This targeted mutant was created and characterized by Deltagen, Inc. View phenotypic data developed by Deltagen.
Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
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Targeted (Reporter, Null/Knockout) | Ptpro | protein tyrosine phosphatase, receptor type, O |
This targeted mutant was created and characterized by Deltagen, Inc. View phenotypic data developed by Deltagen.
The construct insert is reported to be "IRES-lacZ-Neo555G." Upon arrival, these mice had been backcrossed four generations to C57BL/6. During the importation process at The Jackson Laboratory, at least one additional backcross to C57BL/6J mice was performed. The resulting mice are backcrossed a total of at least five generations.
Expressed Gene | lacZ, beta-galactosidase, E. coli |
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Site of Expression | lacZ expression is detected in: brain, spinal cord, retina, heart, kidney, pituitary gland, testis, prostate gland and cervix. |
Allele Name | targeted mutation 1, Deltagen |
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Allele Type | Targeted (Reporter, Null/Knockout) |
Allele Synonym(s) | |
Gene Symbol and Name | Ptpro, protein tyrosine phosphatase, receptor type, O |
Gene Synonym(s) | |
Expressed Gene | lacZ, beta-galactosidase, E. coli |
Site of Expression | lacZ expression is detected in: brain, spinal cord, retina, heart, kidney, pituitary gland, testis, prostate gland and cervix. |
Strain of Origin | 129P2/OlaHsd |
Chromosome | 6 |
Molecular Note | A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. While RNA transcripts are detected in various organs, beta-galactosidase expression from this allele is detectable in brain, spinal cord, retina, heart, kidney, pituitary gland, testis, prostate gland and cervix. |
When using the B6.129P2-Ptprotm1Dgen/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #005832 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous or Wild-type for Ptpro<tm1Dgen> |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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