B6.129P2-Slc18a1^tm1Dgen/J

Stock number: 006432
Product name: VMAT1 KO
Research areas: Research Tools

Description

LacZ expression in these Slc18a1 knock-out/reporter mice is detected in the kidney, urinary bladder, adrenal glands, testis, prostate gland, and cervix.

Detailed description

This targeted mutant was created and characterized by Deltagen, Inc. View phenotypic data developed by Deltagen.

Allele

Symbol: Slc18a1^tm1Dgen
Name: targeted mutation 1, Deltagen
MGI accession ID: MGI:3663332
Generation method: Targeted
Attributes: Reporter; Null/Knockout
Marker symbol: Slc18a1
Marker name: solute carrier family 18 (vesicular monoamine), member 1
Chromosome: 8
Strain of origin: 129P2/OlaHsd
Expressed genes: lacZ,beta-galactosidase,E. coli
Site of expression: Most lacZ striking expression was detected in adrenal medalla. lacZ expression was also observed in renal cortex, a few spermatogenic cells in the testis, epithelium in the prostate gland and in neural ganglia associated with urinary bladder, prostate gland and cervix.
Molecular note: A LacZ-neomycin cassette was inserted into the gene so that the endogenous gene promoter drives expression of beta-galactosidase. Gene expression analysis confirmed the absence of expression in frontal cortex, striatum, hippocampus and adrenal gland. LacZ expression was detected in kidney, urinary bladder, adrenal glands, testis, prostate gland, and cervix.