JAX
Mouse Strain Datasheet - 006234
B6.Cg-Tg(tetO-cre)1Jaw/J
Also Known As: (tetO)7-Cre
These transgenic mice express Cre recombinase under the control of a tetracycline-responsive promoter element (TRE or tetO) and are an effective tool for generating inducible, tissue-specific, targeted mutants to study cell lineage during development. When bred with another transgenic mouse expressing reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA), Cre mediated recombination in the resulting bitransgenic offspring can be regulated with the tetracycline analog, doxycycline.
Donating Investigator
IMR Colony, The Jackson Laboratory
Genetic overview
| Genetic Background | Generation |
|---|---|
|
N11F5
|
Tg(tetO-cre)1Jaw
| Allele Type |
|---|
| Transgenic (Inducible, Recombinase-expressing) |
Base Price
Starting at:
| $255.00 Domestic price for female |
| $329.00 Domestic price for breeder pair |
Detailed Description
Hemizygous transgenic mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. These transgenic mice express Cre recombinase under the control of a tetracycline-responsive promoter element (TRE; tetO). When hemizygotes are bred with another transgenic mouse expressing either reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA) under the control of tissue-specific promoters, Cre recombinase expression and Cre-mediated recombination in the appropriate tissues of the bitransgenic offspring can be regulated with the tetracycline analog, doxycycline. This strain represents an effective tool for generating inducible tissue specific-targeted mutants to study cell lineage during development.
In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
Development
A transgenic construct containing the cre recombinase gene under the control of the tetracycline-responsive promoter element (TRE or tetO), minimal CMV promoter and MT-1 polyadenylation site sequence was injected into mixed C57BL/6 and 129 background embryos. Founder mice were bred to FVB/N animals. Upon arrival at The Jackson Laboratory, these mice were backcrossed to C57BL/6J mice for at least 5 generations.
Expression Data
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
|---|---|
| Site of Expression | widespread, inducible expression of Cre recombinase |
Control Suggestions
Selected References
- Perl AK; Wert SE; Nagy A; Lobe CG; Whitsett JA. 2002. Early restriction of peripheral and proximal cell lineages during formation of the lung. Proc Natl Acad Sci U S A 99(16):10482-7. PubMed: 12145322MGI: J:78365
Tg(tetO-cre)1Jaw
Allele Symbol: Tg(tetO-cre)1Jaw
| Allele Name | transgene insertion 1, Jeffrey A Whitsett |
|---|---|
| Allele Type | Transgenic (Inducible, Recombinase-expressing) |
| Allele Synonym(s) | (tetO)7-CMV-Cre; (tetO)7-CMV-Cretg; (tetO)7-Cre; (tetO)7CMV-Cretg; (tetO)7CMVtg; TRECre; TetOCre; tetO-cre |
| Gene Symbol and Name | Tg(tetO-cre)1Jaw, transgene insertion 1, Jeffrey A Whitsett |
| Gene Synonym(s) | (tetO)7-CMV-Cre; (tetO)7-CMV-Cretg; (tetO)7-Cre; (tetO)7CMV-Cretg; (tetO)7CMVtg; TRECre; tetO-cre |
| Promoter | tetO, tet operator, |
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
| Site of Expression | widespread, inducible expression of Cre recombinase |
| Strain of Origin | 129 and C57BL/6 |
| Chromosome | UN |
| Molecular Note | The transgene is composed of 7 tetO sites, a minimal CMV promoter, and sequence encoding cre recombinase. |
| Mutations Made By | Dr. Andras Nagy, Mount Sinai Hospital |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Research Tools
- Cre-lox System
- Cre Recombinase Expression
- Cre Recombinase Expression: Inducible
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Tetop Tet System
- Tet Expression Systems
- tTA/rtTA Responsive Strains
- Cre-lox System
Genotype: cre related
- Research Tools
- Cre-lox System
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
Mammalian Phenotype Terms by Genotype
The following phenotype relates to a compound genotype created using this strain
Genotype: Tg(Scgb1a1-rtTA)2Jaw/0 Tg(tetO-cre)1Jaw/0
involves: 129 * C57BL/6 * FVB/N
mortality/aging
- mortality/aging
- doxycycline-treated mice do not exhibit perinatal toxicity (MGI Ref ID J:179352)
respiratory system phenotype
- respiratory system phenotype
- doxycycline-treated mice do not exhibit lung pathology or dysfunction (MGI Ref ID J:179352)
- doxycycline-treated mice exhibit minimal focal airspace enlargement unlike Tg(Scgb1a1-rtTA)1Jaw mice (MGI Ref ID J:179352)
References
- Perl AK; Wert SE; Nagy A; Lobe CG; Whitsett JA. 2002. Early restriction of peripheral and proximal cell lineages during formation of the lung. Proc Natl Acad Sci U S A 99(16):10482-7. PubMed: 12145322MGI: J:78365
Additional - Tg(tetO-cre)1Jaw related
- Al-Hasani K; Pfeifer A; Courtney M; Ben-Othman N; Gjernes E; Vieira A; Druelle N; Avolio F; Ravassard P; Leuckx G; Lacas-Gervais S; Ambrosetti D; Benizri E; Hecksher-Sorensen J; Gounon P; Ferrer J; Gradwohl G; Heimberg H; Mansouri A; Collombat P. 2013. Adult Duct-Lining Cells Can Reprogram into beta-like Cells Able to Counter Repeated Cycles of Toxin-Induced Diabetes. Dev Cell 26(1):86-100. PubMed: 23810513MGI: J:198630
- Antony N; Weir JR; McDougall AR; Mantamadiotis T; Meikle PJ; Cole TJ; Bird AD. 2013. cAMP response element binding protein1 is essential for activation of steroyl co-enzyme a desaturase 1 (Scd1) in mouse lung type II epithelial cells. PLoS One 8(4):e59763. PubMed: 23637738MGI: J:200565
- Araujo L; Khim P; Mkhikian H; Mortales CL; Demetriou M. 2017. Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation. Elife 6:. PubMed: 28059703MGI: J:240169
- Autry AE; Adachi M; Cheng P; Monteggia LM. 2009. Gender-specific impact of brain-derived neurotrophic factor signaling on stress-induced depression-like behavior. Biol Psychiatry 66(1):84-90. PubMed: 19358977MGI: J:157287
- Balli D; Ustiyan V; Zhang Y; Wang IC; Masino AJ; Ren X; Whitsett JA; Kalinichenko VV; Kalin TV. 2013. Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition. EMBO J 32(2):231-44. PubMed: 23288041MGI: J:193263
- Basseres DS; Levantini E; Ji H; Monti S; Elf S; Dayaram T; Fenyus M; Kocher O; Golub T; Wong KK; Halmos B; Tenen DG. 2006. Respiratory failure due to differentiation arrest and expansion of alveolar cells following lung-specific loss of the transcription factor C/EBPalpha in mice. Mol Cell Biol 26(3):1109-23. PubMed: 16428462MGI: J:105593
- Berdnikovs S; Abdala-Valencia H; Cook-Mills JM. 2013. Endothelial cell PTP1B regulates leukocyte recruitment during allergic inflammation. Am J Physiol Lung Cell Mol Physiol 304(4):L240-9. PubMed: 23275627MGI: J:194934
- Besnard V; Wert SE; Stahlman MT; Postle AD; Xu Y; Ikegami M; Whitsett JA. 2009. Deletion of Scap in alveolar type II cells influences lung lipid homeostasis and identifies a compensatory role for pulmonary lipofibroblasts. J Biol Chem 284(6):4018-30. PubMed: 19074148MGI: J:147592
- Bird AD; Choo YL; Hooper SB; McDougall AR; Cole TJ. 2014. Mesenchymal glucocorticoid receptor regulates the development of multiple cell layers of the mouse lung. Am J Respir Cell Mol Biol 50(2):419-28. PubMed: 24053134MGI: J:231865
