A chromosome substitution or consomic strain is an inbred strain with one of its chromosomes replaced by the homologous chromosome of another inbred strain. Chromosome substitution strain nomenclature is designated as Host Strain - Chromosome #<Donor Strain>/Laboratory code. For example, C57BL/6J-Chr1A/NaJ carries chromosome 1 for strain A/J (A) on a C57BL/6J background, was constructed in the laboratory of Joseph Nadeau (Na) and is maintained at The Jackson Laboratory (J). Chromosome substitution strains or consomic strains can accelerate quantitative trait loci identification and mapping.
Dr. Joseph Nadeau from Case Western Reserve University developed the C57BL/6J-Chr Y129S1/NaJ strain by placing the Y chromosome from the 129S1/SvImJ donor strain into the C57BL/6J host strain using a marker-assisted series of backcrosses (Nadeau et al., 2000). Pseudo-autosomal portions of the Y chromosome were not screened when creating this consomic. The strain was donated to The Jackson Laboratory in 2004.
Currently there are no related genes or alleles for this strain.