JAX
Mouse Strain Datasheet - 005670
B6.Cg-Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J
Also Known As: ROSA26-rtTA-IRES-EGFP, rtTAflox
These ROSA26-rtTA mice can be used to generate triple mutant mice in which the tissue specificity of a cre-transgenic line and doxycycline inducibility of the rtTA/TRE-controlled transgenes can be combined to regulate expression of a target gene.
Donating Investigator
IMR Colony, The Jackson Laboratory
Genetic overview
| Genetic Background | Generation |
|---|---|
|
F?+F1N11F5
|
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Conditional ready (e.g. floxed), Inducible, Reporter, Transactivator) | Gt(ROSA)26Sor | gene trap ROSA 26, Philippe Soriano |
Detailed Description
Homozygous mutant mice are viable, fertile, normal in size and do not display any behavioral abnormalities. When these gene targeted mice are bred to transgenic strains expressing Cre recombinase, functional rtTA and EGFP activity is observed in the double mutant offspring in the tissues that express cre. These double mutant mice may be bred to transgenic strains carrying genes of interest under the regulation of tetracycline responsive elements (TRE; tetO) to generate triple mutant mice in which the tissue specificity of the cre-transgenic line and doxycycline inducibility of the rtTA/TRE-controlled transgenes can be combined to regulate expression of the target gene.
In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
Development
A targeting vector containing a loxP-flanked phosphoglycerate kinase-neomycin resistance gene -polyadenylation stop sequence (PGK-neo-pA) fragment and a downstream reverse tetracycline-controlled transactivator gene-internal ribosomal entry site-enhanced green fluorescent protein gene-polyadenylation stop sequence (rtTA-IRES-EGFP-pA) fusion protein was inserted between exon 1 and 2 of the endogenous Gt(ROSA)26Sor locus. The construct was electroporated into (129X1/SvJ x 129S1/Sv)-derived R1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into ICR blastocysts and the resulting chimeric males were backcrossed for germ-line transmission to ICR females. Heterozygous offspring were sent to The Jackson Laboratory (as Stock No. 005572). Upon arrival, some mice were backcrossed to C57BL/6J for at least 5 generations to generate this congenic strain (Stock No. 005670).
Expression Data
| Expressed Gene | GFP, Green Fluorescent Protein, |
|---|---|
| Expressed Gene | rtTA, reverse tetracycline-controlled transactivator, E. coli |
| Site of Expression | When these mutant mice are crossed to a strain expressing Cre recombinase, rtTA and EGFP are expressed in the cre-expressing tissues. These mice can be used to generate mutant mice in which the tissue specificity of cre-expression and doxycycline inducibility of the rtTA can be combined. |
Control Suggestions
Selected References
- Belteki G; Haigh J; Kabacs N; Haigh K; Sison K; Costantini F; Whitsett J; Quaggin SE; Nagy A. 2005. Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction. Nucleic Acids Res 33(5):e51. PubMed: 15784609MGI: J:99607
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy
Allele Symbol: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy
| Allele Name | targeted mutation 1, Andras Nagy |
|---|---|
| Allele Type | Targeted (Conditional ready (e.g. floxed), Inducible, Reporter, Transactivator) |
| Allele Synonym(s) | Gt(ROSA)26Sortm1(rtTA)Nagy; Gt(ROSA)26Sortm1Nagy; R26rtTA; ROSA26-rtTA; ROSA26-rtTA-IRES-EGFP; Rosa-eGFP; Rosa26fs-rtTA; rtTAflox |
| Gene Symbol and Name | Gt(ROSA)26Sor, gene trap ROSA 26, Philippe Soriano |
| Gene Synonym(s) | AV258896; Gtrgeo26; Gtrgeo26; Gtrosa26; Gtrosa26; R26; ROSA26; SETD5-AS1; Thumpd3as1; beta geo; expressed sequence AV258896; gene trap ROSA 26; gene trap ROSA b-geo 26 |
| Expressed Gene | GFP, Green Fluorescent Protein, |
| Expressed Gene | rtTA, reverse tetracycline-controlled transactivator, E. coli |