- Bonnavion R; Teinturier R; Jaafar R; Ripoche D; Leteurtre E; Chen YJ; Rehfeld JF; Lepinasse F; Hervieu V; Pattou F; Vantyghem MC; Scoazec JY; Bertolino P; Zhang CX. 2015. Islet Cells Serve as Cells of Origin of Pancreatic Gastrin-Positive Endocrine Tumors. Mol Cell Biol 35(19):3274-83. PubMed: 26169832MGI: J:228228
- Brechbuhl HM; Ghosh M; Smith MK; Smith RW; Li B; Hicks DA; Cole BB; Reynolds PR; Reynolds SD. 2011. beta-Catenin Dosage Is a Critical Determinant of Tracheal Basal Cell Fate Determination. Am J Pathol 179(1):367-79. PubMed: 21703416MGI: J:173999
- Bridges JP; Schehr A; Wang Y; Huo L; Besnard V; Ikegami M; Whitsett JA; Xu Y. 2014. Epithelial SCAP/INSIG/SREBP signaling regulates multiple biological processes during perinatal lung maturation. PLoS One 9(5):e91376. PubMed: 24806461MGI: J:216084
- Broide DH; Lawrence T; Doherty T; Cho JY; Miller M; McElwain K; McElwain S; Karin M. 2005. Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium. Proc Natl Acad Sci U S A 102(49):17723-8. PubMed: 16317067MGI: J:104395
- Chakkalakal SA; Uchibe K; Convente MR; Zhang D; Economides AN; Kaplan FS; Pacifici M; Iwamoto M; Shore EM. 2016. Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation. J Bone Miner Res 31(9):1666-75. PubMed: 26896819MGI: J:239136
- Chapman HA; Li X; Alexander JP; Brumwell A; Lorizio W; Tan K; Sonnenberg A; Wei Y; Vu TH. 2011. Integrin alpha6beta4 identifies an adult distal lung epithelial population with regenerative potential in mice. J Clin Invest 121(7):2855-62. PubMed: 21701069MGI: J:175915
- Chen C; Kudo M; Rutaganira F; Takano H; Lee C; Atakilit A; Robinett KS; Uede T; Wolters PJ; Shokat KM; Huang X; Sheppard D. 2012. Integrin alpha9beta1 in airway smooth muscle suppresses exaggerated airway narrowing. J Clin Invest 122(8):2916-27. PubMed: 22772469MGI: J:190074
- Chen G; Korfhagen TR; Xu Y; Kitzmiller J; Wert SE; Maeda Y; Gregorieff A; Clevers H; Whitsett JA. 2009. SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. J Clin Invest 119(10):2914-24. PubMed: 19759516MGI: J:154639
- Chen G; Wan H; Luo F; Zhang L; Xu Y; Lewkowich I; Wills-Karp M; Whitsett JA. 2010. Foxa2 programs Th2 cell-mediated innate immunity in the developing lung. J Immunol 184(11):6133-41. PubMed: 20483781MGI: J:161217
- Chen H; Zhuang F; Liu YH; Xu B; Del Moral P; Deng W; Chai Y; Kolb M; Gauldie J; Warburton D; Moses HL; Shi W. 2008. TGF-beta receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung. Eur Respir J 32(2):285-95. PubMed: 18321928MGI: J:137996
- Chen J; Tu X; Esen E; Joeng KS; Lin C; Arbeit JM; Ruegg MA; Hall MN; Ma L; Long F. 2014. WNT7B promotes bone formation in part through mTORC1. PLoS Genet 10(1):e1004145. PubMed: 24497849MGI: J:208766
- Chen L; Meng Q; Kao W; Xia Y. 2011. IkappaB kinase beta regulates epithelium migration during corneal wound healing. PLoS One 6(1):e16132. PubMed: 21264230MGI: J:180829
- Chignalia AZ; Vogel SM; Reynolds AB; Mehta D; Dull RO; Minshall RD; Malik AB; Liu Y. 2015. p120-Catenin Expressed in Alveolar Type II Cells Is Essential for the Regulation of Lung Innate Immune Response. Am J Pathol 185(5):1251-63. PubMed: 25773174MGI: J:220680
- Cho HC; Lai CY; Shao LE; Yu J. 2011. Identification of Tumorigenic Cells in KrasG12D-Induced Lung Adenocarcinoma. Cancer Res 71(23):7250-8. PubMed: 22088965MGI: J:178608
- Choi YS; Zhang Y; Xu M; Yang Y; Ito M; Peng T; Cui Z; Nagy A; Hadjantonakis AK; Lang RA; Cotsarelis G; Andl T; Morrisey EE; Millar SE. 2013. Distinct Functions for Wnt/beta-Catenin in Hair Follicle Stem Cell Proliferation and Survival and Interfollicular Epidermal Homeostasis. Cell Stem Cell 13(6):720-33. PubMed: 24315444MGI: J:204142
- Coulson-Thomas VJ; Chang SH; Yeh LK; Coulson-Thomas YM; Yamaguchi Y; Esko J; Liu CY; Kao W. 2015. Loss of corneal epithelial heparan sulfate leads to corneal degeneration and impaired wound healing. Invest Ophthalmol Vis Sci 56(5):3004-14. PubMed: 26024086MGI: J:230966
- Coulson-Thomas VJ; Gesteira TF; Esko J; Kao W. 2014. Heparan sulfate regulates hair follicle and sebaceous gland morphogenesis and homeostasis. J Biol Chem 289(36):25211-26. PubMed: 25053416MGI: J:216871
- Courtney M; Gjernes E; Druelle N; Ravaud C; Vieira A; Ben-Othman N; Pfeifer A; Avolio F; Leuckx G; Lacas-Gervais S; Burel-Vandenbos F; Ambrosetti D; Hecksher-Sorensen J; Ravassard P; Heimberg H; Mansouri A; Collombat P. 2013. The inactivation of Arx in pancreatic alpha-cells triggers their neogenesis and conversion into functional beta-like cells. PLoS Genet 9(10):e1003934. PubMed: 24204325MGI: J:205133
- Dahia CL; Mahoney E; Wylie C. 2012. Shh signaling from the nucleus pulposus is required for the postnatal growth and differentiation of the mouse intervertebral disc. PLoS One 7(4):e35944. PubMed: 22558278MGI: J:231130
- Dave V; Childs T; Xu Y; Ikegami M; Besnard V; Maeda Y; Wert SE; Neilson JR; Crabtree GR; Whitsett JA. 2006. Calcineurin/Nfat signaling is required for perinatal lung maturation and function. J Clin Invest 116(10):2597-609. PubMed: 16998587MGI: J:114501
- Dave V; Wert SE; Tanner T; Thitoff AR; Loudy DE; Whitsett JA. 2008. Conditional deletion of Pten causes bronchiolar hyperplasia. Am J Respir Cell Mol Biol 38(3):337-45. PubMed: 17921358MGI: J:146355
- Denney L; Byrne AJ; Shea TJ; Buckley JS; Pease JE; Herledan GM; Walker SA; Gregory LG; Lloyd CM. 2015. Pulmonary Epithelial Cell-Derived Cytokine TGF-beta1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function. Immunity 43(5):945-58. PubMed: 26588780MGI: J:234576
- Ding BS; Nolan DJ; Guo P; Babazadeh AO; Cao Z; Rosenwaks Z; Crystal RG; Simons M; Sato TN; Worgall S; Shido K; Rabbany SY; Rafii S. 2011. Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization. Cell 147(3):539-53. PubMed: 22036563MGI: J:178690
- Eckle T; Brodsky K; Bonney M; Packard T; Han J; Borchers CH; Mariani TJ; Kominsky DJ; Mittelbronn M; Eltzschig HK. 2013. HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium. PLoS Biol 11(9):e1001665. PubMed: 24086109MGI: J:201805
- Eckle T; Kewley EM; Brodsky KS; Tak E; Bonney S; Gobel M; Anderson D; Glover LE; Riegel AK; Colgan SP; Eltzschig HK. 2014. Identification of hypoxia-inducible factor HIF-1A as transcriptional regulator of the A2B adenosine receptor during acute lung injury. J Immunol 192(3):1249-56. PubMed: 24391213MGI: J:207297
- Ehrman LA; Mu X; Waclaw RR; Yoshida Y; Vorhees CV; Klein WH; Campbell K. 2013. The LIM homeobox gene Isl1 is required for the correct development of the striatonigral pathway in the mouse. Proc Natl Acad Sci U S A 110(42):E4026-35. PubMed: 24082127MGI: J:201994
- El-Hashash AH; Al Alam D; Turcatel G; Bellusci S; Warburton D. 2011. Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol 350(1):112-26. PubMed: 21129374MGI: J:170236
- El-Hashash AH; Turcatel G; Al Alam D; Buckley S; Tokumitsu H; Bellusci S; Warburton D. 2011. Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium. Development 138(7):1395-407. PubMed: 21385765MGI: J:171504
- Ermilov AN; Kumari A; Li L; Joiner AM; Grachtchouk MA; Allen BL; Dlugosz AA; Mistretta CM. 2016. Maintenance of Taste Organs Is Strictly Dependent on Epithelial Hedgehog/GLI Signaling. PLoS Genet 12(11):e1006442. PubMed: 27893742MGI: J:237412
