STOCK Ush1c^dfcr-3J/J

Stock number: 006104
Research areas: Mouse/Human Gene Homologs, Neurobiology Research, Sensorineural Research

Description

Mice homozygous for the deaf circler 3 Jackson mutation display head bobbing and rapid circling and are deaf. This strain is maintained segregating for coat color alleles resulting in agouti and albino mice.

Detailed description

Mice homozygous for the deaf circler 3 Jackson mutation display head bobbing and rapid circling and are deaf. This strain is maintained segregating for coat color alleles resulting in agouti and albino mice.

Development

The deaf circler 3 Jackson re-mutation arose spontaneously in 2002 in STOCK Tg(CAG-Bgeo/GFP)21Lbe/J, which was maintained segregating for the transgene. The mutant subline was selectively sibling bred to removed the transgene while preserving the deaf circler 3 Jackson mutation. This strain has been maintained by breeding heterozygous females with homozygous males and in 2009 reached generation F12.

Allele

Symbol: Ush1c^dfcr-3J
Name: deaf circler 3 Jackson
MGI accession ID: MGI:3842842
Generation method: Spontaneous
Marker symbol: Ush1c
Marker name: USH1 protein network component harmonin
Marker synonyms: 2010016F01Rik; AIE-75; DFNB18; DFNB18A; harmonin; NY-CO-37; NY-CO-38; PDZ-45; PDZ73; PDZ-73; PDZ-73/NY-CO-38; PDZD7C; ush1cpst; Usher syndrome 1C
Chromosome: 7
Strain of origin: STOCK Tg(CAG-Bgeo/GFP)21Lbe/J
Molecular note: A noncomplementation test with the original deaf circler mutation showed that this is an allele of Ush1c.