JAX
Mouse Strain Datasheet - 005732
NOD.Cg-Tg(Lck-cre)548Jxm/AchJ
Also Known As: NOD.Lck-cre
This strain expresses Cre recombinase in thymocytes and is active in T-cells during development.
Donating Investigator
Alexander Chervonsky, The University of Chicago
Genetic overview
| Genetic Background | Generation |
|---|---|
|
001289 NOD/ShiLt |
|
Tg(Lck-cre)548Jxm
| Allele Type |
|---|
| Transgenic (Recombinase-expressing) |
Detailed Description
This strain expresses Cre recombinase in thymocytes and is active in T-cells during development.
Development
The transgenic allele containing a Cre recombinase gene under the control of the Lck promoter from JR3802 - B6.Cg-Tg(Lck-cre)548Jxm/J was transferred to the NOD/Lt background through more than 10 generations of backcrossing. In 2005, the T1DR received hemizygous mice from this congenic NOD transgenic strain at generation N12.
Expression Data
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
|---|---|
| Site of Expression | thymocytes |
Control Suggestions
Selected References
- Garvin AM; Abraham KM; Forbush KA; Farr AG; Davison BL; Perlmutter RM. 1990. Disruption of thymocyte development and lymphomagenesis induced by SV40 T-antigen. Int Immunol 2(2):173-80. PubMed: 1965144MGI: J:109934
Tg(Lck-cre)548Jxm
Allele Symbol: Tg(Lck-cre)548Jxm
| Allele Name | transgene insertion 548, Jamey Marth |
|---|---|
| Allele Type | Transgenic (Recombinase-expressing) |
| Allele Synonym(s) | Lck-cre; Tg(Lck-cre); TgN(Lck-cre)548Jxm; pLck-cre |
| Gene Symbol and Name | Tg(Lck-cre)548Jxm, transgene insertion 548, Jamey Marth |
| Gene Synonym(s) | Lck-cre; Tg(Lck-cre); TgN(Lck-cre)548Jxm |
| Promoter | Lck, lymphocyte protein tyrosine kinase, mouse, laboratory |
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
| Site of Expression | thymocytes |
| Strain of Origin | (C57BL/6 x CBA)F2 |
| Chromosome | UN |
| General Note | Homozygous transgenic mice are viable and have no major defects. |
| Molecular Note | This transgene expresses Cre recombinase under the control of the mouse lck promoter, active in the T cell lineage. |
| Mutations Made By | Jamey Marth, Burnham Inst at Univ Calif Santa Barbara |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Diabetes and Obesity Research
- Type 1 Diabetes (IDDM) Analysis Strains
- NOD Transgenics
- Type 1 Diabetes (IDDM) Analysis Strains
- Research Tools
- Cre-lox System
- Cre Recombinase Expression
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
- Cre-lox System
Genotype: cre related
- Research Tools
- Cre-lox System
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
References
- Garvin AM; Abraham KM; Forbush KA; Farr AG; Davison BL; Perlmutter RM. 1990. Disruption of thymocyte development and lymphomagenesis induced by SV40 T-antigen. Int Immunol 2(2):173-80. PubMed: 1965144MGI: J:109934
Additional - Tg(Lck-cre)548Jxm related
- Azhar M; Yin M; Bommireddy R; Duffy JJ; Yang J; Pawlowski SA; Boivin GP; Engle SJ; Sanford LP; Grisham C; Singh RR; Babcock GF; Doetschman T. 2009. Generation of mice with a conditional allele for transforming growth factor beta 1 gene. Genesis 47(6):423-31. PubMed: 19415629MGI: J:150024
- Bender TP; Kremer CS; Kraus M; Buch T; Rajewsky K. 2004. Critical functions for c-Myb at three checkpoints during thymocyte development. Nat Immunol 5(7):721-9. PubMed: 15195090MGI: J:91122
- Brewer JA; Khor B; Vogt SK; Muglia LM; Fujiwara H; Haegele KE; Sleckman BP; Muglia LJ. 2003. T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation. Nat Med 9(10):1318-22. PubMed: 12949501MGI: J:97484
- Burger ML; Xue L; Sun Y; Kang C; Winoto A. 2014. Premalignant PTEN-deficient thymocytes activate microRNAs miR-146a and miR-146b as a cellular defense against malignant transformation. Blood 123(26):4089-100. PubMed: 24735967MGI: J:213748
