NOD.Cg-(Gpi1-D7Mit346)^C57BL/6J Tg(TcrbAI4)1Dvs/DvsJ

Stock number: 006437

Allele

Symbol: Tg(TcrbAI4)1Dvs
Name: transgene insertion 1, David V Serreze
MGI accession ID: MGI:3057181
Generation method: Transgenic
Attributes: Inserted expressed sequence
Synonyms: AI4bTg
Marker symbol: Tg(TcrbAI4)1Dvs
Marker name: transgene insertion 1, David V Serreze
Marker synonyms: AI4bTg
Chromosome: UN
Strain of origin: NOD/ShiLt
Expressed genes: Tcrb,T cell receptor beta chain,mouse, laboratory
Molecular note: The rearranged Tcrb transgene expressed in these mice is derived from the pancreatic beta cell-reactive CD8 T lymphocyte clone AI4. The transgenic construct contains a Tcrb-V2/Tcrb-D/Tcrb-J cDNA segment.
General note: In conjunction with Rag1^tm1Mom

transgenic mice carrying both the alpha and beta AI4 TCR transgenes exhibit an accelerated development of insulin-dependent diabetes mellitus (IDDM).

homozygous mice are viable and fertile

Allele

MGI accession ID: MGI:105482
Marker symbol: D7Mit346
Marker name: DNA segment, Chr 7, Massachusetts Institute of Technology 346
Chromosome: 7

Allele

MGI accession ID: MGI:95797
Marker symbol: Gpi1
Marker name: glucose phosphate isomerase 1
Marker synonyms: AMF; autocrine motility factor; GNPI; Gpi-1; Gpi-1r; Gpi1-r; Gpi-1s; Gpi1-s; Gpi-1t; Gpi1-t; maturation factor; MF; neuroleukin; NK; NK/GPI; Nlk; Org; PGI; Phi; SA36; SA-36
Chromosome: 7