JAX
Mouse Strain Datasheet - 006096
B6.Cg-Msr1tm1Csk/J
Also Known As: MSR-
Macrophages from these Msr1 knock-out mice show a marked decrease in mLDL uptake in vitro and show an increased susceptibility to bacterial infection. These mice may be useful in studies of immunity and host defense, cholesterol transport in macrophages, macrophage-derived foam cells, and atherosclerosis.
Donating Investigator
Menno de Winther, Maastricht University
Genetic overview
| Genetic Background | Generation |
|---|---|
|
?+N1F9
|
Msr1tm1Csk
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Null/Knockout) | Msr1 | macrophage scavenger receptor 1 |
Research Applications
- Immunology, Inflammation and Autoimmunity Research
Detailed Description
Homozygotes are viable and fertile. Liver sections treated with antibodies against type I and type II macrophage scavenger class A receptors show no protein staining. Homozygous mice have less severe lesion development in Apoe-deficient atherosclerosis model. Peritoneal macrophages have reduced mLDL uptake in vitro. Homozygous mice have increased susceptibility to pathogens. These mice may be useful in studies of immunity and host defense, cholesterol transport in macrophages, macrophage-derived foam cells, and atherosclerosis.
Development
A pGK1neo cassette replaces alpha-helical coiled coil sequence of exon 4 (essential for the formation of functional trimeric receptors) of the endogenous gene. The construct was electroporated into “A3-1” embryonic stem (ES) cells of “129 origin.” Correctly targeted ES cells were injected into C57BL/6J blastocysts and transplanted into the uteri of ICR females. The resulting chimeric males were backcrossed to ICR females and heterozygous mice were bred to generate homozygous mice. During or near 1998, Dr. Hiroshi Suzuki and Dr. Tatsuhiko Kodama sent these mutant mice to Dr. Menno de Winther at Maastricht University in The Netherlands. There, mutant mice were backcrossed to C57BL/6JIco for 12 generations before arriving at The Jackson Laboratory.
Control Suggestions
Msr1tm1Csk
Allele Symbol: Msr1tm1Csk
| Allele Name | targeted mutation 1, Chugai Pharmaceutical Co, Ltd |
|---|---|
| Allele Type | Targeted (Null/Knockout) |
| Allele Synonym(s) | MSR-; Msr1-KO; Msr1tm1Kod; SR-; SR-A-; SR-AI/II KO; SRAKO; SRKO; Scara1_; Scvrtm1; Sra- |
| Gene Symbol and Name | Msr1, macrophage scavenger receptor 1 |
| Gene Synonym(s) | CD204; MRS-A; MSR-A; RGD1564316; SCARA1; SR-A; SR-AI; SR-AII; SR-AIII; SRA; Scara1; Scvr; Scvr; phSR1; phSR2; scavenger receptor |
| Strain of Origin | 129X1/SvJ |
| Chromosome | 8 |
| Molecular Note | A neomycin cassette was inserted into the EcoRI site in exon 4, which encodes the alpha helical coiled-coil structure essential for the formation of functional trimeric receptors. Protein was not detectable by immunostaining of liver sections from homozygous mutant animals. |
| Mutations Made By | Menno de Winther, Maastricht University |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Immunology, Inflammation and Autoimmunity Research
- Inflammation
Mammalian Phenotype Terms by Genotype
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Msr1tm1Csk/Msr1tm1Csk
involves: 129S7/SvEvBrd * C57BL/6J
immune system phenotype
- abnormal macrophage physiology
- macrophage uptake and degradation of acetylated low density lipoproteins involved in the development of atherosclerosis (MGI Ref ID J:91911)
hematopoietic system phenotype
- abnormal macrophage physiology
- macrophage uptake and degradation of acetylated low density lipoproteins involved in the development of atherosclerosis (MGI Ref ID J:91911)
Genotype: Msr1tm1Csk/Msr1tm1Csk
involves: 129X1/SvJ * ICR
mortality/aging
- increased susceptibility to bacterial infection induced morbidity/mortality
- decreased survival after infection with Listeria monocytogenes (MGI Ref ID J:39079)
- increased susceptibility to viral infection induced morbidity/mortality
- decreased survival after infection with herpes simplex virus, HSV-1 (MGI Ref ID J:39079)
immune system phenotype
- increased interleukin-12 secretion
- mutants produce higher levels of Il-12 in vivo in response to CpG oligodeoxynucleotide administration compared to wild-type mice (MGI Ref ID J:110433)
