LacZ expression in these Slc18a1 knock-out/reporter mice is detected in the kidney, urinary bladder, adrenal glands, testis, prostate gland, and cervix.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Targeted (Reporter, Null/Knockout) | Slc18a1 | solute carrier family 18 (vesicular monoamine), member 1 |
This targeted mutant was created and characterized by Deltagen, Inc. View phenotypic data developed by Deltagen.
Expressed Gene | lacZ, beta-galactosidase, E. coli |
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Site of Expression | Most lacZ striking expression was detected in adrenal medalla. lacZ expression was also observed in renal cortex, a few spermatogenic cells in the testis, epithelium in the prostate gland and in neural ganglia associated with urinary bladder, prostate gland and cervix. |
Allele Name | targeted mutation 1, Deltagen |
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Allele Type | Targeted (Reporter, Null/Knockout) |
Allele Synonym(s) | |
Gene Symbol and Name | Slc18a1, solute carrier family 18 (vesicular monoamine), member 1 |
Gene Synonym(s) | |
Expressed Gene | lacZ, beta-galactosidase, E. coli |
Site of Expression | Most lacZ striking expression was detected in adrenal medalla. lacZ expression was also observed in renal cortex, a few spermatogenic cells in the testis, epithelium in the prostate gland and in neural ganglia associated with urinary bladder, prostate gland and cervix. |
Strain of Origin | 129P2/OlaHsd |
Chromosome | 8 |
Molecular Note | A LacZ-neomycin cassette was inserted into the gene so that the endogenous gene promoter drives expression of beta-galactosidase. Gene expression analysis confirmed the absence of expression in frontal cortex, striatum, hippocampus and adrenal gland. LacZ expression was detected in kidney, urinary bladder, adrenal glands, testis, prostate gland, and cervix. |
When using the VMAT1 KO mouse strain in a publication, please cite the originating article(s) and include JAX stock #006432 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous or Wild-type for Slc18a1<tm1Dgen> |
Frozen Mouse Embryo | B6.129P2-Slc18a1<tm1Dgen>/J Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | B6.129P2-Slc18a1<tm1Dgen>/J Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | B6.129P2-Slc18a1<tm1Dgen>/J Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | B6.129P2-Slc18a1<tm1Dgen>/J Frozen Embryos | $3373.50 |
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