The targeting construct contained the "Neo555T" insert. Upon arrival, these mice had been backcrossed four generations to C57BL/6. During the importation process at The Jackson Laboratory, at least one additional backcross to C57BL/6J mice was performed. The resulting mice are backcrossed a total of at least five generations.
|Allele Name||targeted mutation 1, Deltagen|
|Allele Type||Targeted (Null/Knockout)|
|Gene Symbol and Name||Tlr2, toll-like receptor 2|
|Strain of Origin||129S1/Sv-Oca2+ Tyr+ Kitl+|
|Molecular Note||A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase.|