JAX
Mouse Strain Datasheet - 006852
B6.129S6-Per2tm1Jt/J
Also Known As: mPer2Luc
These targeted reporter mutant mice express PER2::LUC bioluminescence similar to endogenous Per2 expression, and may be useful as a real-time reporter of circadian dynamics in different tissues.
Donating Investigator
Dr. Joseph S. Takahashi, Univ Texas Southwestern Medical Ctr
Genetic overview
| Genetic Background | Generation |
|---|---|
|
N11+N1F9
(31-MAR-17) |
Per2tm1Jt
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (No functional change, Reporter) | Per2 | period circadian clock 2 |
Detailed Description
Mice homozygous for this "mPer2Luc" mutation are viable and fertile with no developmental or morphological differences compared to wildtype littermates. Expression of PERIOD2::LUCIFERASE (or mPER2::LUC) fusion protein during peak periods is similar to endogenous pPER2 patterns. Homozygous mice have normal entrainment and circadian behaviors. These mPer2Luc knock-in mice may be useful as a real-time reporter of circadian dynamics in different tissues.
Development
A targeting vector was designed to insert the firefly luciferase (luc) gene (followed by a loxP-flanked neomycin resistance gene) in-frame into exon 23 of the wild-type sequence. The construct was electroporated into 129S6/SvEvTac-derived W4 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6J blastocysts. Chimeric males were bred to C57BL/6J females. Heterozygotes were backcrossed to C57BL/6J inbred mice for 7-11 generations prior to arrival at The Jackson Laboratory.
Expression Data
| Expressed Gene | luc, luciferase, firefly |
|---|---|
| Site of Expression | Circadian patterns of Per2-Luc fusion protein expression is seen in the following peripheral tissues: SCN, cornea, liver, pituitary, kidney, RCA, lung and tail). |
Control Suggestions
Selected References
- Yoo SH; Yamazaki S; Lowrey PL; Shimomura K; Ko CH; Buhr ED; Siepka SM; Hong HK; Oh WJ; Yoo OJ; Menaker M; Takahashi JS. 2004. PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. Proc Natl Acad Sci U S A 101(15):5339-46. PubMed: 14963227MGI: J:89256
Per2tm1Jt
Allele Symbol: Per2tm1Jt
| Allele Name | targeted mutation 1, Joseph S Takahashi |
|---|---|
| Allele Type | Targeted (No functional change, Reporter) |
| Allele Synonym(s) | Per2Luc; mPER2::LUC; mPer2Luc; mPer2Luciferase |
| Gene Symbol and Name | Per2, period circadian clock 2 |
| Gene Synonym(s) | FASPS; FASPS1; mKIAA0347; mPer2; rPER2 |
| Expressed Gene | luc, luciferase, firefly |
| Site of Expression | Circadian patterns of Per2-Luc fusion protein expression is seen in the following peripheral tissues: SCN, cornea, liver, pituitary, kidney, RCA, lung and tail). |
| Strain of Origin | 129S6/SvEvTac |
| Chromosome | 1 |
| Molecular Note | A luciferase gene and floxed neo cassette were inserted between exon 23 and the 3' UTR. Mutant transcript was detected in Northern blot of mutant brains and the Per2-Luc fusion protein was detected in Western blots of mutant kidneys. |
| Mutations Made By | Dr. Joseph Takahashi, Univ Texas Southwestern Medical Ctr |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Neurobiology Research
