JAX Mouse Strain Datasheet - 005673

C.Cg-Tg(Mx1-cre)1Cgn/J

Stock No:: 005673 |; Mx-Cre

Cryo Recovery

Overview

Also Known As: Mx-Cre, Mx1-Cre(BALB/c)

These Mx-Cre mice express a transgene containing cre recombinase directed by the Mx1 promoter.

Donating Investigator

Roberta Pelanda, National Jewish Medical and Research Ctr

Genetic overview

Genetic Background	Generation

Tg(Mx1-cre)1Cgn

Allele Type
Transgenic (Inducible, Recombinase-expressing)

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Research Applications

Research Tools

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Base Price

Starting at:

$2,595.00 Domestic price Cryo Recovery

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Details

Detailed Description

The Cre recombinase is under the control of the Mx1 promoter. This promoter is silent in healthy mice, but can be induced to high levels of transcription by administration of interferon alpha, interferon beta, or synthetic double-stranded RNA (such as poly I:C). When combined with a mutant carrying a gene that has been flanked by loxP recognition sites, the expression of Cre recombinase causes the flanked gene to be removed. This provides researchers with the capability to induce the "knockout" at any time during development. There is ~1% background recombination seen in mice not treated with interferon. The percent deletion of the targeted gene varies depending on tissue type, presumably due to the amount of interferon-responsive cells present or to the availability of interferon in each organ.

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

Development

A transgenic construct containing the mouse Mx1 gene promoter, nuclear localization sequence-modified Cre recombinase and a 2.1 kb fragment from the human growth hormone gene (to provide the splicing and polyadenylation signals) was injected into (C57BL/6J X CBA/J)F2 fertilized eggs. The resulting transgenic mice were crossed to (C57BL/6J x 129Sv)F2 mice for an unknown number of generations. The mice were then backcrossed onto the BALB/cJ background for 10 generations.

Expression Data

Expressed Gene	cre, cre recombinase, bacteriophage P1
Site of Expression	widespread pattern of expression; promoter induced to high levels of transcription by administration of interferon alpha, interferon beta, or synthetic double-stranded RNA; provides capability to induce the "knockout" at any time during development

Control Suggestions

Noncarrier
000651 BALB/cJ

Additional Information

Considerations for Choosing Controls

Selected References

Kuhn R; Schwenk F; Aguet M; Rajewsky K. 1995. Inducible gene targeting in mice. Science 269(5229):1427-9. PubMed: 7660125 MGI: J:67927

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Genetics

Tg(Mx1-cre)1Cgn

Allele Symbol: Tg(Mx1-cre)1Cgn

Allele Name	transgene insertion 1, University of Cologne
Allele Type	Transgenic (Inducible, Recombinase-expressing)
Allele Synonym(s)	Mx-Cre; Mx-Cre 31; Mx1-Cre; Mx1cre; MxCre; MxCre^Tg; Tg(Mx1-cre)^hemi
Gene Symbol and Name	Tg(Mx1-cre)1Cgn, transgene insertion 1, University of Cologne
Gene Synonym(s)	Mx-Cre; Mx-Cre 31; Mx1-Cre; Mx1cre; MxCre
Promoter	Mx1, MX dynamin-like GTPase 1, mouse, laboratory
Expressed Gene	cre, cre recombinase, bacteriophage P1
Site of Expression	widespread pattern of expression; promoter induced to high levels of transcription by administration of interferon alpha, interferon beta, or synthetic double-stranded RNA; provides capability to induce the "knockout" at any time during development
Strain of Origin	(C57BL/6J x CBA/J)F2
Chromosome	10
Molecular Note	This transgene expresses Cre recombinase under the control of an inducible Mx1 promoter, which is silent in healthy mice, and active in the liver and in lymphocytes after induction with IFN or pI-pC. The construct also contains a 2.1 kb fragment from the human growth hormone gene.
Mutations Made By	Dr. Ralf Kuhn, University of Cologne

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Research Tools
- Cre-lox System
  - Cre Recombinase Expression
  - Cre Recombinase Expression: Inducible
- Genetics Research
  - Tissue/Cell Markers
  - Tissue/Cell Markers: Cre-lox System

