behavior/neurological phenotype

• abnormal locomotor behavior
  • in radial maze testing, male mutants backcrossed 5-7 generations show high motor reactivity compared to females or control animals, and entered the closest arm of the maze which prevented them from learning the task
  (MGI Ref ID J:109847)

• abnormal spatial learning
  • upon repeat testing of the same females one month later, difference between mutants and controls is more robust; repeated testing had no effect on performance
  (MGI Ref ID J:109847)
  • 12-13 month old males and females backcrossed 5-7 generations show poorer performance in probe trials in the Morris water maze; females spent less time in correct quadrant until fourth consectutive session
  (MGI Ref ID J:109847)

• decreased vertical activity
  • at 12-13 months, mice backcrossed 5-7 generations show fewer rearing reactions compared to nontransgenic littermates
  (MGI Ref ID J:109847)

• increased anxiety-related response
  • at 12-13 months, females backcrossed 5-7 generations are less active in visiting open arms in plus maze; combined with reduced rearing reactions, females may have higher anxiety levels
  (MGI Ref ID J:109847)

• hypoactivity
  • at 12-13 months, males backcrossed 5-7 generations are less active than controls in inner cells of open field
  (MGI Ref ID J:109847)

• abnormal object recognition memory
  • as females age (13-14 months of age), significant difference compared to female controls is observed in trials with longest (<60 minute) delays
  (MGI Ref ID J:109847)

homeostasis/metabolism phenotype

• amyloid beta deposits
  • 14-15 month old mutants backcrossed 5- or 10 generations tend to have higher accumulation of amyloid compared to Tg(APP695)3Dbo at that age
  (MGI Ref ID J:109847)

nervous system phenotype

• amyloid beta deposits
  • 14-15 month old mutants backcrossed 5- or 10 generations tend to have higher accumulation of amyloid compared to Tg(APP695)3Dbo at that age
  (MGI Ref ID J:109847)