JAX
Mouse Strain Datasheet - 005584
B6.Cg-Tg(Prrx1-cre)1Cjt/J
Also Known As: Prx1-Cre
This transgene expresses Cre recombinase under the control of a Prrx1 derived enhancer, and is expressed in the early limb bud mesenchyme and in a subset of craniofacial mesenchyme. This strain represents an effective tool for generating tissue specific-targeted mutants useful in studies of limb bud development and patterning.
Donating Investigator
Clifford J Tabin, Harvard Medical School
Genetic overview
| Genetic Background | Generation |
|---|---|
|
N12+N3pN2
(19-SEP-16) |
Tg(Prrx1-cre)1Cjt
| Allele Type |
|---|
| Transgenic (Recombinase-expressing) |
Base Price
Starting at:
| $255.00 Domestic price for female |
| $329.00 Domestic price for breeder pair |
Detailed Description
Mice homozygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. These transgenic mice express Cre recombinase under the control of the paired related homeobox 1 promoter. Cre recombinase expression closely patterns endogenous gene expression and is detectable by embryonic day 9.5. Some recombination occurs in the female germline. When crossed with a strain containing a loxP site-flanked sequence of interest, Cre-mediated recombination results in deletion of the flanked sequence in early limb bud mesenchyme. This strain represents an effective tool for generating tissue specific-targeted mutants useful in studies of limb bud development and patterning.
View cre expression characterization.
Development
A transgenic construct containing cre coding sequence under the control of the paired related homeobox 1 promoter was microinjected into B6SJLF2 donor oocytes. Founder animals were backcrossed to C57BL/6J for 12 generations.
Expression Data
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
|---|---|
| Site of Expression | early limb bud mesenchyme and in a subset of craniofacial mesenchyme, some female germline expression |
Control Suggestions
Selected References
- Logan M; Martin JF; Nagy A; Lobe C; Olson EN; Tabin CJ. 2002. Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer. Genesis 33(2):77-80. PubMed: 12112875MGI: J:77872
Tg(Prrx1-cre)1Cjt
Allele Symbol: Tg(Prrx1-cre)1Cjt
| Allele Name | transgene insertion 1, Clifford J Tabin |
|---|---|
| Allele Type | Transgenic (Recombinase-expressing) |
| Allele Synonym(s) | Prx-1 Cre; Prx-cre; Prx1-cre; Prx1cre; Prx1Cre; Tg[Prx1-cre]1Cjt |
| Gene Symbol and Name | Tg(Prrx1-cre)1Cjt, transgene insertion 1, Clifford J Tabin |
| Gene Synonym(s) | Prx-1 Cre; Prx-cre; Prx1-cre; Prx1cre; Prx1Cre |
| Promoter | Prrx1, paired related homeobox 1, rat |
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
| Site of Expression | early limb bud mesenchyme and in a subset of craniofacial mesenchyme, some female germline expression |
| Strain of Origin | (C57BL/6J x SJL/J)F2 |
| Chromosome | UN |
| Molecular Note | This transgene expresses Cre recombinase under the control of a Prrx1 derived enhancer. This transgene is expressed in the early limb bud mesenchyme and in a subset of craniofacial mesenchyme. A germline Cre recombinase activity was observed in female, but not in male, as partially penetrant trait depending on the particular gene flanked by loxP sites. |
| Mutations Made By | Malcolm Logan, National Institute for Medical Research |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Developmental Biology Research
- Craniofacial and Palate Defects
- Orofacial clefting-specific cre expression
- Craniofacial and Palate Defects
- Research Tools
- Cre-lox System
- Cre Recombinase Expression
- Cre-lox System
Genotype: cre related
- Research Tools
- Cre-lox System
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
References
- Logan M; Martin JF; Nagy A; Lobe C; Olson EN; Tabin CJ. 2002. Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer. Genesis 33(2):77-80. PubMed: 12112875MGI: J:77872
Additional - Tg(Prrx1-cre)1Cjt related
