B6Ei.129P2(C)-Cbx2^tm1Cim/EiJ

Stock number: 006002
Product name: B6Ei-cbx2
Strain synonyms: M33-

Description

Homozygous Cbx2^tm1Cim (M33-) mice exhibit skeletal malformations and lethality.

Detailed description

Homozygous Cbx2^tm1Cim (M33-) mice show greatly retarded growth, homeotic transformations of the axial skeleton, sternal and limb malformations and a failure to expand in vitro of several cell types including lymphocytes and fibroblasts. In addition, mutant mice show an aggravation of the skeletal malformations when treated to retinoic acid at embryonic day 7.5. Mutant mice develop to term and appear normal, however, most of the M33 mutant mice (90%) die within 4 weeks and the life span does not exceed 6 weeks.

Allele

Symbol: Cbx2^tm1Cim
Name: targeted mutation 1, Centre d'Immunologie de Marseille Luminy
MGI accession ID: MGI:1857631
Generation method: Targeted
Attributes: Null/Knockout
Synonyms: M33 -
Marker symbol: Cbx2
Marker name: chromobox 2
Marker synonyms: CDCA6; M33; SRXY5
Chromosome: 11
Strain of origin: 129P2/OlaHsd
Molecular note: A neomycin resistance cassette replaced exons 1-4. RT-PCR analysis confirmed the absence of the transcript in homozygous mice.