These transgenic mice have a tamoxifen inducible Cre-mediated recombination system driven by the mouse Plp1, proteolipid protein (myelin) 1 promoter. When crossed with a strain containing a loxP site flanked sequence of interest, the offspring are useful for generating tamoxifen-induced, Cre-mediated targeted deletions. Tamoxifen administration allows for ablation of predetermined genes in oligodendrocytes and Schwann cells, and will also induce Cre recombination in developing embryos of treated mothers and in cultured cells derived from transgenic mice.
Brian Popko, University of Chicago
| Genetic Background | Generation |
|---|---|
|
N10+N3F9
|
| Allele Type |
|---|
| Transgenic (Recombinase-expressing, Inducible) |
Starting at:
| $255.00 Domestic price for female 4-week |
| 333.51 Domestic price for breeder pair |