- Abula K; Muneta T; Miyatake K; Yamada J; Matsukura Y; Inoue M; Sekiya I; Graf D; Economides AN; Rosen V; Tsuji K. 2015. Elimination of BMP7 from the developing limb mesenchyme leads to articular cartilage degeneration and synovial inflammation with increased age. FEBS Lett 589(11):1240-8. PubMed: 25889639MGI: J:221175
- Ahrens MJ; Li Y; Jiang H; Dudley AT. 2009. Convergent extension movements in growth plate chondrocytes require gpi-anchored cell surface proteins. Development 136(20):3463-74. PubMed: 19762422MGI: J:153618
- Ailixiding M; Aibibula Z; Iwata M; Piao J; Hara Y; Koga D; Okawa A; Morita S; Asou Y. 2015. Pivotal role of Sirt6 in the crosstalk among ageing, metabolic syndrome and osteoarthritis. Biochem Biophys Res Commun 466(3):319-26. PubMed: 26362183MGI: J:232869
- Aizawa R; Yamada A; Suzuki D; Iimura T; Kassai H; Harada T; Tsukasaki M; Yamamoto G; Tachikawa T; Nakao K; Yamamoto M; Yamaguchi A; Aiba A; Kamijo R. 2012. Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development. Mech Dev 129(1-4):38-50. PubMed: 22387309MGI: J:184022
- Akiyama H; Chaboissier MC; Martin JF; Schedl A; De Crombrugghe B. 2002. The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev 16(21):2813-28. PubMed: 12414734MGI: J:79879
- Akiyama R; Kawakami H; Wong J; Oishi I; Nishinakamura R; Kawakami Y. 2015. Sall4-Gli3 system in early limb progenitors is essential for the development of limb skeletal elements. Proc Natl Acad Sci U S A 112(16):5075-80. PubMed: 25848055MGI: J:220960
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- Bimonte S; De Angelis A; Quagliata L; Giusti F; Tammaro R; Dallai R; Ascenzi MG; Diez-Roux G; Franco B. 2011. Ofd1 is required in limb bud patterning and endochondral bone development. Dev Biol 349(2):179-91. PubMed: 20920500MGI: J:168038
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- Blitz E; Viukov S; Sharir A; Shwartz Y; Galloway JL; Pryce BA; Johnson RL; Tabin CJ; Schweitzer R; Zelzer E. 2009. Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction. Dev Cell 17(6):861-73. PubMed: 20059955MGI: J:156015
- Bobick BE; Cobb J. 2012. Shox2 regulates progression through chondrogenesis in the mouse proximal limb. J Cell Sci 125(Pt 24):6071-83. PubMed: 23038774MGI: J:200262
- Bruce SJ; Butterfield NC; Metzis V; Town L; McGlinn E; Wicking C. 2010. Inactivation of Patched1 in the mouse limb has novel inhibitory effects on the chondrogenic program. J Biol Chem 285(36):27967-81. PubMed: 20576618MGI: J:166182
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- Cai H; Liu A. 2016. Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling. Proc Natl Acad Sci U S A 113(51):14751-14756. PubMed: 27930311MGI: J:239074
- Calo E; Quintero-Estades JA; Danielian PS; Nedelcu S; Berman SD; Lees JA. 2010. Rb regulates fate choice and lineage commitment in vivo. Nature 466(7310):1110-4. PubMed: 20686481MGI: J:163313
- Canalis E; Kranz L; Zanotti S. 2014. Nemo-like kinase regulates postnatal skeletal homeostasis. J Cell Physiol 229(11):1736-43. PubMed: 24664870MGI: J:232075
- Canalis E; Zanotti S; Beamer WG; Economides AN; Smerdel-Ramoya A. 2010. Connective tissue growth factor is required for skeletal development and postnatal skeletal homeostasis in male mice. Endocrinology 151(8):3490-501. PubMed: 20534727MGI: J:163027
- Cao T; Wang C; Yang M; Wu C; Wang B. 2013. Mouse limbs expressing only the Gli3 repressor resemble those of Sonic hedgehog mutants. Dev Biol 379(2):221-8. PubMed: 23644062MGI: J:199480
- Chakkalakal SA; Uchibe K; Convente MR; Zhang D; Economides AN; Kaplan FS; Pacifici M; Iwamoto M; Shore EM. 2016. Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation. J Bone Miner Res 31(9):1666-75. PubMed: 26896819MGI: J:239136
- Chappuis V; Gamer L; Cox K; Lowery JW; Bosshardt DD; Rosen V. 2012. Periosteal BMP2 activity drives bone graft healing. Bone 51(4):800-9. PubMed: 22846673MGI: J:193357
- Chen J; Holguin N; Shi Y; Silva MJ; Long F. 2015. mTORC2 Signaling Promotes Skeletal Growth and Bone Formation in Mice. J Bone Miner Res 30(2):369-78. PubMed: 25196701MGI: J:218063