Genotype: cre related

Research Tools
- Cre-lox System
- Genetics Research
  - Mutagenesis and Transgenesis
  - Mutagenesis and Transgenesis: Cre-lox System

References

Kuhn R; Schwenk F; Aguet M; Rajewsky K. 1995. Inducible gene targeting in mice. Science 269(5229):1427-9. PubMed: 7660125 MGI: J:67927

Additional - Tg(Mx1-cre)1Cgn related

Abdel-Wahab O; Gao J; Adli M; Dey A; Trimarchi T; Chung YR; Kuscu C; Hricik T; Ndiaye-Lobry D; Lafave LM; Koche R; Shih AH; Guryanova OA; Kim E; Li S; Pandey S; Shin JY; Telis L; Liu J; Bhatt PK; Monette S; Zhao X; Mason CE; Park CY; Bernstein BE; Aifantis I; Levine RL. 2013. Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo. J Exp Med 210(12):2641-59. PubMed: 24218140 MGI: J:208092
Adelman CA; De S; Petrini JH. 2009. Rad50 is dispensable for the maintenance and viability of postmitotic tissues. Mol Cell Biol 29(2):483-92. PubMed: 19001091 MGI: J:144766
Akada H; Akada S; Hutchison RE; Mohi G. 2012. Erythroid lineage-restricted expression of Jak2V617F is sufficient to induce a myeloproliferative disease in mice. Haematologica 97(9):1389-93. PubMed: 22371173 MGI: J:231133
Akada H; Akada S; Hutchison RE; Mohi G. 2014. Loss of wild-type Jak2 allele enhances myeloid cell expansion and accelerates myelofibrosis in Jak2V617F knock-in mice. Leukemia 28(8):1627-35. PubMed: 24480985 MGI: J:212503
Akada H; Akada S; Hutchison RE; Sakamoto K; Wagner KU; Mohi G. 2014. Critical role of Jak2 in the maintenance and function of adult hematopoietic stem cells. Stem Cells 32(7):1878-89. PubMed: 24677703 MGI: J:216787
Akada H; Yan D; Zou H; Fiering S; Hutchison RE; Mohi MG. 2010. Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease. Blood 115(17):3589-97. PubMed: 20197548 MGI: J:184283
Akbar H; Shang X; Perveen R; Berryman M; Funk K; Johnson JF; Tandon NN; Zheng Y. 2011. Gene Targeting Implicates Cdc42 GTPase in GPVI and Non-GPVI Mediated Platelet Filopodia Formation, Secretion and Aggregation. PLoS One 6(7):e22117. PubMed: 21789221 MGI: J:174929
Akerman ME; Pilch J; Peters D; Ruoslahti E. 2005. Angiostatic peptides use plasma fibronectin to home to angiogenic vasculature. Proc Natl Acad Sci U S A 102(6):2040-5. PubMed: 15687502 MGI: J:96503
Akiyama TE; Sakai S; Lambert G; Nicol CJ; Matsusue K; Pimprale S; Lee YH; Ricote M; Glass CK; Brewer HB Jr; Gonzalez FJ. 2002. Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux. Mol Cell Biol 22(8):2607-19. PubMed: 11909955 MGI: J:75777
Akutagawa J; Huang TQ; Epstein I; Chang T; Quirindongo-Crespo M; Cottonham CL; Dail M; Slusher BS; Friedman LS; Sampath D; Braun BS. 2016. Targeting the PI3K/Akt pathway in murine MDS/MPN driven by hyperactive Ras. Leukemia 30(6):1335-43. PubMed: 26965285 MGI: J:231912
Alexaki A; Gupta SD; Majumder S; Kono M; Tuymetova G; Harmon JM; Dunn TM; Proia RL. 2014. Autophagy regulates sphingolipid levels in the liver. J Lipid Res 55(12):2521-31. PubMed: 25332431 MGI: J:217156
Aliprantis AO; Stolina M; Kostenuik PJ; Poliachik SL; Warner SE; Bain SD; Gross TS. 2012. Transient muscle paralysis degrades bone via rapid osteoclastogenesis. FASEB J 26(3):1110-8. PubMed: 22125315 MGI: J:182803
Aliprantis AO; Ueki Y; Sulyanto R; Park A; Sigrist KS; Sharma SM; Ostrowski MC; Olsen BR; Glimcher LH. 2008. NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J Clin Invest 118(11):3775-89. PubMed: 18846253 MGI: J:144598
