B6.129S1-Tlr2^tm1Dgen/J

Stock number: 005846
Product name: Tlr2 KO
Research areas: Immunology, Inflammation and Autoimmunity Research

Detailed description

This targeted mutant was created and characterized by Deltagen, Inc. View phenotypic data developed by Deltagen.

Development

The targeting construct contained the "Neo555T" insert. Upon arrival, these mice had been backcrossed four generations to C57BL/6. During the importation process at The Jackson Laboratory, at least one additional backcross to C57BL/6J mice was performed. The resulting mice are backcrossed a total of at least five generations.

Allele

Symbol: Tlr2^tm1Dgen
Name: targeted mutation 1, Deltagen
MGI accession ID: MGI:3604557
Generation method: Targeted
Attributes: Null/Knockout
Marker symbol: Tlr2
Marker name: toll-like receptor 2
Marker synonyms: CD282; Ly105; TIL4
Chromosome: 3
Strain of origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺
Molecular note: A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase.