JAX
Mouse Strain Datasheet - 006234
B6.Cg-Tg(tetO-cre)1Jaw/J
Also Known As: (tetO)7-Cre
These transgenic mice express Cre recombinase under the control of a tetracycline-responsive promoter element (TRE or tetO) and are an effective tool for generating inducible, tissue-specific, targeted mutants to study cell lineage during development. When bred with another transgenic mouse expressing reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA), Cre mediated recombination in the resulting bitransgenic offspring can be regulated with the tetracycline analog, doxycycline.
Donating Investigator
IMR Colony, The Jackson Laboratory
Genetic overview
| Genetic Background | Generation |
|---|---|
|
N11F5
(20-MAR-17) |
Tg(tetO-cre)1Jaw
| Allele Type |
|---|
| Transgenic (Inducible, Recombinase-expressing) |
Base Price
Starting at:
| $246.50 Domestic price for female |
| $320.50 Domestic price for breeder pair |
Detailed Description
Hemizygous transgenic mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. These transgenic mice express Cre recombinase under the control of a tetracycline-responsive promoter element (TRE; tetO). When hemizygotes are bred with another transgenic mouse expressing either reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA) under the control of tissue-specific promoters, Cre recombinase expression and Cre-mediated recombination in the appropriate tissues of the bitransgenic offspring can be regulated with the tetracycline analog, doxycycline. This strain represents an effective tool for generating inducible tissue specific-targeted mutants to study cell lineage during development.
In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
Development
A transgenic construct containing the cre recombinase gene under the control of the tetracycline-responsive promoter element (TRE or tetO), minimal CMV promoter and MT-1 polyadenylation site sequence was injected into mixed C57BL/6 and 129 background embryos. Founder mice were bred to FVB/N animals. Upon arrival at The Jackson Laboratory, these mice were backcrossed to C57BL/6J mice for at least 5 generations.
Expression Data
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
|---|---|
| Site of Expression | widespread, inducible expression of Cre recombinase |
Control Suggestions
Selected References
- Perl AK; Wert SE; Nagy A; Lobe CG; Whitsett JA. 2002. Early restriction of peripheral and proximal cell lineages during formation of the lung. Proc Natl Acad Sci U S A 99(16):10482-7. PubMed: 12145322MGI: J:78365
Tg(tetO-cre)1Jaw
Allele Symbol: Tg(tetO-cre)1Jaw
| Allele Name | transgene insertion 1, Jeffrey A Whitsett |
|---|---|
| Allele Type | Transgenic (Inducible, Recombinase-expressing) |
| Allele Synonym(s) | (tetO)7-CMV-Cre; (tetO)7-CMV-Cretg; (tetO)7-Cre; (tetO)7CMV-Cretg; (tetO)7CMVtg; TRECre; TetOCre; tetO-cre |
| Gene Symbol and Name | Tg(tetO-cre)1Jaw, transgene insertion 1, Jeffrey A Whitsett |
| Gene Synonym(s) | (tetO)7-CMV-Cre; (tetO)7-CMV-Cretg; (tetO)7-Cre; (tetO)7CMV-Cretg; (tetO)7CMVtg; TRECre; tetO-cre |
| Promoter | tetO, tet operator, |
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
