Homozygotes display impaired balance by wean age. They lean to one side and have difficulty maintaining an upright position, but are fertile and premature death has not been noted. This is a less severe phenotype than that of targeted null mice.
This mutation arose spontaneously on the C57BL/6J inbred background in 2002 and has been maintained by sibling inbreeding.
|Allele Name||mutation 1, Jackson|
|Gene Symbol and Name||Robo3, roundabout guidance receptor 3|
|Strain of Origin||C57BL/6J|
|Molecular Note||This spontaneous mutation has a single A-to-G transition that results in a change in amino acid 130 from histidine to arginine (p.H130R).|