JAX
Mouse Strain Datasheet - 005622
B6.Cg-Shhtm1(EGFP/cre)Cjt/J
Also Known As: Shhgfpcre
Fluorescence in these mice, consistent with the endogenous Shh locus, is detected in the distal posterior region of the limb buds of embryos aged embryonic day 10 to 12. Mice homozygous for the mutation develop a limited limb skeleton and lack digit 2. This mutant mouse strain may be useful in studies of limb patterning and development.
Donating Investigator
Clifford J Tabin, Harvard Medical School
Genetic overview
| Genetic Background | Generation |
|---|---|
|
N7F10
|
Shhtm1(EGFP/cre)Cjt
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Null/Knockout, Recombinase-expressing) | Shh | sonic hedgehog |
Base Price
Starting at:
| $263.00 Domestic price for female |
| $337.00 Domestic price for breeder pair |
Detailed Description
This strain expresses a fusion product involving Enhanced Green Fluorescent Protein (EGFP) and Cre recombinase from the endogenous Shh locus. EGFP and cre expression are consistent with the endogenous gene. Fluorescence is detected in the distal posterior region of the limb buds of embryos aged embryonic day 10 to 12 and colocalizes with the endogenous gene product (mRNA). The donating investigator reports that it is not uncommon for a mosaic expression pattern to be exhibited when the allele is inherited through the female germline. It is recommended that this allele be passed through the male germline when conducting experiments involving cre-induced recombination. Mice homozygous for the mutation develop a limited limb skeleton and lack digit 2. Homozygous mice are not viable or fertile. Heterozygous mutant mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. This mutant mouse strain may be useful in studies of limb patterning and development.
Development
A targeting vector containing a fusion product involving Enhanced Green Fluorescent Protein (EGFP) and Cre recombinase was inserted at the ATG of Shh and disrupted the sequence encoding the first 12 amino acids. The construct was electroporated into 129S6/SvEv-derived TC-1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts. The resulting chimeric animals were crossed to C57BL/6 mice, and the donating investigator reported that they were then backcrossed to the same for at least 5 generations.
A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, all 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to The Jackson Laboratory Repository were on a C57BL/6N genetic background.
Expression Data
| Expressed Gene | GFP, Green Fluorescent Protein, |
|---|---|
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
| Site of Expression | Distal posterior region of the limb buds of embryos aged embryonic day 10 to 12; also a Cre strain. |
Control Suggestions
- Wild-type from the colony
- 000664 C57BL/6J
Additional Information
Selected References
- Harfe BD; Scherz PJ; Nissim S; Tian H; McMahon AP; Tabin CJ. 2004. Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities.. In: . . MGI: J:92504
Shhtm1(EGFP/cre)Cjt
Allele Symbol: Shhtm1(EGFP/cre)Cjt
| Allele Name | targeted mutation 1, Clifford J Tabin |
|---|---|
| Allele Type | Targeted (Null/Knockout, Recombinase-expressing) |
| Allele Synonym(s) | Shh-GFP-Cre; Shh-cre; ShhCreEGFP; ShhGFP-Cre; Shhcre/Gfp; Shhgfpcre; Shhgfp-Cre; Shhgfpcre |
| Gene Symbol and Name | Shh, sonic hedgehog |
| Gene Synonym(s) | Dsh; HHG1; HLP3; HPE3; Hhg1; Hhg1; Hx; Hx; Hxl3; Hxl3; M100081; MCOPCB5; SMMCI; TPT; TPTPS; hedgehog gene 1; hemimelic extra toes; hemimelic extratoes like 3; short digits |