| Site of Expression | When these mutant mice are crossed to a strain expressing Cre recombinase, rtTA and EGFP are expressed in the cre-expressing tissues. These mice can be used to generate mutant mice in which the tissue specificity of cre-expression and doxycycline inducibility of the rtTA can be combined. |
| Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
| Chromosome | 6 |
| Molecular Note | A targeting vector containing a floxed Pgk-neo-pA cassette and a rtTA-IRES-EGFP-pA cassette was inserted into intron 1 of the locus. Upon cre expression, the floxed neo cassette is removed and the ROSA26 promoter drives expression of rtTA and EGFP. Presence of doxycycline results in the formation of an active transcriptional activator and the activation of the responder transgene. |
| Mutations Made By | Gusztav Belteki and Jody Haigh, Mount Sinai Hospital |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Research Tools
- Cre-lox System
- loxP-flanked Sequences
- loxP-flanked Sequences: Test/Reporter
- Fluorescent Proteins
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
- Mutagenesis and Transgenesis: Tetop Tet System
- Tissue/Cell Markers
- Tissue/Cell Markers: Cre-lox System
- Tet Expression Systems
- tTA/rtTA Expressing Strains
- Cre-lox System
Genotype: GFP related
- Research Tools
- Fluorescent Proteins
References
- Belteki G; Haigh J; Kabacs N; Haigh K; Sison K; Costantini F; Whitsett J; Quaggin SE; Nagy A. 2005. Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction. Nucleic Acids Res 33(5):e51. PubMed: 15784609MGI: J:99607
Additional - Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy related
- Akerberg BN; Sarangam ML; Stankunas K. 2015. Endocardial Brg1 disruption illustrates the developmental origins of semilunar valve disease. Dev Biol 407(1):158-72. PubMed: 26100917MGI: J:226941
- Al Alam D; Danopoulos S; Schall K; Sala FG; Almohazey D; Fernandez GE; Georgia S; Frey MR; Ford HR; Grikscheit T; Bellusci S. 2015. Fibroblast growth factor 10 alters the balance between goblet and Paneth cells in the adult mouse small intestine. Am J Physiol Gastrointest Liver Physiol 308(8):G678-90. PubMed: 25721301MGI: J:224169
- Al Alam D; El Agha E; Sakurai R; Kheirollahi V; Moiseenko A; Danopoulos S; Shrestha A; Schmoldt C; Quantius J; Herold S; Chao CM; Tiozzo C; De Langhe S; Plikus MV; Thornton M; Grubbs B; Minoo P; Rehan VK; Bellusci S. 2015. Evidence for the involvement of fibroblast growth factor 10 in lipofibroblast formation during embryonic lung development. Development 142(23):4139-50. PubMed: 26511927MGI: J:239948
- Ben Shoham A; Rot C; Stern T; Krief S; Akiva A; Dadosh T; Sabany H; Lu Y; Kadler KE; Zelzer E. 2016. Deposition of collagen type I onto skeletal endothelium reveals a new role for blood vessels in regulating bone morphology. Development 143(21):3933-3943. PubMed: 27621060MGI: J:237340
- Bojovic B; Booth RE; Jin Y; Zhou X; Crowe DL. 2015. Alternative lengthening of telomeres in cancer stem cells in vivo. Oncogene 34(5):611-20. PubMed: 24531712MGI: J:218628
- Bonilla-Claudio M; Wang J; Bai Y; Klysik E; Selever J; Martin JF. 2012. Bmp signaling regulates a dose-dependent transcriptional program to control facial skeletal development. Development 139(4):709-19. PubMed: 22219353MGI: J:181229
- Bosada FM; Devasthali V; Jones KA; Stankunas K. 2016. Wnt/beta-catenin signaling enables developmental transitions during valvulogenesis. Development 143(6):1041-54. PubMed: 26893350MGI: J:229892
- Boutin AT; Liao WT; Wang M; Hwang SS; Karpinets TV; Cheung H; Chu GC; Jiang S; Hu J; Chang K; Vilar E; Song X; Zhang J; Kopetz S; Futreal A; Wang YA; Kwong LN; DePinho RA. 2017. Oncogenic Kras drives invasion and maintains metastases in colorectal cancer. Genes Dev 31(4):370-382. PubMed: 28289141MGI: J:242160
- Chalamalasetty RB; Garriock RJ; Dunty WC Jr; Kennedy MW; Jailwala P; Si H; Yamaguchi TP. 2014. Mesogenin 1 is a master regulator of paraxial presomitic mesoderm differentiation. Development 141(22):4285-97. PubMed: 25371364MGI: J:217598
