STOCK Ighg1^tm1.1Ksho/J

Stock number: 006052
Product name: IgG1^{Δ m}
Research areas: Immunology, Inflammation and Autoimmunity Research, Research Tools

Description

Both heterozygous and homozygous mutants of this Ighg1^tm1.1Ksho knock-out mutation demonstrate impaired primary and secondary IgG1 responses.

Detailed description

Mice homozygous for the targeted allele are viable and fertile. Both heterozygous and homozygous mutants demonstrate impaired primary and secondary IgG1 responses. Serum IgG1 concentrations in homozygous mutant mice are reduced 71-fold compared to controls. This mutant mouse strain may be useful in studies of the role of IgG1 immunoglobulins in immune responses and in the generation of plasma cells and memory B cells.

Allele

Symbol: Ighg1^tm1.1Ksho
Name: targeted mutation 1.1, Tsuneyasu Kaisho
MGI accession ID: MGI:2669501
Generation method: Targeted
Attributes: Null/Knockout
Synonyms: IgG1^{delta m}
Marker symbol: Ighg1
Marker name: immunoglobulin heavy constant gamma 1 (G1m marker)
Marker synonyms: IgG1; IgG3; Igh-4; Ighg; RGD1359539
Chromosome: 12
Strain of origin: 129P2/OlaHsd
Molecular note: The floxed region containing the exon encoding the transmembrane domain and the stop codon inserted downstream was excised from Igh-4^tm1Ksho via in vivo cre mediated recombination. Protein translated from this allele is not expected to localize to the membrane.