Mice homozygous for the Jackson shaker 2 Jackson mutation display head tossing and circling behavior and have inner ear hair cell loss. Deafness, assessed via ABR, was found as early as 12 days of age.
The Jackson shaker 2 Jackson re-mutation (js-2J) arose spontaneously in the strain B6.Cg-T2J +/+ Qkqk/J in 2002. This mutation was bred away from the T2J and Qkqk mutations by backcross-intercross to C57BL/6J selecting by phenotype. After the fifth backcross-intercross a change in breeding scheme was made to maintain this strain by sibling breeding heterozygous females with homozygous males. This strain reached generation N5F5 in 2006.
|Allele Name||Jackson shaker 2 Jackson|
|Gene Symbol and Name||Ush1g, USH1 protein network component sans|
|Strain of Origin||B6.Cg-T2J +/+ Qkqk-v/J|
|Molecular Note||A 155 base pair deletion was detected within exon 2 that induces a frame-shift coding for 51 altered amino acids followed by a premature stop codon.|
homozygous females will breed, but the litters often need to be fostered.
When using the Jackson shaker 2 Jackson mouse strain in a publication, please cite the originating article(s) and include JAX stock #006111 in your Materials and Methods section.