Mice homozygous for the deaf circler 3 Jackson mutation display head bobbing and rapid circling and are deaf. This strain is maintained segregating for coat color alleles resulting in agouti and albino mice.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Ush1c | USH1 protein network component harmonin |
Mice homozygous for the deaf circler 3 Jackson mutation display head bobbing and rapid circling and are deaf. This strain is maintained segregating for coat color alleles resulting in agouti and albino mice.
The deaf circler 3 Jackson re-mutation arose spontaneously in 2002 in STOCK Tg(CAG-Bgeo/GFP)21Lbe/J, which was maintained segregating for the transgene. The mutant subline was selectively sibling bred to removed the transgene while preserving the deaf circler 3 Jackson mutation. This strain has been maintained by breeding heterozygous females with homozygous males and in 2009 reached generation F12.
Allele Name | deaf circler 3 Jackson |
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Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Ush1c, USH1 protein network component harmonin |
Gene Synonym(s) | |
Strain of Origin | STOCK Tg(CAG-Bgeo/GFP)21Lbe/J |
Chromosome | 7 |
Molecular Note | A noncomplementation test with the original deaf circler mutation showed that this is an allele of Ush1c. |
When using the STOCK Ush1cdfcr-3J/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #006104 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for Ush1c<dfcr-3J> |
Frozen Mouse Embryo | STOCK Ush1c<dfcr-3J>/J | $2595.00 |
Frozen Mouse Embryo | STOCK Ush1c<dfcr-3J>/J | $2595.00 |
Frozen Mouse Embryo | STOCK Ush1c<dfcr-3J>/J | $3373.50 |
Frozen Mouse Embryo | STOCK Ush1c<dfcr-3J>/J | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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