| Site of Expression | widespread, inducible expression of Cre recombinase |
| Strain of Origin | 129 and C57BL/6 |
| Chromosome | UN |
| Molecular Note | The transgene is composed of 7 tetO sites, a minimal CMV promoter, and sequence encoding cre recombinase. |
| Mutations Made By | Dr. Andras Nagy, Mount Sinai Hospital |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Research Tools
- Cre-lox System
- Cre Recombinase Expression
- Cre Recombinase Expression: Inducible
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Tetop Tet System
- Tet Expression Systems
- tTA/rtTA Responsive Strains
- Cre-lox System
Genotype: cre related
- Research Tools
- Cre-lox System
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
Mammalian Phenotype Terms by Genotype
The following phenotype relates to a compound genotype created using this strain
Genotype: Tg(Scgb1a1-rtTA)2Jaw/0 Tg(tetO-cre)1Jaw/0
involves: 129 * C57BL/6 * FVB/N
mortality/aging
- mortality/aging
- doxycycline-treated mice do not exhibit perinatal toxicity (MGI Ref ID J:179352)
respiratory system phenotype
- respiratory system phenotype
- doxycycline-treated mice do not exhibit lung pathology or dysfunction (MGI Ref ID J:179352)
- doxycycline-treated mice exhibit minimal focal airspace enlargement unlike Tg(Scgb1a1-rtTA)1Jaw mice (MGI Ref ID J:179352)
References
- Perl AK; Wert SE; Nagy A; Lobe CG; Whitsett JA. 2002. Early restriction of peripheral and proximal cell lineages during formation of the lung. Proc Natl Acad Sci U S A 99(16):10482-7. PubMed: 12145322MGI: J:78365
Additional - Tg(tetO-cre)1Jaw related
- Al-Hasani K; Pfeifer A; Courtney M; Ben-Othman N; Gjernes E; Vieira A; Druelle N; Avolio F; Ravassard P; Leuckx G; Lacas-Gervais S; Ambrosetti D; Benizri E; Hecksher-Sorensen J; Gounon P; Ferrer J; Gradwohl G; Heimberg H; Mansouri A; Collombat P. 2013. Adult Duct-Lining Cells Can Reprogram into beta-like Cells Able to Counter Repeated Cycles of Toxin-Induced Diabetes. Dev Cell 26(1):86-100. PubMed: 23810513MGI: J:198630
- Antony N; Weir JR; McDougall AR; Mantamadiotis T; Meikle PJ; Cole TJ; Bird AD. 2013. cAMP response element binding protein1 is essential for activation of steroyl co-enzyme a desaturase 1 (Scd1) in mouse lung type II epithelial cells. PLoS One 8(4):e59763. PubMed: 23637738MGI: J:200565
- Araujo L; Khim P; Mkhikian H; Mortales CL; Demetriou M. 2017. Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation. Elife 6:. PubMed: 28059703MGI: J:240169
- Autry AE; Adachi M; Cheng P; Monteggia LM. 2009. Gender-specific impact of brain-derived neurotrophic factor signaling on stress-induced depression-like behavior. Biol Psychiatry 66(1):84-90. PubMed: 19358977MGI: J:157287
- Balli D; Ustiyan V; Zhang Y; Wang IC; Masino AJ; Ren X; Whitsett JA; Kalinichenko VV; Kalin TV. 2013. Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition. EMBO J 32(2):231-44. PubMed: 23288041MGI: J:193263
- Basseres DS; Levantini E; Ji H; Monti S; Elf S; Dayaram T; Fenyus M; Kocher O; Golub T; Wong KK; Halmos B; Tenen DG. 2006. Respiratory failure due to differentiation arrest and expansion of alveolar cells following lung-specific loss of the transcription factor C/EBPalpha in mice. Mol Cell Biol 26(3):1109-23. PubMed: 16428462MGI: J:105593