- Chen CC; Wang L; Plikus MV; Jiang TX; Murray PJ; Ramos R; Guerrero-Juarez CF; Hughes MW; Lee OK; Shi S; Widelitz RB; Lander AD; Chuong CM. 2015. Organ-level quorum sensing directs regeneration in hair stem cell populations. Cell 161(2):277-90. PubMed: 25860610MGI: J:222861
- Chen Z; Huang J; Liu Y; Dattilo LK; Huh SH; Ornitz D; Beebe DC. 2014. FGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands. Development 141(13):2691-701. PubMed: 24924191MGI: J:213873
- Cheng XH; Black M; Ustiyan V; Le T; Fulford L; Sridharan A; Medvedovic M; Kalinichenko VV; Whitsett JA; Kalin TV. 2014. SPDEF inhibits prostate carcinogenesis by disrupting a positive feedback loop in regulation of the Foxm1 oncogene. PLoS Genet 10(9):e1004656. PubMed: 25254494MGI: J:232453
- Chi W; Wu E; Morgan BA. 2013. Dermal papilla cell number specifies hair size, shape and cycling and its reduction causes follicular decline. Development 140(8):1676-83. PubMed: 23487317MGI: J:195121
- Collins MA; Bednar F; Zhang Y; Brisset JC; Galban S; Galban CJ; Rakshit S; Flannagan KS; Adsay NV; Pasca di Magliano M. 2012. Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice. J Clin Invest 122(2):639-53. PubMed: 22232209MGI: J:184378
- Collins MA; Brisset JC; Zhang Y; Bednar F; Pierre J; Heist KA; Galban CJ; Galban S; di Magliano MP. 2012. Metastatic pancreatic cancer is dependent on oncogenic Kras in mice. PLoS One 7(12):e49707. PubMed: 23226501MGI: J:195686
- Cunningham JT; Moreno MV; Lodi A; Ronen SM; Ruggero D. 2014. Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer. Cell 157(5):1088-103. PubMed: 24855946MGI: J:214383
- Dahia CL; Mahoney E; Wylie C. 2012. Shh signaling from the nucleus pulposus is required for the postnatal growth and differentiation of the mouse intervertebral disc. PLoS One 7(4):e35944. PubMed: 22558278MGI: J:231130
- Danopoulos S; Parsa S; Al Alam D; Tabatabai R; Baptista S; Tiozzo C; Carraro G; Wheeler M; Barreto G; Braun T; Li X; Hajihosseini MK; Bellusci S. 2013. Transient Inhibition of FGFR2b-ligands signaling leads to irreversible loss of cellular beta-catenin organization and signaling in AER during mouse limb development. PLoS One 8(10):e76248. PubMed: 24167544MGI: J:209092
- Deng Y; Wang ZV; Tao C; Gao N; Holland WL; Ferdous A; Repa JJ; Liang G; Ye J; Lehrman MA; Hill JA; Horton JD; Scherer PE. 2013. The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism. J Clin Invest 123(1):455-68. PubMed: 23257357MGI: J:194290
- Drogat B; Kalucka J; Gutierrez L; Hammad H; Goossens S; Farhang Ghahremani M; Bartunkova S; Haigh K; Deswarte K; Nyabi O; Naessens M; Ferrara N; Klingmuller U; Lambrecht BN; Nagy A; Philipsen S; Haigh JJ. 2010. Vegf regulates embryonic erythroid development through Gata1 modulation. Blood 116(12):2141-51. PubMed: 20554972MGI: J:164506
- El Andaloussi A; Graves S; Meng F; Mandal M; Mashayekhi M; Aifantis I. 2006. Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus. Nat Immunol 7(4):418-26. PubMed: 16518394MGI: J:112555
- Eshkar-Oren I; Krief S; Ferrara N; Elliott AM; Zelzer E. 2015. Vascular patterning regulates interdigital cell death by a ROS-mediated mechanism. Development 142(4):672-80. PubMed: 25617432MGI: J:218159
- Eshkar-Oren I; Viukov SV; Salameh S; Krief S; Oh CD; Akiyama H; Gerber HP; Ferrara N; Zelzer E. 2009. The forming limb skeleton serves as a signaling center for limb vasculature patterning via regulation of Vegf. Development 136(8):1263-72. PubMed: 19261698MGI: J:147285
- Fisher OS; Deng H; Liu D; Zhang Y; Wei R; Deng Y; Zhang F; Louvi A; Turk BE; Boggon TJ; Su B. 2015. Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex. Nat Commun 6:7937. PubMed: 26235885MGI: J:224922
- Golden EJ; Benito-Gonzalez A; Doetzlhofer A. 2015. The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea. Proc Natl Acad Sci U S A 112(29):E3864-73. PubMed: 26139524MGI: J:223798