- Fong CH; Bebien M; Didierlaurent A; Nebauer R; Hussell T; Broide D; Karin M; Lawrence T. 2008. An antiinflammatory role for IKKbeta through the inhibition of 'classical' macrophage activation. J Exp Med 205(6):1269-76. PubMed: 18490491MGI: J:137075
- Frank DU; Elliott SA; Park EJ; Hammond J; Saijoh Y; Moon AM. 2007. System for inducible expression of cre-recombinase from the Foxa2 locus in endoderm, notochord, and floor plate. Dev Dyn 236(4):1085-1092. PubMed: 17304540MGI: J:119721
- Glaros S; Cirrincione GM; Palanca A; Metzger D; Reisman D. 2008. Targeted knockout of BRG1 potentiates lung cancer development. Cancer Res 68(10):3689-96. PubMed: 18483251MGI: J:135031
- Goncharova EA; Goncharov DA; James ML; Atochina-Vasserman EN; Stepanova V; Hong SB; Li H; Gonzales L; Baba M; Linehan WM; Gow AJ; Margulies S; Guttentag S; Schmidt LS; Krymskaya VP. 2014. Folliculin controls lung alveolar enlargement and epithelial cell survival through E-cadherin, LKB1, and AMPK. Cell Rep 7(2):412-23. PubMed: 24726356MGI: J:211817
- Goto J; Talos DM; Klein P; Qin W; Chekaluk YI; Anderl S; Malinowska IA; Di Nardo A; Bronson RT; Chan JA; Vinters HV; Kernie SG; Jensen FE; Sahin M; Kwiatkowski DJ. 2011. Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex. Proc Natl Acad Sci U S A 108(45):E1070-9. PubMed: 22025691MGI: J:180260
- Grassmeyer J; Mukherjee M; deRiso J; Hettinger C; Bailey M; Sinha S; Visvader JE; Zhao H; Fogarty E; Surendran K. 2017. Elf5 is a principal cell lineage specific transcription factor in the kidney that contributes to Aqp2 and Avpr2 gene expression. Dev Biol 424(1):77-89. PubMed: 28215940MGI: J:241013
- Greenwood KK; Proper SP; Saini Y; Bramble LA; Jackson-Humbles DN; Wagner JG; Harkema JR; LaPres JJ. 2012. Neonatal epithelial hypoxia inducible factor-1alpha expression regulates the response of the lung to experimental asthma. Am J Physiol Lung Cell Mol Physiol 302(5):L455-62. PubMed: 22180657MGI: J:183445
- Hahn DR; Na CL; Weaver TE. 2014. Reserve autophagic capacity in alveolar epithelia provides a replicative niche for influenza A virus. Am J Respir Cell Mol Biol 51(3):400-12. PubMed: 24661119MGI: J:232239
- Han CZ; Juncadella IJ; Kinchen JM; Buckley MW; Klibanov AL; Dryden K; Onengut-Gumuscu S; Erdbrugger U; Turner SD; Shim YM; Tung KS; Ravichandran KS. 2016. Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation. Nature 539(7630):570-574. PubMed: 27820945MGI: J:241315
- Haney SL; Upchurch GM; Opavska J; Klinkebiel D; Hlady RA; Roy S; Dutta S; Datta K; Opavsky R. 2016. Dnmt3a Is a Haploinsufficient Tumor Suppressor in CD8+ Peripheral T Cell Lymphoma. PLoS Genet 12(9):e1006334. PubMed: 27690235MGI: J:235643
- Haney SL; Upchurch GM; Opavska J; Klinkebiel D; Hlady RA; Suresh A; Pirruccello SJ; Shukla V; Lu R; Costinean S; Rizzino A; Karpf AR; Joshi S; Swanson P; Opavsky R. 2016. Promoter Hypomethylation and Expression Is Conserved in Mouse Chronic Lymphocytic Leukemia Induced by Decreased or Inactivated Dnmt3a. Cell Rep 15(6):1190-201. PubMed: 27134162MGI: J:235483
- Hashimoto T; Bergen SE; Nguyen QL; Xu B; Monteggia LM; Pierri JN; Sun Z; Sampson AR; Lewis DA. 2005. Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia. J Neurosci 25(2):372-83. PubMed: 15647480MGI: J:97675
- Heinonen KM; Vanegas JR; Brochu S; Shan J; Vainio SJ; Perreault C. 2011. Wnt4 regulates thymic cellularity through the expansion of thymic epithelial cells and early thymic progenitors. Blood 118(19):5163-73. PubMed: 21937690MGI: J:178890
- Herjan T; Yao P; Qian W; Li X; Liu C; Bulek K; Sun D; Yang WP; Zhu J; He A; Carman JA; Erzurum SC; Lipshitz HD; Fox PL; Hamilton TA; Li X. 2013. HuR is required for IL-17-induced Act1-mediated CXCL1 and CXCL5 mRNA stabilization. J Immunol 191(2):640-9. PubMed: 23772036MGI: J:204952
- Hill JJ; Kolluri N; Hashimoto T; Wu Q; Sampson AR; Monteggia LM; Lewis DA. 2005. Analysis of pyramidal neuron morphology in an inducible knockout of brain-derived neurotrophic factor. Biol Psychiatry 57(8):932-4. PubMed: 15820715MGI: J:102119
- Hlady RA; Novakova S; Opavska J; Klinkebiel D; Peters SL; Bies J; Hannah J; Iqbal J; Anderson KM; Siebler HM; Smith LM; Greiner TC; Bastola D; Joshi S; Lockridge O; Simpson MA; Felsher DW; Wagner KU; Chan WC; Christman JK; Opavsky R. 2012. Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis. J Clin Invest 122(1):163-77. PubMed: 22133874MGI: J:184415
- Hokuto I; Ikegami M; Yoshida M; Takeda K; Akira S; Perl AK; Hull WM; Wert SE; Whitsett JA. 2004. Stat-3 is required for pulmonary homeostasis during hyperoxia. J Clin Invest 113(1):28-37. PubMed: 14702106MGI: J:87622
- Hoshino T; Kato S; Oka N; Imaoka H; Kinoshita T; Takei S; Kitasato Y; Kawayama T; Imaizumi T; Yamada K; Young HA; Aizawa H. 2007. Pulmonary inflammation and emphysema: role of the cytokines IL-18 and IL-13. Am J Respir Crit Care Med 176(1):49-62. PubMed: 17400729MGI: J:147547
- Hsu W; Mirando AJ; Yu HM. 2009. Manipulating gene activity in Wnt1-expressing precursors of neural epithelial and neural crest cells. Dev Dyn 239(1):338-345. PubMed: 19653308MGI: J:155252
- Ihara S; Kida H; Arase H; Tripathi LP; Chen YA; Kimura T; Yoshida M; Kashiwa Y; Hirata H; Fukamizu R; Inoue R; Hasegawa K; Goya S; Takahashi R; Minami T; Tsujino K; Suzuki M; Kohmo S; Inoue K; Nagatomo I; Takeda Y; Kijima T; Mizuguchi K; Tachibana I; Kumanogoh A. 2012. Inhibitory roles of signal transducer and activator of transcription 3 in antitumor immunity during carcinogen-induced lung tumorigenesis. Cancer Res 72(12):2990-9. PubMed: 22659452MGI: J:189293
- Ikegami M; Falcone A; Whitsett JA. 2008. STAT-3 regulates surfactant phospholipid homeostasis in normal lung and during endotoxin-mediated lung injury. J Appl Physiol 104(6):1753-60. PubMed: 18369093MGI: J:183960
- Inoshima I; Inoshima N; Wilke GA; Powers ME; Frank KM; Wang Y; Bubeck Wardenburg J. 2011. A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice. Nat Med 17(10):1310-4. PubMed: 21926978MGI: J:177286
- Inoue D; Kubo H; Taguchi K; Suzuki T; Komatsu M; Motohashi H; Yamamoto M. 2011. Inducible disruption of autophagy in the lung causes airway hyper-responsiveness. Biochem Biophys Res Commun 405(1):13-8. PubMed: 21185264MGI: J:168468
- Joiner AM; Green WW; McIntyre JC; Allen BL; Schwob JE; Martens JR. 2015. Primary Cilia on Horizontal Basal Cells Regulate Regeneration of the Olfactory Epithelium. J Neurosci 35(40):13761-72. PubMed: 26446227MGI: J:226461
- Kaasik K; Kivimae S; Allen JJ; Chalkley RJ; Huang Y; Baer K; Kissel H; Burlingame AL; Shokat KM; Ptacek LJ; Fu YH. 2013. Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock. Cell Metab 17(2):291-302. PubMed: 23395175MGI: J:198048
- Kalin TV; Wang IC; Meliton L; Zhang Y; Wert SE; Ren X; Snyder J; Bell SM; Graf L Jr; Whitsett JA; Kalinichenko VV. 2008. Forkhead Box m1 transcription factor is required for perinatal lung function. Proc Natl Acad Sci U S A 105(49):19330-5. PubMed: 19033457MGI: J:142246
- Katsumoto TR; Kudo M; Chen C; Sundaram A; Callahan EC; Zhu JW; Lin J; Rosen CE; Manz BN; Lee JW; Matthay MA; Huang X; Sheppard D; Weiss A. 2013. The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases. J Clin Invest 123(5):2037-48. PubMed: 23543053MGI: J:201353