| Expressed Gene | GFP, Green Fluorescent Protein, |
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
| Site of Expression | Distal posterior region of the limb buds of embryos aged embryonic day 10 to 12; also a Cre strain. |
| Strain of Origin | Not Specified |
| Chromosome | 5 |
| Molecular Note | A cassette containing an in frame fusion between GFP and cre was inserted at the ATG. Upon recombination, the first 35 base pairs after the ATG were deleted. Fluorescence was detected in the distal posterior region of E10-E12 embryos. |
| Mutations Made By | Clifford Tabin, Harvard Medical School |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Developmental Biology Research
- Embryonic Lethality (Homozygous)
- Limb Patterning Defects
- Skeletal Defects
- Research Tools
- Cre-lox System
- Cre Recombinase Expression
- Cre Recombinase Expression: Germline/Embryonic Expression
- Developmental Biology Research
- Cre-lox System
- Fluorescent Proteins
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
- Cre-lox System
Genotype: GFP related
- Research Tools
- Fluorescent Proteins
Genotype: cre related
- Research Tools
- Cre-lox System
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
Mammalian Phenotype Terms by Genotype
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Shhtm1(EGFP/cre)Cjt/Shhtm1(EGFP/cre)Cjt
Not Specified
cardiovascular system phenotype
- abnormal atrium myocardium morphology
- mutants show reduced muscular development in dorsal wall of atria (MGI Ref ID J:204743)
- abnormal heart left atrium morphology
- (MGI Ref ID J:204743)
- abnormal pulmonary artery morphology
- pulmonary arteries connect to aorta instead of the ouflow tract (MGI Ref ID J:204743)
- abnormal vascular smooth muscle morphology
- reduction in vascular and airway smooth muscle derived from Isl1- and Gli1-positive cardiopulmonary mesoderm progenitors is detected (MGI Ref ID J:204743)
- abnormal vasculogenesis
- embryos have a disorganized vascular endothelial plexus along anterior foregut which does not connect to heart inflow and outflow tracts (MGI Ref ID J:204743)
- absent pulmonary vein
- pulmonary veins from left atrium to lung are absent (MGI Ref ID J:204743)
muscle phenotype
- abnormal vascular smooth muscle morphology
- reduction in vascular and airway smooth muscle derived from Isl1- and Gli1-positive cardiopulmonary mesoderm progenitors is detected (MGI Ref ID J:204743)
limbs/digits/tail phenotype
- abnormal limb bone morphology
- a limited skeletal structure consisting of the humerus, radius and single digit 1 is seen (MGI Ref ID J:92504)
skeleton phenotype
- abnormal limb bone morphology
- a limited skeletal structure consisting of the humerus, radius and single digit 1 is seen (MGI Ref ID J:92504)
respiratory system phenotype
- abnormal respiratory conducting tube morphology
- airway smooth muscle derived from Isl1- and Gli1-positive cardiopulmonary mesoderm progenitors is significantly reduced; airway smooth muscle development is reduced (MGI Ref ID J:204743)
References
- Harfe BD; Scherz PJ; Nissim S; Tian H; McMahon AP; Tabin CJ. 2004. Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities.. In: . . MGI: J:92504
Additional - Shhtm1(EGFP/cre)Cjt related
- Achim K; Peltopuro P; Lahti L; Li J; Salminen M; Partanen J. 2012. Distinct developmental origins and regulatory mechanisms for GABAergic neurons associated with dopaminergic nuclei in the ventral mesodiencephalic region.. In: . . MGI: J:185533
