BKS(Cg)-calre/GrsrJ

Stock number: 005736
Product name: caracul-like recessive
Research areas: Dermatology Research, Developmental Biology Research

Description

Mice carrying this spontaneous mutation are characterized by abnormal vibrissae and progressive hair loss.

Detailed description

The curly coat of this spontaneous homozygous mutant mouse (BKS.Cg m +/+ Lepr^db /J-calre/J) is recognized at 10-12 days of age when hair is fully covering the body. At 2 weeks of age the coat of homozygous mutants looks very curly, and the mutants also have curly vibrissae. After several weeks, the curly phenotype is reduced; the hair becomes fuzzy in appearance, and the vibrissae straighten out and appear normal. Some mutant mice have no whiskers at wean age. Also, in older homozygous and heterzygous mice more whiskers are lost, and homozygous mutants lose more hair as they age. Homozygous mutant mice live normal life spans and breed normally.

Development

The calre mutation arose spontaneously in 2004 in the BKS.Cg-m +/+ Lepr^db/J strain at The Jackson Laboratory. It was maintained by sibling inbreeding for 7 generations, and backcrossed once to C57BLKS/J before embryos were generated for cryopreservation from females that were either homozygous or heterozygous and males that were homozygous.

Allele

Symbol: calre
Name: caracul-like recessive
MGI accession ID: MGI:3584007
Generation method: Spontaneous
Marker symbol: calre
Marker name: caracul-like recessive
Chromosome: 15
Strain of origin: BKS.Cg-Dock7^m +/+ Lepr^db/J