- Carey KT; Tan KH; Ng J; Liddicoat DR; Godfrey DI; Cole TJ. 2013. Nfil3 is a glucocorticoid-regulated gene required for glucocorticoid-induced apoptosis in male murine T cells. Endocrinology 154(4):1540-52. PubMed: 23425966MGI: J:196698
- Case AJ; McGill JL; Tygrett LT; Shirasawa T; Spitz DR; Waldschmidt TJ; Legge KL; Domann FE. 2011. Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge. Free Radic Biol Med 50(3):448-58. PubMed: 21130157MGI: J:168481
- Chang X; Liu F; Wang X; Lin A; Zhao H; Su B. 2011. The Kinases MEKK2 and MEKK3 Regulate Transforming Growth Factor-beta-Mediated Helper T Cell Differentiation. Immunity 34(2):201-12. PubMed: 21333552MGI: J:168978
- Cheng HY; Gaddis DE; Wu R; McSkimming C; Haynes LD; Taylor AM; McNamara CA; Sorci-Thomas M; Hedrick CC. 2016. Loss of ABCG1 influences regulatory T cell differentiation and atherosclerosis. J Clin Invest 126(9):3236-46. PubMed: 27482882MGI: J:237255
- Cheng Y; Zhang Z; Slape C; Aplan PD. 2007. Cre-loxP-mediated recombination between the SIL and SCL genes leads to a block in T-cell development at the CD4- CD8- to CD4+ CD8+ transition. Neoplasia 9(4):315-21. PubMed: 17460775MGI: J:123860
- Cheung AM; Hande MP; Jalali F; Tsao MS; Skinnider B; Hirao A; McPherson JP; Karaskova J; Suzuki A; Wakeham A; You-Ten A; Elia A; Squire J; Bristow R; Hakem R; Mak TW. 2002. Loss of Brca2 and p53 Synergistically Promotes Genomic Instability and Deregulation of T-cell Apoptosis. Cancer Res 62(21):6194-204. PubMed: 12414647MGI: J:79697
- Choi YI; Duke-Cohan JS; Chen W; Liu B; Rossy J; Tabarin T; Ju L; Gui J; Gaus K; Zhu C; Reinherz EL. 2014. Dynamic control of beta1 integrin adhesion by the plexinD1-sema3E axis. Proc Natl Acad Sci U S A 111(1):379-84. PubMed: 24344262MGI: J:206292
- Choi YI; Duke-Cohan JS; Tan J; Gui J; Singh MK; Epstein JA; Reinherz EL. 2013. Plxnd1 expression in thymocytes regulates their intrathymic migration while that in thymic endothelium impacts medullary topology. Front Immunol 4:392. PubMed: 24312099MGI: J:206838
- Cully M; Elia A; Ong SH; Stambolic V; Pawson T; Tsao MS; Mak TW. 2004. grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten+/- mice. Proc Natl Acad Sci U S A 101(43):15358-63. PubMed: 15492213MGI: J:93530
- Davila SJ; Olive AJ; Starnbach MN. 2014. Integrin alpha4beta1 is necessary for CD4+ T cell-mediated protection against genital Chlamydia trachomatis infection. J Immunol 192(9):4284-93. PubMed: 24659687MGI: J:209989
- Delfino DV; Spinicelli S; Pozzesi N; Pierangeli S; Velardi E; Bruscoli S; Martelli MP; Pettirossi V; Falchi L; Kang TB; Riccardi C. 2011. Glucocorticoid-induced activation of caspase-8 protects the glucocorticoid-induced protein Gilz from proteasomal degradation and induces its binding to SUMO-1 in murine thymocytes. Cell Death Differ 18(1):183-90. PubMed: 20671745MGI: J:186338
- Dougan SK; Rava P; Hussain MM; Blumberg RS. 2007. MTP regulated by an alternate promoter is essential for NKT cell development. J Exp Med 204(3):533-45. PubMed: 17312007MGI: J:125365
- Dufner A; Kisser A; Niendorf S; Basters A; Reissig S; Schonle A; Aichem A; Kurz T; Schlosser A; Yablonski D; Groettrup M; Buch T; Waisman A; Schamel WW; Prinz M; Knobeloch KP. 2015. The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells. Nat Immunol 16(9):950-60. PubMed: 26214742MGI: J:233111
- Dzhagalov I; Dunkle A; He YW. 2008. The anti-apoptotic Bcl-2 family member Mcl-1 promotes T lymphocyte survival at multiple stages. J Immunol 181(1):521-8. PubMed: 18566418MGI: J:137400
- Eddahri F; Denanglaire S; Bureau F; Spolski R; Leonard WJ; Leo O; Andris F. 2009. Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities. Blood 113(11):2426-33. PubMed: 19020307MGI: J:146334
