| Allele Name | targeted mutation 1, Deltagen |
| Allele Type | Targeted (Reporter, Null/Knockout, Modified regulatory region) |
| Allele Synonym(s) | Adamts5deltacat; ts5- |
| Gene Symbol and Name | Adamts5, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) |
| Gene Synonym(s) | |
| Expressed Gene | lacZ, beta-galactosidase, E. coli |
|---|
| Site of Expression | lacZ expression is detected in: brain, spinal cord, sciatic nerve, eyes, thymus, spleen, lymph nodes, bone marrow, aorta, heart, lung, liver, pancreas, kidney, urinary bladder, thyroid gland, trachea, pituitary gland, adrenal glands, skeletal muscle, skin, testis, prostate gland, ovary, uterus and cervix. |
|---|
| Strain of Origin | 129P2/OlaHsd |
| Chromosome | 16 |
| Molecular Note | An IRES-lacZ gene was inserted into and replaced 134 nucleotides of exon 2. The deleted region includes that encoding the catalytic active site as well as most of the putative muscle regulatory factor-binding enhancer. The highest levels of RNA transcripts are detectable in pancreas, adrenal gland and white fat. Moderate levels of RNA transcripts are detectable in: olfactory bulb, heart, lung, thymus, skin, gallbladder, testis, epididymis and coagulating gland. Lower levels of RNA transcripts are also detectable in: whole brain, cortex, subcortical region, cerebellum, brainstem, spinal cord, eye, Harderian glands, liver, kidney, spleen, lymph nodes, bone marrow, urinary bladder, pituitary gland, salivary gland, skeletal muscle, tongue, stomach, small intestine, large intestine, cecum, seminal vesicle, prostate gland and uterus. LacZ expression was detected in all organs examined. |
