At birth homozygotes have unpigmented eyes and a very light skin color. The eyes become ruby colored as the mouse matures, but the skin color remains light. The coat is a very light cream color, which is a more severe dilution than that of the original underwhite mutation.
The underwhite like mutation (uwl) arose spontaneously in the C57BL/6J colony at The Jackson Laboratory in 2004, when that strain was at F223, and has been maintained on that background ever since.
|Gene Symbol and Name||uwl, underwhite-like|
|Strain of Origin||C57BL/6J|
|General Note||The underwhite-like (uwl) mutation is thought to be a remutation to Slc45a2, and allelic to the original underwhite mutation (Slc45a2uw). However, a noncomplementation test was not done since the original underwhite mutation is only available as cryopreserved embryos.|