This one of four strains derived from CD-1 mice to study the possible role of relative estrogen responsiveness in experimental Candida vaginitis infection. This strain, as well the others, is less responsive to estradiol than C57BL/6 mice.
Dr. Jimmy Spearow, University of California - Davis
This strain may be homozygous for Gnat2cpfl3, cone photoreceptor function loss 3, which affects bright light (photopic) vision.
Swiss derived CD-1 mice are less responsive to exogenous estradiol than most inbred strains as measured by resistance to decreases in testes weight, spermatogenesis, and spermatid development. Derived from CD-1, the inbred strains CD3/JlsJ, CD7/JlsJ, and CD9/JlsJ mice exhibit a moderate sensitivity to endocrine disruption by estradiol, while CD10/JlsJ mice are highly resistant to endocrine disruption by estradiol. All lines generated in the selection program are significantly less responsive to estradiol than C57BL/6 mice.
The selectively bred strains CD3/JlsJ (Stock No. 006177), CD7/JlsJ (Stock No. 006178), CD9/JlsJ (Stock No. 006179) and CD10/JlsJ (Stock No. 006180) may serve as tools for mapping and characterizing genes responsible for estradiol sensitivity.
SNP data is available for this strain on the Wellcome Trust Centre for Human Genetics site.
This inbred strain was generated at the University of California-Davis as part of a selection program for hyposensitivity or hypersensitivity to exogenous 17-beta-estradiol (E2). All lines were derived from CD-1 mice. This strain reached the 34th generation of inbreeding in 2006. The Jackson Laboratory Repository imported four of these strains in 2006.
|Allele Name||cone photoreceptor function loss 3|
|Allele Synonym(s)||no cones|
|Gene Symbol and Name||Gnat2, guanine nucleotide binding protein, alpha transducing 2|
|Strain of Origin||various|
|General Note||This allele has been detected in the following strains either by genotyping or complementation testing: ALS/LtJ, SENCARA/PtJ, SENCARB/PtJ, SENCARC/PtJ, PN/nBSwUmabJ. (J:122428) The allele has also been reported in NMRI and CD1 (Lluis Montoliu, J:212307)|
|Molecular Note||A single nucleotide substitution of G to A at coding nucleotide 598 in exon 6. This mutation converts codon 200 from aspartic acid to asparagine (p.D200N).|