9):1666-75. PubMed: 26896819MGI: J:239136
- Chen J; Gao Y; Huang H; Xu K; Chen X; Jiang Y; Li H; Gao S; Tao Y; Wang H; Zhang Y; Wang H; Cai T; Gao S. 2015. The combination of Tet1 with Oct4 generates high-quality mouse-induced pluripotent stem cells. Stem Cells 33(3):686-98. PubMed: 25331067MGI: J:223578
- Chu M; Wang L; Wang H; Shen T; Yang Y; Sun Y; Tang N; Ni T; Zhu J; Mailman RB; Wang Y. 2014. A novel role of CDX1 in embryonic epicardial development. PLoS One 9(7):e103271. PubMed: 25068460MGI: J:219002
- Cunningham JT; Moreno MV; Lodi A; Ronen SM; Ruggero D. 2014. Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer. Cell 157(5):1088-103. PubMed: 24855946MGI: J:214383
- D'Alessandro M; Beesley S; Kim JK; Chen R; Abich E; Cheng W; Yi P; Takahashi JS; Lee C. 2015. A tunable artificial circadian clock in clock-defective mice. Nat Commun 6:8587. PubMed: 26617050MGI: J:227998
- Di Stefano B; Sardina JL; van Oevelen C; Collombet S; Kallin EM; Vicent GP; Lu J; Thieffry D; Beato M; Graf T. 2014. C/EBPalpha poises B cells for rapid reprogramming into induced pluripotent stem cells. Nature 506(7487):235-9. PubMed: 24336202MGI: J:207220
- Dickins RA; McJunkin K; Hernando E; Premsrirut PK; Krizhanovsky V; Burgess DJ; Kim SY; Cordon-Cardo C; Zender L; Hannon GJ; Lowe SW. 2007. Tissue-specific and reversible RNA interference in transgenic mice. Nat Genet 39(7):914-21. PubMed: 17572676MGI: J:123006
- Dow LE; Fisher J; O'Rourke KP; Muley A; Kastenhuber ER; Livshits G; Tschaharganeh DF; Socci ND; Lowe SW. 2015. Inducible in vivo genome editing with CRISPR-Cas9. Nat Biotechnol 33(4):390-4. PubMed: 25690852MGI: J:222595
- Dumont-Lagace M; Brochu S; St-Pierre C; Perreault C. 2014. Adult thymic epithelium contains nonsenescent label-retaining cells. J Immunol 192(5):2219-26. PubMed: 24477909MGI: J:209820
- Foudi A; Hochedlinger K; Van Buren D; Schindler JW; Jaenisch R; Carey V; Hock H. 2009. Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells. Nat Biotechnol 27(1):84-90. PubMed: 19060879MGI: J:172421
- Foudi A; Kramer DJ; Qin J; Ye D; Behlich AS; Mordecai S; Preffer FI; Amzallag A; Ramaswamy S; Hochedlinger K; Orkin SH; Hock H. 2014. Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation. J Exp Med :. PubMed: 24711581MGI: J:207446
- Freyer L; Schroter C; Saiz N; Schrode N; Nowotschin S; Martinez-Arias A; Hadjantonakis AK. 2015. A loss-of-function and H2B-Venus transcriptional reporter allele for Gata6 in mice. BMC Dev Biol 15:38. PubMed: 26498761MGI: J:226600
- Furutachi S; Miya H; Watanabe T; Kawai H; Yamasaki N; Harada Y; Imayoshi I; Nelson M; Nakayama KI; Hirabayashi Y; Gotoh Y. 2015. Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells. Nat Neurosci 18(5):657-65. PubMed: 25821910MGI: J:222423
- Golden EJ; Benito-Gonzalez A; Doetzlhofer A. 2015. The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea. Proc Natl Acad Sci U S A 112(29):E3864-73. PubMed: 26139524MGI: J:223798
- Gonzalez-Loyola A; Fernandez-Miranda G; Trakala M; Partida D; Samejima K; Ogawa H; Canamero M; de Martino A; Martinez-Ramirez A; de Carcer G; Perez de Castro I; Earnshaw WC; Malumbres M. 2015. Aurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development. Mol Cell Biol 35(20):3566-78. PubMed: 26240282MGI: J:228221
- Gros J; Hu JK; Vinegoni C; Feruglio PF; Weissleder R; Tabin CJ. 2010. WNT5A/JNK and FGF/MAPK pathways regulate the cellular events shaping the vertebrate limb bud. Curr Biol 20(22):1993-2002. PubMed: 21055947MGI: J:166897