- Chen J; Long F. 2014. mTORC1 signaling controls mammalian skeletal growth through stimulation of protein synthesis. Development 141(14):2848-54. PubMed: 24948603MGI: J:213870
- Chen Q; Sinha K; Deng JM; Yasuda H; Krahe R; Behringer RR; de Crombrugghe B. 2015. Mesenchymal Deletion of Histone Demethylase NO66 in Mice Promotes Bone Formation. J Bone Miner Res 30(9):1608-17. PubMed: 25736226MGI: J:224562
- Chen Y; Gridley T. 2013. Compensatory regulation of the Snai1 and Snai2 genes during chondrogenesis. J Bone Miner Res 28(6):1412-21. PubMed: 23322385MGI: J:211539
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- Cinque L; Forrester A; Bartolomeo R; Svelto M; Venditti R; Montefusco S; Polishchuk E; Nusco E; Rossi A; Medina DL; Polishchuk R; De Matteis MA; Settembre C. 2015. FGF signalling regulates bone growth through autophagy. Nature 528(7581):272-5. PubMed: 26595272MGI: J:228212
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- Compagni A; Logan M; Klein R; Adams RH. 2003. Control of skeletal patterning by ephrinB1-EphB interactions. Dev Cell 5(2):217-30. PubMed: 12919674MGI: J:110732
- Cook JR; Smaldone S; Cozzolino C; Del Solar M; Lee-Arteaga S; Nistala H; Ramirez F. 2012. Generation of Fbn1 conditional null mice implicates the extracellular microfibrils in osteoprogenitor recruitment. Genesis 50(8):635-41. PubMed: 22374917MGI: J:187484
- Cui Y; Niziolek PJ; Macdonald BT; Zylstra CR; Alenina N; Robinson DR; Zhong Z; Matthes S; Jacobsen CM; Conlon RA; Brommage R; Liu Q; Mseeh F; Powell DR; Yang QM; Zambrowicz B; Gerrits H; Gossen JA; He X; Bader M; Williams BO; Warman ML; Robling AG. 2011. Lrp5 functions in bone to regulate bone mass. Nat Med 17(6):684-91. PubMed: 21602802MGI: J:172746
- DeRouen MC; Zhen H; Tan SH; Williams S; Marinkovich MP; Oro AE. 2010. Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation. BMC Dev Biol 10:112. PubMed: 21067603MGI: J:166772
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- Dobrowolski R; Hertig G; Lechner H; Worsdorfer P; Wulf V; Dicke N; Eckert D; Bauer R; Schorle H; Willecke K. 2009. Loss of connexin43-mediated gap junctional coupling in the mesenchyme of limb buds leads to altered expression of morphogens in mice. Hum Mol Genet 18(15):2899-911. PubMed: 19439426MGI: J:150209
- Dong L; Yu WM; Zheng H; Loh ML; Bunting ST; Pauly M; Huang G; Zhou M; Broxmeyer HE; Scadden DT; Qu CK. 2016. Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment. Nature 539(7628):304-308. PubMed: 27783593MGI: J:239412
- Dong Y; Jesse AM; Kohn A; Gunnell LM; Honjo T; Zuscik MJ; O'Keefe RJ; Hilton MJ. 2010. RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development. Development 137(9):1461-71. PubMed: 20335360MGI: J:159860
- Dubail J; Apte SS. 2015. Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics. Matrix Biol 44-46:24-37. PubMed: 25770910MGI: J:224408
- Dubail J; Aramaki-Hattori N; Bader HL; Nelson CM; Katebi N; Matuska B; Olsen BR; Apte SS. 2014. A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web regression. Genesis 52(7):702-12. PubMed: 24753090MGI: J:213412
- Dudanova I; Kao TJ; Herrmann JE; Zheng B; Kania A; Klein R. 2012. Genetic evidence for a contribution of EphA:ephrinA reverse signaling to motor axon guidance. J Neurosci 32(15):5209-15. PubMed: 22496566MGI: J:184451
- Durland JL; Sferlazzo M; Logan M; Burke AC. 2008. Visualizing the lateral somitic frontier in the Prx1Cre transgenic mouse. J Anat 212(5):590-602. PubMed: 18430087MGI: J:209265
- Dy P; Han Y; Lefebvre V. 2008. Generation of mice harboring a Sox5 conditional null allele. Genesis 46(6):294-9. PubMed: 18543318MGI: J:137217
- Dy P; Smits P; Silvester A; Penzo-Mendez A; Dumitriu B; Han Y; de la Motte CA; Kingsley DM; Lefebvre V. 2010. Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage. Dev Biol 341(2):346-59. PubMed: 20206616MGI: J:160493