- Ahn Y; Sanderson BW; Klein OD; Krumlauf R. 2010. Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning.. In: . . MGI: J:168361
- Anderegg A; Lin HP; Chen JA; Caronia-Brown G; Cherepanova N; Yun B; Joksimovic M; Rock J; Harfe BD; Johnson R; Awatramani R. 2013. An Lmx1b-miR135a2 regulatory circuit modulates Wnt1/Wnt signaling and determines the size of the midbrain dopaminergic progenitor pool.. In: . . MGI: J:207519
- Aoto K; Trainor PA. 2015. Co-ordinated brain and craniofacial development depend upon Patched1/XIAP regulation of cell survival.. In: . . MGI: J:218093
- Bell SM; Zhang L; Mendell A; Xu Y; Haitchi HM; Lessard JL; Whitsett JA. 2011. Kruppel-like factor 5 is required for formation and differentiation of the bladder urothelium.. In: . . MGI: J:176604
- Bell SM; Zhang L; Xu Y; Besnard V; Wert SE; Shroyer N; Whitsett JA. 2013. Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium.. In: . . MGI: J:194289
- Belle M; Godefroy D; Dominici C; Heitz-Marchaland C; Zelina P; Hellal F; Bradke F; Chedotal A. 2014. A simple method for 3D analysis of immunolabeled axonal tracts in a transparent nervous system.. In: . . MGI: J:218756
- Bodea GO; Spille JH; Abe P; Andersson AS; Acker-Palmer A; Stumm R; Kubitscheck U; Blaess S. 2014. Reelin and CXCL12 regulate distinct migratory behaviors during the development of the dopaminergic system.. In: . . MGI: J:208337
- Boucherat O; Landry-Truchon K; Berube-Simard FA; Houde N; Beuret L; Lezmi G; Foulkes WD; Delacourt C; Charron J; Jeannotte L. 2015. Epithelial inactivation of Yy1 abrogates lung branching morphogenesis.. In: . . MGI: J:239777
- Boucherat O; Nadeau V; Berube-Simard FA; Charron J; Jeannotte L. 2014. Crucial requirement of ERK/MAPK signaling in respiratory tract development.. In: . . MGI: J:214083
- Chamberlain CE; Jeong J; Guo C; Allen BL; McMahon AP. 2008. Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning.. In: . . MGI: J:132152
- Chang DR; Martinez Alanis D; Miller RK; Ji H; Akiyama H; McCrea PD; Chen J. 2013. Lung epithelial branching program antagonizes alveolar differentiation.. In: . . MGI: J:202949
- Chang H; Smallwood PM; Williams J; Nathans J. 2016. The spatio-temporal domains of Frizzled6 action in planar polarity control of hair follicle orientation.. In: . . MGI: J:228792
- Choi KS; Harfe BD. 2011. Hedgehog signaling is required for formation of the notochord sheath and patterning of nuclei pulposi within the intervertebral discs.. In: . . MGI: J:173333
- Cocas LA; Fernandez G; Barch M; Doll J; Zamora Diaz I; Pleasure SJ. 2016. Cell Type-Specific Circuit Mapping Reveals the Presynaptic Connectivity of Developing Cortical Circuits.. In: . . MGI: J:231657
- Croyle MJ; Lehman JM; O'Connor AK; Wong SY; Malarkey EB; Iribarne D; Dowdle WE; Schoeb TR; Verney ZM; Athar M; Michaud EJ; Reiter JF; Yoder BK. 2011. Role of epidermal primary cilia in the homeostasis of skin and hair follicles.. In: . . MGI: J:171221
- Desai TJ; Brownfield DG; Krasnow MA. 2014. Alveolar progenitor and stem cells in lung development, renewal and cancer.. In: . . MGI: J:207468
- Dixit R; Ai X; Fine A. 2013. Derivation of lung mesenchymal lineages from the fetal mesothelium requires hedgehog signaling for mesothelial cell entry.. In: . . MGI: J:204973
- Domyan ET; Branchfield K; Gibson DA; Naiche LA; Lewandoski M; Tessier-Lavigne M; Ma L; Sun X. 2013. Roundabout receptors are critical for foregut separation from the body wall.. In: . . MGI: J:193400