- Circadian Rhythms
- Research Tools
- Fluorescent Proteins
- Neurobiology Research
Mammalian Phenotype Terms by Genotype
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Per2tm1Jt/Per2tm1Jt
involves: 129S6/SvEvTac * C57BL/6J
normal phenotype
- no abnormal phenotype detected
- mice developed normally and showed no overt morphological abnormalities (MGI Ref ID J:89256)
References
- Yoo SH; Yamazaki S; Lowrey PL; Shimomura K; Ko CH; Buhr ED; Siepka SM; Hong HK; Oh WJ; Yoo OJ; Menaker M; Takahashi JS. 2004. PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. Proc Natl Acad Sci U S A 101(15):5339-46. PubMed: 14963227MGI: J:89256
Additional - Per2tm1Jt related
- Akashi M; Hayasaka N; Yamazaki S; Node K. 2008. Mitogen-activated protein kinase is a functional component of the autonomous circadian system in the suprachiasmatic nucleus. J Neurosci 28(18):4619-23. PubMed: 18448638MGI: J:134974
- An S; Harang R; Meeker K; Granados-Fuentes D; Tsai CA; Mazuski C; Kim J; Doyle FJ 3rd; Petzold LR; Herzog ED. 2013. A neuropeptide speeds circadian entrainment by reducing intercellular synchrony. Proc Natl Acad Sci U S A 110(46):E4355-61. PubMed: 24167276MGI: J:202892
- Anand SN; Maywood ES; Chesham JE; Joynson G; Banks GT; Hastings MH; Nolan PM. 2013. Distinct and separable roles for endogenous CRY1 and CRY2 within the circadian molecular clockwork of the suprachiasmatic nucleus, as revealed by the Fbxl3(Afh) mutation. J Neurosci 33(17):7145-53. PubMed: 23616524MGI: J:196953
- Aton SJ; Huettner JE; Straume M; Herzog ED. 2006. GABA and Gi/o differentially control circadian rhythms and synchrony in clock neurons. Proc Natl Acad Sci U S A 103(50):19188-93. PubMed: 17138670MGI: J:118298
- Baba K; Davidson AJ; Tosini G. 2015. Melatonin Entrains PER2::LUC Bioluminescence Circadian Rhythm in the Mouse Cornea. Invest Ophthalmol Vis Sci 56(8):4753-8. PubMed: 26207312MGI: J:230954
- Baeza-Raja B; Eckel-Mahan K; Zhang L; Vagena E; Tsigelny IF; Sassone-Corsi P; Ptacek LJ; Akassoglou K. 2013. p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. J Neurosci 33(25):10221-34. PubMed: 23785138MGI: J:199564
- Beaule C; Swanstrom A; Leone MJ; Herzog ED. 2009. Circadian modulation of gene expression, but not glutamate uptake, in mouse and rat cortical astrocytes. PLoS One 4(10):e7476. PubMed: 19829696MGI: J:154095
- Bedont JL; LeGates TA; Slat EA; Byerly MS; Wang H; Hu J; Rupp AC; Qian J; Wong GW; Herzog ED; Hattar S; Blackshaw S. 2014. Lhx1 controls terminal differentiation and circadian function of the suprachiasmatic nucleus. Cell Rep 7(3):609-22. PubMed: 24767996MGI: J:211807
- Brooks E; Patel D; Canal MM. 2014. Programming of mice circadian photic responses by postnatal light environment. PLoS One 9(5):e97160. PubMed: 24842115MGI: J:216328
- Buhr ED; Van Gelder RN. 2014. Local photic entrainment of the retinal circadian oscillator in the absence of rods, cones, and melanopsin. Proc Natl Acad Sci U S A 111(23):8625-30. PubMed: 24843129MGI: J:211359