- Berdnikovs S; Abdala-Valencia H; Cook-Mills JM. 2013. Endothelial cell PTP1B regulates leukocyte recruitment during allergic inflammation. Am J Physiol Lung Cell Mol Physiol 304(4):L240-9. PubMed: 23275627MGI: J:194934
- Besnard V; Wert SE; Stahlman MT; Postle AD; Xu Y; Ikegami M; Whitsett JA. 2009. Deletion of Scap in alveolar type II cells influences lung lipid homeostasis and identifies a compensatory role for pulmonary lipofibroblasts. J Biol Chem 284(6):4018-30. PubMed: 19074148MGI: J:147592
- Bird AD; Choo YL; Hooper SB; McDougall AR; Cole TJ. 2014. Mesenchymal glucocorticoid receptor regulates the development of multiple cell layers of the mouse lung. Am J Respir Cell Mol Biol 50(2):419-28. PubMed: 24053134MGI: J:231865
- Bonnavion R; Teinturier R; Jaafar R; Ripoche D; Leteurtre E; Chen YJ; Rehfeld JF; Lepinasse F; Hervieu V; Pattou F; Vantyghem MC; Scoazec JY; Bertolino P; Zhang CX. 2015. Islet Cells Serve as Cells of Origin of Pancreatic Gastrin-Positive Endocrine Tumors. Mol Cell Biol 35(19):3274-83. PubMed: 26169832MGI: J:228228
- Brechbuhl HM; Ghosh M; Smith MK; Smith RW; Li B; Hicks DA; Cole BB; Reynolds PR; Reynolds SD. 2011. beta-Catenin Dosage Is a Critical Determinant of Tracheal Basal Cell Fate Determination. Am J Pathol 179(1):367-79. PubMed: 21703416MGI: J:173999
- Bridges JP; Schehr A; Wang Y; Huo L; Besnard V; Ikegami M; Whitsett JA; Xu Y. 2014. Epithelial SCAP/INSIG/SREBP signaling regulates multiple biological processes during perinatal lung maturation. PLoS One 9(5):e91376. PubMed: 24806461MGI: J:216084
- Broide DH; Lawrence T; Doherty T; Cho JY; Miller M; McElwain K; McElwain S; Karin M. 2005. Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium. Proc Natl Acad Sci U S A 102(49):17723-8. PubMed: 16317067MGI: J:104395
- Chakkalakal SA; Uchibe K; Convente MR; Zhang D; Economides AN; Kaplan FS; Pacifici M; Iwamoto M; Shore EM. 2016. Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation. J Bone Miner Res 31(9):1666-75. PubMed: 26896819MGI: J:239136
- Chapman HA; Li X; Alexander JP; Brumwell A; Lorizio W; Tan K; Sonnenberg A; Wei Y; Vu TH. 2011. Integrin alpha6beta4 identifies an adult distal lung epithelial population with regenerative potential in mice. J Clin Invest 121(7):2855-62. PubMed: 21701069MGI: J:175915
- Chen C; Kudo M; Rutaganira F; Takano H; Lee C; Atakilit A; Robinett KS; Uede T; Wolters PJ; Shokat KM; Huang X; Sheppard D. 2012. Integrin alpha9beta1 in airway smooth muscle suppresses exaggerated airway narrowing. J Clin Invest 122(8):2916-27. PubMed: 22772469MGI: J:190074
- Chen G; Korfhagen TR; Xu Y; Kitzmiller J; Wert SE; Maeda Y; Gregorieff A; Clevers H; Whitsett JA. 2009. SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. J Clin Invest 119(10):2914-24. PubMed: 19759516MGI: J:154639
- Chen G; Wan H; Luo F; Zhang L; Xu Y; Lewkowich I; Wills-Karp M; Whitsett JA. 2010. Foxa2 programs Th2 cell-mediated innate immunity in the developing lung. J Immunol 184(11):6133-41. PubMed: 20483781MGI: J:161217
