These transgenic mice express the human amyloid precursor protein (APP).
Dr. David R Borchelt, University of Florida
Genetic Background | Generation |
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Allele Type |
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Transgenic (Inserted expressed sequence, Humanized sequence) |
These transgenic mice express the human amyloid precursor protein (APP) under the control of the mouse prion protein promoter. Mice that are hemizygous for the transgene are viable and fertile. This mutant mouse strain may be useful in studies of Alzheimer's Disease.
A transgenic construct containing the human amyloid precursor protein (APP) under the control of the mouse prion protein promoter was injected into fertilized C57BL/6J mouse eggs. Founder line A-2 was established. The mice were then maintained by crossing hemizgyous male mice to C57BL/6J female mice.
Expressed Gene | APP, amyloid beta precursor protein, human |
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Site of Expression |
Allele Name | transgene insertion A-2, David R Borchelt |
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Allele Type | Transgenic (Inserted expressed sequence, Humanized sequence) |
Allele Synonym(s) | |
Gene Symbol and Name | Tg(Prnp-APP)A-2Dbo, transgene insertion A-2, David R Borchelt |
Gene Synonym(s) | |
Promoter | Prnp, prion protein, mouse, laboratory |
Expressed Gene | APP, amyloid beta precursor protein, human |
Strain of Origin | C57BL/6 |
Chromosome | UN |
Molecular Note | Mice with this transgene express the human amyloid precursor protein (APP) under control of the mouse prion protein promoter. |
When maintaining a live colony, these mice are bred as hemizygotes.
When using the B6.Cg-Tg(Prnp-APP)A-2Dbo/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #006006 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Hemizygous or Non carrier for Tg(Prnp-APP)A-2Dbo |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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