JAX Mouse Strain Datasheet - 005703

B6.Cg-Tg(ACTFLPe)9205Dym/J

Stock No:: 005703 |; ACTB:FLPe B6J

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Overview

Also Known As: ACTB:FLPe B6J

ACTBFLPe mice are useful for deletion of Frt-flanked genes in a variety of tissues including spinal cord, heart, gonad, and adrenal gland.

Donating Investigator

IMR Colony, The Jackson Laboratory

Genetic overview

Genetic Background	Generation
	N11F9 (07-APR-17)

Tg(ACTFLPe)9205Dym

Allele Type
Transgenic (Recombinase-expressing)

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Research Applications

Research Tools

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Base Price

Starting at:

$246.50 Domestic price for female

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Details

Detailed Description

This transgenic strain expresses a variant of the Saccharomyces cerevisiae FLP1 recombinase gene under the direction of the human ACTB promoter. The FLPe recombinase variant exhibits enhanced thermostability with recombination activity being four-fold and ten-fold that of wildtype FLP at 37^oC and 40^oC, respectively. Mice that are hemizygous for the transgenic allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Recombinase activity is detected in a wide variety of tissues (spinal cord, heart, gonad, adrenal) as early as embryonic day 10.5. This deleter strain is a suitable alternative to, and complement with the Cre-loxP system for in vivo genetic engineering.

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

Development

A transgenic construct containing a FLP1 recombinase variant controlled by the human ACTB promoter (3 kb flanking sequence, 78-bp 5' untranslated region, 832-bp of exon 1) was injected into fertilized eggs from B6SJLF2 mice. Founder animals were obtained and crossed with C57BL/6J mice for at least 5 generations (see SNP note below).

A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. Markers on Chromosomes 11 and 13 are segregating.

Expression Data

Expressed Gene	FLP, FLP recombinase, Saccharomyces cerevisiae
Site of Expression	expression of the enhanced FLP1 recombinase variant (FLPe) is detected in a wide variety of tissues (spinal cord, heart, gonad, adrenal) as early as embryonic day 10.5

Control Suggestions

000664 C57BL/6J

Additional Information

Considerations for Choosing Controls

Selected References

Rodriguez CI; Buchholz F; Galloway J; Sequerra R; Kasper J; Ayala R; Stewart AF; Dymecki SM. 2000. High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP. Nat Genet 25(2):139-40. PubMed: 10835623 MGI: J:78660

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Genetics

Tg(ACTFLPe)9205Dym

Allele Symbol: Tg(ACTFLPe)9205Dym

Allele Name	transgene insertion 9205, Susan Dymecki
Allele Type	Transgenic (Recombinase-expressing)
Allele Synonym(s)	ACT-FLPe; ACTB-Flpe; ACTB::FLPe; ACTB:FLPe; ACTFlpe; CAGG-Flpr; CAGGS-flp; FLPe; Flp; Flp deleter; Tg (ACTFLEe)9205Dym; Tg(ACTB-FlpE)9205Dym; TgaFlpe; TgpCAG-flpe; actin-FLPe; beta-actinFLPe; hACTB-FLPe; hACTB::FLPe
Gene Symbol and Name	Tg(ACTFLPe)9205Dym, transgene insertion 9205, Susan Dymecki
Gene Synonym(s)	ACT-FLPe; ACTB:FLPe; CAGG-Flpr; FLPe; Flp; Flp deleter; TgpCAG-flpe; actin-FLPe; beta-actinFLPe; hACTB-FLPe; hACTB::FLPe
Promoter	ACTB, actin beta, human
Expressed Gene	FLP, FLP recombinase, Saccharomyces cerevisiae
Site of Expression	expression of the enhanced FLP1 recombinase variant (FLPe) is detected in a wide variety of tissues (spinal cord, heart, gonad, adrenal) as early as embryonic day 10.5
Strain of Origin	(C57BL/6 x SJL)F2
Chromosome	UN
General Note	The FLPe recombinase variant exhibits enhanced thermostability with recombination activity being 4X and 10X that of wildtype FLP at 37�C and 40�C, respectively. Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.
Molecular Note	Sequence encoding FLP1 was adjoined to human ACTB promoter sequence, including 3 kb of promoter sequence and an 0.8 kb portion of exon 1. The promoter region drives expression in the germline. Recombinase activity is detected in a wide variety of tissues (spinal cord, heart, gonad, adrenal) as early as embryonic day 10.5.
Mutations Made By	Susan Dymecki, Harvard Medical School

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Research Tools
- FLP-FRT System
  - FLP Recombinase Expression
  - FLP Recombinase Expression: Germline/Embryonic Expression
- Genetics Research
  - Mutagenesis and Transgenesis
  - Mutagenesis and Transgenesis: FLP recombinase

Genotype: FLP related

Research Tools
- Genetics Research
  - Mutagenesis and Transgenesis
  - Mutagenesis and Transgenesis: FLP recombinase

References

Rodriguez CI; Buchholz F; Galloway J; Sequerra R; Kasper J; Ayala R; Stewart AF; Dymecki SM. 2000. High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP. Nat Genet 25(2):139-40. PubMed: 10835623 MGI: J:78660

Additional - Tg(ACTFLPe)9205Dym related

Aanhaanen WT; Brons JF; Dominguez JN; Rana MS; Norden J; Airik R; Wakker V; de Gier-de Vries C; Brown NA; Kispert A; Moorman AF; Christoffels VM. 2009. The Tbx2+ primary myocardium of the atrioventricular canal forms the atrioventricular node and the base of the left ventricle. Circ Res 104(11):1267-74. PubMed: 19423846 MGI: J:155719
Acton SE; Farrugia AJ; Astarita JL; Mourao-Sa D; Jenkins RP; Nye E; Hooper S; van Blijswijk J; Rogers NC; Snelgrove KJ; Rosewell I; Moita LF; Stamp G; Turley SJ; Sahai E; Reis e Sousa C. 2014. Dendritic cells control fibroblastic reticular network tension and lymph node expansion. Nature 514(7523):498-502. PubMed: 25341788 MGI: J:217480
Adams EJ; Chen XW; O'Shea KS; Ginsburg D. 2014. Mammalian COPII coat component SEC24C is required for embryonic development in mice. J Biol Chem 289(30):20858-70. PubMed: 24876386 MGI: J:232065
Adams JW; Wang J; Davis JR; Liaw C; Gaidarov I; Gatlin J; Dalton ND; Gu Y; Ross J Jr; Behan D; Chien K; Connolly D. 2008. Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor. Am J Physiol Heart Circ Physiol 295(2):H509-21. PubMed: 18539757 MGI: J:138227
Adhikari D; Diril MK; Busayavalasa K; Risal S; Nakagawa S; Lindkvist R; Shen Y; Coppola V; Tessarollo L; Kudo NR; Kaldis P; Liu K. 2014. Mastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II. J Cell Biol 206(7):843-53. PubMed: 25246615 MGI: J:215974
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Also Known As: ACTB:FLPe B6J

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