Mice that are homozygous for the mutation are viable and fertile. Screening of third generation mice (G3) on atherogeneic diet identified a 12 week old male (born 12/28/2002) with a weight of 30.71 grams and body fat of 22.38%. Females appear to be more severely affected than males. This mutant mouse strain may be useful in studies of obesity.
This phenotypic deviant was identified following multidose ethylnitrosourea (ENU) treatments to induce mutations in male founder C57BL/6J mice (Stock No. 000664), in complex heart, lung, blood, and sleep disorders at the Mouse Heart, Lung, Blood, and Sleep Disorders (HLBS) Center at The Jackson Laboratory.
|Allele Name||heart, lung and blood, 349A|
|Allele Type||Chemically induced (ENU)|
|Gene Symbol and Name||hlb349A, heart, lung and blood, 349A|
|Strain of Origin||C57BL/6J|
|Molecular Note||This phenotypic mutation was discovered in an ENU mutagenesis screen for abnormal metabolic response to an atherogenic diet.|