- Kawakami-Schulz SV; Verdoni AM; Sattler SG; Jessen E; Kao WW; Ikeda A; Ikeda S. 2014. Serum response factor: positive and negative regulation of an epithelial gene expression network in the destrin mutant cornea. Physiol Genomics 46(8):277-89. PubMed: 24550211MGI: J:208758
- Kida H; Mucenski ML; Thitoff AR; Le Cras TD; Park KS; Ikegami M; Muller W; Whitsett JA. 2008. GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium. Am J Pathol 172(6):1542-54. PubMed: 18467707MGI: J:136187
- Kim KK; Wei Y; Szekeres C; Kugler MC; Wolters PJ; Hill ML; Frank JA; Brumwell AN; Wheeler SE; Kreidberg JA; Chapman HA. 2009. Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest 119(1):213-24. PubMed: 19104148MGI: J:144703
- Kimura T; Kawabe H; Jiang C; Zhang W; Xiang YY; Lu C; Salter MW; Brose N; Lu WY; Rotin D. 2011. Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease. Proc Natl Acad Sci U S A 108(8):3216-21. PubMed: 21300902MGI: J:169296
- Kitamura T; Qian BZ; Soong D; Cassetta L; Noy R; Sugano G; Kato Y; Li J; Pollard JW. 2015. CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages. J Exp Med 212(7):1043-59. PubMed: 26056232MGI: J:226363
- Kobayashi T; Owczarek TB; McKiernan JM; Abate-Shen C. 2015. Modelling bladder cancer in mice: opportunities and challenges. Nat Rev Cancer 15(1):42-54. PubMed: 25533675MGI: J:219292
- Kuperman DA; Huang X; Nguyenvu L; Holscher C; Brombacher F; Erle DJ. 2005. IL-4 receptor signaling in Clara cells is required for allergen-induced mucus production. J Immunol 175(6):3746-52. PubMed: 16148120MGI: J:116729
- Laronda MM; Unno K; Ishi K; Serna VA; Butler LM; Mills AA; Orvis GD; Behringer RR; Deng C; Sinha S; Kurita T. 2013. Diethylstilbestrol induces vaginal adenosis by disrupting SMAD/RUNX1-mediated cell fate decision in the Mullerian duct epithelium. Dev Biol 381(1):5-16. PubMed: 23830984MGI: J:200766
- Le A; Zielinski R; He C; Crow MT; Biswal S; Tuder RM; Becker PM. 2009. Pulmonary epithelial neuropilin-1 deletion enhances development of cigarette smoke-induced emphysema. Am J Respir Crit Care Med 180(5):396-406. PubMed: 19520907MGI: J:167963
- Lescroart F; Chabab S; Lin X; Rulands S; Paulissen C; Rodolosse A; Auer H; Achouri Y; Dubois C; Bondue A; Simons BD; Blanpain C. 2014. Early lineage restriction in temporally distinct populations of Mesp1 progenitors during mammalian heart development. Nat Cell Biol 16(9):829-40. PubMed: 25150979MGI: J:219384
- Li FF; Shen J; Shen HJ; Zhang X; Cao R; Zhang Y; Qui Q; Lin XX; Xie YC; Zhang LH; Jia YL; Dong XW; Jiang JX; Bao MJ; Zhang S; Ma WJ; Wu XM; Shen H; Xie QM; Ke Y. 2012. Shp2 plays an important role in acute cigarette smoke-mediated lung inflammation. J Immunol 189(6):3159-67. PubMed: 22891281MGI: J:189811
- Li J; Feng J; Liu Y; Ho TV; Grimes W; Ho HA; Park S; Wang S; Chai Y. 2015. BMP-SHH signaling network controls epithelial stem cell fate via regulation of its niche in the developing tooth. Dev Cell 33(2):125-35. PubMed: 25865348MGI: J:239282
- Lin C; Yin Y; Bell SM; Veith GM; Chen H; Huh SH; Ornitz DM; Ma L. 2013. Delineating a conserved genetic cassette promoting outgrowth of body appendages. PLoS Genet 9(1):e1003231. PubMed: 23358455MGI: J:223057
- Lin C; Yin Y; Chen H; Fisher AV; Chen F; Rauchman M; Ma L. 2009. Construction and characterization of a doxycycline-inducible transgenic system in Msx2 expressing cells. Genesis 47(5):352-359. PubMed: 19370755MGI: J:148502
- Lin C; Yin Y; Stemler K; Humphrey P; Kibel AS; Mysorekar IU; Ma L. 2013. Constitutive beta-catenin activation induces male-specific tumorigenesis in the bladder urothelium. Cancer Res 73(19):5914-25. PubMed: 23928991MGI: J:202618
- Lin C; Yin Y; Veith GM; Fisher AV; Long F; Ma L. 2009. Temporal and spatial dissection of Shh signaling in genital tubercle development. Development 136(23):3959-67. PubMed: 19906863MGI: J:158288
- Liu J; Dong F; Fung I; Chen E; Allen TD; Deutsch U; Lobe CG. 2014. Postnatal Notch1 activation induces Tcell malignancy in conditional and inducible mouse models. Int J Oncol 45(5):1997-2004. PubMed: 25175815MGI: J:232150
- Liu Y; Sadikot RT; Adami GR; Kalinichenko VV; Pendyala S; Natarajan V; Zhao YY; Malik AB. 2011. FoxM1 mediates the progenitor function of type II epithelial cells in repairing alveolar injury induced by Pseudomonas aeruginosa. J Exp Med 208(7):1473-84. PubMed: 21708928MGI: J:176807
- Liu Z; Obenauf AC; Speicher MR; Kopan R. 2009. Rapid identification of homologous recombinants and determination of gene copy number with reference/query pyrosequencing (RQPS). Genome Res 19(11):2081-9. PubMed: 19797679MGI: J:172930
- Lu K; Reddy R; Berika M; Warburton D; El-Hashash AH. 2013. Abrogation of Eya1/Six1 disrupts the saccular phase of lung morphogenesis and causes remodeling. Dev Biol 382(1):110-23. PubMed: 23895934MGI: J:202226
- Luo Y; Chen H; Ren S; Li N; Mishina Y; Shi W. 2016. BMP signaling is essential in neonatal surfactant production during respiratory adaptation. Am J Physiol Lung Cell Mol Physiol 311(1):L29-38. PubMed: 27190064MGI: J:236055
- Luo Y; El Agha E; Turcatel G; Chen H; Chiu J; Warburton D; Bellusci S; Qian BP; Menke DB; Shi W. 2015. Mesenchymal adenomatous polyposis coli plays critical and diverse roles in regulating lung development. BMC Biol 13:42. PubMed: 26092405MGI: J:225642
- Luo Y; Xu W; Chen H; Warburton D; Dong R; Qian B; Selman M; Gauldie J; Kolb M; Shi W. 2015. A novel profibrotic mechanism mediated by TGFbeta-stimulated collagen prolyl hydroxylase expression in fibrotic lung mesenchymal cells. J Pathol 236(3):384-94. PubMed: 25779936MGI: J:222978
- Ma M; Tian X; Igarashi P; Pazour GJ; Somlo S. 2013. Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease. Nat Genet 45(9):1004-12. PubMed: 23892607MGI: J:205308
- MacKenzie B; Henneke I; Hezel S; Al Alam D; El Agha E; Chao CM; Quantius J; Wilhelm J; Jones M; Goth K; Li X; Seeger W; Konigshoff M; Herold S; Rizvanov AA; Gunther A; Bellusci S. 2015. Attenuating endogenous Fgfr2b ligands during bleomycin-induced lung fibrosis does not compromise murine lung repair. Am J Physiol Lung Cell Mol Physiol 308(10):L1014-24. PubMed: 25820524MGI: J:232268
- Mannik J; Alzayady K; Ghazizadeh S. 2010. Regeneration of multilineage skin epithelia by differentiated keratinocytes. J Invest Dermatol 130(2):388-97. PubMed: 19675579MGI: J:159578
- Manwani N; Gagnon S; Post M; Joza S; Muglia L; Cornejo S; Kaplan F; Sweezey NB. 2010. Reduced viability of mice with lung epithelial-specific knockout of glucocorticoid receptor. Am J Respir Cell Mol Biol 43(5):599-606. PubMed: 20042713MGI: J:177810
- Martis PC; Whitsett JA; Xu Y; Perl AK; Wan H; Ikegami M. 2006. C/EBP{alpha} is required for lung maturation at birth. Development 133(6):1155-64. PubMed: 16467360MGI: J:106543
- Mason-Richie NA; Mistry MJ; Gettler CA; Elayyadi A; Wikenheiser-Brokamp KA. 2008. Retinoblastoma function is essential for establishing lung epithelial quiescence after injury. Cancer Res 68(11):4068-76. PubMed: 18519665MGI: J:136426
- Matsuzaki Y; Besnard V; Clark JC; Xu Y; Wert SE; Ikegami M; Whitsett JA. 2008. STAT3 regulates ABCA3 expression and influences lamellar body formation in alveolar type II cells. Am J Respir Cell Mol Biol 38(5):551-8. PubMed: 18096869MGI: J:149721