- Elftman MD; Hunzeker JT; Mellinger JC; Bonneau RH; Norbury CC; Truckenmiller ME. 2010. Stress-induced glucocorticoids at the earliest stages of herpes simplex virus-1 infection suppress subsequent antiviral immunity, implicating impaired dendritic cell function. J Immunol 184(4):1867-75. PubMed: 20089700MGI: J:159473
- Feng D; Dai S; Liu F; Ohtake Y; Zhou Z; Wang H; Zhang Y; Kearns A; Peng X; Zhu F; Hayat U; Li M; He Y; Xu M; Zhao C; Cheng M; Zhang L; Wang H; Yang X; Ju C; Bryda EC; Gordon J; Khalili K; Hu W; Li S; Qin X; Gao B. 2016. Cre-inducible human CD59 mediates rapid cell ablation after intermedilysin administration. J Clin Invest 126(6):2321-33. PubMed: 27159394MGI: J:237074
- Fukuyama T; Kasper LH; Boussouar F; Jeevan T; van Deursen J; Brindle PK. 2009. Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T-cell development. Mol Cell Biol 29(14):3894-904. PubMed: 19433445MGI: J:150146
- Gaudreau MC; Heyd F; Bastien R; Wilhelm B; Moroy T. 2012. Alternative splicing controlled by heterogeneous nuclear ribonucleoprotein L regulates development, proliferation, and migration of thymic pre-T cells. J Immunol 188(11):5377-88. PubMed: 22523384MGI: J:188749
- Gay D; Kwon O; Zhang Z; Spata M; Plikus MV; Holler PD; Ito M; Yang Z; Treffeisen E; Kim CD; Nace A; Zhang X; Baratono S; Wang F; Ornitz DM; Millar SE; Cotsarelis G. 2013. Fgf9 from dermal gammadelta T cells induces hair follicle neogenesis after wounding. Nat Med 19(7):916-23. PubMed: 23727932MGI: J:199838
- Gebuhr TC; Kovalev GI; Bultman S; Godfrey V; Su L; Magnuson T. 2003. The role of Brg1, a catalytic subunit of mammalian chromatin-remodeling complexes, in T cell development. J Exp Med 198(12):1937-49. PubMed: 14676303MGI: J:87219
- Genetic Resource Science at The Jackson Laboratory. 2012. Expression/Specificity Patterns of Cre Alleles, 2011 Direct Data Submission from Genetic Resource Science :. MGI: J:184578
- Guo F; Hildeman D; Tripathi P; Velu CS; Grimes HL; Zheng Y. 2010. Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis. Proc Natl Acad Sci U S A 107(43):18505-10. PubMed: 20937872MGI: J:165512
- Guo L; Zheng Z; Ai J; Howatt DA; Mittelstadt PR; Thacker S; Daugherty A; Ashwell JD; Remaley AT; Li XA. 2014. Scavenger receptor BI and high-density lipoprotein regulate thymocyte apoptosis in sepsis. Arterioscler Thromb Vasc Biol 34(5):966-75. PubMed: 24603680MGI: J:222905
- Hayakawa M; Hayakawa H; Petrova T; Ritprajak P; Sutavani RV; Jimenez-Andrade GY; Sano Y; Choo MK; Seavitt J; Venigalla RK; Otsu K; Georgopoulos K; Arthur JS; Park JM. 2017. Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction. J Biol Chem 292(5):1762-1772. PubMed: 28011639MGI: J:240712
- He MX; He YW. 2013. A role for c-FLIP(L) in the regulation of apoptosis, autophagy, and necroptosis in T lymphocytes. Cell Death Differ 20(2):188-97. PubMed: 23175183MGI: J:205617
- Hennet T; Hagen FK; Tabak LA; Marth JD. 1995. T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination. Proc Natl Acad Sci U S A 92(26):12070-4. PubMed: 8618846MGI: J:67674
- Herroeder S; Reichardt P; Sassmann A; Zimmermann B; Jaeneke D; Hoeckner J; Hollmann MW; Fischer KD; Vogt S; Grosse R; Hogg N; Gunzer M; Offermanns S; Wettschureck N. 2009. Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility. Immunity 30(5):708-20. PubMed: 19409815MGI: J:149560
- Hock H; Meade E; Medeiros S; Schindler JW; Valk PJ; Fujiwara Y; Orkin SH. 2004. Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. Genes Dev 18(19):2336-41. PubMed: 15371326MGI: J:93052