Allende ML; Zhou D; Kalkofen DN; Benhamed S; Tuymetova G; Borowski C; Bendelac A; Proia RL. 2008. S1P1 receptor expression regulates emergence of NKT cells in peripheral tissues. FASEB J 22(1):307-15. PubMed: 17785606 MGI: J:134801
Alonzi T; Maritano D; Gorgoni B; Rizzuto G; Libert C; Poli V. 2001. Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene activation in the liver. Mol Cell Biol 21(5):1621-32. PubMed: 11238899 MGI: J:67357
Alonzi T; Newton IP; Bryce PJ; Di Carlo E; Lattanzio G; Tripodi M; Musiani P; Poli V. 2004. Induced somatic inactivation of STAT3 in mice triggers the development of a fulminant form of enterocolitis. Cytokine 26(2):45-56. PubMed: 15050604 MGI: J:146716
Ambrogini E; Almeida M; Martin-Millan M; Paik JH; Depinho RA; Han L; Goellner J; Weinstein RS; Jilka RL; O'Brien CA; Manolagas SC. 2010. FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice. Cell Metab 11(2):136-46. PubMed: 20142101 MGI: J:158622
Ammirante M; Luo JL; Grivennikov S; Nedospasov S; Karin M. 2010. B-cell-derived lymphotoxin promotes castration-resistant prostate cancer. Nature 464(7286):302-5. PubMed: 20220849 MGI: J:157973
An J; Gonzalez-Avalos E; Chawla A; Jeong M; Lopez-Moyado IF; Li W; Goodell MA; Chavez L; Ko M; Rao A. 2015. Acute loss of TET function results in aggressive myeloid cancer in mice. Nat Commun 6:10071. PubMed: 26607761 MGI: J:228006
Anwar K; Iqbal J; Hussain MM. 2007. Mechanisms involved in vitamin E transport by primary enterocytes and in vivo absorption. J Lipid Res 48(9):2028-38. PubMed: 17582142 MGI: J:125237
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Araya R; Eckardt D; Maxeiner S; Kruger O; Theis M; Willecke K; Saez JC. 2005. Expression of connexins during differentiation and regeneration of skeletal muscle: functional relevance of connexin43. J Cell Sci 118(Pt 1):27-37. PubMed: 15601660 MGI: J:94694
Arieta Kuksin C; Gonzalez-Perez G; Minter LM. 2015. CXCR4 expression on pathogenic T cells facilitates their bone marrow infiltration in a mouse model of aplastic anemia. Blood 125(13):2087-94. PubMed: 25647836 MGI: J:222051
Arnon TI; Xu Y; Lo C; Pham T; An J; Coughlin S; Dorn GW; Cyster JG. 2011. GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood. Science 333(6051):1898-903. PubMed: 21960637 MGI: J:176118
Artinger EL; Mishra BP; Zaffuto KM; Li BE; Chung EK; Moore AW; Chen Y; Cheng C; Ernst P. 2013. An MLL-dependent network sustains hematopoiesis. Proc Natl Acad Sci U S A 110(29):12000-5. PubMed: 23744037 MGI: J:198726
Assi H; Espinosa J; Suprise S; Sofroniew M; Doherty R; Zamler D; Lowenstein PR; Castro MG. 2014. Assessing the role of STAT3 in DC differentiation and autologous DC immunotherapy in mouse models of GBM. PLoS One 9(5):e96318. PubMed: 24806510 MGI: J:217363
Avagyan S; Aguilo F; Kamezaki K; Snoeck HW. 2011. Quantitative trait mapping reveals a regulatory axis involving peroxisome proliferator-activated receptors, PRDM16, transforming growth factor-beta2 and FLT3 in hematopoiesis. Blood 118(23):6078-86. PubMed: 21967974 MGI: J:179097
Avila A; Vidal PM; Tielens S; Morelli G; Laguesse S; Harvey RJ; Rigo JM; Nguyen L. 2014. Glycine receptors control the generation of projection neurons in the developing cerebral cortex. Cell Death Differ 21(11):1696-708. PubMed: 24926615 MGI: J:230095