- Domyan ET; Ferretti E; Throckmorton K; Mishina Y; Nicolis SK; Sun X. 2011. Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2.. In: . . MGI: J:169134
- Fabian SL; Penchev RR; St-Jacques B; Rao AN; Sipila P; West KA; McMahon AP; Humphreys BD. 2012. Hedgehog-Gli Pathway Activation during Kidney Fibrosis.. In: . . MGI: J:182155
- Fantauzzo KA; Kurban M; Levy B; Christiano AM. 2012. Trps1 and its target gene Sox9 regulate epithelial proliferation in the developing hair follicle and are associated with hypertrichosis.. In: . . MGI: J:194118
- Fausett SR; Brunet LJ; Klingensmith J. 2014. BMP antagonism by Noggin is required in presumptive notochord cells for mammalian foregut morphogenesis.. In: . . MGI: J:213659
- Flandin P; Kimura S; Rubenstein JL. 2010. The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons.. In: . . MGI: J:157830
- Galvis LA; Holik AZ; Short KM; Pasquet J; Lun AT; Blewitt ME; Smyth IM; Ritchie ME; Asselin-Labat ML. 2015. Repression of Igf1 expression by Ezh2 prevents basal cell differentiation in the developing lung.. In: . . MGI: J:220467
- Gandhi D; Molotkov A; Batourina E; Schneider K; Dan H; Reiley M; Laufer E; Metzger D; Liang F; Liao Y; Sun TT; Aronow B; Rosen R; Mauney J; Adam R; Rosselot C; Van Batavia J; McMahon A; McMahon J; Guo JJ; Mendelsohn C. 2013. Retinoid signaling in progenitors controls specification and regeneration of the urothelium.. In: . . MGI: J:204539
- Garriock RJ; Chalamalasetty RB; Kennedy MW; Canizales LC; Lewandoski M; Yamaguchi TP. 2015. Lineage tracing of neuromesodermal progenitors reveals novel Wnt-dependent roles in trunk progenitor cell maintenance and differentiation.. In: . . MGI: J:221408
- Genetic Resource Science at The Jackson Laboratory. 2012. Expression/Specificity Patterns of Cre Alleles, 2012. In: . . MGI: J:184579
- Glasco DM; Pike W; Qu Y; Reustle L; Misra K; Di Bonito M; Studer M; Fritzsch B; Goffinet AM; Tissir F; Chandrasekhar A. 2016. The atypical cadherin Celsr1 functions non-cell autonomously to block rostral migration of facial branchiomotor neurons in mice.. In: . . MGI: J:235628
- Glotzer DJ; Zelzer E; Olsen BR. 2008. Impaired skin and hair follicle development in Runx2 deficient mice.. In: . . MGI: J:132568
- Goss AM; Tian Y; Tsukiyama T; Cohen ED; Zhou D; Lu MM; Yamaguchi TP; Morrisey EE. 2009. Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut.. In: . . MGI: J:153098
- Gredler ML; Seifert AW; Cohn MJ. 2015. Tissue-specific roles of Fgfr2 in development of the external genitalia.. In: . . MGI: J:224075
- Greif DM; Kumar M; Lighthouse JK; Hum J; An A; Ding L; Red-Horse K; Espinoza FH; Olson L; Offermanns S; Krasnow MA. 2012. Radial construction of an arterial wall.. In: . . MGI: J:189012
- Gritli-Linde A; Hallberg K; Harfe BD; Reyahi A; Kannius-Janson M; Nilsson J; Cobourne MT; Sharpe PT; McMahon AP; Linde A. 2007. Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling.. In: . . MGI: J:117334
- Guo C; Balsara ZR; Hill WG; Li X. 2017. Stage- and subunit-specific functions of polycomb repressive complex 2 in bladder urothelial formation and regeneration.. In: . . MGI: J:239161
- Haara O; Fujimori S; Schmidt-Ullrich R; Hartmann C; Thesleff I; Mikkola ML. 2011. Ectodysplasin and Wnt pathways are required for salivary gland branching morphogenesis.. In: . . MGI: J:173573