- Huang X; Ren L; Ye P; Cheng C; Wu J; Wang S; Sun Y; Liu Z; Xie A; Xia J. 2014. Peroxisome proliferator-activated receptor gamma deficiency in T cells accelerates chronic rejection by influencing the differentiation of CD4+ T cells and alternatively activated macrophages. PLoS One 9(11):e112953. PubMed: 25383620MGI: J:225311
- Jia W; He YW. 2011. Temporal regulation of intracellular organelle homeostasis in T lymphocytes by autophagy. J Immunol 186(9):5313-22. PubMed: 21421856MGI: J:172749
- Jia W; Pua HH; Li QJ; He YW. 2011. Autophagy regulates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes. J Immunol 186(3):1564-74. PubMed: 21191072MGI: J:168905
- Jin J; Desai BN; Navarro B; Donovan A; Andrews NC; Clapham DE. 2008. Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science 322(5902):756-60. PubMed: 18974357MGI: J:140630
- Kasper LH; Fukuyama T; Biesen MA; Boussouar F; Tong C; de Pauw A; Murray PJ; van Deursen JM; Brindle PK. 2006. Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development. Mol Cell Biol 26(3):789-809. PubMed: 16428436MGI: J:105505
- Kasper LH; Fukuyama T; Brindle PK. 2014. T-cells null for the MED23 subunit of mediator express decreased levels of KLF2 and inefficiently populate the peripheral lymphoid organs. PLoS One 9(7):e102076. PubMed: 25054639MGI: J:217860
- Khandanpour C; Phelan JD; Vassen L; Schutte J; Chen R; Horman SR; Gaudreau MC; Krongold J; Zhu J; Paul WE; Duhrsen U; Gottgens B; Grimes HL; Moroy T. 2013. Growth factor independence 1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia. Cancer Cell 23(2):200-14. PubMed: 23410974MGI: J:194309
- King CG; Kobayashi T; Cejas PJ; Kim T; Yoon K; Kim GK; Chiffoleau E; Hickman SP; Walsh PT; Turka LA; Choi Y. 2006. TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis. Nat Med 12(9):1088-92. PubMed: 16921377MGI: J:131909
- Kirkland D; Benson A; Mirpuri J; Pifer R; Hou B; Defranco AL; Yarovinsky F. 2012. B Cell-Intrinsic MyD88 Signaling Prevents the Lethal Dissemination of Commensal Bacteria during Colonic Damage. Immunity 36(2):228-38. PubMed: 22306056MGI: J:181331
- Kishimoto H; Ohteki T; Yajima N; Kawahara K; Natsui M; Kawarasaki S; Hamada K; Horie Y; Kubo Y; Arase S; Taniguchi M; Vanhaesebroeck B; Mak TW; Nakano T; Koyasu S; Sasaki T; Suzuki A. 2007. The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells. Blood 109(8):3316-24. PubMed: 17170126MGI: J:145339
- Konkel JE; Maruyama T; Carpenter AC; Xiong Y; Zamarron BF; Hall BE; Kulkarni AB; Zhang P; Bosselut R; Chen W. 2011. Control of the development of CD8alphaalpha(+) intestinal intraepithelial lymphocytes by TGF-beta. Nat Immunol 12(4):312-9. PubMed: 21297643MGI: J:170346
- Kosaka A; Ohkuri T; Ikeura M; Kohanbash G; Okada H. 2015. Transgene-derived overexpression of miR-17-92 in CD8+ T-cells confers enhanced cytotoxic activity. Biochem Biophys Res Commun 458(3):549-54. PubMed: 25677619MGI: J:220491
- Krajewska M; You Z; Rong J; Kress C; Huang X; Yang J; Kyoda T; Leyva R; Banares S; Hu Y; Sze CH; Whalen MJ; Salmena L; Hakem R; Head BP; Reed JC; Krajewski S. 2011. Neuronal deletion of caspase 8 protects against brain injury in mouse models of controlled cortical impact and kainic acid-induced excitotoxicity. PLoS One 6(9):e24341. PubMed: 21957448MGI: J:177668
- Kugler DG; Mittelstadt PR; Ashwell JD; Sher A; Jankovic D. 2013. CD4+ T cells are trigger and target of the glucocorticoid response that prevents lethal immunopathology in toxoplasma infection. J Exp Med 210(10):1919-27. PubMed: 23980098MGI: J:202852
- Lassen LB; Fuchtbauer A; Schmitz A; Sorensen AB; Pedersen FS; Fuchtbauer EM. 2013. Septin9 is involved in T-cell development and CD8+ T-cell homeostasis. Cell Tissue Res 352(3):695-705. PubMed: 23644740MGI: J:205027