- Matsuzaki Y; Xu Y; Ikegami M; Besnard V; Park KS; Hull WM; Wert SE; Whitsett JA. 2006. Stat3 is required for cytoprotection of the respiratory epithelium during adenoviral infection. J Immunol 177(1):527-37. PubMed: 16785550MGI: J:134441
- Meng Q; Mongan M; Carreira V; Kurita H; Liu CY; Kao WW; Xia Y. 2014. Eyelid closure in embryogenesis is required for ocular adnexa development. Invest Ophthalmol Vis Sci 55(11):7652-61. PubMed: 25377219MGI: J:230303
- Miller LA; Wert SE; Clark JC; Xu Y; Perl AK; Whitsett JA. 2004. Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung. Dev Dyn 231(1):57-71. PubMed: 15305287MGI: J:91723
- Miller M; Tam AB; Cho JY; Doherty TA; Pham A; Khorram N; Rosenthal P; Mueller JL; Hoffman HM; Suzukawa M; Niwa M; Broide DH. 2012. ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6. Proc Natl Acad Sci U S A 109(41):16648-53. PubMed: 23011799MGI: J:190332
- Minowada G; Miller YE. 2009. Overexpression of Sprouty 2 in mouse lung epithelium inhibits urethane-induced tumorigenesis. Am J Respir Cell Mol Biol 40(1):31-7. PubMed: 18635814MGI: J:155786
- Monteggia LM; Barrot M; Powell CM; Berton O; Galanis V; Gemelli T; Meuth S; Nagy A; Greene RW; Nestler EJ. 2004. Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc Natl Acad Sci U S A 101(29):10827-32. PubMed: 15249684MGI: J:91563
- Morimoto M; Kopan R. 2009. rtTA toxicity limits the usefulness of the SP-C-rtTA transgenic mouse. Dev Biol 325(1):171-8. PubMed: 19013447MGI: J:143537
- Morimoto M; Liu Z; Cheng HT; Winters N; Bader D; Kopan R. 2010. Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate. J Cell Sci 123(Pt 2):213-24. PubMed: 20048339MGI: J:156690
- Morley TS; Xia JY; Scherer PE. 2015. Selective enhancement of insulin sensitivity in the mature adipocyte is sufficient for systemic metabolic improvements. Nat Commun 6:7906. PubMed: 26243466MGI: J:225001
- Mucenski ML; Nation JM; Thitoff AR; Besnard V; Xu Y; Wert SE; Harada N; Taketo MM; Stahlman MT; Whitsett JA. 2005. Beta-catenin regulates differentiation of respiratory epithelial cells in vivo. Am J Physiol Lung Cell Mol Physiol 289(6):L971-9. PubMed: 16040629MGI: J:105013
- Mucenski ML; Wert SE; Nation JM; Loudy DE; Huelsken J; Birchmeier W; Morrisey EE; Whitsett JA. 2003. beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis. J Biol Chem 278(41):40231-8. PubMed: 12885771MGI: J:85946
- Ng GY; Yeh LK; Zhang Y; Liu H; Feng GS; Kao WW; Liu CY. 2013. Role of SH2-containing tyrosine phosphatase Shp2 in mouse corneal epithelial stratification. Invest Ophthalmol Vis Sci 54(13):7933-42. PubMed: 24204042MGI: J:215136
- Nguyen NM; Kelley DG; Schlueter JA; Meyer MJ; Senior RM; Miner JH. 2005. Epithelial laminin alpha5 is necessary for distal epithelial cell maturation, VEGF production, and alveolization in the developing murine lung. Dev Biol 282(1):111-25. PubMed: 15936333MGI: J:104565
- Nosyreva E; Szabla K; Autry AE; Ryazanov AG; Monteggia LM; Kavalali ET. 2013. Acute suppression of spontaneous neurotransmission drives synaptic potentiation. J Neurosci 33(16):6990-7002. PubMed: 23595756MGI: J:196965
- Opavsky R; Tsai SY; Guimond M; Arora A; Opavska J; Becknell B; Kaufmann M; Walton NA; Stephens JA; Fernandez SA; Muthusamy N; Felsher DW; Porcu P; Caligiuri MA; Leone G. 2007. Specific tumor suppressor function for E2F2 in Myc-induced T cell lymphomagenesis. Proc Natl Acad Sci U S A 104(39):15400-5. PubMed: 17881568MGI: J:125304
- Opavsky R; Wang SH; Trikha P; Raval A; Huang Y; Wu YZ; Rodriguez B; Keller B; Liyanarachchi S; Wei G; Davuluri RV; Weinstein M; Felsher D; Ostrowski M; Leone G; Plass C. 2007. CpG island methylation in a mouse model of lymphoma is driven by the genetic configuration of tumor cells. PLoS Genet 3(9):1757-69. PubMed: 17907813MGI: J:130029
- Ousset M; Van Keymeulen A; Bouvencourt G; Sharma N; Achouri Y; Simons BD; Blanpain C. 2012. Multipotent and unipotent progenitors contribute to prostate postnatal development. Nat Cell Biol 14(11):1131-8. PubMed: 23064263MGI: J:193931
- Pardo-Saganta A; Law BM; Tata PR; Villoria J; Saez B; Mou H; Zhao R; Rajagopal J. 2015. Injury induces direct lineage segregation of functionally distinct airway basal stem/progenitor cell subpopulations. Cell Stem Cell 16(2):184-97. PubMed: 25658372MGI: J:224011
- Park KS; Wells JM; Zorn AM; Wert SE; Laubach VE; Fernandez LG; Whitsett JA. 2006. Transdifferentiation of ciliated cells during repair of the respiratory epithelium. Am J Respir Cell Mol Biol 34(2):151-7. PubMed: 16239640MGI: J:120191
- Perets R; Wyant GA; Muto KW; Bijron JG; Poole BB; Chin KT; Chen JY; Ohman AW; Stepule CD; Kwak S; Karst AM; Hirsch MS; Setlur SR; Crum CP; Dinulescu DM; Drapkin R. 2013. Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models. Cancer Cell 24(6):751-65. PubMed: 24332043MGI: J:207621
- Perl AK; Kist R; Shan Z; Scherer G; Whitsett JA. 2005. Normal lung development and function after Sox9 inactivation in the respiratory epithelium. Genesis 41(1):23-32. PubMed: 15645446MGI: J:95910
- Perl AK; Wert SE; Loudy DE; Shan Z; Blair PA; Whitsett JA. 2005. Conditional recombination reveals distinct subsets of epithelial cells in trachea, bronchi, and alveoli. Am J Respir Cell Mol Biol 33(5):455-62. PubMed: 16055670MGI: J:132772
- Perl AK; Zhang L; Whitsett JA. 2009. Conditional expression of genes in the respiratory epithelium in transgenic mice: cautionary notes and toward building a better mouse trap. Am J Respir Cell Mol Biol 40(1):1-3. PubMed: 19075182MGI: J:179352
- Peters SL; Hlady RA; Opavska J; Klinkebiel D; Novakova S; Smith LM; Lewis RE; Karpf AR; Simpson MA; Wu L; Opavsky R. 2013. Essential role for Dnmt1 in the prevention and maintenance of MYC-induced T-cell lymphomas. Mol Cell Biol 33(21):4321-33. PubMed: 24001767MGI: J:205419
- Peters SL; Hlady RA; Opavska J; Klinkebiel D; Pirruccello SJ; Talmon GA; Sharp JG; Wu L; Jaenisch R; Simpson MA; Karpf AR; Opavsky R. 2014. Tumor suppressor functions of Dnmt3a and Dnmt3b in the prevention of malignant mouse lymphopoiesis. Leukemia 28(5):1138-42. PubMed: 24292811MGI: J:209078
- Planes C; Randrianarison NH; Charles RP; Frateschi S; Cluzeaud F; Vuagniaux G; Soler P; Clerici C; Rossier BC; Hummler E. 2010. ENaC-mediated alveolar fluid clearance and lung fluid balance depend on the channel-activating protease 1. EMBO Mol Med 2(1):26-37. PubMed: 20043279MGI: J:232314
- Proper SP; Saini Y; Greenwood KK; Bramble LA; Downing NJ; Harkema JR; Lapres JJ. 2014. Loss of hypoxia-inducible factor 2 alpha in the lung alveolar epithelium of mice leads to enhanced eosinophilic inflammation in cobalt-induced lung injury. Toxicol Sci 137(2):447-57. PubMed: 24218148MGI: J:207763
- Prunskaite-Hyyrylainen R; Shan J; Railo A; Heinonen KM; Miinalainen I; Yan W; Shen B; Perreault C; Vainio SJ. 2014. Wnt4, a pleiotropic signal for controlling cell polarity, basement membrane integrity, and antimullerian hormone expression during oocyte maturation in the female follicle. FASEB J 28(4):1568-81. PubMed: 24371124MGI: J:225258
- Qiu Z; Elsayed Z; Peterkin V; Alkatib S; Bennett D; Landry JW. 2016. Ino80 is essential for proximal-distal axis asymmetry in part by regulating Bmp4 expression. BMC Biol 14(1):18. PubMed: 26975355MGI: J:229516
