Mice that are homozygous for the mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Screening of third generation mice (G3) identified a fasted 8 week old male (born 12/25/2003) with a plasma HDL level of 97.6 mg/dl, which is approximately 35% higher than controls. HDL levels were 106.9 mg/dl when the mouse was retested one week later. This mutant mouse strain may be useful in studies of hypercholesterolemia.
This phenotypic deviant was identified following multidose ethylnitrosourea (ENU) treatments to induce mutations in male founder C57BL/6J mice (Stock No. 000664) in complex heart, lung, blood, and sleep disorders at the Mouse Heart, Lung, Blood, and Sleep Disorders (HLBS) Center at The Jackson Laboratory.
|Allele Name||heart, lung and blood, 388|
|Allele Type||Chemically induced (ENU)|
|Gene Symbol and Name||hlb388, heart, lung and blood, 388|
|Strain of Origin||C57BL/6J|
|Molecular Note||This mutation was identified in an ENU mutagenesis screen for cardiovascular phenotypes.|