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- El Khassawna T; Toben D; Kolanczyk M; Schmidt-Bleek K; Koennecke I; Schell H; Mundlos S; Duda GN. 2012. Deterioration of fracture healing in the mouse model of NF1 long bone dysplasia. Bone 51(4):651-60. PubMed: 22868293MGI: J:193350
- Emechebe U; Kumar P P; Rozenberg JM; Moore B; Firment A; Mirshahi T; Moon AM. 2016. T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number. Elife 5:. PubMed: 27046536MGI: J:232111
- Eshkar-Oren I; Krief S; Ferrara N; Elliott AM; Zelzer E. 2015. Vascular patterning regulates interdigital cell death by a ROS-mediated mechanism. Development 142(4):672-80. PubMed: 25617432MGI: J:218159
- Eshkar-Oren I; Viukov SV; Salameh S; Krief S; Oh CD; Akiyama H; Gerber HP; Ferrara N; Zelzer E. 2009. The forming limb skeleton serves as a signaling center for limb vasculature patterning via regulation of Vegf. Development 136(8):1263-72. PubMed: 19261698MGI: J:147285
- Eyal S; Blitz E; Shwartz Y; Akiyama H; Schweitzer R; Zelzer E. 2015. On the development of the patella. Development 142(10):1831-9. PubMed: 25926361MGI: J:221660
- Fan Y; Bi R; Densmore MJ; Sato T; Kobayashi T; Yuan Q; Zhou X; Erben RG; Lanske B. 2016. Parathyroid hormone 1 receptor is essential to induce FGF23 production and maintain systemic mineral ion homeostasis. FASEB J 30(1):428-40. PubMed: 26428657MGI: J:237599
- Farin HF; Ludtke TH; Schmidt MK; Placzko S; Schuster-Gossler K; Petry M; Christoffels VM; Kispert A. 2013. Tbx2 terminates shh/fgf signaling in the developing mouse limb bud by direct repression of gremlin1. PLoS Genet 9(4):e1003467. PubMed: 23633963MGI: J:200023
- Francis JC; Radtke F; Logan MP. 2005. Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud. Dev Dyn 234(4):1006-15. PubMed: 16245338MGI: J:102852
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- Galli A; Robay D; Osterwalder M; Bao X; Benazet JD; Tariq M; Paro R; Mackem S; Zeller R. 2010. Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development. PLoS Genet 6(4):e1000901. PubMed: 20386744MGI: J:159210
- Gamer LW; Tsuji K; Cox K; Capelo LP; Lowery J; Beppu H; Rosen V. 2011. BMPR-II is dispensable for formation of the limb skeleton. Genesis 49(9):719-24. PubMed: 21538804MGI: J:175737
- Gao Y; Lan Y; Liu H; Jiang R. 2011. The zinc finger transcription factors Osr1 and Osr2 control synovial joint formation. Dev Biol 352(1):83-91. PubMed: 21262216MGI: J:171478
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- Hayata T; Yoichi; Ezura; Asashima M; Nishinakamura R; Noda M. 2015. Dullard/Ctdnep1 Regulates Endochondral Ossification via Suppression of TGF-beta Signaling. J Bone Miner Res 30(2):318-29. PubMed: 25155999MGI: J:218065
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- Hojo H; Ohba S; Taniguchi K; Shirai M; Yano F; Saito T; Ikeda T; Nakajima K; Komiyama Y; Nakagata N; Suzuki K; Mishina Y; Yamada M; Konno T; Takato T; Kawaguchi H; Kambara H; Chung UI. 2013. Hedgehog-Gli activators direct osteo-chondrogenic function of bone morphogenetic protein toward osteogenesis in the perichondrium. J Biol Chem 288(14):9924-32. PubMed: 23423383MGI: J:197832
- Howard PW; Howard TL; Maurer RA. 2010. Generation of mice with a conditional allele for Ift172. Transgenic Res 19(1):121-6. PubMed: 19521792MGI: J:156426
- Hu JK; McGlinn E; Harfe BD; Kardon G; Tabin CJ. 2012. Autonomous and nonautonomous roles of Hedgehog signaling in regulating limb muscle formation. Genes Dev 26(18):2088-102. PubMed: 22987639MGI: J:187741
- Huang AH; Riordan TJ; Pryce B; Weibel JL; Watson SS; Long F; Lefebvre V; Harfe BD; Stadler HS; Akiyama H; Tufa SF; Keene DR; Schweitzer R. 2015. Musculoskeletal integration at the wrist underlies the modular development of limb tendons. Development 142(14):2431-41. PubMed: 26062940MGI: J:224077
- Intini G; Nyman JS. 2015. Dkk1 haploinsufficiency requires expression of Bmp2 for bone anabolic activity. Bone 75:151-60. PubMed: 25603465MGI: J:221974
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