- Grachtchouk M; Pero J; Yang SH; Ermilov AN; Michael LE; Wang A; Wilbert D; Patel RM; Ferris J; Diener J; Allen M; Lim S; Syu LJ; Verhaegen M; Dlugosz AA. 2011. Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations. J Clin Invest 121(5):1768-81. PubMed: 21519145MGI: J:173930
- Gregorieff A; Liu Y; Inanlou MR; Khomchuk Y; Wrana JL. 2015. Yap-dependent reprogramming of Lgr5(+) stem cells drives intestinal regeneration and cancer. Nature 526(7575):715-8. PubMed: 26503053MGI: J:226759
- Gupte VV; Ramasamy SK; Reddy R; Lee J; Weinreb PH; Violette SM; Guenther A; Warburton D; Driscoll B; Minoo P; Bellusci S. 2009. Overexpression of fibroblast growth factor-10 during both inflammatory and fibrotic phases attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Respir Crit Care Med 180(5):424-36. PubMed: 19498056MGI: J:167964
- Hasenfuss SC; Bakiri L; Thomsen MK; Williams EG; Auwerx J; Wagner EF. 2014. Regulation of steatohepatitis and PPARgamma signaling by distinct AP-1 dimers. Cell Metab 19(1):84-95. PubMed: 24411941MGI: J:210545
- He N; Xiao Z; Yin T; Stubbs J; Li L; Quarles LD. 2011. Inducible expression of Runx2 results in multiorgan abnormalities in mice. J Cell Biochem 112(2):653-65. PubMed: 21268087MGI: J:168061
- Hu He K; Juhl K; Karadimos M; El Khattabi I; Fitzpatrick C; Bonner-Weir S; Sharma A. 2014. Differentiation of pancreatic endocrine progenitors reversibly blocked by premature induction of MafA. Dev Biol 385(1):2-12. PubMed: 24183936MGI: J:205335
- Huebner RJ; Lechler T; Ewald AJ. 2014. Developmental stratification of the mammary epithelium occurs through symmetry-breaking vertical divisions of apically positioned luminal cells. Development 141(5):1085-94. PubMed: 24550116MGI: J:234159
- Huh SH; Warchol ME; Ornitz DM. 2015. Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling. Elife 4:. PubMed: 25915623MGI: J:229246
- Jeansson M; Gawlik A; Anderson G; Li C; Kerjaschki D; Henkelman M; Quaggin SE. 2011. Angiopoietin-1 is essential in mouse vasculature during development and in response to injury. J Clin Invest 121(6):2278-89. PubMed: 21606590MGI: J:174022
- Kapoor A; Yao W; Ying H; Hua S; Liewen A; Wang Q; Zhong Y; Wu CJ; Sadanandam A; Hu B; Chang Q; Chu GC; Al-Khalil R; Jiang S; Xia H; Fletcher-Sananikone E; Lim C; Horwitz GI; Viale A; Pettazzoni P; Sanchez N; Wang H; Protopopov A; Zhang J; Heffernan T; Johnson RL; Chin L; Wang YA; Draetta G; DePinho RA. 2014. Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer. Cell 158(1):185-97. PubMed: 24954535MGI: J:214523
- Kelly MC; Chang Q; Pan A; Lin X; Chen P. 2012. Atoh1 directs the formation of sensory mosaics and induces cell proliferation in the postnatal Mammalian cochlea in vivo. J Neurosci 32(19):6699-710. PubMed: 22573692MGI: J:184847
- Kennedy MW; Chalamalasetty RB; Thomas S; Garriock RJ; Jailwala P; Yamaguchi TP. 2016. Sp5 and Sp8 recruit beta-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription. Proc Natl Acad Sci U S A 113(13):3545-50. PubMed: 26969725MGI: J:232050
- Kim ST; Adair-Kirk TL; Senior RM; Miner JH. 2012. Functional consequences of cell type-restricted expression of laminin alpha5 in mouse placental labyrinth and kidney glomerular capillaries. PLoS One 7(7):e41348. PubMed: 22911783MGI: J:189883
- Kocabas F; Zheng J; Thet S; Copeland NG; Jenkins NA; DeBerardinis RJ; Zhang C; Sadek HA. 2012. Meis1 regulates the metabolic phenotype and oxidant defense of hematopoietic stem cells. Blood 120(25):4963-72. PubMed: 22995899MGI: J:192126
- Kozhemyakina E; Ionescu A; Lassar AB. 2014. GATA6 is a crucial regulator of Shh in the limb bud. PLoS Genet 10(1):e1004072. PubMed: 24415953MGI: J:205405
- Kwong LN; Boland GM; Frederick DT; Helms TL; Akid AT; Miller JP; Jiang S; Cooper ZA; Song X; Seth S; Kamara J; Protopopov A; Mills GB; Flaherty KT; Wargo JA; Chin L. 2015. Co-clinical assessment identifies patterns of BRAF inhibitor resistance in melanoma. J Clin Invest 125(4):1459-70. PubMed: 25705882MGI: J:221902