- Harfe BD; McManus MT; Mansfield JH; Hornstein E; Tabin CJ. 2005. The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb.. In: . . MGI: J:100475
- Harjunmaa E; Kallonen A; Voutilainen M; Hamalainen K; Mikkola ML; Jernvall J. 2012. On the difficulty of increasing dental complexity.. In: . . MGI: J:182586
- Harris KS; Zhang Z; McManus MT; Harfe BD; Sun X. 2006. Dicer function is essential for lung epithelium morphogenesis.. In: . . MGI: J:106072
- Harwell CC; Parker PR; Gee SM; Okada A; McConnell SK; Kreitzer AC; Kriegstein AR. 2012. Sonic hedgehog expression in corticofugal projection neurons directs cortical microcircuit formation.. In: . . MGI: J:183457
- Hayes L; Ralls S; Wang H; Ahn S. 2013. Duration of Shh signaling contributes to mDA neuron diversity.. In: . . MGI: J:193109
- Herriges JC; Verheyden JM; Zhang Z; Sui P; Zhang Y; Anderson MJ; Swing DA; Zhang Y; Lewandoski M; Sun X. 2015. FGF-Regulated ETV Transcription Factors Control FGF-SHH Feedback Loop in Lung Branching.. In: . . MGI: J:240020
- Higashiyama H; Ozawa A; Sumitomo H; Uemura M; Fujino K; Igarashi H; Imaimatsu K; Tsunekawa N; Hirate Y; Kurohmaru M; Saijoh Y; Kanai-Azuma M; Kanai Y. 2017. Embryonic cholecystitis and defective gallbladder contraction in the Sox17-haploinsufficient mouse model of biliary atresia.. In: . . MGI: J:241569
- Hsu YC; Li L; Fuchs E. 2014. Transit-amplifying cells orchestrate stem cell activity and tissue regeneration.. In: . . MGI: J:214395
- Huang YC; Chen F; Li X. 2016. Clarification of mammalian cloacal morphogenesis using high-resolution episcopic microscopy.. In: . . MGI: J:240373
- Ishida K; Murofushi M; Nakao K; Morita R; Ogawa M; Tsuji T. 2011. The regulation of tooth morphogenesis is associated with epithelial cell proliferation and the expression of Sonic hedgehog through epithelial-mesenchymal interactions.. In: . . MGI: J:170606
- Jiang M; Ku WY; Fu J; Offermanns S; Hsu W; Que J. 2013. Gpr177 regulates pulmonary vasculature development.. In: . . MGI: J:199291
- Joksimovic M; Yun BA; Kittappa R; Anderegg AM; Chang WW; Taketo MM; McKay RD; Awatramani RB. 2009. Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis.. In: . . MGI: J:146200
- Joo JH; Taxter TJ; Munguba GC; Kim YH; Dhaduvai K; Dunn NW; Degan WJ; Oh SP; Sugrue SP. 2010. Pinin modulates expression of an intestinal homeobox gene, Cdx2, and plays an essential role for small intestinal morphogenesis.. In: . . MGI: J:164807
- Juuri E; Jussila M; Seidel K; Holmes S; Wu P; Richman J; Heikinheimo K; Chuong CM; Arnold K; Hochedlinger K; Klein O; Michon F; Thesleff I. 2013. Sox2 marks epithelial competence to generate teeth in mammals and reptiles.. In: . . MGI: J:194917
- Juuri E; Saito K; Ahtiainen L; Seidel K; Tummers M; Hochedlinger K; Klein OD; Thesleff I; Michon F. 2012. Sox2+ Stem Cells Contribute to All Epithelial Lineages of the Tooth via Sfrp5+ Progenitors.. In: . . MGI: J:187606
- Kadzik RS; Cohen ED; Morley MP; Stewart KM; Lu MM; Morrisey EE. 2014. Wnt ligand/Frizzled 2 receptor signaling regulates tube shape and branch-point formation in the lung through control of epithelial cell shape.. In: . . MGI: J:213915
- Kasberg AD; Brunskill EW; Steven Potter S. 2013. SP8 regulates signaling centers during craniofacial development.. In: . . MGI: J:200761
- Kim BM; Mao J; Taketo MM; Shivdasani RA. 2007. Phases of canonical Wnt signaling during the development of mouse intestinal epithelium.. In: . . MGI: J:128278
- Kim BM; Miletich I; Mao J; McMahon AP; Sharpe PA; Shivdasani RA. 2007. Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen.. In: . . MGI: J:128378