- Buhr ED; Yue WW; Ren X; Jiang Z; Liao HW; Mei X; Vemaraju S; Nguyen MT; Reed RR; Lang RA; Yau KW; Van Gelder RN. 2015. Neuropsin (OPN5)-mediated photoentrainment of local circadian oscillators in mammalian retina and cornea. Proc Natl Acad Sci U S A 112(42):13093-8. PubMed: 26392540MGI: J:227078
- Castanon-Cervantes O; Wu M; Ehlen JC; Paul K; Gamble KL; Johnson RL; Besing RC; Menaker M; Gewirtz AT; Davidson AJ. 2010. Dysregulation of inflammatory responses by chronic circadian disruption. J Immunol 185(10):5796-805. PubMed: 20944004MGI: J:165628
- Chassard D; Bur I; Poirel VJ; Mendoza J; Simonneaux V. 2015. Evidence for a Putative Circadian Kiss-Clock in the Hypothalamic AVPV in Female Mice. Endocrinology 156(8):2999-3011. PubMed: 25993523MGI: J:225925
- Chen R; Schirmer A; Lee Y; Lee H; Kumar V; Yoo SH; Takahashi JS; Lee C. 2009. Rhythmic PER abundance defines a critical nodal point for negative feedback within the circadian clock mechanism. Mol Cell 36(3):417-30. PubMed: 19917250MGI: J:154857
- Cheng B; Anea CB; Yao L; Chen F; Patel V; Merloiu A; Pati P; Caldwell RW; Fulton DJ; Rudic RD. 2011. Tissue-intrinsic dysfunction of circadian clock confers transplant arteriosclerosis. Proc Natl Acad Sci U S A 108(41):17147-52. PubMed: 21969583MGI: J:177448
- Cheng HY; Alvarez-Saavedra M; Dziema H; Choi YS; Li A; Obrietan K. 2009. Segregation of expression of mPeriod gene homologs in neurons and glia: possible divergent roles of mPeriod1 and mPeriod2 in the brain. Hum Mol Genet 18(16):3110-24. PubMed: 19477955MGI: J:150729
- Cho H; Zhao X; Hatori M; Yu RT; Barish GD; Lam MT; Chong LW; DiTacchio L; Atkins AR; Glass CK; Liddle C; Auwerx J; Downes M; Panda S; Evans RM. 2012. Regulation of circadian behaviour and metabolism by REV-ERB-alpha and REV-ERB-beta. Nature 485(7396):123-7. PubMed: 22460952MGI: J:183855
- Chu A; Zhu L; Blum ID; Mai O; Leliavski A; Fahrenkrug J; Oster H; Boehm U; Storch KF. 2013. Global but not gonadotrope-specific disruption of Bmal1 abolishes the luteinizing hormone surge without affecting ovulation. Endocrinology 154(8):2924-35. PubMed: 23736292MGI: J:201336
- D'Alessandro M; Beesley S; Kim JK; Chen R; Abich E; Cheng W; Yi P; Takahashi JS; Lee C. 2015. A tunable artificial circadian clock in clock-defective mice. Nat Commun 6:8587. PubMed: 26617050MGI: J:227998
- Davidson AJ; Castanon-Cervantes O; Leise TL; Molyneux PC; Harrington ME. 2009. Visualizing jet lag in the mouse suprachiasmatic nucleus and peripheral circadian timing system. Eur J Neurosci 29(1):171-80. PubMed: 19032592MGI: J:145870
- DeBruyne JP; Weaver DR; Reppert SM. 2007. CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock. Nat Neurosci 10(5):543-5. PubMed: 17417633MGI: J:121658
- DeBruyne JP; Weaver DR; Reppert SM. 2007. Peripheral circadian oscillators require CLOCK. Curr Biol 17(14):R538-9. PubMed: 17637349MGI: J:123965
- Dibner C; Sage D; Unser M; Bauer C; d'Eysmond T; Naef F; Schibler U. 2009. Circadian gene expression is resilient to large fluctuations in overall transcription rates. EMBO J 28(2):123-34. PubMed: 19078963MGI: J:144225
- Dolatshad H; Cary AJ; Davis FC. 2010. Differential expression of the circadian clock in maternal and embryonic tissues of mice. PLoS One 5(3):e9855. PubMed: 20352049MGI: J:158725