- Chen H; Zhuang F; Liu YH; Xu B; Del Moral P; Deng W; Chai Y; Kolb M; Gauldie J; Warburton D; Moses HL; Shi W. 2008. TGF-beta receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung. Eur Respir J 32(2):285-95. PubMed: 18321928MGI: J:137996
- Chen J; Tu X; Esen E; Joeng KS; Lin C; Arbeit JM; Ruegg MA; Hall MN; Ma L; Long F. 2014. WNT7B promotes bone formation in part through mTORC1. PLoS Genet 10(1):e1004145. PubMed: 24497849MGI: J:208766
- Chen L; Meng Q; Kao W; Xia Y. 2011. IkappaB kinase beta regulates epithelium migration during corneal wound healing. PLoS One 6(1):e16132. PubMed: 21264230MGI: J:180829
- Chignalia AZ; Vogel SM; Reynolds AB; Mehta D; Dull RO; Minshall RD; Malik AB; Liu Y. 2015. p120-Catenin Expressed in Alveolar Type II Cells Is Essential for the Regulation of Lung Innate Immune Response. Am J Pathol 185(5):1251-63. PubMed: 25773174MGI: J:220680
- Cho HC; Lai CY; Shao LE; Yu J. 2011. Identification of Tumorigenic Cells in KrasG12D-Induced Lung Adenocarcinoma. Cancer Res 71(23):7250-8. PubMed: 22088965MGI: J:178608
- Choi YS; Zhang Y; Xu M; Yang Y; Ito M; Peng T; Cui Z; Nagy A; Hadjantonakis AK; Lang RA; Cotsarelis G; Andl T; Morrisey EE; Millar SE. 2013. Distinct Functions for Wnt/beta-Catenin in Hair Follicle Stem Cell Proliferation and Survival and Interfollicular Epidermal Homeostasis. Cell Stem Cell 13(6):720-33. PubMed: 24315444MGI: J:204142
- Coulson-Thomas VJ; Chang SH; Yeh LK; Coulson-Thomas YM; Yamaguchi Y; Esko J; Liu CY; Kao W. 2015. Loss of corneal epithelial heparan sulfate leads to corneal degeneration and impaired wound healing. Invest Ophthalmol Vis Sci 56(5):3004-14. PubMed: 26024086MGI: J:230966
- Coulson-Thomas VJ; Gesteira TF; Esko J; Kao W. 2014. Heparan sulfate regulates hair follicle and sebaceous gland morphogenesis and homeostasis. J Biol Chem 289(36):25211-26. PubMed: 25053416MGI: J:216871
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- Dahia CL; Mahoney E; Wylie C. 2012. Shh signaling from the nucleus pulposus is required for the postnatal growth and differentiation of the mouse intervertebral disc. PLoS One 7(4):e35944. PubMed: 22558278MGI: J:231130
- Dave V; Childs T; Xu Y; Ikegami M; Besnard V; Maeda Y; Wert SE; Neilson JR; Crabtree GR; Whitsett JA. 2006. Calcineurin/Nfat signaling is required for perinatal lung maturation and function. J Clin Invest 116(10):2597-609. PubMed: 16998587MGI: J:114501
- Dave V; Wert SE; Tanner T; Thitoff AR; Loudy DE; Whitsett JA. 2008. Conditional deletion of Pten causes bronchiolar hyperplasia. Am J Respir Cell Mol Biol 38(3):337-45. PubMed: 17921358MGI: J:146355
- Denney L; Byrne AJ; Shea TJ; Buckley JS; Pease JE; Herledan GM; Walker SA; Gregory LG; Lloyd CM. 2015. Pulmonary Epithelial Cell-Derived Cytokine TGF-beta1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function. Immunity 43(5):945-58. PubMed: 26588780MGI: J:234576
- Ding BS; Nolan DJ; Guo P; Babazadeh AO; Cao Z; Rosenwaks Z; Crystal RG; Simons M; Sato TN; Worgall S; Shido K; Rabbany SY; Rafii S. 2011. Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization. Cell 147(3):539-53. PubMed: 22036563MGI: J:178690
- Eckle T; Brodsky K; Bonney M; Packard T; Han J; Borchers CH; Mariani TJ; Kominsky DJ; Mittelbronn M; Eltzschig HK. 2013. HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium. PLoS Biol 11(9):e1001665. PubMed: 24086109MGI: J:201805