- Qiu Z; Song C; Malakouti N; Murray D; Hariz A; Zimmerman M; Gygax D; Alhazmi A; Landry JW. 2015. Functional interactions between NURF and Ctcf regulate gene expression. Mol Cell Biol 35(1):224-37. PubMed: 25348714MGI: J:224312
- Quinton LJ; Jones MR; Robson BE; Simms BT; Whitsett JA; Mizgerd JP. 2008. Alveolar epithelial STAT3, IL-6 family cytokines, and host defense during Escherichia coli pneumonia. Am J Respir Cell Mol Biol 38(6):699-706. PubMed: 18192501MGI: J:149718
- Rabbani P; Takeo M; Chou W; Myung P; Bosenberg M; Chin L; Taketo MM; Ito M. 2011. Coordinated activation of wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration. Cell 145(6):941-55. PubMed: 21663796MGI: J:173080
- Rampias T; Vgenopoulou P; Avgeris M; Polyzos A; Stravodimos K; Valavanis C; Scorilas A; Klinakis A. 2014. A new tumor suppressor role for the Notch pathway in bladder cancer. Nat Med 20(10):1199-205. PubMed: 25194568MGI: J:227748
- Ren X; Shah TA; Ustiyan V; Zhang Y; Shinn J; Chen G; Whitsett JA; Kalin TV; Kalinichenko VV. 2013. FOXM1 promotes allergen-induced goblet cell metaplasia and pulmonary inflammation. Mol Cell Biol 33(2):371-86. PubMed: 23149934MGI: J:194103
- Saini Y; Greenwood KK; Merrill C; Kim KY; Patial S; Parameswaran N; Harkema JR; LaPres JJ. 2010. Acute cobalt-induced lung injury and the role of hypoxia-inducible factor 1alpha in modulating inflammation. Toxicol Sci 116(2):673-81. PubMed: 20511350MGI: J:162927
- Saini Y; Harkema JR; LaPres JJ. 2008. HIF1alpha is essential for normal intrauterine differentiation of alveolar epithelium and surfactant production in the newborn lung of mice. J Biol Chem 283(48):33650-7. PubMed: 18801745MGI: J:143384
- Saini Y; Kim KY; Lewandowski R; Bramble LA; Harkema JR; Lapres JJ. 2010. Role of hypoxia-inducible factor 1{alpha} in modulating cobalt-induced lung inflammation. Am J Physiol Lung Cell Mol Physiol 298(2):L139-47. PubMed: 19915160MGI: J:157680
- Sato A; Xu Y; Whitsett JA; Ikegami M. 2012. CCAAT/enhancer binding protein-alpha regulates the protease/antiprotease balance required for bronchiolar epithelium regeneration. Am J Respir Cell Mol Biol 47(4):454-63. PubMed: 22652201MGI: J:201240
- Sato A; Yamada N; Ogawa Y; Ikegami M. 2013. CCAAT/enhancer-binding protein-alpha suppresses lung tumor development in mice through the p38alpha MAP kinase pathway. PLoS One 8(2):e57013. PubMed: 23437297MGI: J:197191
- Schmidt JW; Wehde BL; Sakamoto K; Triplett AA; Anderson SM; Tsichlis PN; Leone G; Wagner KU. 2014. Stat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis. Mol Cell Biol 34(7):1363-77. PubMed: 24469394MGI: J:213526
- Shaw AT; Meissner A; Dowdle JA; Crowley D; Magendantz M; Ouyang C; Parisi T; Rajagopal J; Blank LJ; Bronson RT; Stone JR; Tuveson DA; Jaenisch R; Jacks T. 2007. Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. Genes Dev 21(6):694-707. PubMed: 17369402MGI: J:119477
- Shu W; Guttentag S; Wang Z; Andl T; Ballard P; Lu MM; Piccolo S; Birchmeier W; Whitsett JA; Millar SE; Morrisey EE. 2005. Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung. Dev Biol 283(1):226-39. PubMed: 15907834MGI: J:99391
- Simpson DS; Mason-Richie NA; Gettler CA; Wikenheiser-Brokamp KA. 2009. Retinoblastoma family proteins have distinct functions in pulmonary epithelial cells in vivo critical for suppressing cell growth and tumorigenesis. Cancer Res 69(22):8733-41. PubMed: 19887614MGI: J:154440
- Smith RW; Hicks DA; Reynolds SD. 2012. Roles for beta-catenin and doxycycline in the regulation of respiratory epithelial cell frequency and function. Am J Respir Cell Mol Biol 46(1):115-24. PubMed: 21852686MGI: J:191911
- Song X; Fan PD; Bantikassegn A; Guha U; Threadgill DW; Varmus H; Politi K. 2015. ERBB3-Independent Activation of the PI3K Pathway in EGFR-Mutant Lung Adenocarcinomas. Cancer Res 75(6):1035-45. PubMed: 25596284MGI: J:219801
- Souma T; Tompson SW; Thomson BR; Siggs OM; Kizhatil K; Yamaguchi S; Feng L; Limviphuvadh V; Whisenhunt KN; Maurer-Stroh S; Yanovitch TL; Kalaydjieva L; Azmanov DN; Finzi S; Mauri L; Javadiyan S; Souzeau E; Zhou T; Hewitt AW; Kloss B; Burdon KP; Mackey DA; Allen KF; Ruddle JB; Lim SH; Rozen S; Tran-Viet KN; Liu X; John S; Wiggs JL; Pasutto F; Craig JE; Jin J; Quaggin SE; Young TL. 2016. Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity. J Clin Invest 126(7):2575-87. PubMed: 27270174MGI: J:237147
- Sun J; Chen H; Chen C; Whitsett JA; Mishina Y; Bringas P Jr; Ma JC; Warburton D; Shi W. 2008. Prenatal lung epithelial cell-specific abrogation of alk3-bone morphogenetic protein signaling causes neonatal respiratory distress by disrupting distal airway formation. Am J Pathol 172(3):571-82. PubMed: 18258849MGI: J:132011
- Sun KH; Chang Y; Reed NI; Sheppard D. 2016. alpha-Smooth muscle actin is an inconsistent marker of fibroblasts responsible for force-dependent TGFbeta activation or collagen production across multiple models of organ fibrosis. Am J Physiol Lung Cell Mol Physiol 310(9):L824-36. PubMed: 26944089MGI: J:234352
- Switon K; Kotulska K; Janusz-Kaminska A; Zmorzynska J; Jaworski J. 2017. Molecular neurobiology of mTOR. Neuroscience 341:112-153. PubMed: 27889578MGI: J:238268
- Takahashi H; Ogata H; Nishigaki R; Broide DH; Karin M. 2010. Tobacco Smoke Promotes Lung Tumorigenesis by Triggering IKKbeta- and JNK1-Dependent Inflammation. Cancer Cell 17(1):89-97. PubMed: 20129250MGI: J:156928
- Tang W; Zeve D; Suh JM; Bosnakovski D; Kyba M; Hammer RE; Tallquist MD; Graff JM. 2008. White fat progenitor cells reside in the adipose vasculature. Science 322(5901):583-6. PubMed: 18801968MGI: J:178521
- Tang X; Liu XJ; Tian C; Su Q; Lei Y; Wu Q; He Y; Whitsett JA; Luo F. 2013. Foxa2 regulates leukotrienes to inhibit Th2-mediated pulmonary inflammation. Am J Respir Cell Mol Biol 49(6):960-70. PubMed: 23822876MGI: J:231564
- Tata PR; Pardo-Saganta A; Prabhu M; Vinarsky V; Law BM; Fontaine BA; Tager AM; Rajagopal J. 2013. Airway-specific inducible transgene expression using aerosolized doxycycline. Am J Respir Cell Mol Biol 49(6):1048-56. PubMed: 23848320MGI: J:231560
- Taylor A; Tang W; Bruscia EM; Zhang PX; Lin A; Gaines P; Wu D; Halene S. 2014. SRF is required for neutrophil migration in response to inflammation. Blood 123(19):3027-36. PubMed: 24574460MGI: J:210744
- Teta M; Choi YS; Okegbe T; Wong G; Tam OH; Chong MM; Seykora JT; Nagy A; Littman DR; Andl T; Millar SE. 2012. Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skin. Development 139(8):1405-16. PubMed: 22434867MGI: J:183487
- Thomson BR; Heinen S; Jeansson M; Ghosh AK; Fatima A; Sung HK; Onay T; Chen H; Yamaguchi S; Economides AN; Flenniken A; Gale NW; Hong YK; Fawzi A; Liu X; Kume T; Quaggin SE. 2014. A lymphatic defect causes ocular hypertension and glaucoma in mice. J Clin Invest 124(10):4320-4. PubMed: 25202984MGI: J:217296
- Thorel F; Nepote V; Avril I; Kohno K; Desgraz R; Chera S; Herrera PL. 2010. Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature 464(7292):1149-54. PubMed: 20364121MGI: J:159291
- Tian Y; Zhang Y; Hurd L; Hannenhalli S; Liu F; Lu MM; Morrisey EE. 2011. Regulation of lung endoderm progenitor cell behavior by miR302/367. Development 138(7):1235-45. PubMed: 21350014MGI: J:171513
- Tian Y; Zhou R; Rehg JE; Jackowski S. 2007. Role of phosphocholine cytidylyltransferase alpha in lung development. Mol Cell Biol 27(3):975-82. PubMed: 17130238MGI: J:118292
