The Soaa allele from the SWR/J strain was made congenic on the C3HeB/FeJ strain and determines the ‘taste’ phenotype of taste sensitivity to sucrose octaacetate aversion (SOA).
Read More +Genetic Background | Generation |
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000658 C3HeB/FeJ |
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Allele Type | Gene Symbol | Gene Name |
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Not Applicable | Soa | sucrose octaacetate aversion |
Mice homozygous for the dominant a allele exhibit an taster (avoidance as low as <.001mM concentration) phenotype to the bitter compound sucrose octaacetate. This strain may be useful in studies related to the mechanisms of taste.
This congenic was created in the laboratory of Dr. Glayde Whitney at Florida State University in 1994 by introgressing the SWR/J "taster" allele into the C3HeB/FeJ "demitaster" background for at least 12 generations. Mice were tested for avoidance of (a allele) or indifference to (c allele) a 0.1 mM sodium octaacetate (SOA) solution. The colony was maintained by backcrossing for additional 20 generations. In 1999, the colony was transferred to the Monell Chemical Senses Center and backcrossed for another 10 generations. After 40 generations, mice were intercrossed to generate a homozygous colony. The strain was donated to The Jackson Laboratory Repository in 2006 by Dr. Alexander Bachmanov.
Allele Name | sucrose octaacetate aversion, a variant |
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Allele Type | Not Applicable |
Allele Synonym(s) | aversion; SOA taster |
Gene Symbol and Name | Soa, sucrose octaacetate aversion |
Gene Synonym(s) | |
Strain of Origin | Not Applicable |
Chromosome | 6 |
General Note | Alleles in dominance order are : a allele - taster (avoidance at <1mM concentration) in SWR/J; b allele - nontaster (no avoidance) in BDP/J, C57BL/6J, C57BR/cdJ, C57L/J, SJL/J and 129/J; c allele - demitaster (avoidance near saturation) in ABP/Le, AKR/J, BALB/cByJ, BALB/cJ, C3HeB/FeJ, C3H/HeJ, DBA/2J, LP/J, NZB/BINJ, PL/J and RF/J. J:3143 |
When using the taster mouse strain in a publication, please cite the originating article(s) and include JAX stock #006435 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Homozygous for Soa<a>, 1 pair minimum |
Frozen Mouse Embryo | C3Fe.SW-Soa<a>/MonJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | C3Fe.SW-Soa<a>/MonJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | C3Fe.SW-Soa<a>/MonJ Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | C3Fe.SW-Soa<a>/MonJ Frozen Embryos | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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