B6.Cg-Tg(Prnp-APP)A-2Dbo/J

Stock number: 006006
Research areas: Neurobiology Research

Description

These transgenic mice express the human amyloid precursor protein (APP).

Detailed description

These transgenic mice express the human amyloid precursor protein (APP) under the control of the mouse prion protein promoter. Mice that are hemizygous for the transgene are viable and fertile. This mutant mouse strain may be useful in studies of Alzheimer's Disease.

Development

A transgenic construct containing the human amyloid precursor protein (APP) under the control of the mouse prion protein promoter was injected into fertilized C57BL/6J mouse eggs. Founder line A-2 was established. The mice were then maintained by crossing hemizgyous male mice to C57BL/6J female mice.

Allele

Symbol: Tg(Prnp-APP)A-2Dbo
Name: transgene insertion A-2, David R Borchelt
MGI accession ID: MGI:3696803
Generation method: Transgenic
Attributes: Inserted expressed sequence; Humanized sequence
Marker symbol: Tg(Prnp-APP)A-2Dbo
Marker name: transgene insertion A-2, David R Borchelt
Chromosome: UN
Strain of origin: C57BL/6
Expressed genes: APP,amyloid beta precursor protein,human
Molecular note: Mice with this transgene express the human amyloid precursor protein (APP) under control of the mouse prion protein promoter.