Mice that are homozygous for the mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Screening of third generation mice (G3) after 5 weeks on atherogenic high fat diet identified a 13 week old female (born 9/9/2002) with a 4 hour fasted plasma HDL of 136 mg/dl and total cholesterol of 486 mg/dl, which is approximately 174% and 485% (respectively) higher than controls. This mutant mouse strain may be useful in studies of hypercholesterolemia.
This phenotypic deviant was identified following multidose ethylnitrosourea (ENU) treatments to induce mutations in male founder C57BL/6J mice (Stock No. 000664), in complex heart, lung, blood, and sleep disorders at the Mouse Heart, Lung, Blood, and Sleep Disorders (HLBS) Center at The Jackson Laboratory.
|Allele Name||heart, lung and blood 280|
|Allele Type||Chemically induced (ENU)|
|Gene Symbol and Name||Hlb280, heart, lung and blood 280|
|Strain of Origin||C57BL/6J|
|Molecular Note||This phenotypic mutant was identified in an ENU mutagenesis screen.|