These transgenic mice express a chimeric mouse/human amyloid precursor protein (APPswe) under the control of the mouse prion protein promoter. Mice that are hemizygous for the transgene are viable and fertile. More than half of the female hemizygous mice do not survive past 15 months of age. This mutant mouse strain may be useful in studies of Alzheimer's Disease.

These transgenic mice express a chimeric mouse/human amyloid precursor protein (APPswe) under the control of the mouse prion protein promoter. This mutant mouse strain may be useful in studies of Alzheimer's Disease.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. The MMRRC site maintains this strain where you can make a purchase.