A chromosome substitution or consomic strain is an inbred strain with one of its chromosomes replaced by the homologous chromosome of another inbred strain. The C57BL/6J and C3H/HeJ inbred strains were selected for this consomic because they differ in their susceptibility to infectious disease, specifically Chlamydia trachomatis. Consomic strains can accelerate quantitative trait loci identification and mapping.
Drs. Michael Starnbach and Isaac Bernstein-Hanley from Harvard Medical School developed this consomic by replacing Chromosome 3 from the C57BL/6J donor strain into the C3H/HeJ host strain using a marker-assisted series of backcrosses. The set was donated to The Jackson Laboratory in 2006.
Currently there are no related genes or alleles for this strain.