This congenic strain carries a dominant resistance allele (Ctrq-2) at the C. trachomatis resistance QTL on Chromosome 3 from the C57BL/6J strain.
Read More +A chromosome substitution or consomic strain is an inbred strain with one of its chromosomes replaced by the homologous chromosome of another inbred strain. The C57BL/6J and C3H/HeJ inbred strains were selected for this consomic because they differ in their susceptibility to infectious disease, specifically Chlamydia trachomatis. Consomic strains can accelerate quantitative trait loci identification and mapping.
Drs. Michael Starnbach and Isaac Bernstein-Hanley from Harvard Medical School developed this consomic by replacing Chromosome 3 from the C57BL/6J donor strain into the C3H/HeJ host strain using a marker-assisted series of backcrosses. The set was donated to The Jackson Laboratory in 2006.
Currently there are no related genes or alleles for this strain.
When using the C3.B6-Chr3 mouse strain in a publication, please cite the originating article(s) and include JAX stock #006359 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Consomic for Chr 3<C57BL/6J>, 1 pair minimum |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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