- Kim TH; Kim BM; Mao J; Rowan S; Shivdasani RA. 2011. Endodermal Hedgehog signals modulate Notch pathway activity in the developing digestive tract mesenchyme.. In: . . MGI: J:180905
- King P; Paul A; Laufer E. 2009. Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages.. In: . . MGI: J:155826
- Kittappa R; Chang WW; Awatramani RB; McKay RD. 2007. The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age.. In: . . MGI: J:130846
- Kur E; Mecklenburg N; Cabrera RM; Willnow TE; Hammes A. 2014. LRP2 mediates folate uptake in the developing neural tube.. In: . . MGI: J:214694
- Lahti L; Saarimaki-Vire J; Rita H; Partanen J. 2011. FGF signaling gradient maintains symmetrical proliferative divisions of midbrain neuronal progenitors.. In: . . MGI: J:168023
- Li G; Fang L; Fernandez G; Pleasure SJ. 2013. The ventral hippocampus is the embryonic origin for adult neural stem cells in the dentate gyrus.. In: . . MGI: J:201555
- Li S; Morley M; Lu M; Zhou S; Stewart K; French CA; Tucker HO; Fisher SE; Morrisey EE. 2016. Foxp transcription factors suppress a non-pulmonary gene expression program to permit proper lung development.. In: . . MGI: J:234990
- Li S; Wang Y; Zhang Y; Lu MM; Demayo FJ; Dekker JD; Tucker PW; Morrisey EE. 2012. Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2.. In: . . MGI: J:185603
- Li X; Liu Z; Qiu M; Yang Z. 2014. Sp8 plays a supplementary role to Pax6 in establishing the pMN/p3 domain boundary in the spinal cord.. In: . . MGI: J:213871
- Lin C; Fisher AV; Yin Y; Maruyama T; Veith GM; Dhandha M; Huang GJ; Hsu W; Ma L. 2011. The inductive role of Wnt-beta-Catenin signaling in the formation of oral apparatus.. In: . . MGI: J:175262
- Lin C; Yao E; Chuang PT. 2015. A conserved MST1/2-YAP axis mediates Hippo signaling during lung growth.. In: . . MGI: J:224948
- Lin C; Yin Y; Bell SM; Veith GM; Chen H; Huh SH; Ornitz DM; Ma L. 2013. Delineating a conserved genetic cassette promoting outgrowth of body appendages.. In: . . MGI: J:223057
- Lin C; Yin Y; Long F; Ma L. 2008. Tissue-specific requirements of beta-catenin in external genitalia development.. In: . . MGI: J:139251
- Lin C; Yin Y; Veith GM; Fisher AV; Long F; Ma L. 2009. Temporal and spatial dissection of Shh signaling in genital tubercle development.. In: . . MGI: J:158288
- Lin HP; Oksuz I; Hurley E; Wrabetz L; Awatramani R. 2015. Microprocessor Complex Subunit DiGeorge Syndrome Critical Region Gene 8 (Dgcr8) Is Required for Schwann Cell Myelination and Myelin Maintenance.. In: . . MGI: J:225866
- Liu Z; Owen T; Zhang L; Zuo J. 2010. Dynamic expression pattern of Sonic hedgehog in developing cochlear spiral ganglion neurons.. In: . . MGI: J:160591
- Lochovska K; Peterkova R; Pavlikova Z; Hovorakova M. 2015. Sprouty gene dosage influences temporal-spatial dynamics of primary enamel knot formation.. In: . . MGI: J:221422
- Lopez-Rios J; Speziale D; Robay D; Scotti M; Osterwalder M; Nusspaumer G; Galli A; Hollander GA; Kmita M; Zeller R. 2012. GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis.. In: . . MGI: J:184012
- Lu F; Kar D; Gruenig N; Zhang ZW; Cousins N; Rodgers HM; Swindell EC; Jamrich M; Schuurmans C; Mathers PH; Kurrasch DM. 2013. Rax is a selector gene for mediobasal hypothalamic cell types.. In: . . MGI: J:193919
- Lungova V; Verheyden JM; Herriges J; Sun X; Thibeault SL. 2015. Ontogeny of the mouse vocal fold epithelium.. In: . . MGI: J:219800
