Swiss derived CD-1 mice are less responsive to exogenous estradiol than most inbred strains as measured by resistance to decreases in testes weight, spermatogenesis, and spermatid development. Derived from CD-1, the inbred strains CD3/JlsJ, CD7/JlsJ, and CD9/JlsJ mice exhibit a moderate sensitivity to endocrine disruption by estradiol, while CD10/JlsJ mice are highly resistant to endocrine disruption by estradiol. All lines generated in the selection program are significantly less responsive to estradiol than C57BL/6 mice.<br>The selectively bred strains CD3/JlsJ (006177), CD7/JlsJ (<a href="https://www.jax.org/strain/006178">006178</a>), CD9/JlsJ (<a href="https://www.jax.org/strain/006179">006179</a>) and CD10/JlsJ (<a href="https://www.jax.org/strain/006180">006180</a>) may serve as tools for mapping and characterizing genes responsible for estradiol sensitivity.<p>
SNP data is available for this strain on the  <a href=" http://www.well.ox.ac.uk/mouse/INBREDS/"> Wellcome Trust Centre for Human Genetics</a> site.




This one of four strains derived from CD-1 mice to study the possible role of relative estrogen responsiveness in experimental <i>Candida</i> vaginitis infection. This strain, as well the others, is less responsive to estradiol than C57BL/6 mice.

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