Cre expression is driven in neurons of the postnatal cortex and hippocampus of hemizygous mice. These mice may be useful in studies of the nervous system, including Alzheimer's disease.
Fred Van Leuven, Experimental Genetics Group - KULeuven
Genetic Background | Generation |
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N12+N1pN2F16
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Allele Type |
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Transgenic (Recombinase-expressing) |
Starting at:
$278.00 Domestic price for female 4-week |
356.51 Domestic price for breeder pair |
Hemizygous mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. Cre activity is observed in nearly all neurons in cortex and hippocampus. When bred with any mouse containing a loxP-flanked sequence of interest, Cre-mediated recombination will result in postnatal, neuron-specific deletion of the flanked genome. These mice may be useful in studies of the nervous system, including Alzheimer's disease.
View cre expression characterization.
A recombinant vector was designed to place cre recombinase cDNA under control of the mouse Thy1 gene promoter (Thy1.2 sequence). This construct was microinjected into FVB/N pre-nuclear embryos (0.5 day old). A selected founder was bred to FVB/N mice and backcrossed to the same for more than 7 generations. These mice, originally developed by Dr. Fred Van Leuven of The Katholieke Universiteit (Leuven, Belgium) were sent to The Jackson Laboratory from GIGA Transgenics Facility (Liege, Belgium) as hemizygotes in 2006. Upon arrival, mutant mice were bred to FVB/NJ mice for one generation and are now maintained by breeding transgenic mice with FVB/NJ or wildtype siblings.
Expressed Gene | cre, cre recombinase, bacteriophage P1 |
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Site of Expression | neurons of the postnatal cortex and hippocampus |
Allele Name | transgene insertion 1, Fred Van Leuven |
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Allele Type | Transgenic (Recombinase-expressing) |
Allele Synonym(s) | thy1-Cre |
Gene Symbol and Name | Tg(Thy1-cre)1Vln, transgene insertion 1, Fred Van Leuven |
Gene Synonym(s) | |
Promoter | Thy1, thymus cell antigen 1, theta, mouse, laboratory |
Expressed Gene | cre, cre recombinase, bacteriophage P1 |
Site of Expression | neurons of the postnatal cortex and hippocampus |
Strain of Origin | FVB/N |
Chromosome | UN |
Molecular Note | Sequence encoding cre recombinase was adjoined to the mouse Thy1 promoter. Expression was driven in neurons of the postnatal cortex and hippocampus. |
Mutations Made By | Fred Van Leuven, Experimental Genetics Group - KULeuven |
Although the donating investigator reports homozygous mice are viable and fertile, transgenic carriers are bred to wildtype sibling or FVB/NJ mice at The Jackson Laboratory.
When using the FVB/N-Tg(Thy1-cre)1Vln/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #006143 in your Materials and Methods section.
Service/Product | Description | Price |
---|---|---|
Hemizygous for Tg(Thy1-cre)1Vln/ |
Frozen Mouse Embryo | FVB/N-Tg(Thy1-cre)1Vln/J Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | FVB/N-Tg(Thy1-cre)1Vln/J Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | FVB/N-Tg(Thy1-cre)1Vln/J Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | FVB/N-Tg(Thy1-cre)1Vln/J Frozen Embryos | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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