Baena E; Gandarillas A; Vallespinos M; Zanet J; Bachs O; Redondo C; Fabregat I; Martinez-A C; de Alboran IM. 2005. c-Myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver. Proc Natl Acad Sci U S A 102(20):7286-91. PubMed: 15857952 MGI: J:99242
Baena E; Ortiz M; Martinez-A C; de Alboran IM. 2007. c-Myc is essential for hematopoietic stem cell differentiation and regulates Lin(-)Sca-1(+)c-Kit(-) cell generation through p21. Exp Hematol 35(9):1333-43. PubMed: 17637497 MGI: J:126563
Baker SJ; Ma'ayan A; Lieu YK; John P; Reddy MV; Chen EY; Duan Q; Snoeck HW; Reddy EP. 2014. B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development. Proc Natl Acad Sci U S A 111(8):3122-7. PubMed: 24516162 MGI: J:206816
Banerjee ER; Jiang Y; Henderson WR Jr; Latchman Y; Papayannopoulou T. 2009. Absence of alpha 4 but not beta 2 integrins restrains development of chronic allergic asthma using mouse genetic models. Exp Hematol 37(6):715-727.e3. PubMed: 19463772 MGI: J:151240
Banerjee ER; Jiang Y; Henderson WR Jr; Scott LM; Papayannopoulou T. 2007. Alpha4 and beta2 integrins have nonredundant roles for asthma development, but for optimal allergen sensitization only alpha4 is critical. Exp Hematol 35(4):605-17. PubMed: 17379071 MGI: J:123141
Banerjee ER; Latchman YE; Jiang Y; Priestley GV; Papayannopoulou T. 2008. Distinct changes in adult lymphopoiesis in Rag2-/- mice fully reconstituted by alpha4-deficient adult bone marrow cells. Exp Hematol 36(8):1004-13. PubMed: 18468770 MGI: J:139405
Bar C; Povedano JM; Serrano R; Benitez-Buelga C; Popkes M; Formentini I; Bobadilla M; Bosch F; Blasco MA. 2016. Telomerase gene therapy rescues telomere length, bone marrow aplasia, and survival in mice with aplastic anemia. Blood 127(14):1770-9. PubMed: 26903545 MGI: J:232926
Bararia D; Kwok HS; Welner RS; Numata A; Sarosi MB; Yang H; Wee S; Tschuri S; Ray D; Weigert O; Levantini E; Ebralidze AK; Gunaratne J; Tenen DG. 2016. Acetylation of C/EBPalpha inhibits its granulopoietic function. Nat Commun 7:10968. PubMed: 27005833 MGI: J:236743
Barde I; Rauwel B; Marin-Florez RM; Corsinotti A; Laurenti E; Verp S; Offner S; Marquis J; Kapopoulou A; Vanicek J; Trono D. 2013. A KRAB/KAP1-miRNA cascade regulates erythropoiesis through stage-specific control of mitophagy. Science 340(6130):350-3. PubMed: 23493425 MGI: J:195118
Bauer M; Brakebusch C; Coisne C; Sixt M; Wekerle H; Engelhardt B; Fassler R. 2009. Beta1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity. Proc Natl Acad Sci U S A 106(6):1920-5. PubMed: 19179279 MGI: J:144959
Behrens A; Sibilia M; David JP; Mohle-Steinlein U; Tronche F; Schutz G; Wagner EF. 2002. Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver. EMBO J 21(7):1782-90. PubMed: 11927562 MGI: J:75863
Beier F; Foronda M; Martinez P; Blasco MA. 2012. Conditional TRF1 knockout in the hematopoietic compartment leads to bone marrow failure and recapitulates clinical features of dyskeratosis congenita. Blood 120(15):2990-3000. PubMed: 22932806 MGI: J:192926
