Homozygous Cbx2tm1Cim (M33-) mice show greatly retarded growth, homeotic transformations of the axial skeleton, sternal and limb malformations and a failure to expand in vitro of several cell types including lymphocytes and fibroblasts. In addition, mutant mice show an aggravation of the skeletal malformations when treated to retinoic acid at embryonic day 7.5. Mutant mice develop to term and appear normal, however, most of the M33 mutant mice (90%) die within 4 weeks and the life span does not exceed 6 weeks.

Homozygous Cbx2tm1Cim (M33-) mice exhibit skeletal malformations and lethality.

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