Mice of this strain possibly carry a quantitative trait locus (QTL) for atherosclerosis 6.
Read More +Genetic Background | Generation |
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000664 C57BL/6J |
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Allele Type | Gene Symbol | Gene Name |
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QTL | Ath6 | atherosclerosis 6 |
Marker Symbol | Marker Name | |
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D12Mit2 | DNA segment, Chr 12, Massachusetts Institute of Technology 2 | |
D12Mit182 | DNA segment, Chr 12, Massachusetts Institute of Technology 182 |
The QTL, atherosclerosis 6, is thought to be located in the congenic region between D12Mit182 and D12Mit105.
The region (D12Mit182-D12Mit2) has been introgressed from C57BLKS/J to C57BL/6J for a minimum of 11 generations. Additional genotyping in the congenic region indicates that the interval defined by (D12Mit182-D12Mit105) is DBA/2J-like and the interval defined by (D12Mit83-D12Mit60) is C57BL/6J-like. The inbred strain C57BLKS/J originated from the inbred strains C57BL/6J and DBA/2J. Dr. Beverly Paigen generated this strain at The Jackson Laboratory; the strain was cryopreserved in 2006.
Allele Name | C57BLKS/J |
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Allele Type | QTL |
Allele Synonym(s) | |
Gene Symbol and Name | Ath6, atherosclerosis 6 |
Gene Synonym(s) | |
Strain of Origin | C57BLKS/J |
Chromosome | 12 |
General Note | Congenic animals carrying C57BLKS/J-derived DNA at Ath6 (chromosome 12) on a C57BL/6J genetic background display significantly larger lesions on an atherogenic diet compared to background strain C57BL/6J. |
Molecular Note | This allele confers susceptibility to atherosclerosis compared to C57BL/6J. |
Marker Synonym(s) | |
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Chromosome(s) | 12 |
Marker Synonym(s) | |
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Chromosome(s) | 12 |
When using the B6.BKS-(D12Mit182-D12Mit2)/Pgn mouse strain in a publication, please cite the originating article(s) and include JAX stock #006056 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Homozygous, 1 pair minimum |
Frozen Mouse Embryo | B6.BKS-(D12Mit182-D12Mit2)/Pgn Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | B6.BKS-(D12Mit182-D12Mit2)/Pgn Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | B6.BKS-(D12Mit182-D12Mit2)/Pgn Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | B6.BKS-(D12Mit182-D12Mit2)/Pgn Frozen Embryos | $3373.50 |
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