C3Fe.SW-Soa^a/MonJ

Stock number: 006435
Product name: taster
Research areas: Sensorineural Research

Description

The Soa^a allele from the SWR/J strain was made congenic on the C3HeB/FeJ strain and determines the ‘taste’ phenotype of taste sensitivity to sucrose octaacetate aversion (SOA).

Detailed description

Mice homozygous for the dominant a allele exhibit an taster (avoidance as low as <.001mM concentration) phenotype to the bitter compound sucrose octaacetate. This strain may be useful in studies related to the mechanisms of taste.

Development

This congenic was created in the laboratory of Dr. Glayde Whitney at Florida State University in 1994 by introgressing the SWR/J "taster" allele into the C3HeB/FeJ "demitaster" background for at least 12 generations. Mice were tested for avoidance of (a allele) or indifference to (c allele) a 0.1 mM sodium octaacetate (SOA) solution. The colony was maintained by backcrossing for additional 20 generations. In 1999, the colony was transferred to the Monell Chemical Senses Center and backcrossed for another 10 generations. After 40 generations, mice were intercrossed to generate a homozygous colony. The strain was donated to The Jackson Laboratory Repository in 2006 by Dr. Alexander Bachmanov.

Allele

Symbol: Soa^a
Name: sucrose octaacetate aversion, a variant
MGI accession ID: MGI:3689003
Generation method: Not Applicable
Marker symbol: Soa
Marker name: sucrose octaacetate aversion
Chromosome: 6
Strain of origin: Not Applicable
General note: Alleles in dominance order are : a allele - taster (avoidance at <1mM concentration) in SWR/J; b allele - nontaster (no avoidance) in BDP/J, C57BL/6J, C57BR/cdJ, C57L/J, SJL/J and 129/J; c allele - demitaster (avoidance near saturation) in ABP/Le, AKR/J, BALB/cByJ, BALB/cJ, C3HeB/FeJ, C3H/HeJ, DBA/2J, LP/J, NZB/BINJ, PL/J and RF/J. J:3143