These Cre recombinase mice are useful in studies to identify olfactory sensory neuronal lineage and topography in glomeruli in the olfactory bulb.
Peter Mombaerts, Max Planck Research Unit for Neurogenetics
Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
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Targeted (Recombinase-expressing) | Omp | olfactory marker protein |
The coding region and part of the 3' non-translated region of the Omp gene was replaced by Cre. The targeted mutation results in a knockout. Mature olfactory sensory neurons express the Cre recombinase at high levels. Homozygous mice are subfertile.
As an example, when crossed to a strain with widespread expression of GFP and a loxP-flanked Bgeo reporter (see Stock No. 004178), this mutant mouse strain may be useful in lineage tracing.
View cre expression characterization.
The 129P2/OlaHsd derived E14 ES cell was used to generate this targeted mutation and the resulting mice were crossed to C57BL/6, and then intercrossed to homozygosity. The FRT-flanked neo cassette (FNF) is retained within this strain, and can be removed by flp-mediated recombination.
The plasmid that was used to generate this mutation is banked and described at Addgene.
Expressed Gene | cre, cre recombinase, bacteriophage P1 |
---|---|
Site of Expression | mature olfactory sensory neurons |
Allele Name | targeted mutation 4, Peter Mombaerts |
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Allele Type | Targeted (Recombinase-expressing) |
Allele Synonym(s) | OMP-Cre |
Gene Symbol and Name | Omp, olfactory marker protein |
Gene Synonym(s) | |
Expressed Gene | cre, cre recombinase, bacteriophage P1 |
Site of Expression | mature olfactory sensory neurons |
Strain of Origin | 129P2/OlaHsd |
Chromosome | 7 |
Molecular Note | Sequence encoding cre recombinase and a neomycin resistance cassette flanked by FRT sites was substituted in place of the Omp coding region. |
Mutations Made By | Peter Mombaerts, Max Planck Research Unit for Neurogenetics |
When using the OMP-Cre mouse strain in a publication, please cite the originating article(s) and include JAX stock #006668 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous or Wildtype for Omp<tm4(cre)Mom> |
Frozen Mouse Embryo | B6;129P2-Omp<tm4(cre)Mom>/MomJ | $2595.00 |
Frozen Mouse Embryo | B6;129P2-Omp<tm4(cre)Mom>/MomJ | $2595.00 |
Frozen Mouse Embryo | B6;129P2-Omp<tm4(cre)Mom>/MomJ | $3373.50 |
Frozen Mouse Embryo | B6;129P2-Omp<tm4(cre)Mom>/MomJ | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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