- Dudek M; Gossan N; Yang N; Im HJ; Ruckshanthi JP; Yoshitane H; Li X; Jin D; Wang P; Boudiffa M; Bellantuono I; Fukada Y; Boot-Handford RP; Meng QJ. 2016. The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity. J Clin Invest 126(1):365-76. PubMed: 26657859MGI: J:230037
- Duhart JM; Leone MJ; Paladino N; Evans JA; Castanon-Cervantes O; Davidson AJ; Golombek DA. 2013. Suprachiasmatic astrocytes modulate the circadian clock in response to TNF-alpha. J Immunol 191(9):4656-64. PubMed: 24062487MGI: J:206251
- Dumbell R; Leliavski A; Matveeva O; Blaum C; Tsang AH; Oster H. 2016. Dissociation of Molecular and Endocrine Circadian Rhythms in Male Mice Lacking Bmal1 in the Adrenal Cortex. Endocrinology 157(11):4222-4233. PubMed: 27690690MGI: J:240553
- Eckle T; Hartmann K; Bonney S; Reithel S; Mittelbronn M; Walker LA; Lowes BD; Han J; Borchers CH; Buttrick PM; Kominsky DJ; Colgan SP; Eltzschig HK. 2012. Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia. Nat Med 18(5):774-82. PubMed: 22504483MGI: J:183926
- Etchegaray JP; Machida KK; Noton E; Constance CM; Dallmann R; Di Napoli MN; DeBruyne JP; Lambert CM; Yu EA; Reppert SM; Weaver DR. 2009. Casein kinase 1 delta regulates the pace of the mammalian circadian clock. Mol Cell Biol 29(14):3853-66. PubMed: 19414593MGI: J:150148
- Etchegaray JP; Yu EA; Indic P; Dallmann R; Weaver DR. 2010. Casein kinase 1 delta (CK1delta) regulates period length of the mouse suprachiasmatic circadian clock in vitro. PLoS One 5(4):e10303. PubMed: 20421981MGI: J:160138
- Foley NC; Tong TY; Foley D; Lesauter J; Welsh DK; Silver R. 2011. Characterization of orderly spatiotemporal patterns of clock gene activation in mammalian suprachiasmatic nucleus. Eur J Neurosci 33(10):1851-65. PubMed: 21488990MGI: J:177307
- Furutani A; Ikeda Y; Itokawa M; Nagahama H; Ohtsu T; Furutani N; Kamagata M; Yang ZH; Hirasawa A; Tahara Y; Shibata S. 2015. Fish Oil Accelerates Diet-Induced Entrainment of the Mouse Peripheral Clock via GPR120. PLoS One 10(7):e0132472. PubMed: 26161796MGI: J:238380
- Godinho SI; Maywood ES; Shaw L; Tucci V; Barnard AR; Busino L; Pagano M; Kendall R; Quwailid MM; Romero MR; O'neill J; Chesham JE; Brooker D; Lalanne Z; Hastings MH; Nolan PM. 2007. The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period. Science 316(5826):897-900. PubMed: 17463252MGI: J:121578
- Guenthner CJ; Luitje ME; Pyle LA; Molyneux PC; Yu JK; Li AS; Leise TL; Harrington ME. 2014. Circadian rhythms of Per2::Luc in individual primary mouse hepatocytes and cultures. PLoS One 9(2):e87573. PubMed: 24498336MGI: J:212847
- Hablitz LM; Molzof HE; Paul JR; Johnson RL; Gamble KL. 2014. Suprachiasmatic nucleus function and circadian entrainment are modulated by G protein-coupled inwardly rectifying (GIRK) channels. J Physiol 592(Pt 22):5079-92. PubMed: 25217379MGI: J:227593
- Hand LE; Usan P; Cooper GJ; Xu LY; Ammori B; Cunningham PS; Aghamohammadzadeh R; Soran H; Greenstein A; Loudon AS; Bechtold DA; Ray DW. 2015. Adiponectin induces A20 expression in adipose tissue to confer metabolic benefit. Diabetes 64(1):128-36. PubMed: 25190567MGI: J:230199