- Lam DD; Attard CA; Mercer AJ; Myers MG Jr; Rubinstein M; Low MJ. 2015. Conditional expression of Pomc in the Lepr-positive subpopulation of POMC neurons is sufficient for normal energy homeostasis and metabolism. Endocrinology 156(4):1292-302. PubMed: 25594696MGI: J:235109
- Le TT; McGovern VL; Alwine IE; Wang X; Massoni-Laporte A; Rich MM; Burghes AH. 2011. Temporal requirement for high SMN expression in SMA mice. Hum Mol Genet 20(18):3578-91. PubMed: 21672919MGI: J:174960
- Lin HY; Yang LT. 2013. Differential response of epithelial stem cell populations in hair follicles to TGF-beta signaling. Dev Biol 373(2):394-406. PubMed: 23103542MGI: J:192167
- Lin X; Suh JH; Go G; Miner JH. 2014. Feasibility of repairing glomerular basement membrane defects in alport syndrome. J Am Soc Nephrol 25(4):687-92. PubMed: 24262794MGI: J:207595
- Liu J; Willet SG; Bankaitis ED; Xu Y; Wright CV; Gu G. 2013. Non-parallel recombination limits Cre-LoxP-based reporters as precise indicators of conditional genetic manipulation. Genesis 51(6):436-42. PubMed: 23441020MGI: J:204870
- Liu X; Pitarresi JR; Cuitino MC; Kladney RD; Woelke SA; Sizemore GM; Nayak SG; Egriboz O; Schweickert PG; Yu L; Trela S; Schilling DJ; Halloran SK; Li M; Dutta S; Fernandez SA; Rosol TJ; Lesinski GB; Shakya R; Ludwig T; Konieczny SF; Leone G; Wu J; Ostrowski MC. 2016. Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia. Genes Dev 30(17):1943-55. PubMed: 27633013MGI: J:235647
- MacKenzie B; Henneke I; Hezel S; Al Alam D; El Agha E; Chao CM; Quantius J; Wilhelm J; Jones M; Goth K; Li X; Seeger W; Konigshoff M; Herold S; Rizvanov AA; Gunther A; Bellusci S. 2015. Attenuating endogenous Fgfr2b ligands during bleomycin-induced lung fibrosis does not compromise murine lung repair. Am J Physiol Lung Cell Mol Physiol 308(10):L1014-24. PubMed: 25820524MGI: J:232268
- Maes C; Goossens S; Bartunkova S; Drogat B; Coenegrachts L; Stockmans I; Moermans K; Nyabi O; Haigh K; Naessens M; Haenebalcke L; Tuckermann JP; Tjwa M; Carmeliet P; Mandic V; David JP; Behrens A; Nagy A; Carmeliet G; Haigh JJ. 2010. Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones. EMBO J 29(2):424-41. PubMed: 20010698MGI: J:156474
- Manda KR; Tripathi P; Hsi AC; Ning J; Ruzinova MB; Liapis H; Bailey M; Zhang H; Maher CA; Humphrey PA; Andriole GL; Ding L; You Z; Chen F. 2015. NFATc1 promotes prostate tumorigenesis and overcomes PTEN loss-induced senescence. Oncogene :. PubMed: 26477312MGI: J:226088
- Megyola CM; Gao Y; Teixeira AM; Cheng J; Heydari K; Cheng EC; Nottoli T; Krause DS; Lu J; Guo S. 2013. Dynamic migration and cell-cell interactions of early reprogramming revealed by high-resolution time-lapse imaging. Stem Cells 31(5):895-905. PubMed: 23335078MGI: J:196324
- Moriyama M; Fukuhara T; Britschgi M; He Y; Narasimhan R; Villeda S; Molina H; Huber BT; Holers M; Wyss-Coray T. 2011. Complement Receptor 2 Is Expressed in Neural Progenitor Cells and Regulates Adult Hippocampal Neurogenesis. J Neurosci 31(11):3981-3989. PubMed: 21411641MGI: J:170456
- Munoz DM; Singh S; Tung T; Agnihotri S; Nagy A; Guha A; Zadeh G; Hawkins C. 2013. Differential transformation capacity of neuro-glial progenitors during development. Proc Natl Acad Sci U S A 110(35):14378-83. PubMed: 23942126MGI: J:200905
- Nguyen LH; Robinton DA; Seligson MT; Wu L; Li L; Rakheja D; Comerford SA; Ramezani S; Sun X; Parikh MS; Yang EH; Powers JT; Shinoda G; Shah SP; Hammer RE; Daley GQ; Zhu H. 2014. Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models. Cancer Cell 26(2):248-61. PubMed: 25117712MGI: J:214596
- Nguyen LT; Tretiakova MS; Silvis MR; Lucas J; Klezovitch O; Coleman I; Bolouri H; Kutyavin VI; Morrissey C; True LD; Nelson PS; Vasioukhin V. 2015. ERG Activates the YAP1 Transcriptional Program and Induces the Development of Age-Related Prostate Tumors. Cancer Cell 27(6):797-808. PubMed: 26058078MGI: J:222916
- Noah TK; Kazanjian A; Whitsett J; Shroyer NF. 2010. SAM pointed domain ETS factor (SPDEF) regulates terminal differentiation and maturation of intestinal goblet cells. Exp Cell Res 316(3):452-65. PubMed: 19786015MGI: J:156638
