These mice possess loxP sites on either side of exon 1 of the targeted gene. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When used in conjunction with a Cre recombinase-expressing strain, this strain is useful in generating tissue-specific mutants of the floxed allele. These mice may be useful for cardiovascular studies (such as lipid metabolism and fat storage) and obesity research.

 For example, when crossed to a strain expressing Cre recombinase in cardiac muscle cells (see Stock No. <a href="https://www.jax.org/strain/011038">011038</a>), this mutant mouse strain may be useful in studies of cardiac lipid metabolism.

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These floxed mutant mice possess loxP sites flanking exon 1 of the Lpl gene. This strain may be useful for generating conditional mutations in applications related to cardiovascular studies. &nbsp;&nbsp;