- Hirano A; Kurabayashi N; Nakagawa T; Shioi G; Todo T; Hirota T; Fukada Y. 2014. In vivo role of phosphorylation of cryptochrome 2 in the mouse circadian clock. Mol Cell Biol 34(24):4464-73. PubMed: 25288642MGI: J:224319
- Hirao A; Tahara Y; Kimura I; Shibata S. 2009. A balanced diet is necessary for proper entrainment signals of the mouse liver clock. PLoS One 4(9):e6909. PubMed: 19738906MGI: J:153628
- Hirota T; Lee JW; Lewis WG; Zhang EE; Breton G; Liu X; Garcia M; Peters EC; Etchegaray JP; Traver D; Schultz PG; Kay SA. 2010. High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIalpha as a clock regulatory kinase. PLoS Biol 8(12):e1000559. PubMed: 21179498MGI: J:170592
- Hughes AT; Guilding C; Piggins HD. 2011. Neuropeptide Signaling Differentially Affects Phase Maintenance and Rhythm Generation in SCN and Extra-SCN Circadian Oscillators. PLoS One 6(4):e18926. PubMed: 21559484MGI: J:172445
- Husse J; Leliavski A; Tsang AH; Oster H; Eichele G. 2014. The light-dark cycle controls peripheral rhythmicity in mice with a genetically ablated suprachiasmatic nucleus clock. FASEB J 28(11):4950-60. PubMed: 25063847MGI: J:217567
- Inada Y; Uchida H; Umemura Y; Nakamura W; Sakai T; Koike N; Yagita K. 2014. Cell and tissue-autonomous development of the circadian clock in mouse embryos. FEBS Lett 588(3):459-65. PubMed: 24374345MGI: J:206370
- Izumo M; Pejchal M; Schook AC; Lange RP; Walisser JA; Sato TR; Wang X; Bradfield CA; Takahashi JS. 2014. Differential effects of light and feeding on circadian organization of peripheral clocks in a forebrain Bmal1 mutant. Elife 3:. PubMed: 25525750MGI: J:228846
- Jackson CR; Ruan GX; Aseem F; Abey J; Gamble K; Stanwood G; Palmiter RD; Iuvone PM; McMahon DG. 2012. Retinal Dopamine Mediates Multiple Dimensions of Light-Adapted Vision. J Neurosci 32(27):9359-9368. PubMed: 22764243MGI: J:185955
- Ko CH; Yamada YR; Welsh DK; Buhr ED; Liu AC; Zhang EE; Ralph MR; Kay SA; Forger DB; Takahashi JS. 2010. Emergence of noise-induced oscillations in the central circadian pacemaker. PLoS Biol 8(10):e1000513. PubMed: 20967239MGI: J:167074
- Kornmann B; Schaad O; Bujard H; Takahashi JS; Schibler U. 2007. System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock. PLoS Biol 5(2):e34. PubMed: 17298173MGI: J:141590
- Kuljis DA; Loh DH; Truong D; Vosko AM; Ong ML; McClusky R; Arnold AP; Colwell CS. 2013. Gonadal- and sex-chromosome-dependent sex differences in the circadian system. Endocrinology 154(4):1501-12. PubMed: 23439698MGI: J:197457
- Lee H; Chen R; Lee Y; Yoo S; Lee C. 2009. Essential roles of CKIdelta and CKIepsilon in the mammalian circadian clock. Proc Natl Acad Sci U S A 106(50):21359-64. PubMed: 19948962MGI: J:155524
- Lee IT; Chang AS; Manandhar M; Shan Y; Fan J; Izumo M; Ikeda Y; Motoike T; Dixon S; Seinfeld JE; Takahashi JS; Yanagisawa M. 2015. Neuromedin s-producing neurons act as essential pacemakers in the suprachiasmatic nucleus to couple clock neurons and dictate circadian rhythms. Neuron 85(5):1086-102. PubMed: 25741729MGI: J:219926
- Li Q; Loh DH; Kudo T; Truong D; Derakhshesh M; Kaswan ZM; Ghiani CA; Tsoa R; Cheng Y; Sun YE; Colwell CS. 2015. Circadian rhythm disruption in a mouse model of Rett syndrome circadian disruption in RTT. Neurobiol Dis 77:155-64. PubMed: 25779967MGI: J:221609
