Hemizygous mice are viable and fertile with no anatomic abnormalities. Transgene expression is observed in aorta, heart, and brain. Transgenic dimethylarginine dimethylaminohydrolase (DDAH) activity is reflected in a reduction of plasma asymmetric dimethylarginine (ADMA). Nitric oxide synthase (NOS) activity is significantly increased in transgenic skeletal and cardiac muscle. Transgenic mice have lower blood pressure and higher heart rate. Transgenic mice may be useful in studies of atherosclerosis, hypertension, hyperlipidemia, hypercholesterolemia, hyperhomocystinemia, diabetes mellitus, stroke, renal failure, preeclampsia, and other conditions associated with vascular pathophysiology and/or cardiovascular disease.

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These hDDAH-1 mice express a transgene containing human dimethylarginine dimethylaminohydrolase-1 (DDAH-1) and exhibit a reduction of plasma asymmetric dimethylarginine and an increase in nitric oxide synthase (NOS) activity.



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C57BL/6J-Tg(ACTB-DDAH1)1Jpck/J Frozen Embryos