JAX
Mouse Strain Datasheet - 005584
B6.Cg-Tg(Prrx1-cre)1Cjt/J
Also Known As: Prx1-Cre
This transgene expresses Cre recombinase under the control of a Prrx1 derived enhancer, and is expressed in the early limb bud mesenchyme and in a subset of craniofacial mesenchyme. This strain represents an effective tool for generating tissue specific-targeted mutants useful in studies of limb bud development and patterning.
Donating Investigator
Clifford J Tabin, Harvard Medical School
Genetic overview
| Genetic Background | Generation |
|---|---|
|
N12+N3pN2
|
Tg(Prrx1-cre)1Cjt
| Allele Type |
|---|
| Transgenic (Recombinase-expressing) |
Base Price
Starting at:
| $255.00 Domestic price for female |
| $329.00 Domestic price for breeder pair |
Detailed Description
Mice homozygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. These transgenic mice express Cre recombinase under the control of the paired related homeobox 1 promoter. Cre recombinase expression closely patterns endogenous gene expression and is detectable by embryonic day 9.5. Some recombination occurs in the female germline. When crossed with a strain containing a loxP site-flanked sequence of interest, Cre-mediated recombination results in deletion of the flanked sequence in early limb bud mesenchyme. This strain represents an effective tool for generating tissue specific-targeted mutants useful in studies of limb bud development and patterning.
View cre expression characterization.
Development
A transgenic construct containing cre coding sequence under the control of the paired related homeobox 1 promoter was microinjected into B6SJLF2 donor oocytes. Founder animals were backcrossed to C57BL/6J for 12 generations.
Expression Data
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
|---|---|
| Site of Expression | early limb bud mesenchyme and in a subset of craniofacial mesenchyme, some female germline expression |
Control Suggestions
Selected References
- Logan M; Martin JF; Nagy A; Lobe C; Olson EN; Tabin CJ. 2002. Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer. Genesis 33(2):77-80. PubMed: 12112875MGI: J:77872
Tg(Prrx1-cre)1Cjt
Allele Symbol: Tg(Prrx1-cre)1Cjt
| Allele Name | transgene insertion 1, Clifford J Tabin |
|---|---|
| Allele Type | Transgenic (Recombinase-expressing) |
| Allele Synonym(s) | Prx-1 Cre; Prx-cre; Prx1-cre; Prx1cre; Prx1Cre; Tg[Prx1-cre]1Cjt |
| Gene Symbol and Name | Tg(Prrx1-cre)1Cjt, transgene insertion 1, Clifford J Tabin |
| Gene Synonym(s) | Prx-1 Cre; Prx-cre; Prx1-cre; Prx1cre; Prx1Cre |
| Promoter | Prrx1, paired related homeobox 1, rat |
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
| Site of Expression | early limb bud mesenchyme and in a subset of craniofacial mesenchyme, some female germline expression |
| Strain of Origin | (C57BL/6J x SJL/J)F2 |
| Chromosome | UN |
| Molecular Note | This transgene expresses Cre recombinase under the control of a Prrx1 derived enhancer. This transgene is expressed in the early limb bud mesenchyme and in a subset of craniofacial mesenchyme. A germline Cre recombinase activity was observed in female, but not in male, as partially penetrant trait depending on the particular gene flanked by loxP sites. |
| Mutations Made By | Malcolm Logan, National Institute for Medical Research |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Developmental Biology Research
- Craniofacial and Palate Defects
- Orofacial clefting-specific cre expression
- Craniofacial and Palate Defects
- Research Tools
- Cre-lox System
- Cre Recombinase Expression
- Cre-lox System
Genotype: cre related
- Research Tools
- Cre-lox System
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
References
- Logan M; Martin JF; Nagy A; Lobe C; Olson EN; Tabin CJ. 2002. Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer. Genesis 33(2):77-80. PubMed: 12112875MGI: J:77872
Additional - Tg(Prrx1-cre)1Cjt related
- Abula K; Muneta T; Miyatake K; Yamada J; Matsukura Y; Inoue M; Sekiya I; Graf D; Economides AN; Rosen V; Tsuji K. 2015. Elimination of BMP7 from the developing limb mesenchyme leads to articular cartilage degeneration and synovial inflammation with increased age. FEBS Lett 589(11):1240-8. PubMed: 25889639MGI: J:221175
