Mice that are homozygous for the mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Screening of third generation mice (G3) on standard chow identified a 12 week old male (born 9/30/2002) with a low bone mineral content and density as determined by DEXA analysis. Retesting at 18 weeks of age, when bone development has stabilized, confirmed this phenotype. This mutant mouse strain may be useful in studies of bone mineralization.
This phenotypic deviant was identified following multidose ethylnitrosourea (ENU) treatments to induce mutations in male founder C57BL/6J mice (Stock No. 000664), in complex heart, lung, blood, and sleep disorders at the Mouse Heart, Lung, Blood, and Sleep Disorders (HLBS) Center at The Jackson Laboratory.
|Allele Name||heart, lung and blood 324B|
|Allele Type||Chemically induced (ENU)|
|Gene Symbol and Name||hlb324B, heart, lung and blood 324B|
|Strain of Origin||C57BL/6J|
|Molecular Note||This phenotypic mutant was identified in an ENU mutagenesis screen.|