- Lieu YK; Kumar A; Pajerowski AG; Rogers TJ; Reddy EP. 2004. Requirement of c-myb in T cell development and in mature T cell function. Proc Natl Acad Sci U S A 101(41):14853-8. PubMed: 15466706MGI: J:93481
- Liu HH; Xie M; Schneider MD; Chen ZJ. 2006. Essential role of TAK1 in thymocyte development and activation. Proc Natl Acad Sci U S A 103(31):11677-82. PubMed: 16857737MGI: J:111794
- Liu Y; Zhang P; Li J; Kulkarni AB; Perruche S; Chen W. 2008. A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells. Nat Immunol 9(6):632-40. PubMed: 18438410MGI: J:136291
- Luche H; Nageswara Rao T; Kumar S; Tasdogan A; Beckel F; Blum C; Martins VC; Rodewald HR; Fehling HJ. 2013. In vivo fate mapping identifies pre-TCRalpha expression as an intra- and extrathymic, but not prethymic, marker of T lymphopoiesis. J Exp Med 210(4):699-714. PubMed: 23509324MGI: J:197923
- Luche H; Weber O; Nageswara Rao T; Blum C; Fehling HJ. 2007. Faithful activation of an extra-bright red fluorescent protein in 'knock-in' Cre-reporter mice ideally suited for lineage tracing studies. Eur J Immunol 37(1):43-53. PubMed: 17171761MGI: J:117041
- Mak TW; Hakem A; McPherson JP; Shehabeldin A; Zablocki E; Migon E; Duncan GS; Bouchard D; Wakeham A; Cheung A; Karaskova J; Sarosi I; Squire J; Marth J; Hakem R. 2000. Brcal required for T cell lineage development but not TCR loci rearrangement. Nat Immunol 1(1):77-82. PubMed: 10881179MGI: J:63282
- Mao X; Fujiwara Y; Chapdelaine A; Yang H; Orkin SH. 2001. Activation of EGFP expression by cre-mediated excision in a new ROSA26 reporter mouse strain Blood 97(1):324-6. PubMed: 11133778MGI: J:66742
- Maresz K; Pryce G; Ponomarev ED; Marsicano G; Croxford JL; Shriver LP; Ledent C; Cheng X; Carrier EJ; Mann MK; Giovannoni G; Pertwee RG; Yamamura T; Buckley NE; Hillard CJ; Lutz B; Baker D; Dittel BN. 2007. Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells. Nat Med 13(4):492-7. PubMed: 17401376MGI: J:129619
- Masson F; Ghisi M; Groom JR; Kallies A; Seillet C; Johnstone RW; Nutt SL; Belz GT. 2014. Id2 represses E2A-mediated activation of IL-10 expression in T cells. Blood 123(22):3420-8. PubMed: 24723679MGI: J:213132
- Masson F; Minnich M; Olshansky M; Bilic I; Mount AM; Kallies A; Speed TP; Busslinger M; Nutt SL; Belz GT. 2013. Id2-Mediated Inhibition of E2A Represses Memory CD8+ T Cell Differentiation. J Immunol 190(9):4585-94. PubMed: 23536629MGI: J:195516
- McPherson JP; Hande MP; Poonepalli A; Lemmers B; Zablocki E; Migon E; Shehabeldin A; Porras A; Karaskova J; Vukovic B; Squire J; Hakem R. 2006. A role for Brca1 in chromosome end maintenance. Hum Mol Genet 15(6):831-8. PubMed: 16446310MGI: J:106759
- McPherson JP; Lemmers B; Hirao A; Hakem A; Abraham J; Migon E; Matysiak-Zablocki E; Tamblyn L; Sanchez-Sweatman O; Khokha R; Squire J; Hande MP; Mak TW; Hakem R. 2004. Collaboration of Brca1 and Chk2 in tumorigenesis. Genes Dev 18(10):1144-53. PubMed: 15131084MGI: J:90512
- Mei Y; Zhang Y; Yamamoto K; Xie W; Mak TW; You H. 2009. FOXO3a-dependent regulation of Pink1 (Park6) mediates survival signaling in response to cytokine deprivation. Proc Natl Acad Sci U S A 106(13):5153-8. PubMed: 19276113MGI: J:147146
- Mittelstadt PR; Monteiro JP; Ashwell JD. 2012. Thymocyte responsiveness to endogenous glucocorticoids is required for immunological fitness. J Clin Invest 122(7):2384-94. PubMed: 22653054MGI: J:189951
- Miwa T; Zhou L; Kimura Y; Kim D; Bhandoola A; Song WC. 2009. Complement-dependent T-cell lymphopenia caused by thymocyte deletion of the membrane complement regulator Crry. Blood 113(12):2684-94. PubMed: 19136662MGI: J:146538
- Mkhikian H; Mortales CL; Zhou RW; Khachikyan K; Wu G; Haslam SM; Kavarian P; Dell A; Demetriou M. 2016. Golgi self-correction generates bioequivalent glycans to preserve cellular homeostasis. Elife 5:. PubMed: 27269286MGI: J:234082