- increased susceptibility to bacterial infection induced morbidity/mortality
- decreased survival after infection with Listeria monocytogenes (MGI Ref ID J:39079)
- increased susceptibility to viral infection induced morbidity/mortality
- decreased survival after infection with herpes simplex virus, HSV-1 (MGI Ref ID J:39079)
References
Additional - Msr1tm1Csk related
- Amiel E; Acker JL; Collins RM; Berwin B. 2009. Uncoupling scavenger receptor A-mediated phagocytosis of bacteria from endotoxic shock resistance. Infect Immun 77(10):4567-73. PubMed: 19667044MGI: J:153370
- Amiel E; Alonso A; Uematsu S; Akira S; Poynter ME; Berwin B. 2009. Pivotal Advance: Toll-like receptor regulation of scavenger receptor-A-mediated phagocytosis. J Leukoc Biol 85(4):595-605. PubMed: 19112093MGI: J:146918
- Areschoug T; Waldemarsson J; Gordon S. 2008. Evasion of macrophage scavenger receptor A-mediated recognition by pathogenic streptococci. Eur J Immunol 38(11):3068-79. PubMed: 18924218MGI: J:143268
- Arredouani MS; Franco F; Imrich A; Fedulov A; Lu X; Perkins D; Soininen R; Tryggvason K; Shapiro SD; Kobzik L. 2007. Scavenger Receptors SR-AI/II and MARCO limit pulmonary dendritic cell migration and allergic airway inflammation. J Immunol 178(9):5912-20. PubMed: 17442975MGI: J:145827
- Arredouani MS; Yang Z; Imrich A; Ning Y; Qin G; Kobzik L. 2006. The macrophage scavenger receptor SR-AI/II and lung defense against pneumococci and particles. Am J Respir Cell Mol Biol 35(4):474-8. PubMed: 16675784MGI: J:126897
- Beamer CA; Holian A. 2008. Silica suppresses Toll-like receptor ligand-induced dendritic cell activation. FASEB J 22(6):2053-63. PubMed: 18180331MGI: J:136538
- Beamer CA; Holian A. 2005. Scavenger receptor class A type I/II (CD204) null mice fail to develop fibrosis following silica exposure. Am J Physiol Lung Cell Mol Physiol 289(2):L186-95. PubMed: 15849212MGI: J:104753
- Becker M; Cotena A; Gordon S; Platt N. 2006. Expression of the class A macrophage scavenger receptor on specific subpopulations of murine dendritic cells limits their endotoxin response. Eur J Immunol 36(4):950-60. PubMed: 16552714MGI: J:114785
- Bowdish DM; Sakamoto K; Kim MJ; Kroos M; Mukhopadhyay S; Leifer CA; Tryggvason K; Gordon S; Russell DG. 2009. MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosis. PLoS Pathog 5(6):e1000474. PubMed: 19521507MGI: J:162913
- Boyanovsky BB; van der Westhuyzen DR; Webb NR. 2005. Group V secretory phospholipase A2-modified low density lipoprotein promotes foam cell formation by a SR-A- and CD36-independent process that involves cellular proteoglycans. J Biol Chem 280(38):32746-52. PubMed: 16040605MGI: J:102157
- Brown JM; Swindle EJ; Kushnir-Sukhov NM; Holian A; Metcalfe DD. 2007. Silica-directed mast cell activation is enhanced by scavenger receptors. Am J Respir Cell Mol Biol 36(1):43-52. PubMed: 16902192MGI: J:130522
- Chen Y; Pikkarainen T; Elomaa O; Soininen R; Kodama T; Kraal G; Tryggvason K. 2005. Defective microarchitecture of the spleen marginal zone and impaired response to a thymus-independent type 2 antigen in mice lacking scavenger receptors MARCO and SR-A. J Immunol 175(12):8173-80. PubMed: 16339556MGI: J:122271
- Chen Y; Sullivan C; Peng C; Shan Y; Hu Y; Li D; Li S. 2011. A tumor suppressor function of the Msr1 gene in leukemia stem cells of chronic myeloid leukemia. Blood 118(2):390-400. PubMed: 21596859MGI: J:174876
- Chen Y; Wermeling F; Sundqvist J; Jonsson AB; Tryggvason K; Pikkarainen T; Karlsson MC. 2010. A regulatory role for macrophage class A scavenger receptors in TLR4-mediated LPS responses. Eur J Immunol 40(5):1451-60. PubMed: 20162551MGI: J:160959
- Cohen G; Makranz C; Spira M; Kodama T; Reichert F; Rotshenker S. 2006. Non-PKC DAG/phorbol-ester receptor(s) inhibit complement receptor-3 and nPKC inhibit scavenger receptor-AI/II-mediated myelin phagocytosis but cPKC, PI3k, and PLCgamma activate myelin phagocytosis by both. Glia 53(5):538-50. PubMed: 16374778MGI: J:156136
- Cotena A; Gordon S; Platt N. 2004. The class A macrophage scavenger receptor attenuates CXC chemokine production and the early infiltration of neutrophils in sterile peritonitis. J Immunol 173(10):6427-32. PubMed: 15528383MGI: J:94284