- Ahrens MJ; Li Y; Jiang H; Dudley AT. 2009. Convergent extension movements in growth plate chondrocytes require gpi-anchored cell surface proteins. Development 136(20):3463-74. PubMed: 19762422MGI: J:153618
- Ailixiding M; Aibibula Z; Iwata M; Piao J; Hara Y; Koga D; Okawa A; Morita S; Asou Y. 2015. Pivotal role of Sirt6 in the crosstalk among ageing, metabolic syndrome and osteoarthritis. Biochem Biophys Res Commun 466(3):319-26. PubMed: 26362183MGI: J:232869
- Aizawa R; Yamada A; Suzuki D; Iimura T; Kassai H; Harada T; Tsukasaki M; Yamamoto G; Tachikawa T; Nakao K; Yamamoto M; Yamaguchi A; Aiba A; Kamijo R. 2012. Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development. Mech Dev 129(1-4):38-50. PubMed: 22387309MGI: J:184022
- Akiyama H; Chaboissier MC; Martin JF; Schedl A; De Crombrugghe B. 2002. The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev 16(21):2813-28. PubMed: 12414734MGI: J:79879
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- Bobick BE; Cobb J. 2012. Shox2 regulates progression through chondrogenesis in the mouse proximal limb. J Cell Sci 125(Pt 24):6071-83. PubMed: 23038774MGI: J:200262
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- Cai H; Liu A. 2016. Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling. Proc Natl Acad Sci U S A 113(51):14751-14756. PubMed: 27930311MGI: J:239074
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- Chakkalakal SA; Uchibe K; Convente MR; Zhang D; Economides AN; Kaplan FS; Pacifici M; Iwamoto M; Shore EM. 2016. Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation. J Bone Miner Res 31(9):1666-75. PubMed: 26896819MGI: J:239136
- Chappuis V; Gamer L; Cox K; Lowery JW; Bosshardt DD; Rosen V. 2012. Periosteal BMP2 activity drives bone graft healing. Bone 51(4):800-9. PubMed: 22846673MGI: J:193357
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- Chen J; Long F. 2014. mTORC1 signaling controls mammalian skeletal growth through stimulation of protein synthesis. Development 141(14):2848-54. PubMed: 24948603MGI: J:213870
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- Chen Y; Gridley T. 2013. Compensatory regulation of the Snai1 and Snai2 genes during chondrogenesis. J Bone Miner Res 28(6):1412-21. PubMed: 23322385MGI: J:211539
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- Cinque L; Forrester A; Bartolomeo R; Svelto M; Venditti R; Montefusco S; Polishchuk E; Nusco E; Rossi A; Medina DL; Polishchuk R; De Matteis MA; Settembre C. 2015. FGF signalling regulates bone growth through autophagy. Nature 528(7581):272-5. PubMed: 26595272MGI: J:228212
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- Cook JR; Smaldone S; Cozzolino C; Del Solar M; Lee-Arteaga S; Nistala H; Ramirez F. 2012. Generation of Fbn1 conditional null mice implicates the extracellular microfibrils in osteoprogenitor recruitment. Genesis 50(8):635-41. PubMed: 22374917MGI: J:187484
- Cui Y; Niziolek PJ; Macdonald BT; Zylstra CR; Alenina N; Robinson DR; Zhong Z; Matthes S; Jacobsen CM; Conlon RA; Brommage R; Liu Q; Mseeh F; Powell DR; Yang QM; Zambrowicz B; Gerrits H; Gossen JA; He X; Bader M; Williams BO; Warman ML; Robling AG. 2011. Lrp5 functions in bone to regulate bone mass. Nat Med 17(6):684-91. PubMed: 21602802MGI: J:172746
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- El Khassawna T; Toben D; Kolanczyk M; Schmidt-Bleek K; Koennecke I; Schell H; Mundlos S; Duda GN. 2012. Deterioration of fracture healing in the mouse model of NF1 long bone dysplasia. Bone 51(4):651-60. PubMed: 22868293MGI: J:193350
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- Gamer LW; Tsuji K; Cox K; Capelo LP; Lowery J; Beppu H; Rosen V. 2011. BMPR-II is dispensable for formation of the limb skeleton. Genesis 49(9):719-24. PubMed: 21538804MGI: J:175737
- Gao Y; Lan Y; Liu H; Jiang R. 2011. The zinc finger transcription factors Osr1 and Osr2 control synovial joint formation. Dev Biol 352(1):83-91. PubMed: 21262216MGI: J:171478
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- Howard PW; Howard TL; Maurer RA. 2010. Generation of mice with a conditional allele for Ift172. Transgenic Res 19(1):121-6. PubMed: 19521792MGI: J:156426
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