- Nair VS; Oh KI. 2014. Down-regulation of Tet2 prevents TSDR demethylation in IL2 deficient regulatory T cells. Biochem Biophys Res Commun 450(1):918-24. PubMed: 24984151MGI: J:220146
- Newman DM; Sakaguchi S; Lun A; Preston S; Pellegrini M; Khamina K; Bergthaler A; Nutt SL; Smyth GK; Voss AK; Thomas T; Ellmeier W; Belz GT; Allan RS. 2016. Acetylation of the Cd8 Locus by KAT6A Determines Memory T Cell Diversity. Cell Rep 16(12):3311-21. PubMed: 27653692MGI: J:239117
- Nguyen TV; Ke Y; Zhang EE; Feng GS. 2006. Conditional deletion of Shp2 tyrosine phosphatase in thymocytes suppresses both pre-TCR and TCR signals. J Immunol 177(9):5990-6. PubMed: 17056523MGI: J:140530
- O'Donnell N; Zachara NE; Hart GW; Marth JD. 2004. Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viability. Mol Cell Biol 24(4):1680-90. PubMed: 14749383MGI: J:93112
- Pan L; Bradney C; Zheng B; Zhuang Y. 2004. Altered T-dependent antigen responses and development of autoimmune symptoms in mice lacking E2A in T lymphocytes. Immunology 111(2):147-54. PubMed: 15027899MGI: J:88415
- Panattoni M; Sanvito F; Basso V; Doglioni C; Casorati G; Montini E; Bender JR; Mondino A; Pardi R. 2008. Targeted inactivation of the COP9 signalosome impairs multiple stages of T cell development. J Exp Med 205(2):465-77. PubMed: 18268034MGI: J:132114
- Park YJ; Woo M; Kieffer TJ; Hakem R; Safikhan N; Yang F; Ao Z; Warnock GL; Marzban L. 2014. The role of caspase-8 in amyloid-induced beta cell death in human and mouse islets. Diabetologia 57(4):765-75. PubMed: 24442508MGI: J:209495
- Perruche S; Zhang P; Maruyama T; Bluestone JA; Saas P; Chen W. 2009. Lethal effect of CD3-specific antibody in mice deficient in TGF-beta1 by uncontrolled flu-like syndrome. J Immunol 183(2):953-61. PubMed: 19561097MGI: J:151662
- Pioli PD; Dahlem TJ; Weis JJ; Weis JH. 2013. Deletion of Snai2 and Snai3 results in impaired physical development compounded by lymphocyte deficiency. PLoS One 8(7):e69216. PubMed: 23874916MGI: J:204710
- Qiu Z; Song C; Malakouti N; Murray D; Hariz A; Zimmerman M; Gygax D; Alhazmi A; Landry JW. 2015. Functional interactions between NURF and Ctcf regulate gene expression. Mol Cell Biol 35(1):224-37. PubMed: 25348714MGI: J:224312
- Raetz M; Hwang SH; Wilhelm CL; Kirkland D; Benson A; Sturge CR; Mirpuri J; Vaishnava S; Hou B; Defranco AL; Gilpin CJ; Hooper LV; Yarovinsky F. 2013. Parasite-induced T(H)1 cells and intestinal dysbiosis cooperate in IFN-gamma-dependent elimination of Paneth cells. Nat Immunol 14(2):136-42. PubMed: 23263554MGI: J:192614
- Raynor J; Sholl A; Plas DR; Bouillet P; Chougnet CA; Hildeman DA. 2013. IL-15 Fosters Age-Driven Regulatory T Cell Accrual in the Face of Declining IL-2 Levels. Front Immunol 4:161. PubMed: 23805138MGI: J:208318
- Rebholz B; Haase I; Eckelt B; Paxian S; Flaig MJ; Ghoreschi K; Nedospasov SA; Mailhammer R; Debey-Pascher S; Schultze JL; Weindl G; Forster I; Huss R; Stratis A; Ruzicka T; Rocken M; Pfeffer K; Schmid RM; Rupec RA. 2007. Crosstalk between Keratinocytes and Adaptive Immune Cells in an IkappaBalpha Protein-Mediated Inflammatory Disease of the Skin. Immunity 27(2):296-307. PubMed: 17692539MGI: J:124343
- Ritprajak P; Hayakawa M; Sano Y; Otsu K; Park JM. 2012. Cell type-specific targeting dissociates the therapeutic from the adverse effects of protein kinase inhibition in allergic skin disease. Proc Natl Acad Sci U S A 109(23):9089-94. PubMed: 22615377MGI: J:184745
- Roy SG; Stevens MW; So L; Edinger AL. 2013. Reciprocal effects of rab7 deletion in activated and neglected T cells. Autophagy 9(7):1009-23. PubMed: 23615463MGI: J:211733