- Court N; Vasseur V; Vacher R; Fremond C; Shebzukhov Y; Yeremeev VV; Maillet I; Nedospasov SA; Gordon S; Fallon PG; Suzuki H; Ryffel B; Quesniaux VF. 2010. Partial redundancy of the pattern recognition receptors, scavenger receptors, and C-type lectins for the long-term control of Mycobacterium tuberculosis infection. J Immunol 184(12):7057-70. PubMed: 20488784MGI: J:161134
- Dahl M; Bauer AK; Arredouani M; Soininen R; Tryggvason K; Kleeberger SR; Kobzik L. 2007. Protection against inhaled oxidants through scavenging of oxidized lipids by macrophage receptors MARCO and SR-AI/II. J Clin Invest 117(3):757-64. PubMed: 17332894MGI: J:120724
- Devries-Seimon T; Li Y; Yao PM; Stone E; Wang Y; Davis RJ; Flavell R; Tabas I. 2005. Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor. J Cell Biol 171(1):61-73. PubMed: 16203857MGI: J:102612
- Domingo-Gonzalez R; Katz S; Serezani CH; Moore TA; Levine AM; Moore BB. 2013. Prostaglandin E2-induced changes in alveolar macrophage scavenger receptor profiles differentially alter phagocytosis of Pseudomonas aeruginosa and Staphylococcus aureus post-bone marrow transplant. J Immunol 190(11):5809-17. PubMed: 23630358MGI: J:204773
- Eto M; Yoshikawa H; Fujimura H; Naba I; Sumi-Akamaru H; Takayasu S; Itabe H; Sakoda S. 2003. The role of CD36 in peripheral nerve remyelination after crush injury. Eur J Neurosci 17(12):2659-66. PubMed: 12823473MGI: J:89664
- Facciponte JG; Wang XY; Subjeck JR. 2007. Hsp110 and Grp170, members of the Hsp70 superfamily, bind to scavenger receptor-A and scavenger receptor expressed by endothelial cells-I. Eur J Immunol 37(8):2268-79. PubMed: 17615582MGI: J:123549
- Freigang S; Landais E; Zadorozhny V; Kain L; Yoshida K; Liu Y; Deng S; Palinski W; Savage PB; Bendelac A; Teyton L. 2012. Scavenger receptors target glycolipids for natural killer T cell activation. J Clin Invest 122(11):3943-54. PubMed: 23064364MGI: J:193547
- Frenkel D; Wilkinson K; Zhao L; Hickman SE; Means TK; Puckett L; Farfara D; Kingery ND; Weiner HL; El Khoury J. 2013. Scara1 deficiency impairs clearance of soluble amyloid-beta by mononuclear phagocytes and accelerates Alzheimer's-like disease progression. Nat Commun 4:2030. PubMed: 23799536MGI: J:221229
- Fukuhara-Takaki K; Sakai M; Sakamoto Y; Takeya M; Horiuchi S. 2005. Expression of class A scavenger receptor is enhanced by high glucose in vitro and under diabetic conditions in vivo: one mechanism for an increased rate of atherosclerosis in diabetes. J Biol Chem 280(5):3355-64. PubMed: 15556945MGI: J:96978
- Fulton WB; Reeves RH; Takeya M; De Maio A. 2006. A quantitative trait loci analysis to map genes involved in lipopolysaccharide-induced inflammatory response: identification of macrophage scavenger receptor 1 as a candidate gene. J Immunol 176(6):3767-73. PubMed: 16517746MGI: J:129535
- Geier H; Celli J. 2011. Phagocytic Receptors Dictate Phagosomal Escape and Intracellular Proliferation of Francisella tularensis. Infect Immun 79(6):2204-14. PubMed: 21422184MGI: J:171926
- Haasken S; Auger JL; Taylor JJ; Hobday PM; Goudy BD; Titcombe PJ; Mueller DL; Binstadt BA. 2013. Macrophage scavenger receptor 1 (Msr1, SR-A) influences B cell autoimmunity by regulating soluble autoantigen concentration. J Immunol 191(3):1055-62. PubMed: 23794629MGI: J:205440
- Hagiwara SI; Takeya M; Suzuki H; Kodama T; van der Laan LJ; Kraal G ; Kitamura N ; Takahashi K. 1999. Role of macrophage scavenger receptors in hepatic granuloma formation in mice. Am J Pathol 154(3):705-20. PubMed: 10079248MGI: J:53369
- Hamilton RF Jr; Thakur SA; Mayfair JK; Holian A. 2006. MARCO mediates silica uptake and toxicity in alveolar macrophages from C57BL/6 mice. J Biol Chem 281(45):34218-26. PubMed: 16984918MGI: J:117252
- Haworth R; Platt N; Keshav S; Hughes D; Darley E; Suzuki H; Kurihara Y; Kodama T; Gordon S. 1997. The macrophage scavenger receptor type A is expressed by activated macrophages and protects the host against lethal endotoxic shock. J Exp Med 186(9):1431-9. PubMed: 9348300MGI: J:112082
- Helming L; Gordon S. 2007. Macrophage fusion induced by IL-4 alternative activation is a multistage process involving multiple target molecules. Eur J Immunol 37(1):33-42. PubMed: 17154265MGI: J:117069