- Marcheva B; Ramsey KM; Buhr ED; Kobayashi Y; Su H; Ko CH; Ivanova G; Omura C; Mo S; Vitaterna MH; Lopez JP; Philipson LH; Bradfield CA; Crosby SD; JeBailey L; Wang X; Takahashi JS; Bass J. 2010. Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature 466(7306):627-31. PubMed: 20562852MGI: J:162641
- Maywood ES; Fraenkel E; McAllister CJ; Wood N; Reddy AB; Hastings MH; Morton AJ. 2010. Disruption of peripheral circadian timekeeping in a mouse model of Huntington's disease and its restoration by temporally scheduled feeding. J Neurosci 30(30):10199-204. PubMed: 20668203MGI: J:162853
- Mieda M; Ono D; Hasegawa E; Okamoto H; Honma K; Honma S; Sakurai T. 2015. Cellular Clocks in AVP Neurons of the SCN Are Critical for Interneuronal Coupling Regulating Circadian Behavior Rhythm. Neuron 85(5):1103-16. PubMed: 25741730MGI: J:219925
- Miller JE; Granados-Fuentes D; Wang T; Marpegan L; Holy TE; Herzog ED. 2014. Vasoactive intestinal polypeptide mediates circadian rhythms in mammalian olfactory bulb and olfaction. J Neurosci 34(17):6040-6. PubMed: 24760863MGI: J:210611
- Mohawk JA; Baer ML; Menaker M. 2009. The methamphetamine-sensitive circadian oscillator does not employ canonical clock genes. Proc Natl Acad Sci U S A 106(9):3519-24. PubMed: 19204282MGI: J:146448
- Nakamura TJ; Nakamura W; Tokuda IT; Ishikawa T; Kudo T; Colwell CS; Block GD. 2015. Age-Related Changes in the Circadian System Unmasked by Constant Conditions(1,2,3). eNeuro 2(4):. PubMed: 26464996MGI: J:239866
- Nakamura TJ; Sellix MT; Menaker M; Block GD. 2008. Estrogen directly modulates circadian rhythms of PER2 expression in the uterus. Am J Physiol Endocrinol Metab 295(5):E1025-31. PubMed: 18728223MGI: J:142256
- Nam HJ; Boo K; Kim D; Han DH; Choe HK; Kim CR; Sun W; Kim H; Kim K; Lee H; Metzger E; Schuele R; Yoo SH; Takahashi JS; Cho S; Son GH; Baek SH. 2014. Phosphorylation of LSD1 by PKCalpha is crucial for circadian rhythmicity and phase resetting. Mol Cell 53(5):791-805. PubMed: 24582500MGI: J:210640
- Nishide SY; Ono D; Yamada Y; Honma S; Honma K. 2012. De novo synthesis of PERIOD initiates circadian oscillation in cultured mouse suprachiasmatic nucleus after prolonged inhibition of protein synthesis by cycloheximide. Eur J Neurosci 35(2):291-9. PubMed: 22236088MGI: J:184332
- Ohnishi N; Tahara Y; Kuriki D; Haraguchi A; Shibata S. 2014. Warm water bath stimulates phase-shifts of the peripheral circadian clocks in PER2::LUCIFERASE mouse. PLoS One 9(6):e100272. PubMed: 24933288MGI: J:218859
- Oike H; Nagai K; Fukushima T; Ishida N; Kobori M. 2011. Feeding cues and injected nutrients induce acute expression of multiple clock genes in the mouse liver. PLoS One 6(8):e23709. PubMed: 21901130MGI: J:176138
- Papp SJ; Huber AL; Jordan SD; Kriebs A; Nguyen M; Moresco JJ; Yates JR; Lamia KA. 2015. DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. Elife 4:. PubMed: 25756610MGI: J:220692