- Turcatel G; Rubin N; Menke DB; Martin G; Shi W; Warburton D. 2013. Lung mesenchymal expression of Sox9 plays a critical role in tracheal development. BMC Biol 11:117. PubMed: 24274029MGI: J:225175
- Uemura S; Nagaoka T; Yokoyama M; Igarashi M; Kishi M. 2014. A simple and highly efficient method to identify the integration site of a transgene in the animal genome. Neurosci Res 80:91-4. PubMed: 24378375MGI: J:231988
- Ustiyan V; Wert SE; Ikegami M; Wang IC; Kalin TV; Whitsett JA; Kalinichenko VV. 2012. Foxm1 transcription factor is critical for proliferation and differentiation of Clara cells during development of conducting airways. Dev Biol 370(2):198-212. PubMed: 22885335MGI: J:188138
- Van Keymeulen A; Lee MY; Ousset M; Brohee S; Rorive S; Giraddi RR; Wuidart A; Bouvencourt G; Dubois C; Salmon I; Sotiriou C; Phillips WA; Blanpain C. 2015. Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity. Nature 525(7567):119-23. PubMed: 26266985MGI: J:225868
- Van Keymeulen A; Rocha AS; Ousset M; Beck B; Bouvencourt G; Rock J; Sharma N; Dekoninck S; Blanpain C. 2011. Distinct stem cells contribute to mammary gland development and maintenance. Nature 479(7372):189-93. PubMed: 21983963MGI: J:180048
- Verdoni AM; Schuster KJ; Cole BS; Ikeda A; Kao WW; Ikeda S. 2010. A pathogenic relationship between a regulator of the actin cytoskeleton and serum response factor. Genetics 186(1):147-57. PubMed: 20610412MGI: J:164255
- Volckaert T; Dill E; Campbell A; Tiozzo C; Majka S; Bellusci S; De Langhe SP. 2011. Parabronchial smooth muscle constitutes an airway epithelial stem cell niche in the mouse lung after injury. J Clin Invest 121(11):4409-19. PubMed: 21985786MGI: J:178444
- Waclaw RR; Ehrman LA; Pierani A; Campbell K. 2010. Developmental origin of the neuronal subtypes that comprise the amygdalar fear circuit in the mouse. J Neurosci 30(20):6944-53. PubMed: 20484636MGI: J:160511
- Wagh PK; Gardner MA; Ma X; Callahan M; Shannon JM; Wert SE; Messinger YH; Dehner LP; Hill DA; Wikenheiser-Brokamp KA. 2015. Cell- and developmental stage-specific Dicer1 ablation in the lung epithelium models cystic pleuropulmonary blastoma. J Pathol 236(1):41-52. PubMed: 25500911MGI: J:220613
- Wan H; Dingle S; Xu Y; Besnard V; Kaestner KH; Ang SL; Wert S; Stahlman MT; Whitsett JA. 2005. Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis. J Biol Chem 280(14):13809-16. PubMed: 15668254MGI: J:98750
- Wan H; Kaestner KH; Ang SL; Ikegami M; Finkelman FD; Stahlman MT; Fulkerson PC; Rothenberg ME; Whitsett JA. 2004. Foxa2 regulates alveolarization and goblet cell hyperplasia. Development 131(4):953-64. PubMed: 14757645MGI: J:88601
- Wan H; Liu C; Wert SE; Xu W; Liao Y; Zheng Y; Whitsett JA. 2013. CDC42 is required for structural patterning of the lung during development. Dev Biol 374(1):46-57. PubMed: 23219958MGI: J:193093
- Wan H; Luo F; Wert SE; Zhang L; Xu Y; Ikegami M; Maeda Y; Bell SM; Whitsett JA. 2008. Kruppel-like factor 5 is required for perinatal lung morphogenesis and function. Development 135(15):2563-72. PubMed: 18599506MGI: J:138576
- Wan H; Xu Y; Ikegami M; Stahlman MT; Kaestner KH; Ang SL; Whitsett JA. 2004. Foxa2 is required for transition to air breathing at birth. Proc Natl Acad Sci U S A 101(40):14449-54. PubMed: 15452354MGI: J:93473
- Wang IC; Meliton L; Ren X; Zhang Y; Balli D; Snyder J; Whitsett JA; Kalinichenko VV; Kalin TV. 2009. Deletion of Forkhead Box M1 transcription factor from respiratory epithelial cells inhibits pulmonary tumorigenesis. PLoS One 4(8):e6609. PubMed: 19672312MGI: J:152467
- Wang IC; Snyder J; Zhang Y; Lander J; Nakafuku Y; Lin J; Chen G; Kalin TV; Whitsett JA; Kalinichenko VV. 2012. Foxm1 mediates cross talk between Kras/mitogen-activated protein kinase and canonical Wnt pathways during development of respiratory epithelium. Mol Cell Biol 32(19):3838-50. PubMed: 22826436MGI: J:188926
- Wang IC; Ustiyan V; Zhang Y; Cai Y; Kalin TV; Kalinichenko VV. 2014. Foxm1 transcription factor is required for the initiation of lung tumorigenesis by oncogenic Kras(G12D.). Oncogene 33(46):5391-6. PubMed: 24213573MGI: J:216273
- Wang K; Qin S; Liang Z; Zhang Y; Xu Y; Chen A; Guo X; Cheng H; Zhang X; Ke Y. 2016. Epithelial disruption of Gab1 perturbs surfactant homeostasis and predisposes mice to lung injuries. Am J Physiol Lung Cell Mol Physiol 311(6):L1149-L1159. PubMed: 27793798MGI: J:237422
- Wang QA; Tao C; Jiang L; Shao M; Ye R; Zhu Y; Gordillo R; Ali A; Lian Y; Holland WL; Gupta RK; Scherer PE. 2015. Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation. Nat Cell Biol 17(9):1099-111. PubMed: 26280538MGI: J:227352
- Wei W; Zeve D; Suh JM; Wang X; Du Y; Zerwekh JE; Dechow PC; Graff JM; Wan Y. 2011. Biphasic and Dosage-Dependent Regulation of Osteoclastogenesis by beta-Catenin. Mol Cell Biol 31(23):4706-19. PubMed: 21876000MGI: J:178340
- Wei W; Zeve D; Wang X; Du Y; Tang W; Dechow PC; Graff JM; Wan Y. 2011. Osteoclast progenitors reside in the peroxisome proliferator-activated receptor gamma-expressing bone marrow cell population. Mol Cell Biol 31(23):4692-705. PubMed: 21947280MGI: J:178880
- Weng Y; Fang C; Turesky RJ; Behr M; Kaminsky LS; Ding X. 2007. Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice. Cancer Res 67(16):7825-32. PubMed: 17699788MGI: J:124316
- Westphalen K; Gusarova GA; Islam MN; Subramanian M; Cohen TS; Prince AS; Bhattacharya J. 2014. Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity. Nature 506(7489):503-6. PubMed: 24463523MGI: J:206960
- Wheaton AK; Agarwal M; Jia S; Kim KK. 2017. Lung epithelial cell focal adhesion kinase signaling inhibits lung injury and fibrosis. Am J Physiol Lung Cell Mol Physiol 312(5):L722-L730. PubMed: 28283477MGI: J:241577
- Wikenheiser-Brokamp KA. 2004. Rb family proteins differentially regulate distinct cell lineages during epithelial development. Development 131(17):4299-310. PubMed: 15294860MGI: J:92049
- Wu B; Zhang Z; Lui W; Chen X; Wang Y; Chamberlain AA; Moreno-Rodriguez RA; Markwald RR; O'Rourke BP; Sharp DJ; Zheng D; Lenz J; Baldwin HS; Chang CP; Zhou B. 2012. Endocardial cells form the coronary arteries by angiogenesis through myocardial-endocardial VEGF signaling. Cell 151(5):1083-96. PubMed: 23178125MGI: J:193198
- Wuidart A; Ousset M; Rulands S; Simons BD; Van Keymeulen A; Blanpain C. 2016. Quantitative lineage tracing strategies to resolve multipotency in tissue-specific stem cells. Genes Dev 30(11):1261-77. PubMed: 27284162MGI: J:233310
- Xiao Y; Thoresen DT; Williams JS; Wang C; Perna J; Petrova R; Brownell I. 2015. Neural Hedgehog signaling maintains stem cell renewal in the sensory touch dome epithelium. Proc Natl Acad Sci U S A 112(23):7195-200. PubMed: 26015562MGI: J:223401
- Xu B; Chen C; Chen H; Zheng SG; Bringas P Jr; Xu M; Zhou X; Chen D; Umans L; Zwijsen A; Shi W. 2011. Smad1 and its target gene Wif1 coordinate BMP and Wnt signaling activities to regulate fetal lung development. Development 138(5):925-35. PubMed: 21270055MGI: J:169137
- Xu K; Nieuwenhuis E; Cohen BL; Wang W; Canty AJ; Danska JS; Coultas L; Rossant J; Wu MY; Piscione TD; Nagy A; Gossler A; Hicks GG; Hui CC; Henkelman RM; Yu LX; Sled JG; Gridley T; Egan SE. 2010. Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis. Am J Physiol Lung Cell Mol Physiol 298(1):L45-56. PubMed: 19897741MGI: J:155893
