B6;129P2-Adam21^tm1Dgen/J

Stock number: 006431
Product name: Adam21-
Research areas: Research Tools

Description

LacZ expression in these Adam21 knock-out/reporter mice is detected in kidney and testis tissues.

Detailed description

This targeted mutant was created and characterized by Deltagen, Inc. View phenotypic data developed by Deltagen.

Allele

Symbol: Adam21^tm1Dgen
Name: targeted mutation 1, Deltagen
MGI accession ID: MGI:3663320
Generation method: Targeted
Attributes: Reporter; Null/Knockout
Marker symbol: Adam21
Marker name: a disintegrin and metallopeptidase domain 21
Marker synonyms: AABR07065031.1; ADAM 21; ADAM31
Chromosome: 12
Strain of origin: 129P2/OlaHsd
Expressed genes: lacZ,beta-galactosidase,E. coli
Site of expression: lacZ expression was detected kidney and testis. Weak staining was observed in a small number of cells in glomeruli of the kidney and in seminiferous tubules of the testis.
Molecular note: A LacZ-neomycin cassette was inserted into the gene so that the endogenous gene promoter drives expression of beta-galactosidase. RNA transcripts were detected in most tissues tested but not in heart, thymus, bone marrow, and urinary bladder. LacZ expression was detected in kidney and testis tissues. No LacZ expression was detected in nervous, cardiovascular, hematopoietic tissue, the respiratory system, liver, pancreas, urinary bladder, thyroid, pituitary, adrenal, prostate glands, skeletal muscle, skin, ovary, uterus, or cervix.