- Ostrowski SM; Wright MC; Bolock AM; Geng X; Maricich SM. 2015. Ectopic Atoh1 expression drives Merkel cell production in embryonic, postnatal and adult mouse epidermis. Development 142(14):2533-44. PubMed: 26138479MGI: J:224144
- Pan W; Jin Y; Chen J; Rottier RJ; Steel KP; Kiernan AE. 2013. Ectopic expression of activated notch or SOX2 reveals similar and unique roles in the development of the sensory cell progenitors in the mammalian inner ear. J Neurosci 33(41):16146-57. PubMed: 24107947MGI: J:202668
- Pan W; Jin Y; Stanger B; Kiernan AE. 2010. Notch signaling is required for the generation of hair cells and supporting cells in the mammalian inner ear. Proc Natl Acad Sci U S A 107(36):15798-803. PubMed: 20733081MGI: J:164383
- Parsa S; Kuremoto K; Seidel K; Tabatabai R; Mackenzie B; Yamaza T; Akiyama K; Branch J; Koh CJ; Al Alam D; Klein OD; Bellusci S. 2010. Signaling by FGFR2b controls the regenerative capacity of adult mouse incisors. Development 137(22):3743-52. PubMed: 20978072MGI: J:167068
- Parsa S; Ramasamy SK; De Langhe S; Gupte VV; Haigh JJ; Medina D; Bellusci S. 2008. Terminal end bud maintenance in mammary gland is dependent upon FGFR2b signaling. Dev Biol 317(1):121-31. PubMed: 18381212MGI: J:136174
- Pi M; Chen L; Huang M; Luo Q; Quarles LD. 2008. Parathyroid-specific interaction of the calcium-sensing receptor and G alpha q. Kidney Int 74(12):1548-56. PubMed: 18813283MGI: J:162715
- Quach DH; Oliveira-Fernandes M; Gruner KA; Tourtellotte WG. 2013. A sympathetic neuron autonomous role for Egr3-mediated gene regulation in dendrite morphogenesis and target tissue innervation. J Neurosci 33(10):4570-83. PubMed: 23467373MGI: J:196371
- Rockich BE; Hrycaj SM; Shih HP; Nagy MS; Ferguson MA; Kopp JL; Sander M; Wellik DM; Spence JR. 2013. Sox9 plays multiple roles in the lung epithelium during branching morphogenesis. Proc Natl Acad Sci U S A 110(47):E4456-64. PubMed: 24191021MGI: J:202984
- Saha SK; Parachoniak CA; Ghanta KS; Fitamant J; Ross KN; Najem MS; Gurumurthy S; Akbay EA; Sia D; Cornella H; Miltiadous O; Walesky C; Deshpande V; Zhu AX; Hezel AF; Yen KE; Straley KS; Travins J; Popovici-Muller J; Gliser C; Ferrone CR; Apte U; Llovet JM; Wong KK; Ramaswamy S; Bardeesy N. 2014. Mutant IDH inhibits HNF-4alpha to block hepatocyte differentiation and promote biliary cancer. Nature 513(7516):110-4. PubMed: 25043045MGI: J:217109
- Sala FG; Del Moral PM; Tiozzo C; Alam DA; Warburton D; Grikscheit T; Veltmaat JM; Bellusci S. 2011. FGF10 controls the patterning of the tracheal cartilage rings via Shh. Development 138(2):273-82. PubMed: 21148187MGI: J:167739
- Sati L; Zeiss C; Yekkala K; Demir R; McGrath J. 2015. Expression of the CTCFL Gene during Mouse Embryogenesis Causes Growth Retardation, Postnatal Lethality, and Dysregulation of the Transforming Growth Factor beta Pathway. Mol Cell Biol 35(19):3436-45. PubMed: 26169830MGI: J:228230
- Schlegelmilch K; Mohseni M; Kirak O; Pruszak J; Rodriguez JR; Zhou D; Kreger BT; Vasioukhin V; Avruch J; Brummelkamp TR; Camargo FD. 2011. Yap1 acts downstream of alpha-catenin to control epidermal proliferation. Cell 144(5):782-95. PubMed: 21376238MGI: J:171057
- Shamir ER; Coutinho K; Georgess D; Auer M; Ewald AJ. 2016. Twist1-positive epithelial cells retain adhesive and proliferative capacity throughout dissemination. Biol Open 5(9):1216-28. PubMed: 27402962MGI: J:235364
- Sharir A; Stern T; Rot C; Shahar R; Zelzer E. 2011. Muscle force regulates bone shaping for optimal load-bearing capacity during embryogenesis. Development 138(15):3247-59. PubMed: 21750035MGI: J:180904
- Shinoda G; Shyh-Chang N; de Soysa TY; Zhu H; Seligson MT; Shah SP; Abo-Sido N; Yabuuchi A; Hagan JP; Gregory RI; Asara JM; Cantley LC; Moss EG; Daley GQ. 2013. Fetal Deficiency of Lin28 Programs Life-Long Aberrations in Growth and Glucose Metabolism. Stem Cells :. PubMed: 23666760MGI: J:199720