- Eckle T; Kewley EM; Brodsky KS; Tak E; Bonney S; Gobel M; Anderson D; Glover LE; Riegel AK; Colgan SP; Eltzschig HK. 2014. Identification of hypoxia-inducible factor HIF-1A as transcriptional regulator of the A2B adenosine receptor during acute lung injury. J Immunol 192(3):1249-56. PubMed: 24391213MGI: J:207297
- Ehrman LA; Mu X; Waclaw RR; Yoshida Y; Vorhees CV; Klein WH; Campbell K. 2013. The LIM homeobox gene Isl1 is required for the correct development of the striatonigral pathway in the mouse. Proc Natl Acad Sci U S A 110(42):E4026-35. PubMed: 24082127MGI: J:201994
- El-Hashash AH; Al Alam D; Turcatel G; Bellusci S; Warburton D. 2011. Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol 350(1):112-26. PubMed: 21129374MGI: J:170236
- El-Hashash AH; Turcatel G; Al Alam D; Buckley S; Tokumitsu H; Bellusci S; Warburton D. 2011. Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium. Development 138(7):1395-407. PubMed: 21385765MGI: J:171504
- Ermilov AN; Kumari A; Li L; Joiner AM; Grachtchouk MA; Allen BL; Dlugosz AA; Mistretta CM. 2016. Maintenance of Taste Organs Is Strictly Dependent on Epithelial Hedgehog/GLI Signaling. PLoS Genet 12(11):e1006442. PubMed: 27893742MGI: J:237412
- Fong CH; Bebien M; Didierlaurent A; Nebauer R; Hussell T; Broide D; Karin M; Lawrence T. 2008. An antiinflammatory role for IKKbeta through the inhibition of 'classical' macrophage activation. J Exp Med 205(6):1269-76. PubMed: 18490491MGI: J:137075
- Frank DU; Elliott SA; Park EJ; Hammond J; Saijoh Y; Moon AM. 2007. System for inducible expression of cre-recombinase from the Foxa2 locus in endoderm, notochord, and floor plate. Dev Dyn 236(4):1085-1092. PubMed: 17304540MGI: J:119721
- Glaros S; Cirrincione GM; Palanca A; Metzger D; Reisman D. 2008. Targeted knockout of BRG1 potentiates lung cancer development. Cancer Res 68(10):3689-96. PubMed: 18483251MGI: J:135031
- Goncharova EA; Goncharov DA; James ML; Atochina-Vasserman EN; Stepanova V; Hong SB; Li H; Gonzales L; Baba M; Linehan WM; Gow AJ; Margulies S; Guttentag S; Schmidt LS; Krymskaya VP. 2014. Folliculin controls lung alveolar enlargement and epithelial cell survival through E-cadherin, LKB1, and AMPK. Cell Rep 7(2):412-23. PubMed: 24726356MGI: J:211817
- Goto J; Talos DM; Klein P; Qin W; Chekaluk YI; Anderl S; Malinowska IA; Di Nardo A; Bronson RT; Chan JA; Vinters HV; Kernie SG; Jensen FE; Sahin M; Kwiatkowski DJ. 2011. Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex. Proc Natl Acad Sci U S A 108(45):E1070-9. PubMed: 22025691MGI: J:180260
- Greenwood KK; Proper SP; Saini Y; Bramble LA; Jackson-Humbles DN; Wagner JG; Harkema JR; LaPres JJ. 2012. Neonatal epithelial hypoxia inducible factor-1alpha expression regulates the response of the lung to experimental asthma. Am J Physiol Lung Cell Mol Physiol 302(5):L455-62. PubMed: 22180657MGI: J:183445
- Hahn DR; Na CL; Weaver TE. 2014. Reserve autophagic capacity in alveolar epithelia provides a replicative niche for influenza A virus. Am J Respir Cell Mol Biol 51(3):400-12. PubMed: 24661119MGI: J:232239
