With the coding sequence of class I olfactory receptor Or55b10 (formerly Olfr545) excised and replaced with venusYFP, this strain allows assessment of the role of a specific olfactory receptor in olfactory sensory neuron development. Mice carrying this allele display a normal pattern of labeled axons projecting diffusely to a large subset of glomeruli in the dorsal-medial and anterior-medial olfactory bulb, but also an abnormal finding of labeled axons innervating glomeruli at the caudal margins of the olfactory bulb. Co-staining for five dorsal class I olfactory receptors shows 3.8% co-expressing class I olfactory receptor genes and the disrupted Or55b10tm4Mom allele, while co-staining for five dorsal class II olfactory receptors shows no co-expression with the disrupted Or55b10tm4Mom allele.

Venus fluorescent protein replaces the excised Olfr545 gene in these knock-out mice. An abnormal innervation of glomeruli at the caudal margins of the olfactory bulb is observed.

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B6;129P2-Or55b10<tm4Mom>/MomJ Frozen Embryo