Mice homozygous for the sharkey mutation on this predominantly C57BL/6J background have both upper and lower supernumerary incisors with separate roots for the extra teeth. When outcrossed to CAST/EiJ the F2 only have upper supernumerary incisors.
The sharkey (shk) mutation arose spontaneously in a C57BL/6J congenic strain homozygous for the NOD derived H2g7 and carrying a transgene. This transgene has been bred out of this strain, but the strain remains homozygous for H2g7. This mutant subline has been maintained by sibling intercrossing sharkey phenotypic homozygotes and unaffected heterozygotes. In 2007 this strain reached generation F8.
|Allele Name||g7 variant|
|Allele Type||Not Applicable|
|Allele Synonym(s)||H-2g7; H-2g7|
|Gene Symbol and Name||H2, histocompatibility-2, MHC|
|Strain of Origin||Not Applicable|
|General Note||The g7 variant has been observed in the following strains: DBR7, NON.NOD-H2g7|
|Gene Symbol and Name||Sostdc1, sclerostin domain containing 1|
|Strain of Origin||B6.NOD-H2g7|
|Molecular Note||A single base pair deletion in exon 2 results in the introduction of a premature stop codon.|
Homozygotes must have their teeth trimmed and attention must be paid to their ability to eat. The rate of supernumery tooth growth varies within the strain, with the most affected homozygotes requiring tooth trimming approximately once per week. In addition to standard food pellets, ground food should be supplied in the cage.
When using the sharkey mouse strain in a publication, please cite the originating article(s) and include JAX stock #005717 in your Materials and Methods section.