- Hollifield M; Bou Ghanem E; de Villiers WJ; Garvy BA. 2007. Scavenger receptor A dampens induction of inflammation in response to the fungal pathogen Pneumocystis carinii. Infect Immun 75(8):3999-4005. PubMed: 17548480MGI: J:123372
- Huang F; Buttini M; Wyss-Coray T; McConlogue L; Kodama T; Pitas RE; Mucke L. 1999. Elimination of the class A scavenger receptor does not affect amyloid plaque formation or neurodegeneration in transgenic mice expressing human amyloid protein precursors. Am J Pathol 155(5):1741-7. PubMed: 10550330MGI: J:58338
- Husemann J; Loike JD; Kodama T; Silverstein SC. 2001. Scavenger receptor class B type I (SR-BI) mediates adhesion of neonatal murine microglia to fibrillar beta-amyloid. J Neuroimmunol 114(1-2):142-50. PubMed: 11240025MGI: J:241487
- Iftakhar-E-Khuda I; Fair-Makela R; Kukkonen-Macchi A; Elima K; Karikoski M; Rantakari P; Miyasaka M; Salmi M; Jalkanen S. 2016. Gene-expression profiling of different arms of lymphatic vasculature identifies candidates for manipulation of cell traffic. Proc Natl Acad Sci U S A 113(38):10643-8. PubMed: 27601677MGI: J:238349
- Inoue M; Xuan X; Fujisaki K; Igarashi I; Suzuki H. 2006. Short report: role of type I/II scavenger receptors in malarial infection in C57BL/6J mice. Am J Trop Med Hyg 75(1):178-81. PubMed: 16837728MGI: J:135702
- Ishiguro T; Naito M; Yamamoto T; Hasegawa G; Gejyo F; Mitsuyama M; Suzuki H; Kodama T. 2001. Role of macrophage scavenger receptors in response to Listeria monocytogenes infection in mice. Am J Pathol 158(1):179-88. PubMed: 11141491MGI: J:68438
- Jozefowski S; Arredouani M; Sulahian T; Kobzik L. 2005. Disparate regulation and function of the class A scavenger receptors SR-AI/II and MARCO. J Immunol 175(12):8032-41. PubMed: 16339540MGI: J:122238
- Jozefowski S; Sulahian TH; Arredouani M; Kobzik L. 2006. Role of scavenger receptor MARCO in macrophage responses to CpG oligodeoxynucleotides. J Leukoc Biol 80(4):870-9. PubMed: 16882874MGI: J:113090
- Kabamoto S; Bhagat NA; Suzuki H; You M; Kamio T; Tsuji N; Claveria FG; Nagasawa H; Igarashi I; Toyoda Y; Fujisaki K. 2002. Comparison of macrophage scavenger receptor-A knockout mice with wild type ones in the immune response against repeated infestation with Haemaphysalis longicornis. J Vet Med Sci 64(4):355-9. PubMed: 12014582MGI: J:127030
- Kamada N; Kodama T; Suzuki H. 2001. Macrophage scavenger receptor (SR-A I/II) deficiency reduced diet-induced atherosclerosis in C57BL/6J mice. J Atheroscler Thromb 8(1):1-6. PubMed: 11686309MGI: J:117403
- Kobayashi H; Sakashita N; Okuma T; Terasaki Y; Tsujita K; Suzuki H; Kodama T; Nomori H; Kawasuji M; Takeya M. 2007. Class A scavenger receptor (CD204) attenuates hyperoxia-induced lung injury by reducing oxidative stress. J Pathol 212(1):38-46. PubMed: 17370294MGI: J:122097
- Kobayashi Y; Miyaji C; Watanabe H; Umezu H; Hasegawa G; Abo T; Arakawa M; Kamata N; Suzuki H; Kodama T; Naito M. 2000. Role of macrophage scavenger receptor in endotoxin shock J Pathol 192(2):263-72. PubMed: 11004705MGI: J:65024
- Komohara Y; Terasaki Y; Kaikita K; Suzuki H; Kodama T; Takeya M. 2005. Clearance of apoptotic cells is not impaired in mouse embryos deficient in class A scavenger receptor types I and II (CD204). Dev Dyn 232(1):67-74. PubMed: 15580571MGI: J:95137
- Korporaal SJ; Van Eck M; Adelmeijer J; Ijsseldijk M; Out R; Lisman T; Lenting PJ; Van Berkel TJ; Akkerman JW. 2007. Platelet activation by oxidized low density lipoprotein is mediated by CD36 and scavenger receptor-A. Arterioscler Thromb Vasc Biol 27(11):2476-83. PubMed: 17761940MGI: J:135004
- Kunjathoor VV; Febbraio M; Podrez EA; Moore KJ; Andersson L; Koehn S; Rhee JS; Silverstein R; Hoff HF; Freeman MW. 2002. Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages. J Biol Chem 277(51):49982-8. PubMed: 12376530MGI: J:80905
- Li S; Sun Y; Liang CP; Thorp EB; Han S; Jehle AW; Saraswathi V; Pridgen B; Kanter JE; Li R; Welch CL; Hasty AH; Bornfeldt KE; Breslow JL; Tabas I; Tall AR. 2009. Defective phagocytosis of apoptotic cells by macrophages in atherosclerotic lesions of ob/ob mice and reversal by a fish oil diet. Circ Res 105(11):1072-82. PubMed: 19834009MGI: J:170144
- Lin YL; de Villiers WJ; Garvy B; Post SR; Nagy TR; Safadi FF; Faugere MC; Wang G; Malluche HH; Williams JP. 2007. The effect of class a scavenger receptor deficiency in bone. J Biol Chem 282(7):4653-60. PubMed: 17166840MGI: J:120924