- Saba I; Kosan C; Vassen L; Moroy T. 2011. IL-7R-dependent survival and differentiation of early T-lineage progenitors is regulated by the BTB/POZ domain transcription factor Miz-1. Blood 117(12):3370-81. PubMed: 21258009MGI: J:170508
- Sag D; Cekic C; Wu R; Linden J; Hedrick CC. 2015. The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity. Nat Commun 6:6354. PubMed: 25724068MGI: J:221785
- Sagiv Y; Bai L; Wei DG; Agami R; Savage PB; Teyton L; Bendelac A. 2007. A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d. J Exp Med 204(4):921-8. PubMed: 17403933MGI: J:125608
- Salmena L; Hakem R. 2005. Caspase-8 deficiency in T cells leads to a lethal lymphoinfiltrative immune disorder. J Exp Med 202(6):727-32. PubMed: 16157684MGI: J:107455
- Salmena L; Lemmers B; Hakem A; Matysiak-Zablocki E; Murakami K; Au PY; Berry DM; Tamblyn L; Shehabeldin A; Migon E; Wakeham A; Bouchard D; Yeh WC; McGlade JC; Ohashi PS; Hakem R. 2003. Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity. Genes Dev 17(7):883-95. PubMed: 12654726MGI: J:82759
- Sano Y; Park JM. 2014. Loss of epidermal p38alpha signaling prevents UVR-induced inflammation via acute and chronic mechanisms. J Invest Dermatol 134(8):2231-40. PubMed: 24662766MGI: J:212839
- Schmedt C; Tarakhovsky A. 2001. Autonomous maturation of alpha/beta T lineage cells in the absence of COOH-terminal Src kinase (Csk). J Exp Med 193(7):815-26. PubMed: 11283154MGI: J:120548
- Shannon LA; McBurney TM; Wells MA; Roth ME; Calloway PA; Bill CA; Islam S; Vines CM. 2012. CCR7/CCL19 controls expression of EDG-1 in T cells. J Biol Chem 287(15):11656-64. PubMed: 22334704MGI: J:211764
- Shui JW; Hu MC; Tan TH. 2007. Conditional knockout mice reveal an essential role of protein phosphatase 4 in thymocyte development and pre-T-cell receptor signaling. Mol Cell Biol 27(1):79-91. PubMed: 17060460MGI: J:117684
- Stephensen CB; Borowsky AD; Lloyd KC. 2007. Disruption of Rxra gene in thymocytes and T lymphocytes modestly alters lymphocyte frequencies, proliferation, survival and T helper type 1/type 2 balance. Immunology 121(4):484-98. PubMed: 17433077MGI: J:125537
- Stranges PB; Watson J; Cooper CJ; Choisy-Rossi CM; Stonebraker AC; Beighton RA; Hartig H; Sundberg JP; Servick S; Kaufmann G; Fink PJ; Chervonsky AV. 2007. Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity. Immunity 26(5):629-41. PubMed: 17509906MGI: J:123556
- Suliman S; Tan J; Xu K; Kousis PC; Kowalski PE; Chang G; Egan SE; Guidos C. 2011. Notch3 is dispensable for thymocyte beta-selection and Notch1-induced T cell leukemogenesis. PLoS One 6(9):e24937. PubMed: 21931869MGI: J:177688
- Suzuki A; Nakano T; Mak TW; Sasaki T. 2008. Portrait of PTEN: messages from mutant mice. Cancer Sci 99(2):209-13. PubMed: 18201277MGI: J:142484
- Suzuki A; Yamaguchi MT; Ohteki T; Sasaki T; Kaisho T; Kimura Y; Yoshida R; Wakeham A; Higuchi T; Fukumoto M; Tsubata T; Ohashi PS; Koyasu S; Penninger JM; Nakano T; Mak TW. 2001. T cell-specific loss of pten leads to defects in central and peripheral tolerance. Immunity 14(5):523-34. PubMed: 11371355MGI: J:69471
- Talbot S; Abdulnour RE; Burkett PR; Lee S; Cronin SJ; Pascal MA; Laedermann C; Foster SL; Tran JV; Lai N; Chiu IM; Ghasemlou N; DiBiase M; Roberson D; Von Hehn C; Agac B; Haworth O; Seki H; Penninger JM; Kuchroo VK; Bean BP; Levy BD; Woolf CJ. 2015. Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation. Neuron 87(2):341-54. PubMed: 26119026MGI: J:227431
- Ueda T; Sasaki M; Elia AJ; Chio II; Hamada K; Fukunaga R; Mak TW. 2010. Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development. Proc Natl Acad Sci U S A 107(32):13984-90. PubMed: 20679220MGI: J:163707
- Varanasi V; Khan AA; Chervonsky AV. 2014. Loss of the death receptor CD95 (Fas) expression by dendritic cells protects from a chronic viral infection. Proc Natl Acad Sci U S A 111(23):8559-64. PubMed: 24912151MGI: J:211624
