Chromosome X.3 from PWD/Ph has replaced the homologous chromosome of C57BL/6J in this strain of the set of consomic strains with C57BL/6J as background.Read More +
This strain represents one of a panel of inter-species chromosome substitution (or consomic) strains (IC-ISS). Each strain carries a chromosome from the Mus musculus musculus wild-derived strain PWD/Ph introgressed into a Mus musculus domesticus C57BL/6J background. The two species are believed to have diverged 350,000 to one million years ago and exhibit multiple genetic and phenotypic differences. The strain set also includes a conplastic strain (mtPWD/Ph) created by sequential backcrossing of the donor female to the host male. A conplastic strain carries the mitochondrial genome of the donor strain. The IC-ISS strains represent a tool for dissection of quantitative trait loci.
Dr. Jiri Forejt from The Institute of Molecular Genetics, Prague, Czech Republic developed the C57BL/6J-Chr #PWD/Ph/ForeJ strain set by replacing the individual chromosomes from the PWD/Ph donor strain into the C57BL/6J host strain using a marker-assisted series of backcrosses. The Chromosome X consomic is a partial consomic. Chr X.3PWD/Ph indicates that the distal (d) portion of Chromosome X is from the PWD/Ph donor strain. The set was donated to The Jackson Laboratory in 2005.
Currently there are no related genes or alleles for this strain.