- Ling W; Lougheed M; Suzuki H; Buchan A; Kodama T; Steinbrecher UP. 1997. Oxidized or acetylated low density lipoproteins are rapidly cleared by the liver in mice with disruption of the scavenger receptor class A type I/II gene. J Clin Invest 100(2):244-52. PubMed: 9218499MGI: J:41808
- Ma K; Xu Y; Wang C; Li N; Li K; Zhang Y; Li X; Yang Q; Zhang H; Zhu X; Bai H; Ben J; Ding Q; Li K; Jiang Q; Xu Y; Chen Q. 2014. A cross talk between class A scavenger receptor and receptor for advanced glycation end-products contributes to diabetic retinopathy. Am J Physiol Endocrinol Metab 307(12):E1153-65. PubMed: 25352436MGI: J:218532
- Manning-Tobin JJ; Moore KJ; Seimon TA; Bell SA; Sharuk M; Alvarez-Leite JI; de Winther MP; Tabas I; Freeman MW. 2009. Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice. Arterioscler Thromb Vasc Biol 29(1):19-26. PubMed: 18948635MGI: J:159787
- Matsumoto K; Sano H; Nagai R; Suzuki H; Kodama T; Yoshida M; Ueda S; Smedsrod B; Horiuchi S. 2000. Endocytic uptake of advanced glycation end products by mouse liver sinusoidal endothelial cells is mediated by a scavenger receptor distinct from the macrophage scavenger receptor class A. Biochem J 352 Pt 1:233-40. PubMed: 11062078MGI: J:114182
- Montano EN; Boullier A; Almazan F; Binder CJ; Witztum JL; Hartvigsen K. 2013. Development and application of a nonradioactive binding assay of oxidized low-density lipoprotein to macrophage scavenger receptors. J Lipid Res 54(11):3206-14. PubMed: 23997238MGI: J:203430
- Moore KJ; Kunjathoor VV; Koehn SL; Manning JJ; Tseng AA; Silver JM; McKee M; Freeman MW. 2005. Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice. J Clin Invest 115(8):2192-201. PubMed: 16075060MGI: J:100226
- Muczynski V; Bazaa A; Loubiere C; Harel A; Cherel G; Denis CV; Lenting PJ; Christophe OD. 2016. Macrophage receptor SR-AI is crucial to maintain normal plasma levels of coagulation factor X. Blood 127(6):778-86. PubMed: 26608330MGI: J:231550
- Mukhopadhyay S; Chen Y; Sankala M; Peiser L; Pikkarainen T; Kraal G; Tryggvason K; Gordon S. 2006. MARCO, an innate activation marker of macrophages, is a class A scavenger receptor for Neisseria meningitidis. Eur J Immunol 36(4):940-9. PubMed: 16525990MGI: J:114824
- Mukhopadhyay S; Varin A; Chen Y; Liu B; Tryggvason K; Gordon S. 2011. SR-A/MARCO-mediated ligand delivery enhances intracellular TLR and NLR function, but ligand scavenging from cell surface limits TLR4 response to pathogens. Blood 117(4):1319-28. PubMed: 21098741MGI: J:168587
- Naba I; Yoshikawa H; Sakoda S; Itabe H; Suzuki H; Kodama T; Yanagihara T. 2000. Successful generation of peripheral neuropathy with onion-bulb formation in the macrophage scavenger receptor classA knockout mouse treated with isoniazid. Neurosci Lett 290(1):5-8. PubMed: 10925161MGI: J:107986
- Naba I; Yoshikawa H; Sakoda S; Itabe H; Suzuki H; Kodama T; Yanagihara T. 2000. Onion-bulb formation after a single compression injury in the macrophage scavenger receptor knockout mice Exp Neurol 166(1):83-9. PubMed: 11031085MGI: J:65692
- Nakayachi M; Ito J; Hayashida C; Ohyama Y; Kakino A; Okayasu M; Sato T; Ogasawara T; Kaneda T; Suda N; Sawamura T; Hakeda Y. 2015. Lectin-like oxidized low-density lipoprotein receptor-1 abrogation causes resistance to inflammatory bone destruction in mice, despite promoting osteoclastogenesis in the steady state. Bone 75:170-82. PubMed: 25744064MGI: J:221962
- Neyen C; Pluddemann A; Mukhopadhyay S; Maniati E; Bossard M; Gordon S; Hagemann T. 2013. Macrophage scavenger receptor a promotes tumor progression in murine models of ovarian and pancreatic cancer. J Immunol 190(7):3798-805. PubMed: 23447685MGI: J:194838
- Nicoletti A; Caligiuri G; Tornberg I; Kodama T; Stemme S; Hansson GK. 1999. The macrophage scavenger receptor type A directs modified proteins to antigen presentation. Eur J Immunol 29(2):512-21. PubMed: 10064066MGI: J:115253
- Ohnishi K; Komohara Y; Fujiwara Y; Takemura K; Lei X; Nakagawa T; Sakashita N; Takeya M. 2011. Suppression of TLR4-mediated inflammatory response by macrophage class A scavenger receptor (CD204). Biochem Biophys Res Commun 411(3):516-22. PubMed: 21756882MGI: J:175685