- Ventura A; Meissner A; Dillon CP; McManus M; Sharp PA; Van Parijs L; Jaenisch R; Jacks T. 2004. Cre-lox-regulated conditional RNA interference from transgenes. Proc Natl Acad Sci U S A 101(28):10380-5. PubMed: 15240889MGI: J:129426
- Wang HC; Peng V; Zhao Y; Sun XH. 2012. Enhanced Notch activation is advantageous but not essential for T cell lymphomagenesis in Id1 transgenic mice. PLoS One 7(2):e32944. PubMed: 22393458MGI: J:185287
- Wang X; Chang X; Facchinetti V; Zhuang Y; Su B. 2009. MEKK3 is essential for lymphopenia-induced T cell proliferation and survival. J Immunol 182(6):3597-608. PubMed: 19265138MGI: J:145923
- Wang X; Zhang F; Chen F; Liu D; Zheng Y; Zhang Y; Dong C; Su B. 2011. MEKK3 regulates IFN-gamma production in T cells through the Rac1/2-dependent MAPK cascades. J Immunol 186(10):5791-800. PubMed: 21471448MGI: J:173095
- Weischenfeldt J; Damgaard I; Bryder D; Theilgaard-Monch K; Thoren LA; Nielsen FC; Jacobsen SE; Nerlov C; Porse BT. 2008. NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements. Genes Dev 22(10):1381-96. PubMed: 18483223MGI: J:134765
- Wong GW; Knowles GC; Mak TW; Ferrando AA; Zuniga-Pflucker JC. 2012. HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRbeta-selected mouse thymocytes. Blood 120(7):1439-48. PubMed: 22649105MGI: J:189112
- Woolfenden S; Zhu H; Charest A. 2009. A Cre/LoxP conditional luciferase reporter transgenic mouse for bioluminescence monitoring of tumorigenesis. Genesis 47(10):659-666. PubMed: 19603508MGI: J:153565
- Xue L; Chiang L; He B; Zhao YY; Winoto A. 2010. FoxM1, a forkhead transcription factor is a master cell cycle regulator for mouse mature T cells but not double positive thymocytes. PLoS One 5(2):e9229. PubMed: 20169079MGI: J:157994
- Xue L; Nolla H; Suzuki A; Mak TW; Winoto A. 2008. Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice. Proc Natl Acad Sci U S A 105(6):2022-7. PubMed: 18250301MGI: J:131807
- Yi Z; Stunz LL; Bishop GA. 2013. TNF receptor associated factor 3 plays a key role in development and function of invariant natural killer T cells. J Exp Med 210(6):1079-86. PubMed: 23650438MGI: J:200964
- You H; Pellegrini M; Tsuchihara K; Yamamoto K; Hacker G; Erlacher M; Villunger A; Mak TW. 2006. FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal. J Exp Med 203(7):1657-63. PubMed: 16801400MGI: J:124403
- Young JA; Becker AM; Medeiros JJ; Shapiro VS; Wang A; Farrar JD; Quill TA; van Huijsduijnen RH; van Oers NS. 2008. The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functions. Mol Immunol 45(14):3756-66. PubMed: 18614237MGI: J:138871
- Zhang N; He YW. 2005. The antiapoptotic protein Bcl-xL is dispensable for the development of effector and memory T lymphocytes. J Immunol 174(11):6967-73. PubMed: 15905539MGI: J:99012
- Zhang N; He YW. 2005. An essential role for c-FLIP in the efficient development of mature T lymphocytes. J Exp Med 202(3):395-404. PubMed: 16043517MGI: J:100558
- Zhang N; Hopkins K; He YW. 2008. The long isoform of cellular FLIP is essential for T lymphocyte proliferation through an NF-kappaB-independent pathway. J Immunol 180(8):5506-11. PubMed: 18390734MGI: J:134252
- Zheng L; Njauw CN; Martins-Green M. 2007. A hCXCR1 transgenic mouse model containing a conditional color-switching system for imaging of hCXCL8/IL-8 functions in vivo. J Leukoc Biol 82(5):1247-56. PubMed: 17704296MGI: J:127327
- Zhu M; Koonpaew S; Liu Y; Shen S; Denning T; Dzhagalov I; Rhee I; Zhang W. 2006. Negative regulation of T cell activation and autoimmunity by the transmembrane adaptor protein LAB. Immunity 25(5):757-68. PubMed: 17081783MGI: J:116157