These mice possess loxP sites that flank promoter and exon 1 sequences. Mice that are homozygous for this allele are viable and fertile. When used in conjunction with a Cre recombinase-expressing strain, this strain is useful in generating tissue-specific mutants of the floxed allele. Excision of the floxed fragment results in the removal of key regulatory elements and many of the DNA-binding and dimerization residues of the gene.
When bred to a strain expressing Cre recombinase under the control of mouse transgelin promoter (see Stock No. <a href="https://www.jax.org/strain/004746">004746</a> for example), this mutant mouse strain may be useful in studies of cardiovascular disease.

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These floxed mutant mice possess loxP sites that flank promoter and exon 1 sequences of the Srf gene. This strain may be useful for generating conditional mutations in applications related to studies of cardiovascular disease.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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