- Sison K; Eremina V; Baelde H; Min W; Hirashima M; Fantus IG; Quaggin SE. 2010. Glomerular structure and function require paracrine, not autocrine, VEGF-VEGFR-2 signaling. J Am Soc Nephrol 21(10):1691-701. PubMed: 20688931MGI: J:185910
- Souma T; Tompson SW; Thomson BR; Siggs OM; Kizhatil K; Yamaguchi S; Feng L; Limviphuvadh V; Whisenhunt KN; Maurer-Stroh S; Yanovitch TL; Kalaydjieva L; Azmanov DN; Finzi S; Mauri L; Javadiyan S; Souzeau E; Zhou T; Hewitt AW; Kloss B; Burdon KP; Mackey DA; Allen KF; Ruddle JB; Lim SH; Rozen S; Tran-Viet KN; Liu X; John S; Wiggs JL; Pasutto F; Craig JE; Jin J; Quaggin SE; Young TL. 2016. Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity. J Clin Invest 126(7):2575-87. PubMed: 27270174MGI: J:237147
- Speer AL; Al Alam D; Sala FG; Ford HR; Bellusci S; Grikscheit TC. 2012. Fibroblast growth factor 10-fibroblast growth factor receptor 2b mediated signaling is not required for adult glandular stomach homeostasis. PLoS One 7(11):e49127. PubMed: 23133671MGI: J:195033
- Srinivas S; Watanabe T; Lin CS; William CM; Tanabe Y; Jessell TM; Costantini F. 2001. Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev Biol 1(1):4. PubMed: 11299042MGI: J:80963
- Sukumar P; Sedo A; Li J; Wilson LA; O'Regan D; Lippiat JD; Porter KE; Kearney MT; Ainscough JF; Beech DJ. 2012. Constitutively active TRPC channels of adipocytes confer a mechanism for sensing dietary fatty acids and regulating adiponectin. Circ Res 111(2):191-200. PubMed: 22668831MGI: J:212894
- Sung HK; Doh KO; Son JE; Park JG; Bae Y; Choi S; Nelson SM; Cowling R; Nagy K; Michael IP; Koh GY; Adamson SL; Pawson T; Nagy A. 2013. Adipose vascular endothelial growth factor regulates metabolic homeostasis through angiogenesis. Cell Metab 17(1):61-72. PubMed: 23312284MGI: J:195071
- Takase HM; Itoh T; Ino S; Wang T; Koji T; Akira S; Takikawa Y; Miyajima A. 2013. FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration. Genes Dev 27(2):169-81. PubMed: 23322300MGI: J:193313
- Tang S; Snider P; Firulli AB; Conway SJ. 2010. Trigenic neural crest-restricted Smad7 over-expression results in congenital craniofacial and cardiovascular defects. Dev Biol 344(1):233-47. PubMed: 20457144MGI: J:163879
- Thomson BR; Heinen S; Jeansson M; Ghosh AK; Fatima A; Sung HK; Onay T; Chen H; Yamaguchi S; Economides AN; Flenniken A; Gale NW; Hong YK; Fawzi A; Liu X; Kume T; Quaggin SE. 2014. A lymphatic defect causes ocular hypertension and glaucoma in mice. J Clin Invest 124(10):4320-4. PubMed: 25202984MGI: J:217296
- Tremblay AM; Missiaglia E; Galli GG; Hettmer S; Urcia R; Carrara M; Judson RN; Thway K; Nadal G; Selfe JL; Murray G; Calogero RA; De Bari C; Zammit PS; Delorenzi M; Wagers AJ; Shipley J; Wackerhage H; Camargo FD. 2014. The Hippo transducer YAP1 transforms activated satellite cells and is a potent effector of embryonal rhabdomyosarcoma formation. Cancer Cell 26(2):273-87. PubMed: 25087979MGI: J:214602
- Tripathi P; Wang Y; Coussens M; Manda KR; Casey AM; Lin C; Poyo E; Pfeifer JD; Basappa N; Bates CM; Ma L; Zhang H; Pan M; Ding L; Chen F. 2014. Activation of NFAT signaling establishes a tumorigenic microenvironment through cell autonomous and non-cell autonomous mechanisms. Oncogene 33(14):1840-9. PubMed: 23624921MGI: J:212364
- Urbach A; Yermalovich A; Zhang J; Spina CS; Zhu H; Perez-Atayde AR; Shukrun R; Charlton J; Sebire N; Mifsud W; Dekel B; Pritchard-Jones K; Daley GQ. 2014. Lin28 sustains early renal progenitors and induces Wilms tumor. Genes Dev 28(9):971-82. PubMed: 24732380MGI: J:211179
- Vega-Hernandez M; Kovacs A; De Langhe S; Ornitz DM. 2011. FGF10/FGFR2b signaling is essential for cardiac fibroblast development and growth of the myocardium. Development 138(15):3331-40. PubMed: 21750042MGI: J:175538
- Viale A; Pettazzoni P; Lyssiotis CA; Ying H; Sanchez N; Marchesini M; Carugo A; Green T; Seth S; Giuliani V; Kost-Alimova M; Muller F; Colla S; Nezi L; Genovese G; Deem AK; Kapoor A; Yao W; Brunetto E; Kang Y; Yuan M; Asara JM; Wang YA; Heffernan TP; Kimmelman AC; Wang H; Fleming JB; Cantley LC; DePinho RA; Draetta GF. 2014. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature 514(7524):628-32. PubMed: 25119024MGI: J:217085