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Bentmann A; Kawelke N; Moss D; Zentgraf H; Bala Y; Berger I; Gasser JA; Nakchbandi IA. 2010. Circulating fibronectin affects bone matrix, whereas osteoblast fibronectin modulates osteoblast function. J Bone Miner Res 25(4):706-15. PubMed: 19821765 MGI: J:179869
Benz C; Martins VC; Radtke F; Bleul CC. 2008. The stream of precursors that colonizes the thymus proceeds selectively through the early T lineage precursor stage of T cell development. J Exp Med 205(5):1187-99. PubMed: 18458114 MGI: J:136220
Berberich S; Dahne S; Schippers A; Peters T; Muller W; Kremmer E; Forster R; Pabst O. 2008. Differential molecular and anatomical basis for B cell migration into the peritoneal cavity and omental milky spots. J Immunol 180(4):2196-203. PubMed: 18250426 MGI: J:132002
Bereshchenko O; Mancini E; Luciani L; Gambardella A; Riccardi C; Nerlov C. 2012. Pontin is essential for murine hematopoietic stem cell survival. Haematologica 97(9):1291-4. PubMed: 22371176 MGI: J:220926
Berger A; Hoelbl-Kovacic A; Bourgeais J; Hoefling L; Warsch W; Grundschober E; Uras IZ; Menzl I; Putz EM; Hoermann G; Schuster C; Fajmann S; Leitner E; Kubicek S; Moriggl R; Gouilleux F; Sexl V. 2014. PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis. Leukemia 28(3):629-41. PubMed: 24263804 MGI: J:206976
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Besseyrias V; Fiorini E; Strobl LJ; Zimber-Strobl U; Dumortier A; Koch U; Arcangeli ML; Ezine S; Macdonald HR; Radtke F. 2007. Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation. J Exp Med 204(2):331-43. PubMed: 17261636 MGI: J:125373
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Bjorkegren JL; Hagg S; Talukdar HA; Foroughi Asl H; Jain RK; Cedergren C; Shang MM; Rossignoli A; Takolander R; Melander O; Hamsten A; Michoel T; Skogsberg J. 2014. Plasma cholesterol-induced lesion networks activated before regression of early, mature, and advanced atherosclerosis. PLoS Genet 10(2):e1004201. PubMed: 24586211 MGI: J:211003
Bleuming SA; He XC; Kodach LL; Hardwick JC; Koopman FA; Ten Kate FJ; van Deventer SJ; Hommes DW; Peppelenbosch MP; Offerhaus GJ; Li L; van den Brink GR. 2007. Bone morphogenetic protein signaling suppresses tumorigenesis at gastric epithelial transition zones in mice. Cancer Res 67(17):8149-55. PubMed: 17804727 MGI: J:124881
Bohm C; Hayer S; Kilian A; Zaiss MM; Finger S; Hess A; Engelke K; Kollias G; Kronke G; Zwerina J; Schett G; David JP. 2009. The alpha-isoform of p38 MAPK specifically regulates arthritic bone loss. J Immunol 183(9):5938-47. PubMed: 19828631 MGI: J:156807
Bondar T; Medzhitov R. 2010. p53-mediated hematopoietic stem and progenitor cell competition. Cell Stem Cell 6(4):309-22. PubMed: 20362536 MGI: J:158953
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Bourgeois C; Hao Z; Rajewsky K; Potocnik AJ; Stockinger B. 2008. Ablation of thymic export causes accelerated decay of naive CD4 T cells in the periphery because of activation by environmental antigen. Proc Natl Acad Sci U S A 105(25):8691-6. PubMed: 18562288 MGI: J:143955
Brakebusch C; Fillatreau S; Potocnik AJ; Bungartz G; Wilhelm P; Svensson M; Kearney P; Korner H; Gray D; Fassler R. 2002. Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response. Immunity 16(3):465-77. PubMed: 11911830 MGI: J:75623
