LacZ expression in these Adam21 knock-out/reporter mice is detected in kidney and testis tissues.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Targeted (Reporter, Null/Knockout) | Adam21 | a disintegrin and metallopeptidase domain 21 |
This targeted mutant was created and characterized by Deltagen, Inc. View phenotypic data developed by Deltagen.
Expressed Gene | lacZ, beta-galactosidase, E. coli |
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Site of Expression | lacZ expression was detected kidney and testis. Weak staining was observed in a small number of cells in glomeruli of the kidney and in seminiferous tubules of the testis. |
Allele Name | targeted mutation 1, Deltagen |
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Allele Type | Targeted (Reporter, Null/Knockout) |
Allele Synonym(s) | |
Gene Symbol and Name | Adam21, a disintegrin and metallopeptidase domain 21 |
Gene Synonym(s) | |
Expressed Gene | lacZ, beta-galactosidase, E. coli |
Site of Expression | lacZ expression was detected kidney and testis. Weak staining was observed in a small number of cells in glomeruli of the kidney and in seminiferous tubules of the testis. |
Strain of Origin | 129P2/OlaHsd |
Chromosome | 12 |
Molecular Note | A LacZ-neomycin cassette was inserted into the gene so that the endogenous gene promoter drives expression of beta-galactosidase. RNA transcripts were detected in most tissues tested but not in heart, thymus, bone marrow, and urinary bladder. LacZ expression was detected in kidney and testis tissues. No LacZ expression was detected in nervous, cardiovascular, hematopoietic tissue, the respiratory system, liver, pancreas, urinary bladder, thyroid, pituitary, adrenal, prostate glands, skeletal muscle, skin, ovary, uterus, or cervix. |
When using the Adam21- mouse strain in a publication, please cite the originating article(s) and include JAX stock #006431 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous or Wild-type for Adam21<tm1Dgen> |
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