JAX
Mouse Strain Datasheet - 006852
B6.129S6-Per2tm1Jt/J
Also Known As: mPer2Luc
These targeted reporter mutant mice express PER2::LUC bioluminescence similar to endogenous Per2 expression, and may be useful as a real-time reporter of circadian dynamics in different tissues.
Donating Investigator
Dr. Joseph S. Takahashi, Univ Texas Southwestern Medical Ctr
Genetic overview
| Genetic Background | Generation |
|---|---|
|
N11+N1F8
|
Per2tm1Jt
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (No functional change, Reporter) | Per2 | period circadian clock 2 |
Detailed Description
Mice homozygous for this "mPer2Luc" mutation are viable and fertile with no developmental or morphological differences compared to wildtype littermates. Expression of PERIOD2::LUCIFERASE (or mPER2::LUC) fusion protein during peak periods is similar to endogenous pPER2 patterns. Homozygous mice have normal entrainment and circadian behaviors. These mPer2Luc knock-in mice may be useful as a real-time reporter of circadian dynamics in different tissues.
Development
A targeting vector was designed to insert the firefly luciferase (luc) gene (followed by a loxP-flanked neomycin resistance gene) in-frame into exon 23 of the wild-type sequence. The construct was electroporated into 129S6/SvEvTac-derived W4 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6J blastocysts. Chimeric males were bred to C57BL/6J females. Heterozygotes were backcrossed to C57BL/6J inbred mice for 7-11 generations prior to arrival at The Jackson Laboratory.
Expression Data
| Expressed Gene | luc, luciferase, firefly |
|---|---|
| Site of Expression | Circadian patterns of Per2-Luc fusion protein expression is seen in the following peripheral tissues: SCN, cornea, liver, pituitary, kidney, RCA, lung and tail). |
Control Suggestions
Selected References
- Yoo SH; Yamazaki S; Lowrey PL; Shimomura K; Ko CH; Buhr ED; Siepka SM; Hong HK; Oh WJ; Yoo OJ; Menaker M; Takahashi JS. 2004. PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. Proc Natl Acad Sci U S A 101(15):5339-46. PubMed: 14963227MGI: J:89256
Per2tm1Jt
Allele Symbol: Per2tm1Jt
| Allele Name | targeted mutation 1, Joseph S Takahashi |
|---|---|
| Allele Type | Targeted (No functional change, Reporter) |
| Allele Synonym(s) | Per2Luc; mPER2::LUC; mPer2Luc; mPer2Luciferase |
| Gene Symbol and Name | Per2, period circadian clock 2 |
| Gene Synonym(s) | FASPS; FASPS1; mKIAA0347; mPer2; rPER2 |
| Expressed Gene | luc, luciferase, firefly |
| Site of Expression | Circadian patterns of Per2-Luc fusion protein expression is seen in the following peripheral tissues: SCN, cornea, liver, pituitary, kidney, RCA, lung and tail). |
| Strain of Origin | 129S6/SvEvTac |
| Chromosome | 1 |
| Molecular Note | A luciferase gene and floxed neo cassette were inserted between exon 23 and the 3' UTR. Mutant transcript was detected in Northern blot of mutant brains and the Per2-Luc fusion protein was detected in Western blots of mutant kidneys. |
| Mutations Made By | Dr. Joseph Takahashi, Univ Texas Southwestern Medical Ctr |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Neurobiology Research
- Circadian Rhythms
- Research Tools
- Fluorescent Proteins
- Neurobiology Research
Mammalian Phenotype Terms by Genotype
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Per2tm1Jt/Per2tm1Jt
involves: 129S6/SvEvTac * C57BL/6J
normal phenotype
- no abnormal phenotype detected
- mice developed normally and showed no overt morphological abnormalities (MGI Ref ID J:89256)
References
- Yoo SH; Yamazaki S; Lowrey PL; Shimomura K; Ko CH; Buhr ED; Siepka SM; Hong HK; Oh WJ; Yoo OJ; Menaker M; Takahashi JS. 2004. PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. Proc Natl Acad Sci U S A 101(15):5339-46. PubMed: 14963227MGI: J:89256
Additional - Per2tm1Jt related
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