- Guo S; Bai H; Megyola CM; Halene S; Krause DS; Scadden DT; Lu J. 2012. Complex oncogene dependence in microRNA-125a-induced myeloproliferative neoplasms. Proc Natl Acad Sci U S A 109(41):16636-41. PubMed: 23012470MGI: J:190324
- Hasenfuss SC; Bakiri L; Thomsen MK; Hamacher R; Wagner EF. 2014. Activator Protein 1 transcription factor Fos-related antigen 1 (Fra-1) is dispensable for murine liver fibrosis, but modulates xenobiotic metabolism. Hepatology 59(1):261-73. PubMed: 23703832MGI: J:213764
- Hasenfuss SC; Bakiri L; Thomsen MK; Williams EG; Auwerx J; Wagner EF. 2014. Regulation of steatohepatitis and PPARgamma signaling by distinct AP-1 dimers. Cell Metab 19(1):84-95. PubMed: 24411941MGI: J:210545
- Hashimoto K; Yamada Y; Semi K; Yagi M; Tanaka A; Itakura F; Aoki H; Kunisada T; Woltjen K; Haga H; Sakai Y; Yamamoto T; Yamada Y. 2017. Cellular context-dependent consequences of Apc mutations on gene regulation and cellular behavior. Proc Natl Acad Sci U S A 114(4):758-763. PubMed: 28057861MGI: J:239530
- He S; Kim I; Lim MS; Morrison SJ. 2011. Sox17 expression confers self-renewal potential and fetal stem cell characteristics upon adult hematopoietic progenitors. Genes Dev 25(15):1613-27. PubMed: 21828271MGI: J:174416
- Heinonen KM; Vanegas JR; Brochu S; Shan J; Vainio SJ; Perreault C. 2011. Wnt4 regulates thymic cellularity through the expansion of thymic epithelial cells and early thymic progenitors. Blood 118(19):5163-73. PubMed: 21937690MGI: J:178890
- Henneman L; van Miltenburg MH; Michalak EM; Braumuller TM; Jaspers JE; Drenth AP; de Korte-Grimmerink R; Gogola E; Szuhai K; Schlicker A; Bin Ali R; Pritchard C; Huijbers IJ; Berns A; Rottenberg S; Jonkers J. 2015. Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer. Proc Natl Acad Sci U S A 112(27):8409-14. PubMed: 26100884MGI: J:223738
- Hiler D; Chen X; Hazen J; Kupriyanov S; Carroll PA; Qu C; Xu B; Johnson D; Griffiths L; Frase S; Rodriguez AR; Martin G; Zhang J; Jeon J; Fan Y; Finkelstein D; Eisenman RN; Baldwin K; Dyer MA. 2015. Quantification of Retinogenesis in 3D Cultures Reveals Epigenetic Memory and Higher Efficiency in iPSCs Derived from Rod Photoreceptors. Cell Stem Cell 17(1):101-15. PubMed: 26140606MGI: J:224847
- Hirata A; Utikal J; Yamashita S; Aoki H; Watanabe A; Yamamoto T; Okano H; Bardeesy N; Kunisada T; Ushijima T; Hara A; Jaenisch R; Hochedlinger K; Yamada Y. 2013. Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium. Development 140(1):66-75. PubMed: 23222438MGI: J:191050
- Ho R; Papp B; Hoffman JA; Merrill BJ; Plath K. 2013. Stage-specific regulation of reprogramming to induced pluripotent stem cells by Wnt signaling and T cell factor proteins. Cell Rep 3(6):2113-26. PubMed: 23791530MGI: J:199370
- Holl D; Kuckenberg P; Woynecki T; Egert A; Becker A; Huss S; Stabenow D; Zimmer A; Knolle P; Tolba R; Fischer HP; Schorle H. 2011. Transgenic Overexpression of Tcfap2c/AP-2gamma Results in Liver Failure and Intestinal Dysplasia. PLoS One 6(7):e22034. PubMed: 21779369MGI: J:174049
- Hoseini SS; Hapke M; Herbst J; Wedekind D; Baumann R; Heinz N; Schiedlmeier B; Vignali DA; van den Brink MR; Schambach A; Blazar BR; Sauer MG. 2015. Inducible T-cell receptor expression in precursor T cells for leukemia control. Leukemia 29(7):1530-42. PubMed: 25652739MGI: J:222596
- Jaako P; Flygare J; Olsson K; Quere R; Ehinger M; Henson A; Ellis S; Schambach A; Baum C; Richter J; Larsson J; Bryder D; Karlsson S. 2011. Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia. Blood 118(23):6087-96. PubMed: 21989989MGI: J:179085
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