B6.129P2-Ptpro^tm1Dgen/J

Stock number: 005832
Research areas: Cardiovascular Research, Internal/Organ Research, Research Tools

Detailed description

This targeted mutant was created and characterized by Deltagen, Inc. View phenotypic data developed by Deltagen.

Development

The construct insert is reported to be "IRES-lacZ-Neo555G." Upon arrival, these mice had been backcrossed four generations to C57BL/6. During the importation process at The Jackson Laboratory, at least one additional backcross to C57BL/6J mice was performed. The resulting mice are backcrossed a total of at least five generations.

Allele

Symbol: Ptpro^tm1Dgen
Name: targeted mutation 1, Deltagen
MGI accession ID: MGI:3604600
Generation method: Targeted
Attributes: Reporter; Null/Knockout
Marker symbol: Ptpro
Marker name: protein tyrosine phosphatase, receptor type, O
Marker synonyms: D28; GLEPP1; NPHS6; PTP-BK; Ptpn15; PTP-OC; PTP-phi; PTPROt; PTPU2; PTP-U2; RPTP-BK; R-PTP-O
Chromosome: 6
Strain of origin: 129P2/OlaHsd
Expressed genes: lacZ,beta-galactosidase,E. coli
Site of expression: lacZ expression is detected in: brain, spinal cord, retina, heart, kidney, pituitary gland, testis, prostate gland and cervix.
Molecular note: A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. While RNA transcripts are detected in various organs, beta-galactosidase expression from this allele is detectable in brain, spinal cord, retina, heart, kidney, pituitary gland, testis, prostate gland and cervix.