NOD/ShiLt-Tg(GFAP-Cd80)9Mdos/MdosJ

Stock number: 006778
Product name: NOD.GFAP-B7.1
Strain synonyms: NOD.Gfap-B7-1, GFAP-B7-1
Research areas: Diabetes and Obesity Research, Immunology, Inflammation and Autoimmunity Research

Description

These transgenic mice, carrying Cd80 in the construct do not develop diabetes, in contrast to similiar NOD mice carrying a transgene with Cd274 (Stock No. 012310).

Detailed description

Gfap-Cd80 (GFAP-B7-1) transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. The donating investigator reports that transgenic mice are protected from diabetes development.

Development

This transgenic strain carries a T cell co-stimulatory molecule, Cd80 (B7-1), cDNA fused to the glial fibrillary acidic protein (Gfap) promoter. The transgenic construct was injected into NOD/ShiLt fertilized embryos, and progeny of founder 9 were mated to NOD/ShiLt. In 2006, the T1DR received hemizygous mice that were mated to NOD/ShiLtJ (Stock No. 001976) prior to sibling mating.

Allele

Symbol: Tg(GFAP-CD80)9Mdos
Name: transgene insertion 9, H Michael Dosch
MGI accession ID: MGI:3701469
Generation method: Transgenic
Attributes: Inserted expressed sequence
Marker symbol: Tg(GFAP-CD80)9Mdos
Marker name: transgene insertion 9, H Michael Dosch
Chromosome: UN
Strain of origin: NOD/ShiLt
Expressed genes: CD80,CD80 molecule,human
Molecular note: This transgene contains cDNA encoding CD80 under control of the glial fibrillary acidic protein promoter.