STOCK Or8a1b^tm2Mom/MomJ

Stock number: 006652
Product name: ΔM72
Strain synonyms: GFP->M72-IRES-taulacZ
Research areas: Research Tools, Sensorineural Research

Development

This targeted mutation was generated in 129P2/OlaHsd derived E14 ES cells and the resulting mice from clone W213 were crossed to Tg(EIIa-cre) bearing mice to excise the loxP flanked pgkneo (LNL) cassette. Although Tg(EIIa-cre) was generated in FVB/N mice, it was backcrossed onto C57BL/6J prior to this cross. The offspring were intercrossed and the transgene was selectively bred out of this line. Thus, this STOCK background is predominantly C57BL/6J and 129P2/OlaHsd. In 2007 sperm were cryopreserved from homozygous males.

Allele

Symbol: Or8a1b^tm2Mom
Name: targeted mutation 2, Peter Mombaerts
MGI accession ID: MGI:3047226
Generation method: Targeted
Attributes: Reporter; Null/Knockout
Marker symbol: Or8a1b
Marker name: olfactory receptor family 8 subfamily A member 1B
Chromosome: 9
Strain of origin: 129P2/OlaHsd
Expressed genes: lacZ,beta-galactosidase,E. coli; GFP,Green Fluorescent Protein,
Site of expression: GFP and lacZ are observed in olfactory sensory neurons located in the dorsal epithelium.
Molecular note: The coding region was replaced with GFP and IRES-taulacZ.