These mice carry a spontaneous mutation of the Limk2 gene characterized by a white spot on the eye.
Read More +Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous | Limk2 | LIM motif-containing protein kinase 2 |
Although the Lepob mutation has been selected against, it may still be segregating in this strain.
Subsequently, likely as a consequence of infection, homozygotes develop a small white spot and atypical growth of blood vessels on the cornea of each eye, although occasionally only one eye is affected.
The whe mutation arose spontaneously in the strain B6(V)-Lepob/J in 2003. Although the strain was maintained by sibling mating, phenotypically non-obese breeders were selected in order to breed the Lepob mutation out of the line. Nevertheless, obese mice were still present in this strain at generation F4. In 2006 C57BL/6J females and whe homozygous males at generation F5 were used for in vitro fertilization to generate embryos for cryopreservation.
Allele Name | white eyes |
---|---|
Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Limk2, LIM motif-containing protein kinase 2 |
Gene Synonym(s) | |
Strain of Origin | B6.Cg-Lepob/J |
Chromosome | 11 |
Molecular Note | A spontaneous mutation results in a C-to-A point mutation in the first base of intron 12. This eliminates the exon 12 splice donor site by changing it from G-GT to G-TT. |
When using the white eyes mouse strain in a publication, please cite the originating article(s) and include JAX stock #005624 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for Lep<ob>-whe |
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
What information were you hoping to find through your search?
How easy was it to find what you were looking for?
We may wish to follow up with you. Enter your email if you are happy for us to connect and reachout to you with more questions.
Please Enter a Valid Email Address
Thank you for sharing your feedback! We are working on improving the JAX Mice search. Come back soon for exciting changes.