FVB/NJ-Tg(GART)2Eri/DnJ

Stock number: 006109
Product name: GART-2

Description

This transgenic strain carries the human glycinamide ribonucleotide formyltransferase (GART) gene driven by its own promoter.

Detailed description

This transgene drives minimal human GART mRNA expression and no protein was detected. Auditory startle response may be decreased at 5 months of age, but ABR studies did not detect a hearing deficit.

Development

This transgene was created in FVB/NJ by David Patterson at the Eleanor Roosevelt Institute and maintained on that genetic background. In 2006 this strain was imported into the laboratory of Muriel Davisson at The Jackson Laboratory and embryos were generated for cryopreservation from hemizygous males bred to FVB/NJ females.

Allele

Symbol: Tg(GART)2Eri
Name: transgene insertion 2, Eleanor Roosevelt Institute
MGI accession ID: MGI:4867205
Generation method: Transgenic
Attributes: Inserted expressed sequence; Humanized sequence
Marker symbol: Tg(GART)2Eri
Marker name: transgene insertion 2, Eleanor Roosevelt Institute
Chromosome: UN
Strain of origin: FVB/NJ
Expressed genes: GART,phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase,human
Molecular note: The sequence for the human GART gene under its own promoter was randomly inserted into the genome by pronuclear injection into FVB/NJ, with this allele coming from line P8E5_P7139.