- Ono K; Nishitani C; Mitsuzawa H; Shimizu T; Sano H; Suzuki H; Kodama T; Fujii N; Fukase K; Hirata K; Kuroki Y. 2006. Mannose-binding lectin augments the uptake of lipid A, Staphylococcus aureus, and Escherichia coli by Kupffer cells through increased cell surface expression of scavenger receptor A. J Immunol 177(8):5517-23. PubMed: 17015738MGI: J:139434
- Ozment TR; Ha T; Breuel KF; Ford TR; Ferguson DA; Kalbfleisch J; Schweitzer JB; Kelley JL; Li C; Williams DL. 2012. Scavenger receptor class a plays a central role in mediating mortality and the development of the pro-inflammatory phenotype in polymicrobial sepsis. PLoS Pathog 8(10):e1002967. PubMed: 23071440MGI: J:195597
- Palecanda A; Paulauskis J; Al-Mutairi E; Imrich A; Qin G; Suzuki H; Kodama T; Tryggvason K; Koziel H; Kobzik L. 1999. Role of the scavenger receptor MARCO in alveolar macrophage binding of unopsonized environmental particles. J Exp Med 189(9):1497-506. PubMed: 10224290MGI: J:110931
- Platt N; Suzuki H; Kodama T; Gordon S. 2000. Apoptotic thymocyte clearance in scavenger receptor class A-deficient mice is apparently normal. J Immunol 164(9):4861-7. PubMed: 10779795MGI: J:124530
- Pluddemann A; Hoe JC; Makepeace K; Moxon ER; Gordon S. 2009. The macrophage scavenger receptor A is host-protective in experimental meningococcal septicaemia. PLoS Pathog 5(2):e1000297. PubMed: 19214213MGI: J:162700
- Qian J; Yi H; Guo C; Yu X; Zuo D; Chen X; Kane JM 3rd; Repasky EA; Subjeck JR; Wang XY. 2011. CD204 suppresses large heat shock protein-facilitated priming of tumor antigen gp100-specific T cells and chaperone vaccine activity against mouse melanoma. J Immunol 187(6):2905-14. PubMed: 21832164MGI: J:179257
- Qian L; Li X; Fang R; Wang Z; Xu Y; Zhang H; Bai H; Yang Q; Zhu X; Ben J; Xu Y; Chen Q. 2014. Class A scavenger receptor deficiency augments angiotensin II-induced vascular remodeling. Biochem Pharmacol 90(3):254-64. PubMed: 24875449MGI: J:214379
- Qiu Y; Dayrit JK; Davis MJ; Carolan JF; Osterholzer JJ; Curtis JL; Olszewski MA. 2013. Scavenger receptor A modulates the immune response to pulmonary Cryptococcus neoformans infection. J Immunol 191(1):238-48. PubMed: 23733871MGI: J:205358
- Rahaman SO; Lennon DJ; Febbraio M; Podrez EA; Hazen SL; Silverstein RL. 2006. A CD36-dependent signaling cascade is necessary for macrophage foam cell formation. Cell Metab 4(3):211-21. PubMed: 16950138MGI: J:129743
- Raizman JE; Chen YX; Seibert T; Hibbert B; Cuerrier CM; Salari S; Zhao X; Hu T; Shi C; Ma X; Simard T; Caravaggio J; Rayner K; Bowdish D; Moore K; O'Brien ER. 2013. Heat shock protein-27 attenuates foam cell formation and atherogenesis by down-regulating scavenger receptor-A expression via NF-kappaB signaling. Biochim Biophys Acta 1831(12):1721-8. PubMed: 23939398MGI: J:204093
- Ramakrishnan R; Tyurin VA; Veglia F; Condamine T; Amoscato A; Mohammadyani D; Johnson JJ; Zhang LM; Klein-Seetharaman J; Celis E; Kagan VE; Gabrilovich DI. 2014. Oxidized lipids block antigen cross-presentation by dendritic cells in cancer. J Immunol 192(6):2920-31. PubMed: 24554775MGI: J:209897
- Raycroft MT; Harvey BP; Bruck MJ; Mamula MJ. 2012. Inhibition of antigen trafficking through scavenger receptor A. J Biol Chem 287(8):5310-6. PubMed: 22215667MGI: J:182435
- Ren D; Wang X; Ha T; Liu L; Kalbfleisch J; Gao X; Williams D; Li C. 2013. SR-A deficiency reduces myocardial ischemia/reperfusion injury; involvement of increased microRNA-125b expression in macrophages. Biochim Biophys Acta 1832(2):336-46. PubMed: 23123599MGI: J:198842
- Robbins CS; Hilgendorf I; Weber GF; Theurl I; Iwamoto Y; Figueiredo JL; Gorbatov R; Sukhova GK; Gerhardt LM; Smyth D; Zavitz CC; Shikatani EA; Parsons M; van Rooijen N; Lin HY; Husain M; Libby P; Nahrendorf M; Weissleder R; Swirski FK. 2013. Local proliferation dominates lesional macrophage accumulation in atherosclerosis. Nat Med 19(9):1166-72. PubMed: 23933982MGI: J:201890
- Rotshenker S; Reichert F; Gitik M; Haklai R; Elad-Sfadia G; Kloog Y. 2008. Galectin-3/MAC-2, Ras and PI3K activate complement receptor-3 and scavenger receptor-AI/II mediated myelin phagocytosis in microglia. Glia 56(15):1607-13. PubMed: 18615637MGI: J:156259