Braun BS; Archard JA; Van Ziffle JA; Tuveson DA; Jacks TE; Shannon K. 2006. Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo. Blood 108(6):2041-4. PubMed: 16720837 MGI: J:115071
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Brooks R; Fuhler GM; Iyer S; Smith MJ; Park MY; Paraiso KH; Engelman RW; Kerr WG. 2010. SHIP1 inhibition increases immunoregulatory capacity and triggers apoptosis of hematopoietic cancer cells. J Immunol 184(7):3582-9. PubMed: 20200281 MGI: J:160073
Broske AM; Vockentanz L; Kharazi S; Huska MR; Mancini E; Scheller M; Kuhl C; Enns A; Prinz M; Jaenisch R; Nerlov C; Leutz A; Andrade-Navarro MA; Jacobsen SE; Rosenbauer F. 2009. DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction. Nat Genet 41(11):1207-15. PubMed: 19801979 MGI: J:155126
Bungartz G; Land H; Scadden DT; Emerson SG. 2012. NF-Y is necessary for hematopoietic stem cell proliferation and survival. Blood 119(6):1380-9. PubMed: 22072554 MGI: J:181647
Buonamici S; Trimarchi T; Ruocco MG; Reavie L; Cathelin S; Mar BG; Klinakis A; Lukyanov Y; Tseng JC; Sen F; Gehrie E; Li M; Newcomb E; Zavadil J; Meruelo D; Lipp M; Ibrahim S; Efstratiadis A; Zagzag D; Bromberg JS; Dustin ML; Aifantis I. 2009. CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia. Nature 459(7249):1000-4. PubMed: 19536265 MGI: J:197167
Burgess MR; Hwang E; Firestone AJ; Huang T; Xu J; Zuber J; Bohin N; Wen T; Kogan SC; Haigis KM; Sampath D; Lowe S; Shannon K; Li Q. 2014. Preclinical efficacy of MEK inhibition in Nras-mutant AML. Blood 124(26):3947-55. PubMed: 25361812 MGI: J:220778
Buza-Vidas N; Cismasiu VB; Moore S; Mead AJ; Woll PS; Lutteropp M; Melchiori L; Luc S; Bouriez-Jones T; Atkinson D; O'Carroll D; Jacobsen SE; Nerlov C. 2012. Dicer is selectively important for the earliest stages of erythroid development. Blood 120(12):2412-6. PubMed: 22869792 MGI: J:191447
Byon JC; Chen J; Doty RT; Abkowitz JL. 2013. FLVCR is necessary for erythroid maturation, may contribute to platelet maturation, but is dispensable for normal hematopoietic stem cell function. Blood 122(16):2903-10. PubMed: 24021674 MGI: J:204083
Byrnes JR; Duval C; Wang Y; Hansen CE; Ahn B; Mooberry MJ; Clark MA; Johnsen JM; Lord ST; Lam WA; Meijers JC; Ni H; Ariens RA; Wolberg AS. 2015. Factor XIIIa-dependent retention of red blood cells in clots is mediated by fibrin alpha-chain crosslinking. Blood 126(16):1940-8. PubMed: 26324704 MGI: J:230677
Cai X; Gaudet JJ; Mangan JK; Chen MJ; De Obaldia ME; Oo Z; Ernst P; Speck NA. 2011. Runx1 loss minimally impacts long-term hematopoietic stem cells. PLoS One 6(12):e28430. PubMed: 22145044 MGI: J:182271
Cales C; Roman-Trufero M; Pavon L; Serrano I; Melgar T; Endoh M; Perez C; Koseki H; Vidal M. 2008. Inactivation of the polycomb group protein Ring1B unveils an antiproliferative role in hematopoietic cell expansion and cooperation with tumorigenesis associated with Ink4a deletion. Mol Cell Biol 28(3):1018-28. PubMed: 18039844 MGI: J:130397
Camerer E; Regard JB; Cornelissen I; Srinivasan Y; Duong DN; Palmer D; Pham TH; Wong JS; Pappu R; Coughlin SR. 2009. Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. J Clin Invest 119(7):1871-9. PubMed: 19603543 MGI: J:152547
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Also Known As: Mx-Cre, Mx1-Cre(BALB/c)

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