- Mahoney JE; Mori M; Szymaniak AD; Varelas X; Cardoso WV. 2014. The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors.. In: . . MGI: J:213950
- Maier JA; Harfe BD. 2011. Nuclei Pulposi Formation From the Embryonic Notochord Occurs Normally in GDF-5-Deficient Mice.. In: . . MGI: J:178272
- Maier JA; Lo Y; Harfe BD. 2013. Foxa1 and Foxa2 are required for formation of the intervertebral discs.. In: . . MGI: J:195910
- Mao J; Kim BM; Rajurkar M; Shivdasani RA; McMahon AP. 2010. Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract.. In: . . MGI: J:160363
- McCracken KW; Aihara E; Martin B; Crawford CM; Broda T; Treguier J; Zhang X; Shannon JM; Montrose MH; Wells JM. 2017. Wnt/beta-catenin promotes gastric fundus specification in mice and humans.. In: . . MGI: J:243618
- Mori M; Hazan R; Danielian PS; Mahoney JE; Li H; Lu J; Miller ES; Zhu X; Lees JA; Cardoso WV. 2017. Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis.. In: . . MGI: J:241925
- Mori M; Mahoney JE; Stupnikov MR; Paez-Cortez JR; Szymaniak AD; Varelas X; Herrick DB; Schwob J; Zhang H; Cardoso WV. 2015. Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors.. In: . . MGI: J:238903
- Morimoto M; Nishinakamura R; Saga Y; Kopan R. 2012. Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells.. In: . . MGI: J:190886
- Munne PM; Tummers M; Jarvinen E; Thesleff I; Jernvall J. 2009. Tinkering with the inductive mesenchyme: Sostdc1 uncovers the role of dental mesenchyme in limiting tooth induction.. In: . . MGI: J:144193
- Norrie JL; Lewandowski JP; Bouldin CM; Amarnath S; Li Q; Vokes MS; Ehrlich LI; Harfe BD; Vokes SA. 2014. Dynamics of BMP signaling in limb bud mesenchyme and polydactyly.. In: . . MGI: J:214075
- Nouri N; Awatramani R. 2017. A novel floor plate boundary defined by adjacent En1 and Dbx1 microdomains distinguishes midbrain dopamine and hypothalamic neurons.. In: . . MGI: J:240032
- Nouri N; Patel MJ; Joksimovic M; Poulin JF; Anderegg A; Taketo MM; Ma YC; Awatramani R. 2015. Excessive Wnt/beta-catenin signaling promotes midbrain floor plate neurogenesis, but results in vacillating dopamine progenitors.. In: . . MGI: J:231849
- Omori A; Harada M; Ohta S; Villacorte M; Sugimura Y; Shiraishi T; Suzuki K; Nakagata N; Ito T; Yamada G. 2011. Epithelial Bmp (Bone morphogenetic protein) signaling for bulbourethral gland development: a mouse model for congenital cystic dilation.. In: . . MGI: J:176595
- Oommen S; Otsuka-Tanaka Y; Imam N; Kawasaki M; Kawasaki K; Jalani-Ghazani F; Anderegg A; Awatramani R; Hindges R; Sharpe PT; Ohazama A. 2012. Distinct roles of MicroRNAs in epithelium and mesenchyme during tooth development.. In: . . MGI: J:186496
- Pan JH; Adair-Kirk TL; Patel AC; Huang T; Yozamp NS; Xu J; Reddy EP; Byers DE; Pierce RA; Holtzman MJ; Brody SL. 2014. Myb permits multilineage airway epithelial cell differentiation.. In: . . MGI: J:218553
- Peng T; Frank DB; Kadzik RS; Morley MP; Rathi KS; Wang T; Zhou S; Cheng L; Lu MM; Morrisey EE. 2015. Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration.. In: . . MGI: J:226770
- Peng T; Tian Y; Boogerd CJ; Lu MM; Kadzik RS; Stewart KM; Evans SM; Morrisey EE. 2013. Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor.. In: . . MGI: J:204743
- Prochazka J; Pantalacci S; Churava S; Rothova M; Lambert A; Lesot H; Klein O; Peterka M; Laudet V; Peterkova R. 2010. Patterning by heritage in mouse molar row development.. In: . . MGI: J:163666
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