- Seimon TA; Nadolski MJ; Liao X; Magallon J; Nguyen M; Feric NT; Koschinsky ML; Harkewicz R; Witztum JL; Tsimikas S; Golenbock D; Moore KJ; Tabas I. 2010. Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress. Cell Metab 12(5):467-82. PubMed: 21035758MGI: J:167910
- Seimon TA; Obstfeld A; Moore KJ; Golenbock DT; Tabas I. 2006. Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages. Proc Natl Acad Sci U S A 103(52):19794-9. PubMed: 17167049MGI: J:118240
- Shi S; Blumenthal A; Hickey CM; Gandotra S; Levy D; Ehrt S. 2005. Expression of many immunologically important genes in Mycobacterium tuberculosis-infected macrophages is independent of both TLR2 and TLR4 but dependent on IFN-alphabeta receptor and STAT1. J Immunol 175(5):3318-28. PubMed: 16116224MGI: J:113220
- Shimizu M; Yasuda H; Hara K; Takahashi K; Nagata M; Yokono K. 2014. The dual role of scavenger receptor class A in development of diabetes in autoimmune NOD mice. PLoS One 9(10):e109531. PubMed: 25343451MGI: J:223101
- Suzuki H; Kurihara Y; Takeya M; Kamada N; Kataoka M; Jishage K ; Ueda O ; Sakaguchi H ; Higashi T ; Suzuki T ; Takashima Y ; Kawabe Y ; Cynshi O ; Wada Y ; Honda M ; Kurihara H ; Aburatani H ; Doi T ; Matsumoto A ; Azuma S ; Noda T ; Toyoda Y ; Itakura H; Yazaki Y ; Kodama T ; et al. 1997. A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature 386(6622):292-6. PubMed: 9069289MGI: J:39079
- Takakura Y; Takagi T; Hashiguchi M; Nisihikawa M; Yamashita F; Doi T; Imanishi T; Suzuki H; Kodama T; Hashida M. 1999. Characterization of plasmid DNA binding and uptake by peritoneal macrophages from class a scavenger receptor knockout mice. Pharm Res 16(4):503-8. PubMed: 10227703MGI: J:54878
- Takemura K; Sakashita N; Fujiwara Y; Komohara Y; Lei X; Ohnishi K; Suzuki H; Kodama T; Mizuta H; Takeya M. 2010. Class A scavenger receptor promotes osteoclast differentiation via the enhanced expression of receptor activator of NF-kappaB (RANK). Biochem Biophys Res Commun 391(4):1675-80. PubMed: 20036645MGI: J:157090
- Tamura Y; Osuga J; Adachi H; Tozawa R; Takanezawa Y; Ohashi K; Yahagi N; Sekiya M; Okazaki H; Tomita S; Iizuka Y; Koizumi H; Inaba T; Yagyu H; Kamada N; Suzuki H; Shimano H; Kadowaki T; Tsujimoto M; Arai H; Yamada N; Ishibashi S. 2004. Scavenger receptor expressed by endothelial cells I (SREC-I) mediates the uptake of acetylated low density lipoproteins by macrophages stimulated with lipopolysaccharide. J Biol Chem 279(30):30938-44. PubMed: 15145948MGI: J:91911
- Terpstra V; van Berkel TJ. 2000. Scavenger receptors on liver Kupffer cells mediate the in vivo uptake of oxidatively damaged red blood cells in mice. Blood 95(6):2157-63. PubMed: 10706889MGI: J:110359
- Tewalt EF; Maynard JC; Walters JJ; Schell AM; Berwin BL; Nicchitta CV; Norbury CC. 2008. Redundancy renders the glycoprotein 96 receptor scavenger receptor A dispensable for cross priming in vivo. Immunology 125(4):480-91. PubMed: 18489571MGI: J:144444
- Thelen T; Hao Y; Medeiros AI; Curtis JL; Serezani CH; Kobzik L; Harris LH; Aronoff DM. 2010. The class A scavenger receptor, macrophage receptor with collagenous structure, is the major phagocytic receptor for Clostridium sordellii expressed by human decidual macrophages. J Immunol 185(7):4328-35. PubMed: 20810988MGI: J:164310
- Theurl I; Hilgendorf I; Nairz M; Tymoszuk P; Haschka D; Asshoff M; He S; Gerhardt LM; Holderried TA; Seifert M; Sopper S; Fenn AM; Anzai A; Rattik S; McAlpine C; Theurl M; Wieghofer P; Iwamoto Y; Weber GF; Harder NK; Chousterman BG; Arvedson TL; McKee M; Wang F; Lutz OM; Rezoagli E; Babitt JL; Berra L; Prinz M; Nahrendorf M; Weiss G; Weissleder R; Lin HY; Swirski FK. 2016. On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver. Nat Med 22(8):945-51. PubMed: 27428900MGI: J:240122
- Thomas CA; Li Y; Kodama T; Suzuki H; Silverstein SC; El Khoury J. 2000. Protection from lethal gram-positive infection by macrophage scavenger receptor-dependent phagocytosis. J Exp Med 191(1):147-56. PubMed: 10620613MGI: J:59246
- Todt JC; Hu B; Curtis JL. 2008. The scavenger receptor SR-A I/II (CD204) signals via the receptor tyrosine kinase Mertk during apoptotic cell uptake by murine macrophages. J Leukoc Biol 84(2):510-8. PubMed: 18511575MGI: J:138416