- Volckaert T; Campbell A; Dill E; Li C; Minoo P; De Langhe S. 2013. Localized Fgf10 expression is not required for lung branching morphogenesis but prevents differentiation of epithelial progenitors. Development 140(18):3731-42. PubMed: 23924632MGI: J:204465
- Volckaert T; Dill E; Campbell A; Tiozzo C; Majka S; Bellusci S; De Langhe SP. 2011. Parabronchial smooth muscle constitutes an airway epithelial stem cell niche in the mouse lung after injury. J Clin Invest 121(11):4409-19. PubMed: 21985786MGI: J:178444
- Wang J; Greene SB; Bonilla-Claudio M; Tao Y; Zhang J; Bai Y; Huang Z; Black BL; Wang F; Martin JF. 2010. Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism. Dev Cell 19(6):903-12. PubMed: 21145505MGI: J:169047
- Wang Y; Jarad G; Tripathi P; Pan M; Cunningham J; Martin DR; Liapis H; Miner JH; Chen F. 2010. Activation of NFAT signaling in podocytes causes glomerulosclerosis. J Am Soc Nephrol 21(10):1657-66. PubMed: 20651158MGI: J:185917
- Wehn AK; Chapman DL. 2010. Tbx18 and Tbx15 null-like phenotypes in mouse embryos expressing Tbx6 in somitic and lateral plate mesoderm. Dev Biol 347(2):404-13. PubMed: 20832395MGI: J:166775
- Wehn AK; Gallo PH; Chapman DL. 2009. Generation of transgenic mice expressing Cre recombinase under the control of the Dll1 mesoderm enhancer element. Genesis 47(5):309-313. PubMed: 19298012MGI: J:148512
- Willet SG; Hale MA; Grapin-Botton A; Magnuson MA; MacDonald RJ; Wright CV. 2014. Dominant and context-specific control of endodermal organ allocation by Ptf1a. Development 141(22):4385-94. PubMed: 25371369MGI: J:217597
- Xu K; Nieuwenhuis E; Cohen BL; Wang W; Canty AJ; Danska JS; Coultas L; Rossant J; Wu MY; Piscione TD; Nagy A; Gossler A; Hicks GG; Hui CC; Henkelman RM; Yu LX; Sled JG; Gridley T; Egan SE. 2010. Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis. Am J Physiol Lung Cell Mol Physiol 298(1):L45-56. PubMed: 19897741MGI: J:155893
- Ying H; Kimmelman AC; Lyssiotis CA; Hua S; Chu GC; Fletcher-Sananikone E; Locasale JW; Son J; Zhang H; Coloff JL; Yan H; Wang W; Chen S; Viale A; Zheng H; Paik JH; Lim C; Guimaraes AR; Martin ES; Chang J; Hezel AF; Perry SR; Hu J; Gan B; Xiao Y; Asara JM; Weissleder R; Wang YA; Chin L; Cantley LC; DePinho RA. 2012. Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell 149(3):656-70. PubMed: 22541435MGI: J:186194
- Zanconato F; Cordenonsi M; Piccolo S. 2016. YAP/TAZ at the Roots of Cancer. Cancer Cell 29(6):783-803. PubMed: 27300434MGI: J:232329
- Zhang F; Feridooni T; Hotchkiss A; Pasumarthi KB. 2015. Divergent cell cycle kinetics of midgestation ventricular cells entail a higher engraftment efficiency after cell transplantation. Am J Physiol Cell Physiol 308(3):C220-8. PubMed: 25411333MGI: J:223879
- Zhang Y; Morris JP 4th; Yan W; Schofield HK; Gurney A; Simeone DM; Millar SE; Hoey T; Hebrok M; Pasca di Magliano M. 2013. Canonical Wnt Signaling Is Required for Pancreatic Carcinogenesis. Cancer Res 73(15):4909-4922. PubMed: 23761328MGI: J:199468
- Zhang Y; Yan W; Collins MA; Bednar F; Rakshit S; Zetter BR; Stanger BZ; Chung I; Rhim AD; di Magliano MP. 2013. Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance. Cancer Res 73(20):6359-74. PubMed: 24097820MGI: J:205411
- Zhao R; Fallon TR; Saladi SV; Pardo-Saganta A; Villoria J; Mou H; Vinarsky V; Gonzalez-Celeiro M; Nunna N; Hariri LP; Camargo F; Ellisen LW; Rajagopal J. 2014. Yap tunes airway epithelial size and architecture by regulating the identity, maintenance, and self-renewal of stem cells. Dev Cell 30(2):151-65. PubMed: 25043474MGI: J:213949
- von Gise A; Lin Z; Schlegelmilch K; Honor LB; Pan GM; Buck JN; Ma Q; Ishiwata T; Zhou B; Camargo FD; Pu WT. 2012. YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy. Proc Natl Acad Sci U S A 109(7):2394-9. PubMed: 22308401MGI: J:182615