Mice that are heterozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Homozygous mice are embryonic lethal. These mutant mice may be useful in studies of immune function, including apoptosis, B and T cell development, and bone marrow cell differentiation. When bred to a strain with loxP sites inserted into the same targeted allele (Stock No. <a href="https://www.jax.org/strain/006088">006088</a>) and a strain with a Cd19 null allele and expressing Cre recombinase during the B lymphocyte development (Stock No. <a href="https://www.jax.org/strain/004126">004126</a>), this mutant mouse strain may be useful in studies of lymphocyte development.
 When bred to a strain with loxP sites inserted into the same targeted allele (Stock No. <a href="https://www.jax.org/strain/006088">006088</a>) and a strain expressing interferon inducible Cre recombinase in the lymphocytes (Stock No. <a href="https://www.jax.org/strain/003556">003556</a>), this mutant mouse strain may be useful in studies of lymphocyte development.

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In these Mcl1tm2Sjk knock-out mice portions of Mcl-1 exons 1 and 2 were replaced with an internal ribosome entry site allowing the expression of a neomycin–b-galactosidase fusion protein, but lack detectable expression of MCL-1 protein.

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