- Haney SL; Upchurch GM; Opavska J; Klinkebiel D; Hlady RA; Roy S; Dutta S; Datta K; Opavsky R. 2016. Dnmt3a Is a Haploinsufficient Tumor Suppressor in CD8+ Peripheral T Cell Lymphoma. PLoS Genet 12(9):e1006334. PubMed: 27690235MGI: J:235643
- Haney SL; Upchurch GM; Opavska J; Klinkebiel D; Hlady RA; Suresh A; Pirruccello SJ; Shukla V; Lu R; Costinean S; Rizzino A; Karpf AR; Joshi S; Swanson P; Opavsky R. 2016. Promoter Hypomethylation and Expression Is Conserved in Mouse Chronic Lymphocytic Leukemia Induced by Decreased or Inactivated Dnmt3a. Cell Rep 15(6):1190-201. PubMed: 27134162MGI: J:235483
- Hashimoto T; Bergen SE; Nguyen QL; Xu B; Monteggia LM; Pierri JN; Sun Z; Sampson AR; Lewis DA. 2005. Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia. J Neurosci 25(2):372-83. PubMed: 15647480MGI: J:97675
- Heinonen KM; Vanegas JR; Brochu S; Shan J; Vainio SJ; Perreault C. 2011. Wnt4 regulates thymic cellularity through the expansion of thymic epithelial cells and early thymic progenitors. Blood 118(19):5163-73. PubMed: 21937690MGI: J:178890
- Herjan T; Yao P; Qian W; Li X; Liu C; Bulek K; Sun D; Yang WP; Zhu J; He A; Carman JA; Erzurum SC; Lipshitz HD; Fox PL; Hamilton TA; Li X. 2013. HuR is required for IL-17-induced Act1-mediated CXCL1 and CXCL5 mRNA stabilization. J Immunol 191(2):640-9. PubMed: 23772036MGI: J:204952
- Hill JJ; Kolluri N; Hashimoto T; Wu Q; Sampson AR; Monteggia LM; Lewis DA. 2005. Analysis of pyramidal neuron morphology in an inducible knockout of brain-derived neurotrophic factor. Biol Psychiatry 57(8):932-4. PubMed: 15820715MGI: J:102119
- Hlady RA; Novakova S; Opavska J; Klinkebiel D; Peters SL; Bies J; Hannah J; Iqbal J; Anderson KM; Siebler HM; Smith LM; Greiner TC; Bastola D; Joshi S; Lockridge O; Simpson MA; Felsher DW; Wagner KU; Chan WC; Christman JK; Opavsky R. 2012. Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis. J Clin Invest 122(1):163-77. PubMed: 22133874MGI: J:184415
- Hokuto I; Ikegami M; Yoshida M; Takeda K; Akira S; Perl AK; Hull WM; Wert SE; Whitsett JA. 2004. Stat-3 is required for pulmonary homeostasis during hyperoxia. J Clin Invest 113(1):28-37. PubMed: 14702106MGI: J:87622
- Hoshino T; Kato S; Oka N; Imaoka H; Kinoshita T; Takei S; Kitasato Y; Kawayama T; Imaizumi T; Yamada K; Young HA; Aizawa H. 2007. Pulmonary inflammation and emphysema: role of the cytokines IL-18 and IL-13. Am J Respir Crit Care Med 176(1):49-62. PubMed: 17400729MGI: J:147547
- Hsu W; Mirando AJ; Yu HM. 2009. Manipulating gene activity in Wnt1-expressing precursors of neural epithelial and neural crest cells. Dev Dyn 239(1):338-345. PubMed: 19653308MGI: J:155252
- Ihara S; Kida H; Arase H; Tripathi LP; Chen YA; Kimura T; Yoshida M; Kashiwa Y; Hirata H; Fukamizu R; Inoue R; Hasegawa K; Goya S; Takahashi R; Minami T; Tsujino K; Suzuki M; Kohmo S; Inoue K; Nagatomo I; Takeda Y; Kijima T; Mizuguchi K; Tachibana I; Kumanogoh A. 2012. Inhibitory roles of signal transducer and activator of transcription 3 in antitumor immunity during carcinogen-induced lung tumorigenesis. Cancer Res 72(12):2990-9. PubMed: 22659452MGI: J:189293