- Xu M; Horrell J; Snitow M; Cui J; Gochnauer H; Syrett CM; Kallish S; Seykora JT; Liu F; Gaillard D; Katz JP; Kaestner KH; Levin B; Mansfield C; Douglas JE; Cowart BJ; Tordoff M; Liu F; Zhu X; Barlow LA; Rubin AI; McGrath JA; Morrisey EE; Chu EY; Millar SE. 2017. WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation. Nat Commun 8:15397. PubMed: 28589954MGI: J:242196
- Xu W; Liu C; Kaartinen V; Chen H; Lu CH; Zhang W; Luo Y; Shi W. 2013. TACE in perinatal mouse lung epithelial cells promotes lung saccular formation. Am J Physiol Lung Cell Mol Physiol 305(12):L953-63. PubMed: 24142516MGI: J:210193
- Yamamoto H; Yun EJ; Gerber HP; Ferrara N; Whitsett JA; Vu TH. 2007. Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis. Dev Biol 308(1):44-53. PubMed: 17583691MGI: J:124125
- Yamamoto K; Ferrari JD; Cao Y; Ramirez MI; Jones MR; Quinton LJ; Mizgerd JP. 2012. Type I alveolar epithelial cells mount innate immune responses during pneumococcal pneumonia. J Immunol 189(5):2450-9. PubMed: 22844121MGI: J:189861
- Yanagi S; Kishimoto H; Kawahara K; Sasaki T; Sasaki M; Nishio M; Yajima N; Hamada K; Horie Y; Kubo H; Whitsett JA; Mak TW; Nakano T; Nakazato M; Suzuki A. 2007. Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice. J Clin Invest 117(10):2929-40. PubMed: 17909629MGI: J:127405
- Yang MY; Hilton MB; Seaman S; Haines DC; Nagashima K; Burks CM; Tessarollo L; Ivanova PT; Brown HA; Umstead TM; Floros J; Chroneos ZC; St Croix B. 2013. Essential Regulation of Lung Surfactant Homeostasis by the Orphan G Protein-Coupled Receptor GPR116. Cell Rep 3(5):1457-64. PubMed: 23684610MGI: J:196943
- Yang YP; Thorel F; Boyer DF; Herrera PL; Wright CV. 2011. Context-specific {alpha}-to-{beta}-cell reprogramming by forced Pdx1 expression. Genes Dev 25(16):1680-5. PubMed: 21852533MGI: J:174673
- Yang Z; Hai B; Qin L; Ti X; Shangguan L; Zhao Y; Wiggins L; Liu Y; Feng JQ; Chang JY; Wang F; Liu F. 2013. Cessation of epithelial Bmp signaling switches the differentiation of crown epithelia to the root lineage in a beta-catenin-dependent manner. Mol Cell Biol 33(23):4732-44. PubMed: 24081330MGI: J:206086
- Yee M; Buczynski BW; O'Reilly MA. 2014. Neonatal hyperoxia stimulates the expansion of alveolar epithelial type II cells. Am J Respir Cell Mol Biol 50(4):757-66. PubMed: 24188066MGI: J:232090
- Yin Y; Betsuyaku T; Garbow JR; Miao J; Govindan R; Ornitz DM. 2013. Rapid induction of lung adenocarcinoma by fibroblast growth factor 9 signaling through FGF receptor 3. Cancer Res 73(18):5730-41. PubMed: 23867472MGI: J:204282
- Yu L; Moriguchi T; Souma T; Takai J; Satoh H; Morito N; Engel JD; Yamamoto M. 2014. GATA2 regulates body water homeostasis through maintaining aquaporin 2 expression in renal collecting ducts. Mol Cell Biol 34(11):1929-41. PubMed: 24636993MGI: J:215365
- Yu TS; Dandekar M; Monteggia LM; Parada LF; Kernie SG. 2005. Temporally regulated expression of Cre recombinase in neural stem cells. Genesis 41(4):147-53. PubMed: 15789426MGI: J:97312
- Yun EJ; Lorizio W; Seedorf G; Abman SH; Vu TH. 2016. VEGF and endothelium-derived retinoic acid regulate lung vascular and alveolar development. Am J Physiol Lung Cell Mol Physiol 310(4):L287-98. PubMed: 26566904MGI: J:233191
- Zeve D; Seo J; Suh JM; Stenesen D; Tang W; Berglund ED; Wan Y; Williams LJ; Lim A; Martinez MJ; McKay RM; Millay DP; Olson EN; Graff JM. 2012. Wnt signaling activation in adipose progenitors promotes insulin-independent muscle glucose uptake. Cell Metab 15(4):492-504. PubMed: 22482731MGI: J:184458
- Zhang S; Loch AJ; Radtke F; Egan SE; Xu K. 2013. Jagged1 is the major regulator of Notch-dependent cell fate in proximal airways. Dev Dyn 242(6):678-86. PubMed: 23526493MGI: J:198224
- Zhang W; Menke DB; Jiang M; Chen H; Warburton D; Turcatel G; Lu CH; Xu W; Luo Y; Shi W. 2013. Spatial-temporal targeting of lung-specific mesenchyme by a Tbx4 enhancer. BMC Biol 11:111. PubMed: 24225400MGI: J:225177
- Zhang X; Zhang Y; Tao B; Teng L; Li Y; Cao R; Gui Q; Ye M; Mou X; Cheng H; Hu H; Zhou R; Wu X; Xie Q; Ning W; Lai M; Shen H; Feng GS; Ke Y. 2012. Loss of Shp2 in alveoli epithelia induces deregulated surfactant homeostasis, resulting in spontaneous pulmonary fibrosis. FASEB J 26(6):2338-50. PubMed: 22362894MGI: J:187436
- Zhang Y; Andl T; Yang SH; Teta M; Liu F; Seykora JT; Tobias JW; Piccolo S; Schmidt-Ullrich R; Nagy A; Taketo MM; Dlugosz AA; Millar SE. 2008. Activation of {beta}-catenin signaling programs embryonic epidermis to hair follicle fate. Development 135(12):2161-72. PubMed: 18480165MGI: J:136961
- Zhang Y; Call MK; Yeh LK; Liu H; Kochel T; Wang IJ; Chu PH; Taketo MM; Jester JV; Kao WW; Liu CY. 2010. Aberrant expression of a beta-catenin gain-of-function mutant induces hyperplastic transformation in the mouse cornea. J Cell Sci 123(Pt 8):1285-94. PubMed: 20332116MGI: J:159631
- Zhang Y; Goss AM; Cohen ED; Kadzik R; Lepore JJ; Muthukumaraswamy K; Yang J; DeMayo FJ; Whitsett JA; Parmacek MS; Morrisey EE. 2008. A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration. Nat Genet 40(7):862-70. PubMed: 18536717MGI: J:138407
- Zhang Y; Lam O; Nguyen MT; Ng G; Pear WS; Ai W; Wang IJ; Kao WW; Liu CY. 2013. Mastermind-like transcriptional co-activator-mediated Notch signaling is indispensable for maintaining conjunctival epithelial identity. Development 140(3):594-605. PubMed: 23293291MGI: J:194073
- Zhang Y; Yeh LK; Zhang S; Call M; Yuan Y; Yasunaga M; Kao WW; Liu CY. 2015. Wnt/beta-catenin signaling modulates corneal epithelium stratification via inhibition of Bmp4 during mouse development. Development 142(19):3383-93. PubMed: 26443636MGI: J:225349
- Zhao H; Feng J; Seidel K; Shi S; Klein O; Sharpe P; Chai Y. 2014. Secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor. Cell Stem Cell 14(2):160-73. PubMed: 24506883MGI: J:210170
- Zhao R; Fallon TR; Saladi SV; Pardo-Saganta A; Villoria J; Mou H; Vinarsky V; Gonzalez-Celeiro M; Nunna N; Hariri LP; Camargo F; Ellisen LW; Rajagopal J. 2014. Yap tunes airway epithelial size and architecture by regulating the identity, maintenance, and self-renewal of stem cells. Dev Cell 30(2):151-65. PubMed: 25043474MGI: J:213949
- Zhou H; Liu Y; He F; Mo L; Sun TT; Wu XR. 2010. Temporally and spatially controllable gene expression and knockout in mouse urothelium. Am J Physiol Renal Physiol 299(2):F387-95. PubMed: 20427471MGI: J:162511
- Zhou J; Qu Z; Yan S; Sun F; Whitsett JA; Shapiro SD; Xiao G. 2015. Differential roles of STAT3 in the initiation and growth of lung cancer. Oncogene 34(29):3804-14. PubMed: 25284582MGI: J:224261
- Zhu Y; Pires KM; Whitehead KJ; Olsen CD; Wayment B; Zhang YC; Bugger H; Ilkun O; Litwin SE; Thomas G; Kozma SC; Abel ED. 2013. Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth. PLoS One 8(1):e54221. PubMed: 23342106MGI: J:195854
- Zhu Y; Soto J; Anderson B; Riehle C; Zhang YC; Wende AR; Jones D; McClain DA; Abel ED. 2013. Regulation of fatty acid metabolism by mTOR in adult murine hearts occurs independently of changes in PGC-1alpha. Am J Physiol Heart Circ Physiol 305(1):H41-51. PubMed: 23624629MGI: J:198951