A chromosome substitution or consomic strain is an inbred strain with one of its chromosomes replaced by the homologous chromosome of another inbred strain. The C57BL/6J and C3H/HeJ inbred strains were selected for this consomic because they differ in their susceptibility to infectious disease, specifically Chlamydia trachomatis. Consomic strains can accelerate quantitative trait loci identification and mapping.

This congenic strain carries a dominant resistance allele (Ctrq-2) at the C. trachomatis resistance QTL on Chromosome 3 from the C57BL/6J strain.

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