- Ikegami M; Falcone A; Whitsett JA. 2008. STAT-3 regulates surfactant phospholipid homeostasis in normal lung and during endotoxin-mediated lung injury. J Appl Physiol 104(6):1753-60. PubMed: 18369093MGI: J:183960
- Inoshima I; Inoshima N; Wilke GA; Powers ME; Frank KM; Wang Y; Bubeck Wardenburg J. 2011. A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice. Nat Med 17(10):1310-4. PubMed: 21926978MGI: J:177286
- Inoue D; Kubo H; Taguchi K; Suzuki T; Komatsu M; Motohashi H; Yamamoto M. 2011. Inducible disruption of autophagy in the lung causes airway hyper-responsiveness. Biochem Biophys Res Commun 405(1):13-8. PubMed: 21185264MGI: J:168468
- Joiner AM; Green WW; McIntyre JC; Allen BL; Schwob JE; Martens JR. 2015. Primary Cilia on Horizontal Basal Cells Regulate Regeneration of the Olfactory Epithelium. J Neurosci 35(40):13761-72. PubMed: 26446227MGI: J:226461
- Kaasik K; Kivimae S; Allen JJ; Chalkley RJ; Huang Y; Baer K; Kissel H; Burlingame AL; Shokat KM; Ptacek LJ; Fu YH. 2013. Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock. Cell Metab 17(2):291-302. PubMed: 23395175MGI: J:198048
- Kalin TV; Wang IC; Meliton L; Zhang Y; Wert SE; Ren X; Snyder J; Bell SM; Graf L Jr; Whitsett JA; Kalinichenko VV. 2008. Forkhead Box m1 transcription factor is required for perinatal lung function. Proc Natl Acad Sci U S A 105(49):19330-5. PubMed: 19033457MGI: J:142246
- Katsumoto TR; Kudo M; Chen C; Sundaram A; Callahan EC; Zhu JW; Lin J; Rosen CE; Manz BN; Lee JW; Matthay MA; Huang X; Sheppard D; Weiss A. 2013. The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases. J Clin Invest 123(5):2037-48. PubMed: 23543053MGI: J:201353
- Kawakami-Schulz SV; Verdoni AM; Sattler SG; Jessen E; Kao WW; Ikeda A; Ikeda S. 2014. Serum response factor: positive and negative regulation of an epithelial gene expression network in the destrin mutant cornea. Physiol Genomics 46(8):277-89. PubMed: 24550211MGI: J:208758
- Kida H; Mucenski ML; Thitoff AR; Le Cras TD; Park KS; Ikegami M; Muller W; Whitsett JA. 2008. GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium. Am J Pathol 172(6):1542-54. PubMed: 18467707MGI: J:136187
- Kim KK; Wei Y; Szekeres C; Kugler MC; Wolters PJ; Hill ML; Frank JA; Brumwell AN; Wheeler SE; Kreidberg JA; Chapman HA. 2009. Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest 119(1):213-24. PubMed: 19104148MGI: J:144703
- Kimura T; Kawabe H; Jiang C; Zhang W; Xiang YY; Lu C; Salter MW; Brose N; Lu WY; Rotin D. 2011. Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease. Proc Natl Acad Sci U S A 108(8):3216-21. PubMed: 21300902MGI: J:169296
- Kitamura T; Qian BZ; Soong D; Cassetta L; Noy R; Sugano G; Kato Y; Li J; Pollard JW. 2015. CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages. J Exp Med 212(7):1043-59. PubMed: 26056232MGI: J:226363
- Kobayashi T; Owczarek TB; McKiernan JM; Abate-Shen C. 2015. Modelling bladder cancer in mice: opportunities and challenges. Nat Rev Cancer 15(1):42-54. PubMed: 25533675MGI: J:219292
- Kuperman DA; Huang X; Nguyenvu L; Holscher C; Brombacher F; Erle DJ. 2005. IL-4 receptor signaling in Clara cells is required for allergen-induced mucus production. J Immunol 175(6):3746-52. PubMed: 16148120MGI: J:116729
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