- Parsons MJ; Brancaccio M; Sethi S; Maywood ES; Satija R; Edwards JK; Jagannath A; Couch Y; Finelli MJ; Smyllie NJ; Esapa C; Butler R; Barnard AR; Chesham JE; Saito S; Joynson G; Wells S; Foster RG; Oliver PL; Simon MM; Mallon AM; Hastings MH; Nolan PM. 2015. The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis. Cell 162(3):607-21. PubMed: 26232227MGI: J:223990
- Perelis M; Marcheva B; Ramsey KM; Schipma MJ; Hutchison AL; Taguchi A; Peek CB; Hong H; Huang W; Omura C; Allred AL; Bradfield CA; Dinner AR; Barish GD; Bass J. 2015. Pancreatic beta cell enhancers regulate rhythmic transcription of genes controlling insulin secretion. Science 350(6261):aac4250. PubMed: 26542580MGI: J:226753
- Plikus MV; Vollmers C; de la Cruz D; Chaix A; Ramos R; Panda S; Chuong CM. 2013. Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling. Proc Natl Acad Sci U S A 110(23):E2106-15. PubMed: 23690597MGI: J:197414
- Puram RV; Kowalczyk MS; de Boer CG; Schneider RK; Miller PG; McConkey M; Tothova Z; Tejero H; Heckl D; Jaras M; Chen MC; Li H; Tamayo A; Cowley GS; Rozenblatt-Rosen O; Al-Shahrour F; Regev A; Ebert BL. 2016. Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML. Cell 165(2):303-16. PubMed: 27058663MGI: J:234501
- Qu Z; Zhang H; Huang M; Shi G; Liu Z; Xie P; Li H; Wang W; Xu G; Zhang Y; Yang L; Huang G; Takahashi JS; Zhang WJ; Xu Y. 2016. Loss of ZBTB20 impairs circadian output and leads to unimodal behavioral rhythms. Elife 5:. PubMed: 27657167MGI: J:238019
- Razzoli M; Karsten C; Yoder JM; Bartolomucci A; Engeland WC. 2014. Chronic subordination stress phase advances adrenal and anterior pituitary clock gene rhythms. Am J Physiol Regul Integr Comp Physiol 307(2):R198-205. PubMed: 24829500MGI: J:240917
- Reale ME; Webb IC; Wang X; Baltazar RM; Coolen LM; Lehman MN. 2013. The transcription factor Runx2 is under circadian control in the suprachiasmatic nucleus and functions in the control of rhythmic behavior. PLoS One 8(1):e54317. PubMed: 23372705MGI: J:195796
- Ruan GX; Allen GC; Yamazaki S; McMahon DG. 2008. An autonomous circadian clock in the inner mouse retina regulated by dopamine and GABA. PLoS Biol 6(10):e249. PubMed: 18959477MGI: J:141081
- Schroeder AM; Truong D; Loh DH; Jordan MC; Roos KP; Colwell CS. 2012. Voluntary scheduled exercise alters diurnal rhythms of behaviour, physiology and gene expression in wild-type and vasoactive intestinal peptide-deficient mice. J Physiol 590(Pt 23):6213-26. PubMed: 22988135MGI: J:203022
- Shi G; Xie P; Qu Z; Zhang Z; Dong Z; An Y; Xing L; Liu Z; Dong Y; Xu G; Yang L; Liu Y; Xu Y. 2016. Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function. Cell Rep 14(4):823-34. PubMed: 26776516MGI: J:240095
- Shi SQ; Ansari TS; McGuinness OP; Wasserman DH; Johnson CH. 2013. Circadian disruption leads to insulin resistance and obesity. Curr Biol 23(5):372-81. PubMed: 23434278MGI: J:199735
- Shimomura K; Kumar V; Koike N; Kim TK; Chong J; Buhr ED; Whiteley AR; Low SS; Omura C; Fenner D; Owens JR; Richards M; Yoo SH; Hong HK; Vitaterna MH; Bass J; Pletcher MT; Wiltshire T; Hogenesch J; Lowrey PL; Takahashi JS. 2013. Usf1, a suppressor of the circadian Clock mutant, reveals the nature of the DNA-binding of the CLOCK:BMAL1 complex in mice. Elife 2:e00426. PubMed: 23580255MGI: J:198519