- Tsujita K; Kaikita K; Hayasaki T; Honda T; Kobayashi H; Sakashita N; Suzuki H; Kodama T; Ogawa H; Takeya M. 2007. Targeted deletion of class A macrophage scavenger receptor increases the risk of cardiac rupture after experimental myocardial infarction. Circulation 115(14):1904-11. PubMed: 17389263MGI: J:135372
- Tyurin VA; Cao W; Tyurina YY; Gabrilovich DI; Kagan VE. 2011. Mass-spectrometric characterization of peroxidized and hydrolyzed lipids in plasma and dendritic cells of tumor-bearing animals. Biochem Biophys Res Commun 413(1):149-53. PubMed: 21872574MGI: J:177532
- Usui HK; Shikata K; Sasaki M; Okada S; Matsuda M; Shikata Y; Ogawa D; Kido Y; Nagase R; Yozai K; Ohga S; Tone A; Wada J; Takeya M; Horiuchi S; Kodama T; Makino H. 2007. Macrophage scavenger receptor-a-deficient mice are resistant against diabetic nephropathy through amelioration of microinflammation. Diabetes 56(2):363-72. PubMed: 17259380MGI: J:121943
- Van Berkel TJ; Van Velzen A; Kruijt JK; Suzuki H; Kodama T. 1998. Uptake and catabolism of modified LDL in scavenger-receptor class A type I/II knock-out mice. Biochem J 331(Pt 1):29-35. PubMed: 9512458MGI: J:114274
- Varin A; Mukhopadhyay S; Herbein G; Gordon S. 2010. Alternative activation of macrophages by IL-4 impairs phagocytosis of pathogens but potentiates microbial-induced signalling and cytokine secretion. Blood 115(2):353-62. PubMed: 19880493MGI: J:156317
- Wang MD; Kiss RS; Franklin V; McBride HM; Whitman SC; Marcel YL. 2007. Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathways. J Lipid Res 48(3):633-45. PubMed: 17148552MGI: J:120283
- Wang W; He B; Shi W; Liang X; Ma J; Shan Z; Hu Z; Danesh FR. 2012. Deletion of scavenger receptor A protects mice from progressive nephropathy independent of lipid control during diet-induced hyperlipidemia. Kidney Int 81(10):1002-14. PubMed: 22377830MGI: J:198185
- Wang XY; Facciponte J; Chen X; Subjeck JR; Repasky EA. 2007. Scavenger receptor-A negatively regulates antitumor immunity. Cancer Res 67(10):4996-5002. PubMed: 17510431MGI: J:121736
- Wang Z; DiDonato JA; Buffa J; Comhair SA; Aronica MA; Dweik RA; Lee NA; Lee JJ; Thomassen MJ; Kavuru M; Erzurum SC; Hazen SL. 2016. Eosinophil Peroxidase Catalyzed Protein Carbamylation Participates in Asthma. J Biol Chem 291(42):22118-22135. PubMed: 27587397MGI: J:237283
- Wermeling F; Chen Y; Pikkarainen T; Scheynius A; Winqvist O; Izui S; Ravetch JV; Tryggvason K; Karlsson MC. 2007. Class A scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupus. J Exp Med 204(10):2259-65. PubMed: 17893199MGI: J:126041
- Xu Y; Qian L; Zong G; Ma K; Zhu X; Zhang H; Li N; Yang Q; Bai H; Ben J; Li X; Xu Y; Chen Q. 2012. Class A scavenger receptor promotes cerebral ischemic injury by pivoting microglia/macrophage polarization. Neuroscience 218:35-48. PubMed: 22652221MGI: J:192417
- Yi H; Guo C; Yu X; Gao P; Qian J; Zuo D; Manjili MH; Fisher PB; Subjeck JR; Wang XY. 2011. Targeting the Immunoregulator SRA/CD204 Potentiates Specific Dendritic Cell Vaccine-Induced T-cell Response and Antitumor Immunity. Cancer Res 71(21):6611-20. PubMed: 21914786MGI: J:177377
- Yi H; Yu X; Gao P; Wang Y; Baek SH; Chen X; Kim HL; Subjeck JR; Wang XY. 2009. Pattern recognition scavenger receptor SRA/CD204 down-regulates Toll-like receptor 4 signaling-dependent CD8 T-cell activation. Blood 113(23):5819-28. PubMed: 19349620MGI: J:149497
- Yu H; Ha T; Liu L; Wang X; Gao M; Kelley J; Kao R; Williams D; Li C. 2012. Scavenger receptor A (SR-A) is required for LPS-induced TLR4 mediated NF-kappaB activation in macrophages. Biochim Biophys Acta 1823(7):1192-8. PubMed: 22627090MGI: J:185204
- Zhu FG; Reich CF; Pisetsky DS. 2001. The role of the macrophage scavenger receptor in immune stimulation by bacterial DNA and synthetic oligonucleotides. Immunology 103(2):226-34. PubMed: 11412310MGI: J:110433
- Zhu X; Zong G; Zhu L; Jiang Y; Ma K; Zhang H; Zhang Y; Bai H; Yang Q; Ben J; Li X; Xu Y; Chen Q. 2014. Deletion of class A scavenger receptor deteriorates obesity-induced insulin resistance in adipose tissue. Diabetes 63(2):562-77. PubMed: 24170693MGI: J:209015
- de Winther MP; Gijbels MJ; van Dijk KW; van Gorp PJ; suzuki H; Kodama T; Frants RR; Havekes LM; Hofker MH. 1999. Scavenger receptor deficiency leads to more complex atherosclerotic lesions in APOE3Leiden transgenic mice. Atherosclerosis 144(2):315-21. PubMed: 10407492MGI: J:56239