- Shimomura K; Lowrey PL; Vitaterna MH; Buhr ED; Kumar V; Hanna P; Omura C; Izumo M; Low SS; Barrett RK; LaRue SI; Green CB; Takahashi JS. 2010. Genetic suppression of the circadian Clock mutation by the melatonin biosynthesis pathway. Proc Natl Acad Sci U S A 107(18):8399-403. PubMed: 20404168MGI: J:160321
- Shostak A; Meyer-Kovac J; Oster H. 2013. Circadian regulation of lipid mobilization in white adipose tissues. Diabetes 62(7):2195-203. PubMed: 23434933MGI: J:208543
- Smyllie NJ; Chesham JE; Hamnett R; Maywood ES; Hastings MH. 2016. Temporally chimeric mice reveal flexibility of circadian period-setting in the suprachiasmatic nucleus. Proc Natl Acad Sci U S A 113(13):3657-62. PubMed: 26966234MGI: J:231071
- Uchida H; Nakamura TJ; Takasu NN; Todo T; Sakai T; Nakamura W. 2016. Cryptochrome-dependent circadian periods in the arcuate nucleus. Neurosci Lett 610:123-8. PubMed: 26542738MGI: J:228748
- Wang CY; Shie SS; Hsieh IC; Tsai ML; Wen MS. 2015. FTO modulates circadian rhythms and inhibits the CLOCK-BMAL1-induced transcription. Biochem Biophys Res Commun 464(3):826-32. PubMed: 26188089MGI: J:228836
- Wang X; Tang J; Xing L; Shi G; Ruan H; Gu X; Liu Z; Wu X; Gao X; Xu Y. 2010. Interaction of MAGED1 with nuclear receptors affects circadian clock function. EMBO J 29(8):1389-400. PubMed: 20300063MGI: J:200375
- Webb AB; Angelo N; Huettner JE; Herzog ED. 2009. Intrinsic, nondeterministic circadian rhythm generation in identified mammalian neurons. Proc Natl Acad Sci U S A 106(38):16493-8. PubMed: 19805326MGI: J:153227
- Wu C; Sui G; Archer SN; Sassone-Corsi P; Aitken K; Bagli D; Chen Y. 2014. Local receptors as novel regulators for peripheral clock expression. FASEB J 28(11):4610-6. PubMed: 25145629MGI: J:217766
- Xie Z; Su W; Liu S; Zhao G; Esser K; Schroder EA; Lefta M; Stauss HM; Guo Z; Gong MC. 2015. Smooth-muscle BMAL1 participates in blood pressure circadian rhythm regulation. J Clin Invest 125(1):324-36. PubMed: 25485682MGI: J:219608
- Xing L; An Y; Shi G; Yan J; Xie P; Qu Z; Zhang Z; Liu Z; Pan D; Xu Y. 2017. Correlated evolution between CK1delta Protein and the Serine-rich Motif Contributes to Regulating the Mammalian Circadian Clock. J Biol Chem 292(1):161-171. PubMed: 27879317MGI: J:240646
- Yeung CY; Gossan N; Lu Y; Hughes A; Hensman JJ; Bayer ML; Kjaer M; Kadler KE; Meng QJ. 2014. Gremlin-2 is a BMP antagonist that is regulated by the circadian clock. Sci Rep 4:5183. PubMed: 24897937MGI: J:227245
- Yoder JM; Brandeland M; Engeland WC. 2014. Phase-dependent resetting of the adrenal clock by ACTH in vitro. Am J Physiol Regul Integr Comp Physiol 306(6):R387-93. PubMed: 24477539MGI: J:208259
- Zhang X; Patel SP; McCarthy JJ; Rabchevsky AG; Goldhamer DJ; Esser KA. 2012. A non-canonical E-box within the MyoD core enhancer is necessary for circadian expression in skeletal muscle. Nucleic Acids Res 40(8):3419-30. PubMed: 22210883MGI: J:196858
- Zhang Y; Andrews GK; Wang L. 2012. Zinc-induced Dnmt1 expression involves antagonism between MTF-1 and nuclear receptor SHP. Nucleic Acids Res 40(11):4850-60. PubMed: 22362755MGI: J:197706